BrainMap

Mrs. Valentina Uivarosi

Dr.

Professor - UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Researcher | Teaching staff | Scientific reviewer | PhD supervisor

Web of Science ResearcherID: B-4282-2013; https://publons.com/researcher/2672575/valentina-uivarosi/

Curriculum Vitae (13/05/2024)

Expertise & keywords

Development of anticancer nanoparticulate systems based on novel metal complexes Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-5143 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU"

Project partners: INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Project website: https://www.virology.ro/ro/cercetare/proiecte/proiect-ped-383-2020

Abstract:

A new generation of efficient metal-based drugs needs to be developed in order to overcome the biological, biopharmaceutical and biomedical drawbacks of standard chemotherapy. Use of metallo-drugs in cancer treatment has been hampered by an indaquate pharmacokinetic profile that limited the access to the biological target. This has led to the development of novel technologies based on nanostructured materials, acting as vectors for metallodrug delivery or simply as protectors of active species of the complexes for amplifying their activities and reducing their degradation. The aim of the project is to develop and validate new liposomal systems for transport and delivery of 2 promising anticancer agents previously studied by our research group. Nanoparticulate drug carrier systems will improve the therapeutic effectiveness and safety profile of these novel anticancer agents. The efficiency of these nanoformulations will be evaluated in terms of stability, drug entrapment efficiency, release behaviour, cell uptake, cytotoxicity, farmacotoxicology and pharmacokinetics. The project specific objectives are: 1) Development of liposomal systems validated at the laboratory level with novel anticancer agents; 2) Estimation the in vitro biological activity of the liposomal systems on various cell lines, including drug resistant cell lines, identifying biomarkers involved in modulating their biological activity; 3) Estimating the pharmaco-toxicological and pharmacokinetic profile of liposomal systems. Nanoparticles provide an enhanced bioavailability, in vivo stability, intestinal permeability, solubility, sustained and targeted delivery, therapeutic effectiveness of the anticancer drugs. The proposed project is a complex, interdisciplinary study related to biomedical international research, that aims to intends to transform modern methods, worldwide used in pharmacological, immunological and molecular biology studies, in instruments used for the translation to oncology.

Development of Novel, Multi-target-directed Polypyridyl Metal Complexes with Pyrimidine-like Ligands as Efficient Anticancer Drug Candidates Call name: P 1 - SP 1.1 - Proiecte de cercetare Postdoctorală
PN-III-P1-1.1-PD-2019-1312 2020 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Project website: https://umfcd.ro/cercetare-si-dezvoltare/proiecte/proiecte-nationale/p1-1-1-pd-2019-1312-dezvoltarea-unor-noi-complecsi-metalici-cu-actiune-asupra-unor-tinte-moleculare-diverse-ce-contin-liganzi-de-tip-polipiridil-si-pirimidinic-si-pirimidinic-ag-antit-nov

Abstract:

Cancer, listed as a chronic degenerative non-communicable disease by the World Health Organization (WHO), is a leading cause of death worldwide, deeply impacting the lives of millions. Medicinal inorganic chemistry reached the mainstream in the 1960s when cisplatin (cis-Pt(NH3)2Cl2) was successfully applied in cancer treatment for the first time. Thereafter, other platinum (Pt)-based chemotherapeutics (e.g. carboplatin and oxaliplatin) have been, and continue to be, widely used in the treatment of cancer. In agreement with recent trends in drug development, this project aims at the design of effective metal drugs/prodrugs for anticancer therapy. The main working hypothesis consists in the fact that simultaneous release of two or more bioactive moieties inside the cancer cells often triggers several processes that together determine the fate of the cell. The general objective of this proposal refers to the study of the therapeutic potential of octahedral M(II)-polypyridyl complexes (where M = Pt, Pd, Ru, Os) bearing one O,N or O,O-chelating ligand, namely orotic acid and isoorotic acid, and two N,N identical chemical entities, namely 2,2'-bipyridine and 1, 10-phenanthroline. Following the synthesis of the target compounds, their structural characterization (NMR, MS, IR, UV-vis, elemental analysis, thermogravimetric analysis) and computational studies (structure optimization based on DFT calculations) will be performed. Furthermore, these results will be followed by studies on the interactions with biomacromolecules (DNA, proteins) and evaluation of the anticancer activity and mechanism of action of the newly synthesized metal complexes.

DESIGN, EVALUATION AND MODELING OF DRUG RELEASE MECHANISM FOR NOVEL TOPICAL MULTIPARTICULATE DELIVERY SYSTEMS Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0813 2017 - 2018

Role in this project: Key expert

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO)

Affiliation: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Project website: https://umfcd.ro/cercetare-si-dezvoltare/proiecte/proiecte-nationale/proectarea-evaluarea-si-modelarea-mecanismului-de-eliberare-a-medicamentului-pentru-noi-sisteme-multiparticulate-de-cedare-topica/

Abstract:

TOPMULTINOV project is a new and modern concept for the development of smart biomaterial supports usable in burned skin repair. Efficient regeneration of burned skin is still a clinical challenge, obtaining of an adequate drug release support being a top approach in the field of biomaterials. The general objective of this project consists of the design, evaluation and modeling of an anti-inflammatory drug release mechanism from topical multiparticulate systems that will ensure a controlled release for burns healing. As a novelty element of the project, ensuring a proper anti-inflammatory drug delivery from spongious collagen-based supports using different techniques that allow a gradual degradation of collagen support and a slow release of drug is mentioned. The vehicle formulation in the drug delivery sciences is a critical quality attribute which needs special attention for tailor made design to rationalize the system development. Thus, the project presents a new approach concerning the preparation of release supports like collagen-based spongious matrices with an anti-inflammatory drug incorporated in free form, in free and encapsulated form, and in encapsulated form respectively, to model and control its release rate. The results generated by the preparation, physico-chemical and morphological characterization as well as the in vitro studies of drug release and testing of the designed topical systems on animal model will be disseminated at conferences, in specialty articles, and by patent application. The pluridisciplinarity and complementarity of both teams provide high level of scientific/technical experiences to ensure a successful project achievement. TOPMULTINOV is perfectly integrated in the national and European strategies with respect to the impact on human health for improved health and life quality.

Self-emulsifying delivery system for new metal complexes as materials with potential health use Call name:
15BM/2016 2016 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Project website:

Abstract:

Studies on soil-plant-food-man correlations to obtain a food supplement with an increased content in iron of herbal origin Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1572 2014 - 2017

Role in this project:

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); HOFIGAL EXPORT IMPORT SA (RO); AGROECO BIOTERRA SRL (RO)

Affiliation: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Project website: http://saliferoveg.umf.ro/index.html

Abstract:

Iron deficiency anemia (IDA) is the most common form of anemia in the world and the most frequent form of anemia in pregnant women. It is estimated that IDA has a prevalence of 2% among adult men and 9–20% among adult women. The multiple negative effects of anemia on health and quality of life justify the interventions designed to prevent and control anemia and the most important such intervention is the use of iron-containing food supplements.

The core objective of this project is to develop an iron-containing food supplement, using iron in its natural form, as an extract from plants rich in this oligoelement and, for this purpose, at exploring the correlations between soil, plants and the developed food supplement, to ensure an optimal use in humans. There are very few food supplements of botanical origin containing iron on the Romanian market (most of those available use iron salts). There is only a food supplement of Chinese origin containing iron (10 mg/tablet) and folic acid, the iron being derived from an extract of the so-called “black fungi powder” (with no taxonomic identification of the fungi species) and one manufactured locally (in two slightly different formulas) but with very small amounts of iron (“Fier biologic”, containing much less than 1.0 mg of Fe per capsule).

For this purpose we would explore the correlation between soil iron and iron in plants, by analyzing iron contents in at least 10 plant species (for at least 2 parts of the plant species – root, stem, leaf, seeds) grown on various soils in Romania and using statistical methods of regression to verify the relationship between the two variables. Because – as shown in section 1.2. – iron bioavailability is most often affected by other components of the plants (especially phytates, polyphenols and flavonoids), we will also investigate the influence of the soils on the flavonoids and polyphenol contents (as phytates is most often found in significant amounts only in seeds and grains we will not investigate phytate).

Very little research has been concerned up to now to the correlation between plant iron uptake and polyphenols or flavonoid content in various plant parts. We will also explore the relationship between the ontogenetic stages of plants and their iron uptake. The studies published up to date have only looked into this relationship in a small number of species and have produced inconsistent results. These results will allow us to make a scientifically sound decision on what parts of the plants to use, at what maturity stage to be collected and grown on what soils, as starting material for an extract rich in iron. We will also investigate the best iron extraction method from herbal sources and the main variables affecting the efficiency of the extraction process of iron in its natural form from plants (the following variables will be investigated: extraction method, solvent, temperature, herbal product:solvent ratio, extraction time and particle size) and the possibility of obtaining and characterizing a standardized extract (to be used as a raw material for a finished product). Finally, we will formulate and develop an iron-containing food supplement of herbal origin at the prototype stage.

The project will create research synergies through the collaboration of three partners: the University of Medicine and Pharmacy “Carol Davila” Bucharest (with a multidisciplinary team comprising experts in pharmaceutical botany, phytochemistry, analytical chemistry, physical chemistry, pharmaceutical chemistry, pharmacology, pharmaceutical technology) SC Hofigal Export Import, one of the most important manufacturers of food supplements of herbal origin on the Romanian market and SC Agroeco Bioterra SRL, a company specialized in ecologically cultivating medicinal herbal species, being independently certified in this sense.

INNOVATIVE THERAPEUTIC PRODUCTS WITH PROPHILACTIC AND CURATIVE ACTION FOR ZOO-VETERINARY SECTOR Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0953 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA

Project partners: UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); ASOCIATIA CENTRU DE CERCETARE STIINTIFICA IN DOMENIUL BIOCHIMIEI APLICATE SI BIOTEHNOLOGIEI (BIOTEHNOL) (RO); BIOING S.A. (RO); HOFIGAL EXPORT IMPORT SA (RO)

Affiliation: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Project website: http://sanovet.fifim.ro/

Abstract:

Title: „INNOVATIVE THERAPEUTIC PRODUCTS WITH PROPHILACTIC AND CURATIVE ACTION FOR ZOO-VETERINARY SECTOR”

Acronym: SANOVET

Program: PARTNERSHIPS

Subprogram: “ Applied Collaborative Research Projects”

Domain 5 - Agriculture, food safety and security

Research thematic: 5.1.4. Methods, techniques and technologies for growth and diversification of animal production and fisheries, veterinary protection insurance Animal health is a concern for all European citizens. This concern stems from the public health, food safety and food security aspects, which are related to animal health but also to economic costs that animal disease outbreaks can trigger. This project uses a very common and a high economical and ecologically impact disease model like inflammation, as a paradigm for a conceptual and practical approach aimed to capitalize inexpensive and available resources.

The project goal is to improve the level of veterinary protection by developing a semi - solid phytoproduct from indigenous flora with topical application.

Main objectives that will ensure the achievement of project aim are:

1. Obtaining crops to exploit the curative potential of Anthriscus sp.;

2. Obtaining the phytocomplex;

3. Evaluating extracts pharmacological viability;

4. Obtaining an innovative phytoproduct .

The results of this research project will be materialized through:

1. Development and characterization of a herbal extract enriched in active ingredients with a complex chemical structure, non-toxic, based on original recipe obtained from association of fractionated extract with volatile oil from Anethum sp properly processed,

2. Highlighting the biologic activity, which plays a role in sustaining and accelerating the healing process by in vivo testing of herbal extract,

3. Creating a new topic semisolid phytoproduct.

The project addresses to a major agricultural problem in an interdisciplinary aggregate approach in order to achieve high yields results with a low economical input and a great environmental safety.

Design and development of transport and delivery systems for new ruthenium compunds with antitumor activity Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1454 2012 - 2016

Role in this project: Project coordinator

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); INSTITUTUL ONCOLOGIC PROF.DR.ALEXANDRU TRESTIOREANU BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO); PHARMA SERV INTERNATIONAL SRL (RO)

Affiliation: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Project website: http://cercetare-umf.ro/uploads_ro/592/Pagina_web_136_2012-actualizata_2016.pdf

Abstract:

The proposed cooperative study is a complex interdisciplinary approach aimed at developing pharmaceutical product models with significant antitumor action and minimal side effects. During the project, three pharmaceutical systems that include some ruthenium complexes will be studied regarding solubility, capacity to transport and deliver the active substance at the final site of action, the antitumor activity and the side effects. The final scope of the project is to select the system (or systems) who best meet the requirements regarding bioavailability and pharmaco-toxicological properties for a possible inclusion in the clinical trials of the studied ruthenium complexes.

The proposed project has least three main goals. First, we want to develop pharmaceutical systems for improve the solubility of some ruthenium compounds in order to achieve a better pharmacokinetic profile for these compounds. Second, we intend to evaluate the antitumor activity of the developed systems using various cell lines from solid tumors and in vivo, comparing to cisplatin as reference substance. Third, we intend to evaluate the general toxicity of the developed systems, comparing to cisplatin. Additionally, we want to explore the possibility of development of these products as oral drugs and to establish what kind of cancer can be treated with these agents.

Development of improved solubility systems with complex combinations of new ruthenium (II) and quinolone antibiotics and their anticancer activity testing Call name:
541/2011 2012 - 2014

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Project website:

Abstract:

Synthesis, characterization and evaluation of therapeutic potential of some new complexes of oxovanadium(IV) with natural ligands Call name:
PNII 61042/2007 2007 - 2010

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" ()

Project website:

Abstract:

Synthesis, characterization and testing of biological activity of some new ruthenium complexes, potential alternative to platinum therapy Call name:
PNII 61-048/2007 2007 - 2010

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" ()

Project website:

Abstract:

Studies concerning the obtaining of transdermal hormonal systems using the lyposomes as transport and drug controlled release vectors Call name:
61-024/2007 2007 - 2010

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (); UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (); PHARMA SERV INTERNATIONAL SRL ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" ()

Project website:

Abstract:

Dezvoltarea unui sistem integrat pentru creşterea calității activității didactice şi asigurarea respectării deontologiei și eticii academice la nivelul Şcolii doctorale a UMF “Carol Davila” Bucureşti Call name: Fondul de Dezvoltare Instituţională - FDI - Competiţia 2018
CNFIS-FDI-2018-0515 2018 -

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Affiliation:

Project website:

Abstract:

Obiectivul general al proiectului îl reprezintă creşterea calităţii programului de pregătire doctorală la nivelul UMFCD şi asigurarea unui cadru de desfăşurare a cercetării doctorale cu respectarea deontologiei şi eticii academice.

Obiectivele specifice:

OS1. Restructurarea conţinutului curriculei programului de pregătire bazat pe studii universitare avansate, creșterea vizibilității și accesibilității ofertei curriculare şi asigurarea flexibilităţii în pregătire a studentilor-doctoranzi

OS2. Dezvoltarea şi implementarea unui sistem de evaluare a activităţii didactice de predare în cadrul programului de pregătire bazat pe studii universitare avansate

OS3. Dezvoltarea unui sistem de evaluare şi monitorizare a activităţii de îndrumare desfășurată de conducătorii de doctorat

OS4. Dezvoltarea unui sistem de evaluare şi monitorizare a activităţii doctoranzilor

OS5. Dezvoltarea unor instrumente suport pentru activitatea de pregătire doctorală a studenţilor doctoranzi

OS6. Dezvoltarea unui instrument de susţinere a respectării deontologiei şi eticii academice în pregătirea doctorală

Call name: Premierea obtinerii atestatului de abilitare - Competitia 2015
PN-II-RU-ABIL-2015-2-0242 2015 -

Role in this project:

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Affiliation: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Project website:

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects