BrainMap

Sorina Nicoleta Voicu

PhD Scientific Researcher

- UNIVERSITATEA BUCURESTI

Researcher

Curriculum Vitae (19/07/2023)

Expertise & keywords

Dynamics of nanoparticles transport through cellular barriers relevant for toxicology and drug delivery systems Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-1375 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO)

Affiliation:

Project website: https://unibuc.ro/cercetare/promovarea-rezultatelor-cercetarii/proiecte-de-cercetare/proiecte-cu-finantare-nationala/trans-nano-bio/?lang=en

Abstract:

As the full understanding of the mechanism of nanoparticles (NPs) transport across the biological barriers has not yet been achieved, re-evaluation of the in vitro models used to analyze the transport in correlation with the NPs characteristics is mandatory. The present project aims to perform a complex analysis of the biological effects and transport mechanism of NPs with different characteristics (chemical structures, sizes, surfaces) through several important biological barriers (skin, lung, intestinal and blood-brain barriers). The results will generate robust computational 3D models for predicting the behavior, performance and toxicity of NPs in vivo, and also for designing nano-devices with improved efficiency in this “online” era. Using commercially available in vitro barriers or cell culture models developed by the team members based on their expertise, the effects triggered during exposure to NPs will be analyzed. The implementation of the specific objectives will bring multiple elements of originality and innovation in the field of cell culture models, nanotoxicology, nanomedicine and bioinformatics, in which the project leader and team members have significant and representative scientific achievements. This project has an important social and economic impact, with applicable directions in drug delivery purposes, diagnostic imaging or other biomedical applications.

New gemmotherapy-based Coryllus avelana reinforced with chrysin/cyclodextrin nanocomplexes designed for liver fibrosis in diabetes mellitus Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3609 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA DE VEST "VASILE GOLDIŞ" ARAD (RO); PLANTEXTRAKT S.R.L. (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://unibuc.ro/cercetare/promovarea-rezultatelor-cercetarii/proiecte-de-cercetare/proiecte-cu-finantare-nationala/pn-iii-p2-2-1-ped-2019-3609-262ped/

Abstract:

Diabetes and liver fibrosis are two chronic diseases, but the co-existence of the two pathologies is certainly much more debilitating than each of these entities independently, with a significant impact on the quality of life. In this project, we aimed to develop a novel formulation of Coryllus avelana gemmotherapic extract reinforced with chrysin, based on the nanoformulations of chrysin-cyclodextrin complexes (CAG-CHR/Cyclo). Based on our preliminary results, we start the project from TRL2. In order to achieve TRL4, we will accomplish the following objectives: (1) in the first stage we aimed to obtain the newly CAG-CHR/Cyclo. We will develop a two-step method for the formulation of this composite system, at first the nanoformulation of chrysin, then the additive process of the extract. The nanofromulation will be made by the complexation of chrysin by hydroxypropyl-beta cyclodextrin (HPBCD) and randomly methylated beta cyclodextrin (RAMEB). The characterization of the complex and the complex+extract system will be characterized by analytical methods; (2). in the second stage the products obtained previously, will be tested for anti-oxidant and anti-fibrotic potential by in vitro experiments made by UB; (3). in the third stage, the best ranked gemmotherapy-nanocomplex will be validated for the anti-fibrotic potential on CCl4-induced liver fibrosis in diabetic mice, which confirmes the level of TRL4 at the end of the project.

Advanced nanoparticle-based materials with synergistic effect on neuronal oxidative stress and beta-amyloid fibrillation for preventive treatment in Alzheimer's disease Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-4657 2020 - 2022

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://www.icechim-pd.ro/ro/syst_heter/sisteme_heterogene_nanonerves.html

Abstract:

This project aims to develop and to validate a new product and its technology with application in preventive treatment of Alzheimer's disease. This new product includes bioactive ingredients with effect on neuronal oxidative stress (curcumin) and beta-amyloid fibrillation (Ag and ZnO functionalized nanoparticles), and a nanocarrier (PEG-functionalized silica particles), that can act itself as a beta-amyloid fibrillation inhibitor. The main project novelty is related to: (i) study of the interaction of new formulations based on Ag or ZnO NPs and Curcumin encapsulated in functionalized silica NPs with beta amyloid fibrils and (ii) a sistematic and rational scientific approach to strike a balance between the effect of modifying the kinetics of amyloid beta fibril formation and the prevention of toxic effects (otherwise known) on neurons. Project objectives are: (i) to optimize product components and to improve their compatibility; (ii) to develop demonstration model, through components integration and (iii) to test and to validate the demonstration model, on laboratory conditions. Objectives are related to different TRLs: improved compatibility and optimal composition of new formulations based on Ag or ZnO NPs and Curcumin encapsulated in functionalized silica NPs (1st objective) allow properties analysis and improvement (TRL 3). Components integration (2nd objective) and product testing in laboratory conditions (3rd objective) permit technological development up to TRL 4.

Selection and dissemination of antibiotic resistance genes from wastewater treatment plants into the aquatic environment and clinical reservoirs Call name: P 4 - Proiecte Complexe de Cercetare de Frontieră
PN-III-P4-ID-PCCF-2016-0114 2018 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO); INSTITUTUL NATIONAL DE BOLI INFECTIOASE ''PROF.DR.MATEI BALS'' (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://bios.unibuc.ro/Proiecte/pn-iii-p4-id-pccf-2016-0114.html

Abstract:

The RADAR project aims to assess the prevalence and dissemination of antibiotic resistance (AR) from urban, clinical and industrial wastewater into the aquatic environment via wastewater treatment plants (WWTPs). Moreover, RADAR will give information on the environmental and clinical resistome, identifying the possible mechanisms of AR emergence and spread.

Scientific objectives: i) investigation of WTTPs resistome to establish the prevalence of AR bacteria (ARB)/genes (ARGs) in the environmental samples from upstream-WWTP-downstream transects; ii) evaluation of selected antibiotics (beta-lactams, fluoroquinolones and macrolides) occurrence in both WWTP’ influent and effluent; iii) comparative analysis of geographically and time related ARB/ARGs from wastewaters and clinical sources; iv) assessing and prediction how the presence/absence of ARGs and their relative abundance depending on a class of geographical, hydrological, physico-chemical and microbiological factors.

Methodology: The urban, clinical, farming and industrial wastewater will be monitored by physico-chemical, microbiological methods and metagenomics throughout various steps, i.e.: 1000 m upstream river, influent, different treatment steps inside WWTP, effluent and 200 m downstream river. Wild fish from the receiving river after discharge of WWTP effluent will be also analyzed. The following analyses will be performed: i) LC/MS and HPLC techniques to monitor the levels of selected antibiotics; ii) isolation and identification of ARB belonging to ESKAPE species; iii) evaluation of metagenomic resistome by bioinformatic data processing; iv) environmental and clinical ARGs and plasmids sequencing; v) analyzing the potential of ARGs for transferability and environmental/clinical risk by mapping the insertion loci of transposable elements and the ARGs potential to mobilize the resistance genes in a bioreactor model; vi) elaboration of a prediction model for the occurrence of ARB/ARGs

Evaluation by FRET of the physiological stability of nanogels incorporating MRI contrast agents Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-Franța (bilaterale)
PN-III-P3-3.1-PM-RO-FR-2019-0204 2019 - 2021

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); University of Reims Champagne Ardenne Institut de Chimie Moléculaire de Reims (FR)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://unibuc.ro/cercetare/promovarea-rezultatelor-cercetarii/proiecte-de-cercetare/proiecte-cu-finantare-nationala/6bm-2019-pniii-p3-3-1-pm-ro-fr-2019-0204/?lang=en

Abstract:

This project is in line with the contribution of nanotechnology to the encapsulation of active substances dedicated to medical imaging. Its objective is to provide responses regarding the stability of nanogels that incorporate gadolinium-based commercial contrast agents (GdCAs) for magnetic resonance imaging (MRI). Fluorescent nanogels will be developed, and their stability will be assessed by Förster resonance energy transfer (FRET) technique, depending on the medium of incubation. The in vitro evaluation of these fluorescent nanogels will be performed by fluorescence microscopy on different cell lines. Also, the biocompatibility of nanogels and their biological effects will be investigated using cell cultures. Within this project, the scientific cooperation between the two research groups from Romania and France will be consolidated. The expected results will include the bilateral visits of the involved researchers, co-publications, and international patents for fluorescent nanogels used in medical imaging.

Advanced Innovative approaches for predictable regenerative medicine Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0782 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" (RO); INSTITUTUL ONCOLOGIC PROF.DR.I.CHIRICUTA CLUJ-NAPOCA (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://unibuc.ro/cercetare/promovarea-rezultatelor-cercetarii/proiecte-de-cercetare/proiecte-cu-finantare-nationala/65pccdi-2018/

Abstract:

Considering that HEALTH is one of the main areas of public priority, the approach of interdisciplinary researches with applicability in Regenerative Medicine can significantly contribute to improving the quality of life of patients with tissue defects. The aim of the project is to create a consortium with complementary research experience in the field of regenerative medicine, which will efficiently use the human resource and modern research infrastructures newly created for the implementation of innovative technologies, with the aim of developing and transferring the results to the economic environment. The project aims to develop new technological products in the form of biocompatible biomaterials designed for bone reconstruction (P1), nerves (P2), soft tissues (P3) and breast reconstruction after tumor resection (P4).

Integrated development project for advanced medical treatment technologies Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0728 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO); INSTITUTUL DE BIOCHIMIE (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA PITESTI (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://teramed.inflpr.ro/

Abstract:

In order to increase community’s quality of life, the aim of the project proposal entitled “Integrated development project for advanced medical treatment technologies” (TERAMED) is to develop novel technologies with respect to the treatment of osseous and cutaneous conditions and oncological disorders. Given our experience in healthcare research and the current requirements of multidisciplinary and interinstitutional collaboration towards the personalized treatment purpose, the TERAMED project aims genuine synthesis and processing of biomaterials, but also functional and therapeutic evaluation relevant for clinical trials. The main objectives of the “Medical devices functionalized by laser technologies and alternatives for enhanced osseous integration and regeneration” subproject are to design and produce inorganic, composite or hybrid coatings for superior osteoconductive and osteoinductive performances of titanium-based implants. Smart wound patches and polymeric gels functionalized with antimicrobial and wound healing biomolecules incorporated within micro- and nanoparticles constitute the purpose of the “Medical devices (patches and gels) based on composite biomaterials obtained by laser, plasma and radiation technologies and alternatives for enhanced healing of cutaneous injuries” subproject. The “Technologies based on magnetic triggered nanostructures for oncological therapy: early diagnosis and targeted treatment” subproject aims the development of multifunctional medical devices for specific and selective diagnosis and treatment of breast cancer and melanoma. The general impact of the TERAMED project ensues from the beneficial conjunction of the clinical potential of the proposed medical devices, the feasible technological transfer and the economic advantages of interinstitutional collaboration.

Interinstitutional program of developing advanced eco-nanotechnology solutions for multifunctional treatments of leather and textile materials Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0743 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://www.nipne.ro/proiecte/pn3/7-proiecte.html

Abstract:

Developing integrated functionalization eco nano technologies using physical techniques (gamma irradiation, plasma activation, electrodeposition) and nanocomposites with antibacterial, antistatic or hydrophobization properties will produce textile and leather materials with multifunctional advanced properties. Replacing and reducing volatile organic compounds that negatively impact the environment will set the premises of transferring advanced technologies to companies manufacturing medical articles, protection equipment, sports equipment or for other applications and creating thus new research services by PHYSforTeL consortium partners to the benefit of the traditional industrial sector of textile and leather industry.

The development in oncology of novel radiopharmaceuticals and nuclear techniques for diagnostic imaging and personalized treatment at molecular level Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0769 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); INSTITUTUL DE BIOCHIMIE (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); INSTITUTUL CLINIC FUNDENI (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://www.nipne.ro/proiecte/pn3/9-proiecte.html

Abstract:

The ONCORAD project and the associated technological platform in Radiobiology, is built on the concepts of translational medicine and has as main objective the development of innovative targeted radiopharmaceuticals and nuclear medicine techniques for diagnostic imaging and improved radiotherapy in cancer. ONCORAD is based on the unique expertise of the coordinator (IFIN Horia Hulubei, Magurele) ) in the field of radioisotopes and radiopharmaceuticals, complemented by the exquisite know how of partner institutions in the field of biomedical research (INCD Victor Babes, Cantacuzino National Research Institute and Biochemistry Institute, Bucharest) and clinics (Fundeni Clinical Institute and Colentina Clinical Hospital, Bucharest), along with the expertise of INCD for Isotopic and molecular Techniques, Cluj-Napoca in nanotechnologies/nanomedicine. The multidisciplinary effort is focused in 4 interconnected research projects in the field of oncology and nuclear medicine. Additionally, the ONCORAD project will sustain the development of the partner institutions by supporting new jobs for young researchers and their extensive training, infrastructure development, and transfer of knowhow, technologies and good laboratory practices among partners and towards interested third parties. ONCORAD will build an organizational structure for enhanced interdisciplinary collaboration in the field of radiobiology, in the benefit of research, patients and oncologists. The project is a premise for future participation of the consortium in large-scale projects and in European networks/platforms in the field of nuclear medicine and nanomedicine, enlarge the research services and technological transfer for clinical applications.

Multi-disciplinary platform for regional institutional capacity enhancing in dermatooncology and dermato-pathology domains Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0341 2018 - 2021

Role in this project:

Coordinating institution: SPITALUL CLINIC "COLENTINA" BUCURESTI

Project partners: SPITALUL CLINIC "COLENTINA" BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" (RO); INSTITUTUL DE BIOCHIMIE (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://cdpcolentina.ro/buton11pathderm.html

Abstract:

Dermato-oncology and dermato-pathology address the most frequent pathology, but the medical training is scarce, hence the new diagnosis and treatment approaches in skin cancers are frugaly tought in residency and in post-universitary training. Thus, the medical act is hindered by the “in-house” training of the clinicians that can lead to low quality medical serivces for the patient. The project re-unites 6 prestigious institutes that have prior collaborated (Bucharest, Cluj): an university hospital, a national institute, a Romanian Academy national institute and 3 universities (two medical ones) that propose for the first time on national level a research and training platform for dermato-oncology and dermato-pathology developing 4 multi-disciplinary projects. Project 1 developps an improved diagnostic and prognostic markers for the most frequent skin cancers- squamous cell and basal cell carcinomas. Project 2 identify the markers for improved prognosis and therapy monitoring in cutaneous melanoma. Project 3 develops new methologies for therapy testing in dermato-oncology and dermato-pathology. Project 4 completes the training slope of young researchers and medical doctors to increase the medical services quality (decrease social costs of the dermato-oncology pathology) and to increase the research results in the biomedical domain. We estimate a significant impact of the results on the institutional capacity consolidation regarding human resources (13 new research positions, several training stages, several work visits) and infrastructure (upgrading of the existent infrastructure); 3 patents, 3 new sets of biomarkers for diagnostic/prognostic/monitoring for the increase of the health care system, RD services, and international visibility improvement.

Smart materials for medical applications Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0407 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://intelmatupb.wixsite.com/intelmat

Abstract:

INTELMAT project represents advanced research in the field of synthesis and application of smart materials for medical engineering in order to solve essential features of some acute/chronic diseases of large occurrence. 5 thematic directions are taking into consideration: 1. Developing of a controlled-release system of complex micro-colloidal architectures based on bacterial cellulose and hydrogels used for management of chronically wounds which aims to overcome the limitations of classical treatments; 2. Developing of new biomaterials specially designed with targeted action for treatment of inflammatory diseases of gastrointestinal segment; 3. Synthesis of new generation of composite membrane materials for artificial kidneys based on biocompatible polymers and derivative graphene; 4. Developing of some auto-assembly 3D platforms with controlled-released drugs based on polymeric nanoparticles and composite nanogels for the therapy of colon-rectal cancer; 5. Developing of innovative technologies for the synthesis of some 1D nano-architectures (nanowires) with controlled morphology, with applications in producing of non-enzimatic electrochemical biosensors.

From the classical nutrition to precise nutrition in animal production, scientific basis for the nutrition security of the population Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0473 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIOLOGIE SI NUTRITIE ANIMALA - IBNA BALOTESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIOLOGIE SI NUTRITIE ANIMALA - IBNA BALOTESTI (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA BABES BOLYAI (RO); INSTITUTUL DE BIOCHIMIE (RO); UNIVERSITATEA "ŞTEFAN CEL MARE" DIN SUCEAVA (RO); UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://www.ibna.ro/proiecte-de-cercetare/item/110-pn-iii-p1-1-2-pccdi-2017-0473

Abstract:

The overall objective of the project is to strengthen the institutional capacity of IBNA by developing new research directions based on „omics” technologies – nutrigenomics, toxicogenomics, proteomics, metabolomics – and to relaunch the Laboratory of Biotechnology. This will generate a set of innovative outcomes in animal nutrition. The innovative aspects of the project include: use of agro-food wastes as adsorption and detoxifying agents for feed contaminants; testing the effect of phytoadditives (plants or plant extracts not yet used for such purposes) as antibiotic replacers (willow bark extracts) on the interaction between the intestinal tract physiology and the intestinal microflora; investigation of several less characterized and used protein-oleaginous sources (cowpea, Jerusalem artichoke, etc.); in vitro experimental models to evaluate the decontaminating potential of wastes under conditions of concurrent fungal, viral and microbial contamination; development of new feeding products which ensure a more efficient use of the protein in ruminants.

The project covers three regions of development and the partners are prestigious institutions, with complementary infrastructure and expertise, with converging scientific interests. The consolidation of new directions will enhance, both for IBNA (the relaunched institution), and for its partners, their capacity of applying for/running research projects, allowing studies with a high level of complexity, which generate practical results, relevant for the development of the animal production sector.

The project will impact on the human resources, the budget allowing the employment of 14 researchers (of which 10 by IBNA), whose specialisation is already ensured; it will also support the enhancement of the scientific expertise of the senior researchers by using vouchers. The training periods will enrich the portfolio of methods and techniques that can be applied for the directions in which IBNA aims to develop/relaunch.

Mobilitate cercetător Sorina Nicoleta Voicu Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori, 2019
PN-III-P1-1.1-MC-2019-1407 2019 - 2019

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website:

Abstract:

Establishing nanomaterial grouping/ classification strategies according to toxicity and biological effects for supporting risk assessment Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERA-SIINN-NanoToxClass 2015 - 2019

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://www.unibuc.ro/cercetare/promovarea-rezultatelor-cercetarii/proiecte-de-cercetare/proiecte-cu-finantare-nationala/13-siinn-2015/

Abstract:

Currently, risk assessment of manufactured nanomaterials (MNM) is done on a case-by-case basis.Given the broad range of different MNM including all possible variations such as size, shape or coating this is a laborious, time- and cost- intensive process. Testing all MNM variants for all possible endpoints is not feasible. One solution to overcome this problem is grouping of MNM. Here we will focus on grouping according to toxicity and biological effects in humans and mammals. We will establish criteria for grouping on the basis of well-established toxicity endpoints, and include novel approaches such as transcriptomics, proteomics and metabolomics. We will consider existing data from finished projects and published studies. Experimental work in the project is planned in a targeted,selective manner, mainly focussing on high content or Omics data delivering information on modes of action. Validation of grouping will be carried out for a few selected MNM.

Biotechnology for demonstration of the anticancer potential of drug loaded carbon nanoarchitectures using multicellular tumor spheroids Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0904 2017 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://www.unibuc.ro/cercetare/promovarea-rezultatelor-cercetarii/proiecte-de-cercetare/proiecte-cu-finantare-nationala/183ped-2017/

Abstract:

The current proposal represents a biotechnological experimental model for control of cancer progression and invasiveness assuming a central emphasis in cancer research and treatment. It is a continuity of innovative biotechnological approach in tailoring carbon nanoarchitectures loaded with platinum-drugs in order to maximize their efficiency on triple negative breast cancer (TNBC) cells. This type of cancer is defined by the lack of expression of the three receptors commonly found in breast cancer cells (for estrogen, progesterone and HER2), thus making the chemotherapy ineffective. Intracellular drug delivery might be a very promising alternative in targeting intracellular molecules involved in essential signaling pathways which may be of benefit in the treatment of TNBC. Our preliminary results showed that, carbon nanoarchitectures conjugated with therapeutic drugs have a cooperative contribution to reactive oxygen species generation and to significantly growth inhibition of triple negative MDA-MB231 cancer cells by inducing autophagy. Starting with this results related to functionalized 1D carbon nanoarchitectures with drugs and their preliminary characterization (physico-chemical and biological), the current project represents a more mature step in both material (introducing 2D carbon nanoarchitectures) and biological (3D tumor model) considerations. The objectives of the project include the investigation of tumor spheroid - nanosystem interaction, monitoring of internalization and retention and evaluation of the anti-tumoral and anti-invasion potential of drug loaded carbon-based nanoarchitectures. Finally, we will evaluate the expression of several proteins of PI3K/AKT/NF-kB, MAPK/ERK/p38 and Notch signaling pathways promoting invasiveness and tumor cells growth and confirm the effectiveness of the tailored nano-product.

Increasing performance/competitiveness by improving the technology of smart products fabrication with superior biocompatibility and antibacterial properties for cosmeto-medical applications Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0142 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); SONNENKREUZ SRL (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://www.unibuc.ro/n/cercetare/94BG-2016.php

Abstract:

The purpose of this project is to increase the performance and the competitiveness of SC Sonnenkreuz SRL by using the expertise existing in the research organizations, University of Bucharest and INCDCP-ICECHIM, for developing and optimizing the modern technology for producing silver colloid dispersions, in order to obtain a product with higher biocompatibility and antimicrobial properties. To accomplish the purpose of the project, a full compliance between the requirements and the problems identified by the economic agent and the project objectives was followed. Two directions for innovating the final product and the manufacturing processes will be pursued: (i) obtaining of various colloid silver dispersions stabilized with polymers having intrinsic antibacterial activity, to achieve a synergistic effect and (ii) optimizing the production technology by electrochemical method by ensuring the control of nanoparticles growth. The knowledge transfer will include also the collaboration with the economic agent in order to identify the possibility of a subsequent development of other cosmeto-medical products based on the dispersions of silver nanoparticles with improved properties. For developing the quality assurance system at the economic agent, the collaboration between the partners UB and INCDCP-ICECHIM with SC Sonnenkreuz SRL will be intensified in order to accomplish the analyzes required for the characterization of the final products and to monitor the manufacturing process. Cooperation with the economic partner will be fulfilled by the activities of entrepreneurship knowledge transfer towards the researchers/PhD students/Master students involved in the project. Development of the new product and improvement of the technology will provide opportunities for practical training for master students, with a complex topic. The publishable scientific results will be widely disseminated in communications and articles in specialized journals.

Initiating a new range of phytotherapeutic products in the portfolio of S.C. PlantExtrakt SRL. Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0100 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA DE VEST "VASILE GOLDIŞ" ARAD (RO); PLANTEXTRAKT S.R.L. (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://www.unibuc. ro/n/cercetare/proiecte/ 12BG2016.php

Abstract:

PlantExtrakt is a company with over 20 years of experience in processing the herbs for producing phyto-therapeutic, gemo-therapeutic preparations, and homeopathic medicines. The production and quality control flows are GMP certified. By processing in fresh state and cold extraction (Plantextrakt fabrication method) the phyto-complex responsible for the therapeutic action is kept unaltered.

The company produces about 650 different types of mother tinctures, of which only 27 are marketed as such, the rest being used as raw material in the manufacturing of the homeopathic preparations. Thus, the company has planned to open a line of phyto-therapeutic products of mother tinctures with antioxidant and anti-inflammatory therapeutic activity in specific organ pathologies. PlantExtrakt owns the full technology of production of these tinctures and devices of chemical characterisation but it does not have the capacity to test the biological properties of these phyto-therapeutic products in its own laboratories.

Objectives: selecting the antioxidant mother tinctures from the range of tinctures produced by PlantExtrakt; opening a line of phyto-therapeutic products by production and validation of the first product meant for the therapy of the intestinal inflammation; promoting the new line of phyto-therapeutic products; developing the students’/ PhD candidates’ practical skills.

Impact: Initiating a new line of phyto-therapeutic products by manufacturing, testing, validating and promoting the new product meant for the therapy of the intestinal inflammation, we consider that it would bring a market impetus to the range of mother tincture products of the company. We estimate that the sales for these extracts will increase with 10-20% annually, ever since its launching on the market. Thus, they will contribute both to the increase of the business turnover for the products range of Mother Tinctures with about 10% and to the general business turnover of the company with 2-5%.

Contributions to enhancing the Sanimed SRL’s competitiveness by the knowledge assimilation and potential production implementation of some 3D collagen-polymer hybrid matrices intended to tissue repair Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0397 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://www.unibuc.ro/prof/micut_m/

Abstract:

The project proposal mainly aims at knowledge transfer to economic operator regarding the obtaining and development of 3D collagen-polymer hybrid biomaterials intended to biomedical applications. The practical implementation of the proposal should lead to enhancing competitiveness of private economic entity in order to develop itself in the near and middle-term future. In line with economic partner, the public entities University of Bucharest and ICECHIM (project partners) have identified aspects of scientific and technological existing at private partner, the weaknesses and strengths of these aspects, as a useful basis for designing new collagen-based hybrid biomaterials. In addition, the purpose that such kind of biomaterials be used in the process of tissue repair requires accounting a number of key characteristics against which it is possible to design, realize and develop this kind of hybrid collagen-polymer system: biocompatibility, bioresorbability, mechanical properties, internal and external morphology and manufacturing technology.

Magnetic-luminescent Fe-Si hybrid nanoparticles designed for biomedical aplications Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1698 2017 - 2018

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://llp.inflpr.ro/PED114_RO, http://llp.inflpr.ro/PED114_EN

Abstract:

The project proposal has as the main scope to develop a laboratory validated original system: a stabilised and bio-tested suspension based on Fe-Si nanoparticles synthesized beginning with a single step laser pyrolysis procedure. The project proposes two nanostructure configurations: nanoparticle aggregates containing separate Si and Fe based nanocrystals or composite nanoparticles with Fe based core and Si-based shell. Thus, a dual: magnetic (Fe based) and luminescent (Si quantum dots-based) material will be synthesized. By magnetic separation, only the part with significant magnetism will be further processed. By oxidative thermal/wet acid treatments the mean size of Si nanocrystals will be tuned to 2-5 nm size in order to generate visible photoluminescence. The obtained nanoparticles will be dispersed and stabilized using PEG derivatives, L-Dopa, CMCNa, threonine, dextran, chitosan, etc. The base fluids will be those commonly used in biological research (ex. FBS), so the as synthesized nanoparticles must be properly stabilised using a steric repulsion strategy. The as prepared suspension contains hybrid nanoparticles or aggregates with Fe based nanodomains (metallic, oxides and/or carbides) and Si nanocrystals (less than 5 nm). In this combination a supperparamagnetic and luminescent material will result. Finally, the demonstration model of the optimised product “stabilised dispersion with Fe-Si hybrid nanoparticles” will be validated based on 6 parameters: nanoscale particle size (TEM and XRD investigations), their magnetic respond (magnetic susceptibility, saturation magnetization etc), photoluminescence efficiency, the suspension stability (hydrodynamic-size evaluation during the time), comprehensive tests to evaluate their biocompatibility (cell viability, the effectiveness in inhibiting specific biofunctions-IC50 index, membrane integrity, oxidative stress, cell internalization for normal and carcinoma cells) and magnetically induced hyperthermia effect.

Innovative antibacterial and self-cleaning photocatalytic textiles Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0419 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); UNIVERSITATEA BUCURESTI (RO); STOFE BUHUSI S.A. (RO); C & A COMPANY IMPEX SRL (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://cleantexproject.ro/

Abstract:

The negative impact of pollution on human health and environment pushed the R&D efforts to develop clean technologies and products according to the green chemistry principles, making regulation, control, clean-up and remediation unnecessary.

The project’ target is the development of new multifunctional textiles providing simultaneously photocatalytic, auto-sterilizing, self-cleaning and enhanced antimicrobial properties based on innovative graphene oxide/TiO2 nanocomposites able to decompose pollutants in safe, non-toxic compounds, using only solar light.

The present project aims at developing the 4th generation of green photocatalysts by:

• synthesis of graphene oxide/doped titanium oxide (GOT) with efficient absorption under UV and visible light

• formulation of GOT composites as highly adherent solution;

• development of photocatalytic textiles by deposition of photocatalytic compounds in one-step technology;

• evaluation of photocatalytic/self-cleaning/antimicrobial performances of synthesized photocatalysts and textiles against usual pollutants and pathogenic microorganisms,

• biocompatibility/cytotoxicity testing of cells cultures toward photocatalytic compounds.

The original contribution of the project consists in:

• optimal assembly and interfacial coupling of the TiO2 nanoparticles over the graphene oxide sheets;

• innovative adhesive graphene oxide/TiO2 (GOT) formulations, ensuring a high and stable dispersion and a strong adherence of the composites to the textile substrate, while preserving the genuine physical and mechanical properties of textile;

• homogeneously and firmly adherent photocatalytic coatings by one step deposition of GOT at room temperature, reducing the raw materials, utilities and manpower consumption;

• new investigations on graphene/TiO2 cytotoxicity and biocompatibiliy.

The indicators proposed to be achieved:

- eco-friendly products: minimum 2 types of composites nanopowders; min. 2 types of textile materials with high photocatalytic and antibacterial efficacy; self-cleaning and antibacterial work wear and protective equipment; clean technologies: one step synthesis of powder composites; one step deposition and fixation of synthesized compounds on textiles;

- innovations: 1 patent describing the innovative GOT synthesis and one-step deposition of nanocomposites; minimum 2 ISI rated scientific papers, minimum 2 presentations at national and international conferences.

The innovative approach for the production of high quality photocatalytic textiles is based on an efficient, environmentally clean and easily implementable at industrial-scale process, one step deposition and fixation of environmentally friendly nano composites. This finishing technology combined with a proper adhesive photocatalysts formulation will eliminate the post-treatment steps, and consequently high consumption of chemicals, water and energy and will allow the achievement of highly adherent, durable, uniform coating thin layers preserving the genuine physical properties and colour of the textiles. The easy application on conventionally existing production lines, ensure a wide spread of the finishing technology. The approval of the present project will contribute to concentration of human and material resources with the aim to achieve the above mentioned research tasks and the implementation of results in Romania, with special amelioration of the economic situation of SMEs active in textiles and chemical industry and significant improvements of human health and environment quality.

Electro-Plasmonics for the analysis of the dynamics of cellular processes and biomolecular interactions - BioScope Call name: Complex Exploratory Research Projects - PCCE-2011 call
PN-II-ID-PCCE-2011-2-0075 2012 - 2016

Role in this project:

Coordinating institution: CENTRUL INTERNATIONAL DE BIODINAMICA

Project partners: CENTRUL INTERNATIONAL DE BIODINAMICA (RO); SC INSTITUTUL DE OPTOELECTRONICA SA (RO); CENTRUL INTERNATIONAL DE BIODINAMICA (RO); Universitatea din Bucuresti (RO); CENTRUL INTERNATIONAL DE BIODINAMICA (RO)

Affiliation: Universitatea din Bucuresti (RO)

Project website: http://www.biodyn.ro/php/biodyn.php?act=Projects&idm=5&idsm=11&locale=en

Abstract:

Whereas experiments on processes at single cell level are highly demanded by biomedical industry they currently raise serious technical challenges. Therefore, BioScope project advances the State of the Art by proposing creation of the Electro-Plasmonic Analysis System (EPAS), an innovative engineered system integrating advanced optics and electronics that will reveal the dynamics of electrical and morphological properties of relevant intracellular structures and biointerfaces with an unprecedented temporal (1 ms) and spatial (200 nm) resolution.

A multidisciplinary consortium will develop EPAS by harnessing Surface Plasmon Resonance, SPR, Magnetism (to increase SPR and thus overall sensitivity), Optogenetics (to control cell properties through light for calibration purposes), Modelling (to reveal details of how cells in electric field affect SPR), Bioinformatics (for the analysis of data) and Biochemistry (to validate/substantiate the results).

Novel analytic capabilities of EPAS to perform fast, noninvasively and label free, thorough in situ measurements for gaining new insights into cellular processes (such as changes in adherence, conformation, and organelle distribution, swelling / shrinking, exo- and endocytosis, neurotransmitter release, electrical spiking, etc.) at single cell level will be explored.

BioScope results will facilitate creation of the next generation of (single)cell-based analytical platforms likely to support breakthrough applications spanning from quality control of food and aquatic media to bio-medical ones coping with analysis of interaction mechanisms between selected cells and various stimuli (including those fostering new pharmacological products), cell assays as alternatives to animal (preclinical) testing, or last but not least, supporting cutting-edge cell-based “Disease in a Dish” approaches.

NEW CONCEPTS AND STRATEGIES FOR THE DEVELOPMENT OF KNOWLEDGE OF NEW BIOCOMPATIBLE STRUCTURES IN BIOENGINEERING Call name: Complex Exploratory Research Projects - PCCE-2008 call
PN-II-ID-PCCE-2008-0248 2010 - 2013

Role in this project:

Coordinating institution: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA

Project partners: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA NICOLAE SIMIONESCU-LABORATORUL DE CELULE STEM SI TERAPIE CELULARA (RO); UNIVERSITATEA POLITEHNICA BUCURESTI-FACULTATEA DE CHIMIE APLICATA SI STIINTA MATERIALELOR (RO); UNIVERSITATEA POLITEHNICA BUCURESTI-CENTRUL NATIONAL DE CONSULTANTA PENTRU PROTECTIA MEDIULUI (RO); INSTITUTUL DE CHIMIE FIZICA ILIE MURGULESCU (RO); UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, CENTRUL DE BIOMATERIALE, INSTITUTUL DE CERCETARI EXPERIMENTALE SI INTERDISCIPLINARE (RO); INSTITUTUL DE CERCETARE-DEZVOLTARE PENTRU CHIMIE SI PETROCHIMIE BUCURESTI (RO)

Affiliation: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA (RO)

Project website: http://www.pcce248.weebly.com

Abstract:

IN TISSUE ENGINEERING (TE) THE COMBINED KNOWLEDGE FROM BIOLOGY AND ENGINEERING

IS DIRECTED TOWARDS THE POSSIBILITY TO RESTORE LOST OR DAMAGED TISSUE. THE

GENERAL AIM OF THIS PROJECT IS TO CONSOLIDATE A CROSS-DISCIPLINARY TEAM OF

COLLABORATING INVESTIGATORS TO CARRY OUT SOME CELL-SUPPORT CONSTRUCTS (CSC)

WITH POSSIBLE APPLICATIONS IN REGENERATION/REPAIR OF SOFT AND HARD TISSUES AND IT

DOES NOT ASSUME PRE-CLINICAL AND CLINICAL TRIALS. THIS APPLICATION CONTAINS THREE

SPECIFIC OBJECTIVES: 1- OBTAINMENT OF NEW SUPPORT 3-D STRUCTURES DESIGNED TO

CULTIVATE OSTEOBLASTS AND HUMAN MESENCHYMAL STEM CELLS (HMSC) TO OBTAIN CSCS

WITH CHARACTERIZED ARCHITECTURE AND MECHANICAL PROPERTIES, USEFUL IN BONE TISSUE

ENGINEERING; 2 - DEVELOPMENT OF REGENERATION STRATEGIES OF ADIPOSE TISSUE BY

IMPLANTATION OF PREADIPOCYTES IN 3-D HYDROGEL SCAFFOLDS, THAT MIMIC

EXTRACELLULAR MATRIX, DESTINED TO THE RECONSTRUCTION OF SOFT TISSUE DEFECTS

(SEVERE TRAUMAS, DEEP BURNS OR TUMOR RESECTIONS) AND 3 - STUDY OF THE EFFECTS OF 3-

D CULTURE AND GROWTH FACTORS ON THE CHONDROGENIC DIFFERENTIATION OF HMSC CELLS

TO OBTAIN SOME INVESTIGATION MODELS OF THEIR POTENTIAL IN CARTILAGE TISSUE

REGENERATION. THE PROJECT PRESENTS VIABILITY, INNOVATION, COMPLEXITY AND

INTERDISCIPLINARY EXCHANGE BECAUSE: 1 - IT IS A CONSORTIUM WHICH CONSISTS FROM

PARTNERS WITH COMPLEMENTALLY COMPETENCES WHO ENGAGE TO ACT AS A UNITY IN THE

FOLLOWING FIELDS: CELLULAR AND MOLECULAR BIOLOGY, CHEMISTRY AND PHYSICS OF

MATERIALS, ENGINEERING SCIENCES – IN ORDER TO GET ALL OBJECTIVES; 2 - THE PARTNERS

ARE STAFFS WITH A GOOD, STRONG REPUTATION ON THEIR FIELD, AND THEY HAVE THE

NECESSARY MANAGERIAL EXPERIENCE AS WELL AS THE HUMAN RESOURCES AND PERFORMING

EQUIPMENTS AND 3 - THE PARTNERSHIP WAS PARTIALLY CONSOLIDATED DURING PREVIOUS

COLLABORATIONS AND WHICH SUSTAIN IT. ACCOMPLISHMENT OF THE OBJECTIVES OF THIS

PROJECT CONSTITUTES A SCIENTIFIC CHALLENGE FOR ANY SCIENTIFIC TEAM AROUND THE

WORLD.

FLUORESCENT SILICA NANOPARTICLES BASED IMAGING TECHNOLOGY - EVALUATION OF TISSUE TOXICITY DUE TO IN VIVO BIOACUMULATION USING BIOCHEMICAL AND MOLECULAR APPROACHES Call name: Projects for Young Research Teams - TE-2010 call
PN-II-RU-TE-2010-0127 2010 - 2013

Role in this project:

Coordinating institution: UNIVERSITATEA DIN BUCURESTI

Project partners: UNIVERSITATEA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA DIN BUCURESTI (RO)

Project website: http://dbbm.bio.unibuc.ro/page.php?id=36&lang=en,

Abstract:

QUANTUM DOTS REPRESENT NANO-PARTICLES WITH SPECIAL OPTIC ATTRIBUTES THAT STIRRED THE INTEREST OF RESEARCHERS FROM THE DOMAIN OF BIOLOGY AND MEDICINE. THE FLUORESCENT PROPERTIES THEY POSSES COMPRISE THE REASON THEY ARE USED AS FLUORESCENT PROBES WHICH ARE ABLE TO DETECT SPECIFIC BIOMARKERS IN VITRO AND IN VIVO, AT CELLULAR, TISSUE AND WHOLE-ORGANISM LEVEL. SILICA-BASED NANOPARTICLES ARE BEING EXTENSIVELY USED IN THE FOOD AND COSMETIC INDUSTRIES BUT ALSO IN IMMAGISTICS AND TARGETED TRANSPORT OF THERAPEUTIC DRUGS. DATA REGARDING THE TOXICOLOGICAL EFFECTS OF THESE NANOPARTICLES IN VIVO AND THE MECHANISMS BEHIND THEIR ACTIVITY ARE STILL INSUFFICIENTLY STUDIED. INFORMATION PUBLISHED SUGGEST THAT NANOPARTICLES CAN INDUCE CYTOTOXIC EFFECTS IN VITRO IN VARIOUS CELL TYPES WHILE THEIR IN VIVO PROPERTIES ARE LESS STUDIED. THE AIM OF THIS STUDY IS TO INVESTIGATE THE IN VIVO EFFECTS INDUCED AFTER THE INTRA-PERITONEAL INJECTION OF A FLUORESCENT SILICA-BASED NANOPARTICLE SUSPENSION IN CARASSIUS SP. INDIVIDUALS. OUR GOAL IS TO COMPLETE A COMPLEX AND COMPARATIVE STUDY OF DIFFERENT TYPES OF TISSUES OBTAINED AFTER THE EXPOSURE OF FISH TO SILICA-BASED FLUORESCENT NANOPARTICLES. UP TO DATE, NO IN VIVO COMPARATIVE STUDY HAS BEEN PERFORMED REGARDING THE EFFECTS OF SILICA-BASED FLUORESCENT NANOPARTICLES IN TISSUES WHERE THEY ACCUMULATE AFTER INTRA-PERITONEAL INJECTION. MAKING USE OF OUR EXPERIENCE GAINED IN THE DOMAIN OF IN VIVO ANALYSIS OF OXIDATIVE STRESS TRIGGERED BY HEAVY METALS AND PESTICIDES POISONING, WE SHALL ATTEMPT TO IDENTIFY THE CYTOTOXICITY MECHANISMS INDUCED BY THESE NANO-PARTICLES AT MOLECULAR AND BIOCHEMICAL LEVEL.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects