BrainMap

Mr. Vasile Iulian Antoniac

Professor

Professor - UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI

Teaching staff

Prof.Dr. Habil. Vasile Iulian Antoniac obtained his M.E., Ph.D. and Postdoc degrees in Materials Science at the National University of Science and Technology, POLITEHNICA Bucharest, Romania. During his career, he brings major contribution related to the biodegradable magnesium alloys, bioceramics and composite coatings, innovative metallic implants, retrieval implant analysis. He published more than 200 papers (h-index ISI 30; Scopus 33; Google Scholar 36) and give more than 60 lectures as plenary invited or keynote speaker at conferences. Professor Iulian Antoniac have achieved in 2023 the feat of ranking in the top 2% of the world’s most cited scientists according to the latest ELSEVIER report. Also, he was elected in 2023 as Fellow of Biomaterials Science and Engineering (FBSE), by the International Union of Societies for Biomaterials Science and Engineering (IUSBSE) for his excellent professional standing and high achievements in the field of Biomaterials Science and Engineering.

Web of Science ResearcherID: https://www.webofscience.com/wos/author/record/D-4802-2014

Curriculum Vitae (10/05/2024)

Expertise & keywords

Meta-structures made by composite coatings on biodegradable Mg-Ca implants for bone regeneration Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2591 2021 - 2023

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO)

Affiliation:

Project website: http://www.smmmf.pub.ro/magicbone/

Abstract:

Main objective of the project is the development of one composite coatings with polymer-based (cellulose acetate, collagen, polylactic acid or chitosan) reinforced with Mg and Mg-substituted hydroxyapatite particles, for biodegradable implants made by Mg-Ca alloy, followed by in vitro cell based tests for evaluating biocompatibility and osseointegration activity. Obtained coated implants will be characterized not just from structural and morphological point of view, but also for mechanical properties and surface properties. Several specific tests for evaluation of the osseointegration will be performed, like study of coating hydrolysis at physiological pH, degradation compounds, flows and proteins retention. After the chosen of best coating material for osseointegration, a commission constituted by independent experts will validate the proposed experimental model. The project objectives are totally feasible, due to the previous experience and results obtained by the project leader and his research team, as well as the equipment available for synthesis, characterization and testing. The project results will be innovative and relevant in relation to the national and international state of the art because the final composite coatings is a new solution from materials point of view, and new coated biodegradable implant will have a better osseointegration, controlled biodegradability and proper mechanical properties during degradation process, like a magic bone (MAGICBONE).

Improving the management of bedsores by using efficient wound dressings with plant extracts Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-5236 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); HOFIGAL EXPORT IMPORT SA (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.smmmf.pub.ro/research/projects/biocure

Abstract:

The project addresses a topic which is very modern and actual at national and international level in the field of biomaterials used as drug delivery systems, namely the bedsores type wound management. These wounds have a high and growing importance in the recent years, being one of the mortality main causes associated with immobility in case of paralyzed, comatose or restrained patients, very high costs being involved for treating bedsore complications and consequences. For this purpose, the project proposes the development of intelligent biopatches as concrete and convenient solution for the topical treatment of bedsores, avoiding in this way the affected area debridement or surgical interventions on larger areas. The BIOCURE wound dressing, object of this research, consists of a protective liner, baking layer, adhesive system and drug and essential oils encapsulated release support, the drug and essential oils being released in a controlled manner directly at cutaneous wound level in order to maintain all time a constant concentration on wound. As biodegradable polymers for loading antibiotic drugs and microcapsules of essential oils we will use some compositions of collagen, poloxamer, alginate, to offer an adequate support for drug release. The essential oils will be encapsulated within dendritic polymers like β-cyclodextrins. In the frame of this project, we will develop a classical acrylic adhesives and a new advanced adhesive from the categories of soft silicone adhesives which will be used in the development of the substrate-adhesive component of the biopatches. The biopatches prototypes obtained within this project will include both the component biopolymer support for and essential oils encapsulated, having optimal release characteristics in relation with the application site and therapeutical indication, and also the substrate-adhesive component biocompatible and adequate for application in cutaneous wounds like bedsores.

Smart materials for medical applications Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0407 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: https://intelmatupb.wixsite.com/intelmat

Abstract:

INTELMAT project represents advanced research in the field of synthesis and application of smart materials for medical engineering in order to solve essential features of some acute/chronic diseases of large occurrence. 5 thematic directions are taking into consideration: 1. Developing of a controlled-release system of complex micro-colloidal architectures based on bacterial cellulose and hydrogels used for management of chronically wounds which aims to overcome the limitations of classical treatments; 2. Developing of new biomaterials specially designed with targeted action for treatment of inflammatory diseases of gastrointestinal segment; 3. Synthesis of new generation of composite membrane materials for artificial kidneys based on biocompatible polymers and derivative graphene; 4. Developing of some auto-assembly 3D platforms with controlled-released drugs based on polymeric nanoparticles and composite nanogels for the therapy of colon-rectal cancer; 5. Developing of innovative technologies for the synthesis of some 1D nano-architectures (nanowires) with controlled morphology, with applications in producing of non-enzimatic electrochemical biosensors.

OBTAINING AND EXPERTISE OF NEW BIOCOMPATIBLE MATERIALS FOR MEDICAL APPLICATIONS Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0239 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Project partners: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO); UNIVERSITATEA PENTRU STIINŢELE VIEŢII "ION IONESCU DE LA BRAD" DIN IAŞI (RO); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); UNIVERSITATEA "DUNAREA DE JOS" (RO); UNIVERSITATEA DE MEDICINA, FARMACIE, STIINTE SI TEHNOLOGIE ”GEORGE EMIL PALADE” DIN TARGU MURES (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU FIZICA TEHNICA-IFT IASI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU INGINERIE ELECTRICA ICPE - CA BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.medicalmetmat.tuiasi.ro/

Abstract:

The Complex Project "OBTAINING AND EXPERTISE OF NEW BIOCOMPATIBLE MATERIALS FOR MEDICAL APPLICATIONS" - MedicalMetMat, is proposed by a consortium of 10 partners, coordinated by Technical Univ."Gh. Asachi" of Iasi. It is a complementary and interdisciplinary scientific consortium of specialists from 2 technical universities (TUIASI and UPBucharest), 2 medicine universities (UMF Iasi, UMF Tg Mures), a veterinary medicine university (USAMV Iaşi), UAIC Iasi and UDJG Galati universities and as well 3 R&D institutes with possibilities for economic recovery (IFT Iasi, INOE Magurele and ICPE-CA). The consortium proposes the realization of 5 research projects, 4 focusing on the production and expertise of metallic biomaterials for various medical applications (biodegradable materials for orthopedics-Pr1-ORTOMAG, biomaterials for medical prosthesis-Pr2-BioTIT, biomaterials for dental applications-Pr3-BIODENTRUT and biocompatible alloys with high entropy for medical applications-Pr4-HEAMED). These projects provided production stages, structural/physico-chemical/mechanical analyses performed by specialists from technical universities and research institutes; In vitro cell viability tests, conducted by specialists from the medicine universities and in vivo determinations (veterinary specialists) by osseointegration study and the resorption rate by animal experimental model, which will conduct to the expertise and approval of these metallic materials for the manufacturing of medical applications. Project Pr5-SOLION presents methods for increasing biocompatibility for the obtained biomaterials in the previous 4 projects, through specific coatings and aerosols systems.

Results dissemination of the Complex Project is aimed to patenting and recommending for the approval of optimal compositions, for implementation in the economic/medical environment and preparation of technology transfer to producers and beneficiaries in the field of production and distribution of medical devices.

SOL-2020-2 5. The development of innovative decontamination solutions against SARS-CoV-2 virus (surfaces, equipments, close and open spaces) Call name: P 2 - SP 2.1 - Soluţii - 2020 - 2
PN-III-P2-2.1-SOL-2020-2-0399 2020 - 2020

Role in this project:

Coordinating institution: Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie

Project partners: Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNITATEA MILITARA 02433 BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); SPITALUL UNIVERSITAR DE URGENTA BUCURESTI (RO); STIMPEX S.A. (RO)

Affiliation:

Project website: https://www.nbce.ro/?page_id=895

Abstract:

The project's scope consist in the development of an innovative decontamination solution, with antimicrobial and antiviruses effects, using a mixture of quaternary ammonium salts and gold or silver nanoparticles as active compounds, and also the development of a complex system for solution dispersion.

Biogenic Inks combining marine collagen and ionic-doped calcium phosphates for bone tissue engineering Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-M-ERA.NET II-BiogenInk 2017 - 2020

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.biogenink.eu

Abstract:

BiogenInk aims the development of bioinspired and bioresorbable inks for additive manufacturing, composed of marine collagen and ionic-doped calcium phosphates, as building blocks for the production of advanced scaffolds towards bone regeneration, promoting innovation in health sector, mainly on orthopaedic therapies. It is pretended to establish a sustainable and eco-friendly raw materials pipeline, including the production of a novel biological collagen crosslinker from a combined bioremediation strategy, which specific formulations mimics bone tissue composition. These printing materials will be further used to develop functional scaffolds, based in real clinical cases, recapitulating the complexity of bone structures obtained through a reverse engineering approach. A simple and standardized procedure from acquisition of imaging data to the production of patient case-specific biomaterials by 3D printing will be established, with potential to be successfully translated into clinics.

Composite scaffolds with biological functions for bone tissue engineering Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-China (bilaterale)
PN-III-P3-3.1-PM-RO-CN-2018-0201 2018 - 2019

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); National Engineering Research Center for Biomaterials (CN)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.biobone.srb.ro

Abstract:

BIOBONE aims the development of bioinspired and bioresorbable scaffolds, composed by biodegradable magnesium alloys as substrate combined with bioceramic coating granted biological functions, as building blocks for the production of advanced scaffolds towards bone regeneration, promoting innovation in health sector, mainly on orthopaedic therapies. It is pretended to establish a sustainable and eco-friendly raw materials pipeline, including the production of a novel biological scaffolds, which specific formulations mimics bone tissue composition. Advanced biomaterials and technologies will be further used to develop functional scaffolds, based in real clinical cases, recapitulating the complexity of bone structures obtained through a reverse engineering approach. A simple and standardized procedure from acquisition of imaging data to the production of patient case-specific biomaterials by 3D printing will be established, with potential to be successfully translated into clinics.

Composite scaffolds with biological functions for bone tissue engineering Call name:
PN-III-P3-3.1-PM-RO-CN-2018-0201 2017 - 2018

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); National Engineering Research Center for Biomaterials, Sichuan University (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website:

Abstract:

BIOBONE urmărește dezvoltarea scaffold-urilor compozite cu funcții

biologice pentru inginerie tisulară osoasă, bazate pe biomateriale

avansate, compuse din aliaje de magneziu biodegradabile combinate

cu acoperiri bioceramice cu funcții biologice, utilizabile ca blocuri

pentru producerea de scaffold-uri în vederea regenerării osoase,

promovând inovația în sectorul sănătății, în special în terapiile

ortopedice. Se va creea un flux de materii prime durabile și ecologice,

inclusiv producerea de scaffold-uri avansate cu funcții biologice,

avand compoziții specifice care imită compoziția țesutului osos.

Biomateriale și technologii avansate vor fi utilizate pentru a dezvolta

suporturi funcționale, bazate pe cazuri clinice reale, refăcandu-se

complexitatea structurilor osoase obținute printr-o abordare inginerie

inversă. Se va stabili o procedură simplă și standardizată de la

achiziționarea de date imagistice la producția de biomateriale

specifice pacientului prin imprimare 3D, cu potențialul de a fi

translate cu succes în clinici.

CBECIMAT 2018 Mobility Project Call name:
PN-III-P1-1.1-MC2018-0615 2018 - 2018

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website:

Abstract:

Mobility project for participation as invited speaker at the conference CBECIMAT 2018, organized in Foz do Iguazu, Brasil.

Nanoencapsulated eugenol advanced compounds with addressability in dental medicine Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0455 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); TITUS & SONS SRL (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.umft.ro/pniiip221bg20160455_519

Abstract:

The aim of the present project proposal is to increase the performance and competitivity of S.C TITUS&SONS S.R.L using the expertise and technology existent in the University of Medicine and Pharmacy Victor Babes Timisoara and Politehnica University of Bucharest. The success of the present project proposal is guaranteed by the team who is comprised by members with national and international research expertise. They will be involved in the research activities, as well in the data analysis, validation, and improvement of the S.C TITUS&SONS S.R.L products, the final endpoint being the increase of their competitivity and quality. The specific objectives of the project are: 1. The manufacture of new compounds starting from the original formula of the company product with the addition of nanoencapsulated eugenol. 2. Evaluation of the in vitro effects of these novel compounds on primary normal human oral keratinocytes - NHOK and tumor line cells of oral squamous cancer - SCC-4. 3. Evaluation of bioenergetic profile of normal and tumor cells treated with these compounds. 4. Evaluation of the in vivo effects on SKH-1 animal models of these novel compounds with histopathologic analysis. 5. The assessment of physical-chemical parameters. 6. Interconnection of informations from chemical, biological, physical, and informatics point of view

SPECTRAL TECHNOLOGY FOR ADVANCED SECURING OF THE DOCUMENTS Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0338 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); OPTOELECTRONICA - 2001 S.A. (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.ecomet.pub.ro/cercetare/proiecte/specsedo/

Abstract:

Project context. The document falsification practice affects over 80% of significant companies, that implies financial damages evaluated at more than 7% gross world product.

Strategy. Optoelectronics 2001 SA, Romanian leader in optoelectronic security, has adopted the strategy of putting high-tech equipments on the market for original document protecting and to detect forgeries in accordance with an effective marketing policy.

Project necessity. The beneficiary expertise in the field of fluorescence spectroscopy,analytical spectrometry and complex characterization of the security markers is poor and it requires the transfer of expertise from Materials Science and Engineering Faculty (UPB-SIM)

Director objective. Increasing the performance and competitiveness of the Optoelectronics 2001 SA using the existing experience in UPB-SIM to develop a technology based on selective fluorescence markers that will be very difficult to be countered by counterfeiters.

Project structure. The project will be developed in4 stages over a period of 24 months (4 + 6 + 6 + 8) with 30 activities (6 + 8 + 9 + 7). The project budget is 460,000 lei, of which 362 317 lei personal expenses, 7103 lei logistics and 90 579lei overheads.

Contractor expertise. In the project are involved 8 internationally recognized specialists as experts in spectrometry, diffractometry and morpho-structural characterization of the materials. The team has published over 100 books and articles that demonstrate expertise in question.

Successful premises. There is a powerful infrastructure (FTIR, XRFS, XRD, AAS, SEM, TEM, OM) for markers complete characterization which is compatible or complementary to the beneficiary infrastructure. The laboratories competence is proven by RENAR accreditation. The Project Director has successfully managed other 5 research projects.Research failure risk. The risk of failure in research due to the contracting parties has not been identified. Only majeure force may be considered.

Biodegradable Implants from Magnesium Alloys used in Foot and Ankle Surgery Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-2267 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); MEDICAL ORTOVIT S.R.L. (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.biomagia.eu

Abstract:

The field of medical materials is very important into the general frame of materials science. The advanced technologies from engineering and medicine developed in the last years, associated with the society demand related to the better daily life conditions and returning to work after some trauma followed by the bone fracture make this field to be a dynamic one. As a consequence, many new materials and implantable medical devices were developed recently and the tendency is to continue those efforts using an interdisciplinary approach based on the knowledge and skill from different field like materials science, physics, biology and medicine.

Also, there is a need in healthcare for cost-efficient treatments, including those for implantable devices for orthopaedic surgery. Foot & ankle surgery is an emerging direction of the orthopaedic surgery and the number of patients who need this kind of surgical intervention is higher. At this moment, is clearly an intensive trend in orthopaedic surgery to use the bioresorbable implants for trauma surgery, but for the foot & ankle surgery the resorbable trauma implants made by polymeric (PLLA) or composite materials (PLLA reinforced with TCP or Hap) didn’t show the clinical advantage because the implants didn’t have a necessary mechanical properties and their degradation rate is much faster than the healing of bone fracture. Magnesium alloys are strong candidates for obtaining biodegradable implants who require better mechanical properties, biocompatibility and slow degradation rates. The consortium that made the BIOMAGIA project proposal is interdisciplinary and comprises a university, two research institutes and two companies. The partners are one of the best research groups in their field (UPB-materials science/biomaterials; INOE200-physics/coatings; IBPC-biology/biocompatibility testing; R&D-materials industry/casting, processing metallic materials; MOV-medical devices industry/medicine, instruments and implants for orthopaedic surgery), with strong skills, capacities, and who were involved in many national and international projects. BIOMAGIA will contribute to the major demand for intelligent biomaterials and smart implants in orthopaedic surgery which are resorbed by the body upon remodelling the bone tissue by the development of new aluminium free magnesium implant materials with tailored properties specific for a biodegradable implant used in foot and ankle surgery. To reach this goal, carefully selected materials and processing routes will be combined with a comprehensive research to elucidate the correlation between magnesium alloys chemical composition, microstructural aspects and processing techniques, surface modifications, related to the corrosion processes in vitro and in vivo who modulate the degradation rate, hydrogen release, and implant resorbtion. The project members are confident that based on their skills and previous results will be able to pass the current barriers like the absence of specific commercial magnesium alloys tailored for orthopaedics applications, the manufacturing technology and the lacking scientific knowledge about the degradation rate based on the corrosion mechanism, hydrogen release and toxicity. The ultimate goal of the project will be a prototype implant for foot & ankle surgery with a new design based on the achievements in this consortium, which brings together leading scientists from various research fields: material scientists and mechanical engineers, physician and experts in surface engineering, biologist and medical scientists. BIOMAGIA collectively covers basically all aspects, the instrumental techniques and approaches necessary to tackle successfully the challenge to understand, and ultimately control, interactions at the material-bone interface. The full achievements of this research are gained because we cover the full value chain from fundamental engineering research towards hospitals and in vivo studies and implant production.

Multifunctional coatings for load bearing implants made of a novel titanium-based alloy Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1958 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); TEHNOMED IMPEX CO S.A. (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.osseopromote.inoe.ro./

Abstract:

The actual challenge in the orthopaedic surgery is to obtain orthopaedic implants with good mechanical, physical, chemical and surface compatibility with the bone. But the difficulties are remarkable, because these characteristics fail in time and, in general, it is difficult for a single material to have all the required properties.

The main goal of the present project is to give innovative solutions to increase the service life of load bearing implants by:

- Preparation in a levitation melting furnace of a novel type of alloy consisting of only biocompatible elements (Ti, Zr, Nb), in order to replace Ti6Al4V, the most popular alloy in the present, but which consists of elements (Al, V) causing cytotoxic and allergic reactions. The novel alloy is I nsystem Ti-Zr-Nb. It is expected that an optimum Nb content in the alloy composition will be found, for achieving a Young’s modulus close to that of the bone, which was an important target for the researchers in the last two decades.

- Preparation of novel types of osteoconductive coatings, by magnetron sputtering method, as follows:

• osteoconductive coatings in mono (type 1) and bilayer (type 2) structures, in order to enhance the osteoconductive capability of the TiZr30Nbx alloy:

˗ type 1: MeC+IA (Me-metal, C-carbon, IA-inorganic additive), by addition in the MeC film composition (Me = Ti, Zr, Nb) of small amounts of various IA (Ca3(PO4)2, TiSi);

˗ type 2: MeC/(IA + TiO2), where IA is Ca3(PO4)2 and MeC is the bottom layer and (IA+TiO2) is the top layer. It is expected that such structures will reveal an optimum combination of the coating microhardness, adhesion, residual stress, toughness, friction, corrosion-wear resistance, osteoconduction and biocompatibility. The MeC films are produced to enhance the adhesion of the osteoconductive coatings to metallic substrates, because the films consist of elements which are found in the bioalloy composition.

• use of a complex magnetron set-up, containing a high vacuum system and equipped with 5 different cathodes made of pure metallic or alloyed targets, able to work simultaneously or alternatively.

Magnetic biomimetic scaffods as alternative strategy for bone tissue repair and engineering Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-2287 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "GR. TH. POPA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "GR. TH. POPA" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA "ION IONESCU DE LA BRAD" (RO); VODIMEDICOR S.R.L. (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.umfiasi.ro/Cercetare/sr/Projects/Pages/132.aspx

Abstract:

Strategies for developing of new alternative therapies are necessary due to the complications and limitations associated with the current bone grafts substitutes. The using of biodegradable scaffolds in tissue engineering is constantly increasing since such biomaterials have become fundamental tools to help the body rebuild damaged or diseased tissues. The benefit of using a biodegradable scaffold consists in the capacity of the tissue to completely heal itself without remaining foreign entities. In some cases, the drug pre-loading techniques reduce the delivery of localized, controllable and long-term biochemical stimuli, thus impairing the tissue regeneration potential in the scaffold. Additional, in some diseases with degeneration risk (bone tumours) after bone tumour resection, only few available bone reconstruction and substitution material can be used as chemotherapeutics carriers. Therefore, it is impetuous to find multifunctional bone reconstructive scaffolds for bone tumour therapy. In this context the main concept of the project is to develop magnetic scaffolds via biomimetic methods as alternative for actual regenerative medicine for bone repair. The new therapy involves the use of magnetic scaffolds as guiding matrix for circulator magnetic nanoparticles which are functionalized with growth factors, drugs or other bio-agents. Once in the magnetic scaffold, the magnetic carriers successively release the bio-agents that they are transporting, so that the bio-agents can be taken up by the tissue during the regeneration process. The released bio-agents have indisputable roles in the facilitation of osteoblast proliferation, differentiation and subsequent bone formation and regulation. Additional, chemotherapeutical drugs can be loaded and targeted to the magnetic scaffold via magnetic field.The general objectives of the project are: (G1) Development of high added value in bone scaffolding (magnetic biomimetic composites as guiding matrix for osteoiductive bio-actives and chemical agents, with natural bone – like morphology and properties) (scientific impact); (G2) Promoting of a manufacturing technology for a magnetic osteoinductive scaffold that will be subsequently used as bone substitute (technological impact); (G3) Increasing the competitiveness and creativeness by stimulation of the young researchers in conceptual thought and their training in methods of scientific and technological research (long-term educational impact); (G4)The development of new therapy based on solutions that integrate materials engineering and biological processes and medical approach (economical impact); (G5) Increasing the qualification of human resources by stimulation of professional training on the new advanced therapies, bio-inspired technologies, bio-characterization, biomaterials processing and analysis of new advanced medical devices (social impact).

The MAGBIOTISS consortium comprises 5 partners from 3 different domains (academic, university, 1 partner from industry medium) which have agreed to launch in this project. Furthermore, the partnership reflects a combination of fundamental and applicative research as practiced in academia and of pragmatic engineering technology and new therapy development as represented by the industrial partner. Since MAGBIOTISS is strongly connected to health – new therapies - regenerative medicine and novel therapies based on medical devices (new magnetic guiding scaffolds), it is anticipated that MAGBIOTISS will contribute to growth in modern therapies by direct or indirect effects via developing the following activities: - Methods and protocols for testing of new magnetic biomimetic scaffolds and scientific data to support this methodology. - Strategies for new therapeutic applications and prototypes/examples of guiding scaffolds for the safe regeneration of the bone. - Development and safe production of the new bioactive-loaded magnetic scaffolds.

Innovative and ecological technology for the recovery of nonferrous metals from electrical and electronic equipment wastes (WEEE) using microwaves energy Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0681 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU METALE NEFEROASE SI RARE - IMNR

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU METALE NEFEROASE SI RARE - IMNR (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); CLAUDIU TOPROM SRL (RO); CP MED LABORATORY SRL (RO)

Affiliation: CLAUDIU TOPROM SRL (RO)

Project website: http://www.ecomicrorec.imnr.ro

Abstract:

The major objective of the project is the development of an innovative technology and of a new installation, for the ecological processing of WEEEs in microwave field. The method is applied for the first time in Romania, and the implementation in the economy will have a considerable impact on reducing the environment pollution, increasing the degree of WEEE contained nonferrous metals recovery and their reintroduction in the economic cycle. The project theme integrates in PCCA 2013 domain 3 themes 3.2.3 Technologies for disassembling complex products and revaluing component subassemblies. The project addresses the key issue in the field of environment protection: reducing pollution and activities harmful for human health by decreasing the WEEE quantity, developing innovative technologies for reintroduction in the economic cycle of important sources of nonferrous metals and diminishing CO2 emissions. The project responds to PCCA 2013 objectives by: ►consortium constitution (one prestigious university, 2 national research institutes and 2 economic agents, one specialized in microwave applications) and joint performing of research activities →objective Stimulation of research-development activity performed in partnership ►developing advanced technologies in environment ecologization by innovative processes for WEEE processing in microwave field →objective Connecting applicative research to the requirements of the economic environment by developing advanced products and technologies ►the significant co-financing of the research expenditures and active SME involvement → objective Growth stimulation of private sector expenditures in research-development ► the acquisition of efficient equipment and the integration of young PhD students in the work groups contributes to the objective Developing the infrastructure and the competencies of the human resources. The major scientific and technological objectives of the project are: i. developing the process of WEEE melting and treatment of resulting gases in microwave field ii. hydrometallurgical and electrochemical separation of the metals in the multicomponent alloy resulting from melting by: soluble anode electrolysis, acid and alkaline solutions electrodeposition, ionic liquid extraction iii. improvement of WEEE processing in microwave field iv. innovative technology for ecological WEEE processing v. demonstration and validation of the new installation. The novelty and originality of the project consist in: a. WEEE melting in microwave field and complete separation of the metallic fraction b. treatment system for gases resulting from WEEE melting by thermal oxidation in microwave field of harmful compounds and transformation in nonpolluting compounds, not applied in Romania c. complete selective separation of metals in the multicomponent alloy resulting from melting, by modern methods: chemical, electrochemical and ionic liquids. The main project results are: ●innovative and ecological technology for WEEE processing in microwave field ●innovative installation for ecological WEEE processing (including gas treatment system in microwave field) ●patent applications ●dissemination by ISI indexed articles, conferences, workshops, seminaries. Project impact/potential benefits: ►strengthening the cooperation between research organizations and economic agents ► research infrastructure development and increasing the institutional capacity of the partners for participation in national and international RD projects► increasing SME competitivity by developing advanced technologies for ecological WEEE processing and increasing the turnover by 5-10%► patent exploitation► social impact by increasing life and environment quality, creation of 3 jobs► environment impact: ecological technologies for WEEE processing, recycling contained metals, decreasing energy consumption by 30%.

Intelligent colaborative online platform for design and manufacturing personalized guides in orthopedic surgery Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0251 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); SPITALUL CLINIC "COLENTINA" BUCURESTI (RO); OSF GLOBAL SERVICES SRL (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://poigo.osf-demo.com/

Abstract:

The approach of using surgical guides based on patient specific data enrolls in the current trend of personalized medicine in which the focus is on individuals by tailoring the medical interventions according to their characteristics and needs. The need of patient specific surgical instruments can arise from routine activities – in order to ease/simplify certain procedures or to improve performances – or be determined by new and complicated procedures, for situations not encountered before, leading to important decrease of operation time and help to avoid complications. In orthopedic applications, patient-specific guides can exactly match patient bone structures, materializing the planned trajectory for drilling, tapping, cutting or aligning. Therefore, their use improve the accuracy of different procedure (e.g. for trauma surgery as inserting pedicle screws in vertebrae, knee or hip, for inserting plates for osteotomies around the knee or applying guides for different steps in arthroplasty, etc.), helping the surgeons to better orient during intervention, decreasing the surgery time, costs and risks of infections and reduce x-ray radiation exposure during surgery.

Currently, the processes of designing and manufacturing patient specific instruments and guides are hampered by the difficulty to quantify and to translate the surgeon requirements in terms of design/manufacturing specifications, in the context of a complicated communication between physician and engineer. Thus, there is a need of bridging the gap between surgeons’ ideas and needs and their practical materialization in new medical tools. Surgeon-engineer cooperation and information sharing for correctly establishing the correspondence between requirements and design, material and manufacturing issues is mandatory for all the process steps, the use of intelligent decision support systems representing the best solution for overcoming the miscommunication problems and ensuring a degree of automation to a design process which otherwise has to be totally resumed for each patient/clinical case.

In this context, the project proposes the development of an e-health platform which provides, in a collaborative environment, all the necessary knowledge and computer-aided tools for translating the surgeons’ needs in technical specifications required for the design and manufacturing of patient specific guides for orthopedic surgery.

The surgical needs are structured using different sets of questions adapted to the intervention type. The answers to these questionnaires will support capturing design intents, as correctly and complete as possible. In this purpose, an inference engine is developed and implemented in the platform. Rules which corroborate medical knowledge and design, material and manufacturing specifications are set in order to be used as input for the inference engine. Moreover, the platform integrates communication tools between surgeon and engineer, needed to solve different situations such as conflicting criteria or eliminate unfeasible designs from early stages. These tools are specific to web communication, but include also a 3D viewer which offers the possibility to visualize the guides’ designs, measure some geometrical features, etc., offering visual aids for collaborative virtual design.

Thus, the design/manufacturing workflow uses as input the patient CT/MRI data, clinical principles, current practices and available evidence incorporated in a medical knowledge database, questionnaires answers, and supplementary information provided through the conversation surgeon-engineer – all these in a “visible” manner using the platform interface, while the design process itself uses and integrates specific knowledge and tools for medical and mechanical modeling. The manufacturing specifications (material, process, surface quality, accuracy etc.) are also deployed from the surgeons input and are adapted based on the surgical specificity and patient characteristics.

New molecularly imprinted polymers (MIPs) developed for the sensitive and fast analysis of nitrofuran based antibiotics Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0203 2014 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); COSFEL ACTUAL S.R.L. (RO); CP MED LABORATORY SRL (RO)

Affiliation: COSFEL ACTUAL S.R.L. (RO)

Project website: http://www.chimie.unibuc.ro/cercetare/analitica/proiect%20197_2014%20Victor%20David.pdf

Abstract:

The objectives of this project are the synthesis of two molecularly imprinted polymers (MIPs) and their use for the development of two analytical methods for the detection of nitrofuran based drugs/metabolites. The illegal use of nitrofuran based drugs (furazolidone, furaltadone, nitrofurantoin, nitrofurazone, etc.) by the livestock industry as growth promoters leads to the apparition of new dangerous bacteria strains that are resistant to antibiotic and produces dangerous metabolites that remain for a long time in meat. The EU regulations impose the control of biological relevant samples collected from living animals (urine, blood), meat from slaughter houses or traders and prepared foods. The current analysis techniques are long and expensive due to complexity of the sample matrix and low concentration of the analytes. The two MIPs synthesized in this project will be used in two different analytical applications: (1) the development of affinity based sensors and (2) for sample pre-treatment by solid phase extraction (SPE) before chromatographic analysis. The sensors will be used for rapid screening of biological samples and constructed by the immobilization of the MIPs on a transducer and detection using an appropriate detection technique like electrochemical impedance spectroscopy (EIS) or quartz crystal microbalance (QCM). The main advantages of the sample pre-treatment with MIPs in chromatographic analysis are analyte isolation and concentration from complex matrices. Due to the high polarity and low detectability in UV-VIs absorption, the project will be focused also on derivatization of chosen analytes in order to enhance their hydrophobicity and fluorescence labeling. This procedure is carried out after extraction of analytes from samples by means of MIPs. The project is industrial driven and the consortium will take important steps in order to prepare a successful commercialization of the developed MIPs such as: (1) the MIPs development and optimization at laboratory scale will take into account not only the analytical performances, but also the requirements to adapt the synthesis to the industrial mass production, (2) the production of the developed MIPs will be tested at industrial scale level by the SME that will continue the post-project production and (3) the developed MIPs will be thoroughly tested by a laboratory specialized in analytical services in order to evaluate the fulfillment of end-user needs.

Biocompatible coatings for enhanced bond strength of ceramic to metal in dental restorations Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1240 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GR. TH. POPA" (RO); DIPADENT GROUP SRL (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.coat4dent.eu

Abstract:

The main scientific objective of this project is to obtain a new variety of high bond nanostructured coatings, based on nc-MeN/a-Si3N4 and nc-MeON/a-Si3N4 nanocomposites (nc-nanocrystalline, a-amorphous, Me – metal (Ti, Zr, Cr or Al), N – nitrogen, O - oxygen), in mono, multilayered and graded structures, with good hardness, high adhesion to metallic and ceramic substrates, low internal stress, high resistance against wear, corrosion and oxidation, high fracture toughness, good biocompatibility to tooth and to oral environment.

In the present project we propose to enhance bond strength of ceramic to metal in dental restorations by inserting novel biocompatible nanocomposite coatings between the metal and ceramics, by means of the cathodic arc technique:

- nanocomposite single layer coatings (nc – MeSiN or nc – MeSiON), where Me is Ti, Zr, Cr or Al,

- nanocomposite mutilayer coatings (nc – MeSiN/MeN and nc – MeSiON /MeN),

- nanocomposite graded MeN/MeSiN/MeSiON coatings.

The scientific expectation is that such coatings enhance the adhesion of ceramic to metallic substrates (NiCr or CoCr alloys), leading to longer service life of the dental restoration. Also, the proposed coatings would effectively prevent the adverse oxidation of NiCr and CoCr alloys and would ensure good biocompatibility in oral environment, having colours close to natural teeth. The great challenges of the project are to obtain a high bond of ceramic to metal and dental restorations with color closed to natural teeth.

23rd Brazilian Materials Science and Engineering Congress Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2018-0615 2018 -

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website:

Abstract:

project title Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru tineri cercetători din diaspora
PN-III-P1-1.1-MCT-2017-0047 2017 -

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website:

Abstract:

Call name: Premierea obtinerii atestatului de abilitare - Competitia 2015
PN-II-RU-ABIL-2015-2-0192 2015 -

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website:

Abstract:

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