BrainMap

Mr. Vasile-Sorin Manoiu

PhD

Researcher - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Researcher

Curriculum Vitae (21/07/2021)

Expertise & keywords

Bio-produse dermato-cosmetice pe baza de uleiuri vegetale si fitocomplecsi cu actiune anti-acneica Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1761 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); HOFIGAL EXPORT IMPORT SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://org1.chim.pub.ro/i_lacatusu/PN-II_PCCA_Phytocosmetics_LacatusuI.htm

Abstract:

Worldwide consumers are nowadays interested in using health products that ensure the desired health benefits and in the same time satisfy the required safety aspects. The natural bio-active compounds including vegetable oils and extracts isolated from various local vegetal raw materials may constitute the basis for the development of a large range of safer medical products, by comparing with those obtained from synthetic substances.

The project entitled "Safe bio-cosmeceuticals based on vegetable oils and phytochemicals for acne treatment" (Acronym PHYTO-COSMETIC) has a strong relevance for the “Biotechnology research field” (section 6), thematic area 6.1.1. „Design and development of new drugs with maximum efficiency and minimal secondary effects” and it will be developed by a multidisciplinary consortium between University POLITEHNICA of Bucharest (CO), National Institute of Research and Development for Biological Sciences Bucharest (P1), National Institute for Chemical-Pharmaceutical Research and Development Bucharest (P2) and the co-financing company Hofigal S.A., Bucharest (P3).

The general objective of this proposal is to design and synthesize advanced and functional nanocarrier systems based on vegetable oils (e.g. Hemp oil, Linseed oil, Safﬂower oil, Wheat Germ oil) and co-loaded with selective natural extracts (e.g. Marigold extracts, Carrot extract, Aztec Marigold) and to explore their efficiency in developing safe bio-cosmetic products with multiple cosmetic and dermatological properties. The multiple co-encapsulations into appropriate bio-compatible nanocarriers and the testing of their applicability (with specific in vitro and in vivo tests) represent a significant progress in both research fields – bio-nanotechnology and cosmetic dermatology.

This general objective will be achieved by implementing the following specific objectives proposed for the five Workpackages of the project:

I. Rationale selection of bio-active vegetable oils for design of some bio-compatible lipid nanocarriers able to co-encapsulate phytochemicals.

II. Establishing the optimal synthesis conditions for an efficient co-encapsulation of two kinds of phytochemicals, based on a proper correlation between types of lipid core – surfactants mixture – bio-active vegetable oil.

III. Tailoring the bio-compatible lipid nanocarriers based on vegetable oils as host matrices for obtaining an appropriate sustained release of the natural compounds encountered in phytochemicals.

IV. Demonstrating the ability and functionality of the synthesized bio-compatible lipid nanocarriers co-encapsulated with various vegetable extracts to develop new bio-cosmetic prototypes, by in vitro and in vivo evaluation of the cosmetic and pharmaceutical efficiency.

V. Elaborating of bio-cosmetic prototypes for the treatment of different dermatological disorders.

VI. Implementing two safe and efficient bio-cosmeceutical products with simultaneous anti-acne, anti-inflammatory and anti-oxidant activities, on Romanian market, by research-technology transfer from laboratory to pilot scale.

VII. Elaborating the scientific and economic strategy for implementing on Romanian market.

The research results will lead to the development of 2 advanced bio-cosmetic products that possess a wide range of efficiency due to the high content of natural compounds encountered in the same particle, which can compensate and even improve the specific properties of synthetic drugs with reported side effects.

The whole research developed in this project starts from the complex aspect of bio-nano-technology used for processing local vegetable sources and covers multiple activities that cross through multidisciplinary scientific fields and achieve the target objective of "safe and effective bio-cosmetic products".

Technology for protective biofortification with selenium of cruciferous crops for production of functional food with a constant and sure content of chemopreventives compounds. Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0267 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); TESO SPEC SRL (RO); ECO FRUCT SRL (RO); UNIVERSITATEA "SPIRU HARET" (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/Safesel/index.html

Abstract:

Selenium (Se) is an important element for human and animal nutrition because of its function in a number of physiological processes. Cultivation of the selenium biofortified plants can be an effective way of producing functional foods, which determine benefits to human health.

The project aims to develop a biotechnology of obtaining safe functional food, with an optimal content of chemopreventive compounds, by selenium protective biofortification of cruciferous crops. Biofortification of the food chain through treatments applied to plants (agronomic biofortification) have the advantage of a supplementation with controlled levels of seleno-compounds with a high bioavailability, widely available to different categories of people exposed to risks of chronic diseases. Selenium, (although it is not recognized as an essential trace element for plants) stimulates their growth and plays a role in protecting plants from phytopathogenic agents, oxidative stress and hydro-stress. Treatment of plants with selenium also has an effect of improving the resistance of plants to drought, in which water stress is combined with the oxidative one.

The originality of the project is resulting from the integrated approach, which focus on both safe and effective supplementation with selenium of the food chain, and cruciferous plants protection against abiotic stress (lack of water, high temperature, excessive solar radiation) and biotic stress (pests and diseases).

The project proposes the development and application of some products as new inputs in the selenium protective biofortification of cruciferous plants, by which to re-balance the sulfur metabolism, maintaining the formation of the optimal level of chemopreventive selenocompounds.

The project objectives are: development of new means of technological intervention (spraying adjuvants, products with controlled release of betaine, nitric oxide inductors in plant tissues), testing and identifying the best solutions for the integration of new technological means of intervention in cruciferous crop technology, proving the character of safe functional food.

The main activities foreseen to be achieved in the project are: obtaining and testing of spraying adjuvants and betaine-based products, obtaining and testing inducers of nitric oxide in plant tissues; simultaneous application of new inputs and treatments with selenium; integrating new technologies of biofortification with sustainable cruciferous cultivation practices; development and validation of 3R tests to prove the functional food character; results dissemination and exploitation.

The end products of the project are: (i) a technology for biofortification of cruciferous crops, which includes new innovative products / agricultural inputs, intended to maximize the protective effects of selenium and accumulation of chemopreventive selenocompounds constant levels, and methods of their application; (ii) selenium biofortified functional foods, affordable, with reproducible biological effects and maximum safety for human health.

The expected result following the practical implementation of this project is a safe, effective and affordable way of food chain selenium supplementation.

The project is proposed to be achieved within an interdisciplinary consortium including partners with complementary and synergistic role: a national research and development institute (NIRDBS), an university (USH), and two SMEs (Teso Spec and Ecofruct). Partners representing all disciplines have the necessary infrastructure for the development of biofortification protective technologies with selenium of cruciferous crops and for characterization of the resulted vegetable products as safe and efficient functional foods.

Antimicrobial bionanocomposites for medical applications Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-0979 2012 - 2016

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); I.C.P.E. BISTRITA S.A. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.icmpp.ro/intranet/grant_files/bionanomed/

Abstract:

BIONANOMED project aims both to obtain a new class of advanced materials, BIONANOCOMPOSITES based on mixtures of synthetic polymers with natural polymers, optimized with silver nanoparticles (antiallergenic effect), as well as the establishment of their processing technologies to obtain biocompatible, biodegradable, antimicrobial medical devices. In this context, our objectives are: bioactivation of biodegradable synthetic polymers (based on novel modified PLA, PVA, PU polymers synthetized during project development) with natural polymers (chitosan, starch, cellulose, elastin, chondroitin sulfate, hyaluronic acid) to increase their biocompatibility; obtaining silver nanoparticles with controlled sizes; optimization of bionanocomposites containing natural/synthetic polymers by imprinting antimicrobial properties; their physico-chemical and biological characterization to establish their domain of use; development of a technology for obtaining a biodegradable medical device with antimicrobial properties:"urinary drainage tube”-UDT. The selected natural polymers possess properties like biocompatibility, antimicrobial, hemostatic, fungistatic activity, have reactive hydroxyl groups available for further modification to impart required characteristics, are safe, non-toxic, exhibit regenerative effect on connective tissue, which are necessary to achieve the final purpose. New biological methods will be developed for in-depth characterization of new biomaterials which will assure their safe implementation in industrial and medical practice.

Based on optimized formulations and laboratory technology elaborated by research groups and also proved experience in obtaining traditional plastic medical devices, SME co-financing the project will realize the medical device – UDT which will be tested, packed and sterilized according to existing requirements for such products (Directive 93/42 CEE) and finally implemented in their production leading to diversify it, increased jobs and benefits

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects