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Romania
Citizenship:
Romania
Ph.D. degree award:
1998
Mr.
Vasile
Chis
Prof.dr.
-
UNIVERSITATEA BABES BOLYAI
Researcher | Teaching staff | Scientific reviewer | PhD supervisor
Web of Science ResearcherID:
B-5552-2011
Personal public profile link.
Expertise & keywords
Molecular physics
Biomolecular physics
Ab initio modeling
Spectroscopy
Computational chemitry
Projects
Publications & Patents
Entrepreneurship
Reviewer section
NANO-BIOSENZING OF ATHEROSCLEROSIS AND THROMBOSIS BY SURFACE ENHANCED SPATIAL OFFSET RAMAN SPECTROSCOPY (SESORS)
Call name:
Projects for Young Research Teams - TE-2012 call
PN-II-RU-TE-2012-3-0227
2013
-
2016
Role in this project:
Coordinating institution:
UNIVERSITATEA BABES BOLYAI
Project partners:
UNIVERSITATEA BABES BOLYAI (RO)
Affiliation:
UNIVERSITATEA BABES BOLYAI (RO)
Project website:
http://atom.ubbcluj.ro/lszabo/pages/research_en.htm
Abstract:
The objective of this project is to develope conjugated nanoparticles for nano-biosenzing of ahterosclerosis and thrombosis by means of surface enhanced spatial offset Raman spectroscopy (SESORS). Atheroscerosis and thrombosis are the major cause of morbidity, regarding cardiovascular diseases. Therefore, the understanding of their molecular structure and their interaction with biologiccal medium. For this, combining the results of several spectroscopic methods, such as FTIR, Raman and UV-Vis, is very suitable because they give quantitative and qualitative informations about the molecules beeing investigated. By functionalizing gold nanoparticles with some molecules one can get biosenzors which specifically bind to desired tissue. Because heparin and C-reactive protein are binding to atherosclerotic and respectively thrombotic tissue, the conjugation of the nanoparticles with this drugs will yield nano-biosenzors which can be used for the detection of the diseases. After their fabrication, they will be tested on different tissues and on celular cultures regarding biocompatibility and to enhance their half-life. SESORS permits to get information from obscured objects, such as deep tissue. Therefore, after the injection of the conjugated gold nanoparticles which will be used as Raman markers and drug-carriors, using the SESORS technique one can detect them in deep tissue, up to 45-50 mm. This opens the possibility for detecting diseased tissue, but also for its spatial imaging.
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BIOFUNCTIONAL NANOPARTICLES FOR DEVELOPMENT OF NEW METHODS OF IMAGING, SENSING, DIAGNOSTIC AND THERAPY IN BIOLOGICAL ENVIRONMENT (NANOBIOFUN)
Call name:
Complex Exploratory Research Projects - PCCE-2008 call
PN-II-ID-PCCE-2008-0129
2010
-
2013
Role in this project:
Coordinating institution:
UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA, CENTRUL DE NANOSTIINTE SI NANOTEHNOLOGII
Project partners:
UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA, CENTRUL DE NANOSTIINTE SI NANOTEHNOLOGII (RO); UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA, CENTRUL DE BIOLOGIE MOLECULARA (RO); UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA, CENTRUL DE MATERIALE AVANSATE SI TEHNOLOGII (RO); UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA, LABORATOR DE STRUCTURI MOLECULARE SI MODELLING (RO); UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA, CENTRUL DE BIONANOSTRUCTURI SI SISTEME MOLECULARE COMPLEXE (RO); UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA, LABORATOR DE MODELARE COMPUTATIONALA A SISTEMELOR NANOSTRUCTURATE (RO); UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA, LABORATOR DE NANO-ALOTROPI AI CARBONULUI (RO); UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA, LABORATOR DE ELECTROCHIMIE SI CHIMIE SUPRAMOLECULARA (RO)
Affiliation:
UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA, CENTRUL DE BIONANOSTRUCTURI SI SISTEME MOLECULARE COMPLEXE (RO)
Project website:
http://www.phys.ubbcluj.ro/~dana.maniu/Web_ID_PCCE/
Abstract:
THE NANOBIOFUN PROJECT BRINGS TOGETHER EXPERTISES FROM 8 RESEARCH CENTERS IN PHYSICS, CHEMISTRY AND BIOLOGY TO ADDRESS THE DEVELOPMENT OF INNOVATIVE METHODS OF MOLECULAR SENSING, IMAGING, DIAGNOSTIC AND THERAPY IN BIOLOGICAL SYSTEMS BY COMBINING THE UNIQUE PHYSICAL PROPERTIES OF NOBLE-METAL NANOPARTICLES (NPS) WITH THEIR CHEMICAL SPECIFICITY AND EASY WAY OF BIOFUNCTIONALIZATION. KEY SCIENTIFIC ELEMENTS OF THE PROJECT ARE (1) TO PROVIDE A BIOLOGICAL FUNCTION ( CELL TARGETING) TO AN ARTIFICIAL NANO-OBJECT IN ORDER TO TACKLE A SPECIFIC BIOLOGICAL ISSUE, AND (2) TO FABRICATE TAILORED NANO-OBJECTS ABLE TO TRANSFER / INDUCE A PHYSICAL SIGNAL ( LIGHT OR ELECTRIC CURRENT) TO A BIOLOGICAL ENTITY (BIOMOLECULE AND CELL) IN ORDER TO PROBE ITS STRUCTURE AND PROPERTIES IN A CONTROLLED MANNER. SPECIFICALLY, THE PROJECT ADDRESSES THE DEVELOPMENT OF PLASMON-RESONANT NPS AS NEW OPTICAL LABELS FOR BIOLOGICAL MOLECULES, MEMBRANE AND CELLS AS WELL AS MULTIFUNCTIONAL AGENTS FOR CANCER DIAGNOSTIC AND THERAPY. THE PROJECT WILL TARGET THE FABRICATION OF GOLD NPS AND HYBRID METAL/POLYMER/SILICA/ STRUCTURES OF SPECIFIC SHAPE, SIZE (2-200 NM) AND DESIRED OPTICAL PROPERTIES AND REALIZE THEIR CONJUGATION WITH RELEVANT (BIO)MOLECULES / PROTEINS / DNA / BIOPOLYMERS. AS A MAJOR RESULT OF THIS PROJECT WILL TO DEMONSTRATE AN ORIGINAL APPROACH IN CANCER THERAPY GIVEN BY THE ABILITY OF GOLD NANOPARTICLES TO MEDIATE HYPERTHERMIA INDUCTION TO KILL CANCER CELLS UPON LASER IRRADIATION, THEREBY FUNCTIONING AS SELECTIVE THERMAL NANO-SCALPELS. THE PROJECT WILL CONTRIBUTE ON THE INVESTIGATION OF BIOLOGICAL EFFECTS OF BIOCONJUGATED GOLD NANOPARTICLES ON VARIOUS NORMAL AND TUMOR CELLS CULTURES.AN IMPORTANT OUTCOME OF THIS PROJECT WILL BE THE PRODUCTION OF COST EFFECTIVE, ULTRA SENSITIVE, REPRODUCIBLE AND STABLE NANOSTRUCTURED SUBSTRATES FOR SURFACE-ENHANCED SPECTROSCOPY AND ELECTROCHEMICAL SENSORS. BESIDES THE SCIENTIFIC GOALS, TRAINING AND EDUCATION WILL BE ALSO KEY RESULTS OF THE PROJECT.
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Studii Doctorale in Romania – Organizarea Scolilor Doctorale
Call name:
POSDRU/5/1.5/S/1
2008
-
2011
Role in this project:
Key expert
Coordinating institution:
INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH
Project partners:
INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); UNIVERSITATEA BABES BOLYAI (RO)
Affiliation:
UNIVERSITATEA BABES BOLYAI (RO)
Project website:
Abstract:
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Understanding Ionic Liquids as Novel Solvent in Green Chemistry
Call name:
INTAS Ref. Nr. 06-1000031-10105, SEE-ERA.NET Pilot Joint Call
2007
-
2008
Role in this project:
Partner team leader
Coordinating institution:
Technical University Vienna
Project partners:
Technical University Vienna (RO); UNIVERSITATEA BABES BOLYAI (RO); UNIVERSITATEA BABES BOLYAI (RO)
Affiliation:
UNIVERSITATEA BABES BOLYAI (RO)
Project website:
Abstract:
Ionic liquids (ILs) are salts composed by organic cations and inorganic or organic anions that are liquid near room temperature. The potential of ILs to provide a non-volatile solvent system has become a practical target for reducing waste and hazards by eliminating traditional volatile organic solvents. For these reasons, in the last few years, ILs have attracted great attention as “green and designer” media for chemical reactions.
Despite the extensive work carried out on applications of ionic liquids there is still a lack of fundamental knowledge about their structure and physico-chemical properties. In this context, a deeper insight into the interactions between different solvents, such water and ILs is needed in order to better understand the properties of ILs based mixed solvents.
Thus, a complete experimental and theoretical approach is proposed aiming to obtain the electronic molecular structure of ILs and their interaction modes in the presence of water molecules. For these purposes, infrared and Raman spectroscopy will be employed for the study of different ionic liquid - water mixtures. Data analysis performed using multivariate curve resolution (MCR) will offer information regarding the presence of different monomer or/and dimer species upon increasing water concentration in ionic liquids or by modifying the temperature of the mixtures. Also Two Dimensional Correlation Spectroscopy (2DCoS) will be used as a method that is spreading the modulated spectra over a second spectral dimension, thus enhancing spectral resolution. Furthermore, Density Functional Theory (DFT) calculations will be employed for modelling the ionic liquid - water monomer/dimer structure as well as for vibrational spectra prediction. Thus, the calculated molecular structures will be validated by comparing the calculated vibrational bands with those obtained experimentally. In this way, assessments about the interaction modes and electronic structures of the ionic liquid - water monomer/dimer clusters will be obtained. These information is of great importance for understanding the ILs structure and its interaction modes at molecular level.
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FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator
List of research grants as partner team leader
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
[T: 0.4982, O: 170]