BrainMap

Mrs. Stela Maria Pruneanu

Dr.

Senior Researcher I - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Researcher

Curriculum Vitae (03/09/2019)

Expertise & keywords

Graphene-porphyrin supramolecular assemblies for chemical and electrochemical detection of hydrogen peroxide-an oxidative stress marker Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0305 2015 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/ru305/index.htm

Abstract:

The aim of the present project proposal is to develop innovative research in the field of graphene-based nanomaterials as advanced and functional materials. Additionally, the project will tackle aspects regarding the supramolecular behavior of graphene with porphyrin derivatives. The graphene-porphyrin assemblies will be formed by two different approaches – one that involves the oxidation of graphite and its reduction in the presence of nitrogen containing molecules and the other method involves the porphyrin mediated direct liquid-phase exfoliation of graphite. The two types of graphene-based nanomaterials are expected to present different electronic properties with direct implication on their application as chemical or electrochemical sensors of hydrogen peroxide – a known stable oxidative stress marker. In this respect, the peroxidase-like activity of the graphene-porphyrin assemblies will be assessed by the oxidation reaction of a peroxidase substrate. This project will also open new directions for exploring more of their possible applications.

New nanocomposites based on biocompatible polymers and graphene for dental applications Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1282 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BABES BOLYAI (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); APEL LASER S.R.L. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/biograf/

Abstract:

In modern dentistry, both the early prevention of tooth decay and the development of new and efficient restorative materials are generally targeted. Although tremendous efforts have been made in promoting oral hygiene and fluoridation, the prevention of early caries lesions are still challenges for dental research and public health. Recent studies have indicated that nanotechnology might provide novel strategies in dentistry.

Graphene consists in a one-atom-thick planar sheet of sp2–bonded carbon atoms arranged in a hexagonal lattice. Graphene is considered to be the “thinnest and strongest material in the universe” and therefore it has remarkable physical and chemical properties, including superior Young’s modulus (1 TPa) and tensile strength (130 GPa). Recent studies have shown that graphene can be used as nanofiller and can dramatically improve the properties of polymer-based composites at a very low loading (0.1-5 wt.%).The results so far reported in the literature indicated that graphene/polymer composites are promising multifunctional materials with significantly improved tensile strength and elastic modulus, electrical and thermal conductivity. Despite some challenges and the fact that carbon nanotubes/polymer composites are sometimes better in some particular performance, graphene/polymer composites may have wide applications in dentistry due to their outstanding properties and the availability of graphene in a large quantity and at low cost.

Within the BIOGRAF project we plan to develop: ► a new nanocomposite material based on biocompatible polymers and graphene to be used in dental restorations ► new ex vivo tests to identify the host reaction to this material, in relationship with some biologic risk indicators. The final aim of the project is to develop modern and standardized therapies of caries lesions through the development of the novel nanocomposite material based on biocompatible polymers and graphene.

The present research project fits very well into the research domain 7. Materials, processes and innovative products since a new nanocomposite material with graphene will be manufactured which will fulfill the bio-safety criteria and have biocompatible properties with the local cellular environment. By its specific objectives BIOGRAF corresponds to the research thematic 7.1.6. Advanced materials and biomaterials for improving the quality of life (health, sport, education) because: ► a new nanocomposite material with graphene will be developed, for better medical treatments ► complex inter-/multidisciplinary studies will be performed, in order to elaborate and validate new standardized therapies based on advanced materials ►the development of a new perspective in dentistry, based on advanced theoretical and practical knowledge ► a research network will be developed which can ensure human resources for the top scientific research ► articles will be published in highly-ranked journals (ISI) ► research papers will be presented at international conferences ►valuable information will be disseminated among PhD/PostDoc students and researchers in the field of nanocomposite materials ►the equipments that will be purchased will develop the existing R&D infrastructure.

BIOGRAF project is aiming to deliver the following end-product(s)/ expected results:

► a new nanocomposite material with graphene, to be used in dental restoration therapy

► one laboratory technology for the synthesis of the nanocomposite material

►3 ISI papers, in highly ranked journals

►a patent.

Graphene-metal nanoparticles based electrodes for detection of pharmaceutical pollutants Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0125 2011 - 2016

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Tehnologii Izotopice si Moleculare

Project partners: Institutul National de Cercetare-Dezvoltare pentru Tehnologii Izotopice si Moleculare (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Tehnologii Izotopice si Moleculare (RO)

Project website: http://www.itim-cj.ro/PNCDI/idei125/index.htm

Abstract:

Graphene-based materials have recently attracted considerable interest both from the experimental and theoretical scientific communities. Graphene is a monolayer of sp2 hybridized carbon atoms which are packed into a honeycomb crystal structure. Due to their exceptional thermal and mechanical properties as well as high electrical conductivity, graphene sheets have a variety of applications in battery, field-effect transistors and electromechanical resonators. Their applicability as biosensors has now started to emerge, due to significant advantages over the classical electrodes, such as electrocatalytic effect, enhancement of mass transport and high effective surface area.

This project proposal brings up novelties through the original method used to obtain nanostructured material (graphene-metal nanoparticles composite) as well as through the way of its application (detection and degradation of pharmaceutical pollutants). This project has a multidisciplinary research area. The research activities within this project will provide: (a) new approaches for preparation of graphene-metal nanoparticles composite; (b) explanations about the intriguing properties associated with graphene-metal nanoparticles composite; (c) experimental solutions related to the assembly of metal nanoparticles on graphene platelets; (d) application of graphene-metal nanoparticles composite in electrocatalytic detection of two pharmaceutical pollutants: carbamazepine and captopril

Synthesis of high purity graphene by CCVD-IH method on noble-metal catalyst for studying DNA oxidation Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0129 2011 - 2016

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare Dezvoltare pentru Tehnologii Izotopice si Moleculare

Project partners: Institutul National de Cercetare Dezvoltare pentru Tehnologii Izotopice si Moleculare (RO)

Affiliation:

Project website: http://www.itim-cj.ro/PNCDI/idei129/index.htm

Abstract:

This project proposes the identification of parameters necessary to obtain in a single step synthesis high-purity graphenes, decorated with Au or Pt nanoparticles. To accomplish this task, we propose the development and study of novel Au or Pt supported on MgO catalytic systems, that can be used in the inductive heating-CCVD method, to grow composites of graphenes and Au/Pt nanoparticles. We propose to study the influence of the synthesis conditions on the morphology of the graphene layers and the uniformity of Au/Pt nanoparticles distribution throughout the graphitic structure. The integration of the noble metal nanoparticles (Au, Pt) into the graphitic structure of layers, rather than just attaching them chemically on the graphitic surface, has some major advantages related to the electronic properties, better structural integrity, and better distribution uniformity. Finally, the graphenes decorated with Au or Pt nanoparticles will be used as active components into highly sensitive electrochemical electrodes to study the oxidation processes of adenine, guanine and DNA strands. These studies could be the foundation for the development of new technologies with high sensitivity and specificity towards the understanding of various bio-chemical reactions that could include the DNA degradation. Moreover, the results of this study could be integrated in technological platforms used for the detection of various deseases and medical conditions.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator	Download (139.68 kb) 24/05/2017
List of research grants as partner team leader
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects	Download (47.42 kb) 09/05/2016