BrainMap

Ramona Cioboata

MD PhD

Lecturer - UNIVERSITATEA DE MEDICINA SI FARMACIE CRAIOVA

Researcher | Teaching staff

Web of Science ResearcherID: not public

Expertise & keywords

Tuberculosis and Diabetes - Accelerated Epigenetic Ageing TanDeM-AGE; Call name:
PNRR-III-C9-2023-I8 2024 - 2026

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE CRAIOVA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE CRAIOVA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE CRAIOVA ()

Project website: https://www.umfcv.ro/ro/cercetare/granturi/accelerated-epigenetic-ageing-linked-to-detrimental-outcomes-of-combined-diabetes-tuberculosis-and-post-tuberculosis-disease-tub

Abstract:

Vitamin D deficiency and immunogenetic factors in relation to Tuberculosis (RID-TB) Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-2548 2015 - 2017

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE CRAIOVA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE CRAIOVA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE CRAIOVA (RO)

Project website: http://umfcv.ro/rid-tb

Abstract:

Tuberculosis (TB) is a global health problem with an estimated 2 million deaths per year. There is an urgent need for interventions to prevent infection after exposure to M. tuberculosis, and progression from latent TB infection (LTBI) to active TB. We hypothesize that vitamin D deficiency is associated with increased risk of TB infection and progression to active TB, through autophagy and altered M.tb induced cytokine responses.

In this study we will include patients with active TB, and screen their household for LTBI. We will then examine their vitamin D status, and genetic polymorphisms in the vitamin D immune signaling pathway and autophagy. In a subgroup we will examine in-vitro immune response to M.tb, using whole blood cytokine assays, in relation to vitamin D status and relevant genetic polymorphisms. Finally, using multivariable logistic regression, vitamin D deficiency, and haplotypes for VDR and downstream signaling and effector molecules will be correlated with active TB and LTBI, taking known risk factors for TB into account. Patient specimens including DNA and microbioma will be archived.

This study, with a highly competent research team, combines careful field epidemiology with cutting edge genetics, immunology and systems biology. It will generate unique data and strengthen TB control in Romania through household screening. It may provide biological basis for vitamin D supplementation in LTBI and/or active TB.

Concurrent Tuberculosis and Diabetes Mellitus;unraveling the causal link, and improving care Call name: EC-FP7
FP7-105829-305279 2013 - 2017

Role in this project: Partner team leader

Coordinating institution: LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE

Project partners: LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER (GB); ACADEMISCH ZIEKENHUIS LEIDEN (NL); STICHTING RADBOUD UNIVERSITEIT (NL); EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH (DE); ACADEMISCH ZIEKENHUIS GRONINGEN (NL); UNIVERSITAS PAJAJARAN (ID); UNIVERSITATEA DE MEDICINA SI FARMACIE DIN CRAIOVA (RO); UNIVERSITY OF OTAGO (NZ); ST GEORGE'S HOSPITAL MEDICAL SCHOOL (GB); UNIVERSIDAD PERUANA CAYETANO HEREDIA (PE); STELLENBOSCH UNIVERSITY (ZA); MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV (DE)

Affiliation: ACADEMISCH ZIEKENHUIS LEIDEN (NL)

Project website: https://ec.europa.eu/research-and-innovation/en/projects/success-stories/all/understanding-correlation-between-diabetes-and-tuberculosis

Abstract:

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