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Romania
Citizenship:
Romania
Ph.D. degree award:
2011
Raluca Maria
Pop
PhD
Researcher
-
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"
Researcher
Web of Science ResearcherID:
not public
Personal public profile link.
Curriculum Vitae (06/07/2023)
Expertise & keywords
Food chemistry
Phytochemical analysis
Bioactive compounds
Antioxidant Activity
High performance liquid chromatography, Mass spectrometry
Metabolomics
Chemometrics
Experimental pharmacology
Drug analysis
Oxidative stress
Inflammation
ELISA, PCR
Projects
Publications & Patents
Entrepreneurship
Reviewer section
Iron oxide nanoparticles transported by probiotics - cytotoxicity, bioavailability and their influence on intestinal microflora
Call name:
P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2126
2021
-
2023
Role in this project:
Coordinating institution:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA
Project partners:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA (RO)
Affiliation:
Project website:
https://pronanoiron.usamvcluj.ro/
Abstract:
Anemia is a global issue affecting 2 billion people. Over 52% of pregnant women suffer from anemia. Scientists' bigger concern is iron bioavailability and gastrointestinal side effects. A promising approach for anemia treatment is the utilization of iron oxide nanoparticles. We will empower the iron oxide nanoparticles with probiotics from Lactobacillus and Bifidobacterium species, leading to a reduction of gastrointestinal discomfort, an increase in iron absorption and reduced problems pose of toxicity.
Our overall objective is to design, develop and test an innovative probiotic (Lactobacillus and Bifidobacteria) carrier iron oxide nanoparticles suitable for i) anemia treatment with ii) minimum side effects (no cytotoxicity) that sustain iii) optimum iron absorption mechanism and iv) ensure the gut microbiota health, in order to maximize their impact. Specific objectives will be achieved through seven work packages (WP1-7):
WP1-Synthesis and characterization
WP2-Functionalization
WP3 -In vitro simulated gastrointestinal interventions
WP4-In vitro cellular uptake and cytotoxicity
WP5-In vivo validation of the anemia treatment using probiotic iron oxide nanoparticles
WP6-Scientific and social innovation, dissemination, communication & exploitation
WP7-Management
The potential impact on budgets for health care is considerable; considering that over 30% of the population is anemic, many due to iron deficiency. The research will encourage an interdisciplinary approach.
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Next generation sequencing - a valuable tool for assessing the impact of additional somatic mutations in young patients with non-BCR-ABL myeloproliferative neoplasms
Call name:
P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-1603
2020
-
2022
Role in this project:
Coordinating institution:
UNIVERSITATEA DE MEDICINA, FARMACIE, STIINTE SI TEHNOLOGIE ”GEORGE EMIL PALADE” DIN TARGU MURES
Project partners:
UNIVERSITATEA DE MEDICINA, FARMACIE, STIINTE SI TEHNOLOGIE ”GEORGE EMIL PALADE” DIN TARGU MURES (RO)
Affiliation:
UNIVERSITATEA DE MEDICINA, FARMACIE, STIINTE SI TEHNOLOGIE ”GEORGE EMIL PALADE” DIN TARGU MURES (RO)
Project website:
https://www.umfst.ro/universitate/cercetare/departament-proiecte-europene/proiecte/cercetare/fonduri-nationale/uefiscdi/te-2019-adrian-trifa.html
Abstract:
Patients with non-BCR-ABL myeloproliferative neoplasms (polycythemia vera, essential thrombocythemia, primary myelofibrosis) harbor specific somatic driver mutations in JAK2, CALR or MPL genes. In recent years, additional mutations in various genes, such as TET2, ASXL1, DNMT3A, SRSF2, U2AF1, have been discovered frequently in these patients. Some of these additional mutations influence the prognosis of these patients. Especially in primary myelofibrosis, additional mutations in several genes have detrimental consequences, decreasing dramatically the overall survival. The role of these additional mutations was analyzed in patients older than 65 years, which represent the greatest proportion of MPN patients. Young patients with MPN (under 40 years old) represent a subgroup very poorly characterized so far. These particular patients seem to have a better prognosis than their older counterparts. The role of additional mutations was not assessed in this subgroup of MPN patients. The project proposes the development of a next generation sequencing (NGS) panel, comprising 13 genes: ASXL1, TET2, U2AF1, SRSF2, EZH2, DNMT3A, IDH1, IDH2, TP53, RUNX1, CBL, SF3B1, SH2B3. Additional mutations will be searched in these genes in 100 young patients (less than 40 years old) and 50 older patients (more than 65 years old), all of them with a definite diagnosis of MPN (harboring one driver mutation in JAK2, CALR or MPL genes). Mutations identified by NGS will be confirmed by Sanger sequencing. We will search for correlations between these additional mutations and various biological and clinical features of the patients included in the study. A comparative analysis of these correlations will be performed between young and older MPN patients. This project will allow us to characterize the landscape of additional mutations, and their consequences, in young patients with non-BCR-ABL MPN.
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From DISCOvery to products: A next-generation pipeline for the sustainable generation of high-value plant products
Call name:
2013
-
2017
Role in this project:
Key expert
Coordinating institution:
ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE
Project partners:
ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE (RO)
Affiliation:
ROYAL HOLLOWAY AND BEDFORD NEW COLLEGE (RO)
Project website:
https://cordis.europa.eu/project/rcn/110947/factsheet/en
Abstract:
Read more
Combined fungus extract - drug-loaded nanoparticles in the treatment of cystic and alveolar echinococcosis
Call name:
2016
-
2017
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"
Project partners:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)
Affiliation:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)
Project website:
Abstract:
Read more
Effect of esterification on the stability and antioxidant capacity of xanthophylls – from model systems to food systems
Call name:
Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0721
2011
-
2016
Role in this project:
Key expert
Coordinating institution:
Universitatea de Stiinte Agricole si Medicina Veterinara Cluj-Napoca
Project partners:
Universitatea de Stiinte Agricole si Medicina Veterinara Cluj-Napoca (RO)
Affiliation:
Universitatea de Stiinte Agricole si Medicina Veterinara Cluj-Napoca (RO)
Project website:
http://www.usamvcluj.ro/cercetare/CAROSTAB
Abstract:
The stability of carotenoids in food is affected by three major factors: light, temperature, and concentration of oxygen. Thermal treatment and light exposure induce variable losses of carotenoids, depending on their severity and length, but also on their chemical structure. They also lead to the formation of degradation products and isomers, with different colours and different biological properties. Studies pointing out the stability of xanthophyll esters (CE) are relatively scarce and the results are contradictory. The aim of this project is to evaluate the thermal and photochemical stability of carotenol esters, as well as the influence of esterification on the antioxidant activity of β-cryptoxanthin (BCR) and zeaxanthin (ZEA. Both pigments are bioactive compounds, with known beneficial effects on human health. The approach of this research is based on gradual acquisition of knowledge from the results obtained for single components (BCR and ZEA esters with different fatty acids) to the investigation of complex food matrices rich in carotenol esters (sea buckthorn and apricot. In order to accomplish this integrative approach, modern techniques will be used – LC/MS and GC/MS. The knowledge gain will improve the understanding of mechanisms of thermal and photochemical degradation of CE and could bring valuable information about the optimal conditions for storage and processing of plant derived food, in order to increase their nutritional value.
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TESTING THE ANTIOXIDANT, ANTIPROLIFERATIVE AND PROAPOPTOTIC PROPERTIES OF BLUEBERRY POLYPHENOL EXTRACT ON TUMORAL CELL CULTURE
Call name:
Projects for Young Research Teams - TE-2010 call
PN-II-RU-TE-2010-0168
2010
-
2013
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA DIN CLUJ-NAPOCA
Project partners:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA DIN CLUJ-NAPOCA (RO)
Affiliation:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA DIN CLUJ-NAPOCA (RO)
Project website:
http://www.usamvcluj.ro/TE 186 AFINE/
Abstract:
IN OUR COUNTRY, BLACK BLUEBERRIES (VACCINIUM MYRTILLUS L.) GROW IN HILLS ACID AREAS (MAJORITY) BUT IS ALSO FOUND IN CULTURE. BESIDES THEIR WATER, SUCROSE, PROTEIN AND PECTIC SUBSTANCES CONTENT, BLUEBERRIES CONTAIN A HIGH CONCENTRATION OF ANTIOXIDANTS WHICH NEUTRALIZE FREE RADICALS RESPONSIBLE FOR THE PRODUCTION OF DEGENERATIVE DISEASES. DUE TO MULTIPLE BENEFICIAL EFFECTS ON HUMAN HEALTH OF BLUEBERRIES (IMPROVE EYESIGHT, PREVENT MACULAR DEGENERATION, ANTIDIABETIC AND ANTITUMOR PROPERTIES), THEY ARE CONSUMED FREQUENTLY IN NATURALLY FORM AND AS VARIOUS PREPARATIONS (SUPPLEMENTS NUTRITIONAL).
RESEARCH SHOWS THEIR CYTOTOXIC EFFECT (BY VIABILITY CELL) ON VARIOUS TUMOR CELLS: COLON, PROSTATE AND LIVER CELLS.
THERE IS NO LITERATURE DATA RELATING ON CYTOTOXIC EFFECT TO THE BLUEBERRY EXTRACT ON OVARIAN AND BREAST TUMOR CELLS.
THE MAIN PURPOSE OF THIS PROJECT IS TESTING THE ANTIOXIDANT EFFECT OF TOTAL POLYPHENOL EXTRACT AND THE ANTHOCYANINS EXTRACT AND THEIR PROAPOPTPTIC EFFECT ON OVARIAN AND BREAST TUMOR CELLS.
THIS WILL BE ACHIEVED BY FURTHER AIMS:
O1-THE EXTRACTION FLAVONOIDS BIOACTIVE COMPOUNDS AND EXTRACTS CHARACTERIZATION USING HIGH PERFORMANCE LIQUID CHROMATOGRAPHIC (HPLC)
O2–DOSING THE BIOACTIVE COMPOUNDS: TOTAL POLYPHENOLS, TOTAL ANTHOCYANINS, TOTAL FLAVONOIDS
O3 - EVALUATION IN VITRO OF ANTIOXIDANT ACTIVITY FOR THE EXTRACTS USING ANTIOXIDANT METHODS
O4 - TESTING THE CYTOTOXIC EFFECTS OF THE TOTAL EXTRACTS AND ANTHOCYANIN FRACTION EXTRACT ON OVARIAN AND BREAST TUMOR CELLS.
O5-EVALUATION OF ANTIOXIDANT STATUS OF THE CELLS TREATED WITH BLUEBERRY EXTRACT
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Applications in agriculture and medicine of some essential amino acids complex with biometals
Call name:
IDEAS NCod ID_1486
2009
-
2011
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA
Project partners:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA (RO)
Affiliation:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA (RO)
Project website:
Abstract:
Read more
Evaluation of potential antioxidant effect of some natural compounds (carotenoids and polyphenols) in cultured RPE cells
Call name:
PNCD II Idei ID_854
2007
-
2010
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA
Project partners:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA (RO)
Affiliation:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA (RO)
Project website:
Abstract:
Read more
Advanced methodologies (instrumental and chemometric) applied for the evaluation of specific fingerprint of functional food
Call name:
PN II 51049/2007
2007
-
2010
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA
Project partners:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA (RO)
Affiliation:
UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA (RO)
Project website:
Abstract:
Read more
17th World Congress on Nutrition and Food Chemistry
Call name:
P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2018-1359
2018
-
Role in this project:
Project coordinator
Coordinating institution:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"
Project partners:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)
Affiliation:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)
Project website:
Abstract:
Read more
FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
[T: 0.6843, O: 270]