BrainMap

Mrs. Stefania Gheorghe

PhD in biology

Researcher - INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Researcher

I am scientific Researcher grade II (Biochemist) with more than 16 years’ experience in the field of pollution control (specifically in ecotoxicology studies). I have a PhD in Life science – Biology, University of Bucharest, Faculty of Biology, Biochemistry Department. My studies were focused on ecotoxicological characterization of surfactants from different matrices (like surface water, waste water, sludge and also from products) and risk assessment on aquatic environment (fish, invertebrate and algae). Managerial activities in six national projects and five research contracts as project manager / project responsible / project manager and team member in more than 40 national and international projects. Scientific contribution (> 70 published papers; >35 ISI papers ); >20 BDI papers; three book chapters; > 250 citations:; Web of Science h-index =10; Expertise in quality management SR EN ISO/CEI 17025, SR EN ISO 9001 , SR EN ISO 19011. Associate editor at RJEEC journal.

Web of Science ResearcherID: ABA-4171-2020

Curriculum Vitae (21/03/2024)

Expertise & keywords

Eco-friendly solutions for monitoring and protecting the biodiversity of integrated systems, as well as for preventing their destruction Call name:
PN 23 22 02 01 2022 - 2026

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Project website:

Abstract:

Microplastics - Ecotoxicological effects and mechanisms of action in Cyprinus carpio fish Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0073 2022 - 2024

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO)

Project website: https://www.incdecoind.ro/microplastice-efecte-ecotoxicologice-si-mecanisme-de-actiune-in-pesti-microplasfish/

Abstract:

Is know that plastic pollution is the main pollution problem from our century being a worldwide concern. The waters systems are the most affected. Once entered in the aquatic environment, microplastics impact living organisms, posing hazards also on human health. Many studies reported macro / microplastics pollution in rivers but the extent of these products toxicity impact and mechanisms of action on the aquatic biota including fish are yet unclear or unknown. The proposed research project will be of significant importance in the development of knowledge in the field of environment and human health protection.

The project proposes a complex study on the microplastics toxicity using as target organisms the fish Cyprinus carpio, the most common fish from Romanian freshwater with important ecological and economic implications. The project intends to contribute to the knowledge’s development concerning microplastics ecotoxicology and to the understanding of their mechanisms of action in order to highlight their risk on aquatic life and also on human health taking into consideration that the carp is a considerable source of food for humans. The impact of microplastics on fish will be assessed based on ecotoxicological evaluation, investigation of antioxidant system changes, histopathological alterations as well as changes at molecular level. The toxic effects will be analyzed for their specificity in order to be considered biomarkers for microplastics pollution.

Research on the transfer of emerging contaminants from abiotic environmental factors to aquatic organisms and plants through bioaccumulation - Call name:
PN 19 04 01 01 2019 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Project website: http://www.incdecoind.ro

Abstract:

Antidiabetic drugs are among the most prescribed and consumed pharmaceuticals worldwide. Their occurrence in environment was little investigated due of lack of analytical methods for their detection in waters. In this work has been developed a selective SPE-UHPLC/MS/MS method for isolation, identification and quantification of some antidiabetic compounds. The 3 selected analytes (glyburide, glimepiride and repaglinide) were separated on Eclipse C18 LC column at 30°C using isocrat elution with mobile phase of acetonitrile: 0.04% acetic acid (60/40, v/v %). The optimal flow rate was 0.2 mL/min and the injected volume was 10 µL. The contaminants were detected in negative electrospray ionization mode (ESI-) by Multiple Reaction Monitoring (MRM). Collision energy, fragmentor voltages were optimized to obtain high sensitivity. Optimization of SPE-LC-MS/MS parameters gave low quantification limit values between 0.27 and 11.1 ng/L. The organic pollutants were isolated from waste water samples on Strata C18 cartridges. The linear regressions were drawn in the interval of 1-100n g/L with good determination coefficients. Spike recovery rates were between 74.5 and 88.2% for waste water, with satisfactory precisions (RSD

Selection and dissemination of antibiotic resistance genes from wastewater treatment plants into the aquatic environment and clinical reservoirs Call name: P 4 - Proiecte Complexe de Cercetare de Frontieră
PN-III-P4-ID-PCCF-2016-0114 2018 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO); INSTITUTUL NATIONAL DE BOLI INFECTIOASE ''PROF.DR.MATEI BALS'' (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO)

Project website: https://bios.unibuc.ro/Proiecte/pn-iii-p4-id-pccf-2016-0114.html

Abstract:

The RADAR project aims to assess the prevalence and dissemination of antibiotic resistance (AR) from urban, clinical and industrial wastewater into the aquatic environment via wastewater treatment plants (WWTPs). Moreover, RADAR will give information on the environmental and clinical resistome, identifying the possible mechanisms of AR emergence and spread.

Scientific objectives: i) investigation of WTTPs resistome to establish the prevalence of AR bacteria (ARB)/genes (ARGs) in the environmental samples from upstream-WWTP-downstream transects; ii) evaluation of selected antibiotics (beta-lactams, fluoroquinolones and macrolides) occurrence in both WWTP’ influent and effluent; iii) comparative analysis of geographically and time related ARB/ARGs from wastewaters and clinical sources; iv) assessing and prediction how the presence/absence of ARGs and their relative abundance depending on a class of geographical, hydrological, physico-chemical and microbiological factors.

Methodology: The urban, clinical, farming and industrial wastewater will be monitored by physico-chemical, microbiological methods and metagenomics throughout various steps, i.e.: 1000 m upstream river, influent, different treatment steps inside WWTP, effluent and 200 m downstream river. Wild fish from the receiving river after discharge of WWTP effluent will be also analyzed. The following analyses will be performed: i) LC/MS and HPLC techniques to monitor the levels of selected antibiotics; ii) isolation and identification of ARB belonging to ESKAPE species; iii) evaluation of metagenomic resistome by bioinformatic data processing; iv) environmental and clinical ARGs and plasmids sequencing; v) analyzing the potential of ARGs for transferability and environmental/clinical risk by mapping the insertion loci of transposable elements and the ARGs potential to mobilize the resistance genes in a bioreactor model; vi) elaboration of a prediction model for the occurrence of ARB/ARGs

Promotion, identification and development of knowledge transfer partnerships in the field of industrial ecology Call name:
P40_300/105581 POC-A1.-A.1.2.3.-G-2015 2016 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO)

Project website: https://partenerecoind.incdecoind.ro/

Abstract:

Obiectivul general al proiectului constă în îmbunătățirea transferului de cunoștințe, tehnologie și personal cu competențe de CDI în domeniul ecologiei industriale între Institutul Național de Cercetare-Dezvoltare pentru Ecologie Industrială – ECOIND și întreprinderi aparținând sectorului economic, prin promovarea, identificarea și concretizarea unor parteneriate cu acestea, în scopul atingerii unor obiective de cercetare-dezvoltare-inovare comune și a creșterii valorii adăugate la nivelul unor produse/procese/servicii și/sau tehnologii.

INCD ECOIND institutional development project Call name:
PNCDI III - CDI NR. 2PFE/16.10.2018 2015 - 2020

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Project website:

Abstract:

Biocide - from regulation to ecological impact Call name:
PN 18-05 02 01 2018 - 2018

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Project website:

Abstract:

Computerized monitoring technology of microbiological parameters of drinking water, used for nationwide water quality management Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0965 2017 - 2018

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU MECATRONICA SI TEHNICA MASURARII

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU MECATRONICA SI TEHNICA MASURARII (RO); INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO)

Project website: http://www.incdmtm.ro/biowater/

Abstract:

The project aims to obtain an computerized technology, applicable nationwide, for multi-criteria characterization of the microbiological drinking water samples in order to monitor its quality in real-time, and hardware and software modules, for real-time acquisition, measurement, storage, secured transmission and viewing of digital data for microbiological parameters of drinking water and more. They will allow stakeholders to implement this technology with minimal cost and without changing their technical infrastructure.

Development of an information technology meet the needs of improving water quality assessment methods. Lately, European organizations involved in updating regulations concerning water management (WHO, OECD) insisted on the need to improve evaluation methods and management of microbiological safety of drinking water. They suggest switching from using monitoring as a tool for checking the finished product towards the concept of using monitoring results as a starting point for risk management actions.

The proposed information technology envisages two directions of project's development:

1. Starting from existing control procedures of microbiological parameters, imposed by Law. 458/2002, a nationwide computer network will be created, accessible through the Internet, having as nodes the operators of drinking water and a national coordinating center.

2.The technology will implement a new concept useful in treating microbiological accidental contamination which is the possibility to perform measurements of microbiological and physics - chemical parameters, using a portable electronic module, energy autonomous, placed "into contaminated area", which can wirelessly transmits data to the drinking water distribution operators' servers, and from here towards the authority’s server, where it can be displayed, in real time, in a dual graphic-text form, allowing viewing the time evolution of contamination removal.

Bioaccumulation assessment of heavy metals in aquatic organisms and highlighting of stress biomarkers Call name:
PN 16-25 02 04 2016 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Project website:

Abstract:

Assessment of adverse effects caused by certain pharmaceutical products on aquatic organisms and ecological risk characterization, in accordance with international regulations Call name:
PN 09-13 01 01 2009 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Project website:

Abstract:

PRODUCTION OF LOW CHOLESTEROL CONSUMER EGGS, NEW PRODUCT ON THE ROMANIAN MARKET Call name: Dezvoltare Produse - Sisteme - Tehnologii - 2012
PN-II-IN-DPST-2012-1-0085 2013 - 2015

Role in this project:

Coordinating institution: AVICOLA BUCURESTI S.A.

Project partners: AVICOLA BUCURESTI S.A. (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIOLOGIE SI NUTRITIE ANIMALA - IBNA BALOTESTI (RO); INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO); MARNEWS CONSULTING S.R.L. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO)

Project website: http://www.avicolabucuresti.ro/proiect

Abstract:

Since the feeding habits of the population changed considerably during the past 50 years, with a higher consumption of animal foods, the number of people with cardio-vascular diseases increased in a worryingly manner. This created a constant pressure on the national budget for social insurances. The eggs have a particular place among the foods that supply essential nutrients for the humans, but the hen egg is perceived by the consumers as being rather unhealthy because of its high cholesterol. Within this context, the decrease of the hen egg cholesterol and the improvement of the feeding quality of the eggs, in general, is a priority for the poultry research. For this food with outstanding feeding qualities, readily available, the reduction of the cholesterol level might not just protect or improve the health state of the consumers, but will also produce economic-financial benefits because the reticence of the consumers will decrease and thus the demand for consumer eggs will increase.

The project aimed to develop innovative feeding solutions based on natural local resources, which to decrease the egg cholesterol. Such kind of egg is something new for the Romanian market; it represents a clear way of transforming ideas into innovative products with potential on the real market. A functional food is obtained by decreasing the egg cholesterol, through nutrition and using friendly feeding solutions, which has significant implications for a higher food safety and security.

The project consortium consists of S.C. AVICOLA BUCURESTI S.A.(CO), the National Research-Development Institute for Animal Biology and Nutrition – IBNA Baloteşti (P1), the National Research-Development Institute for Industrial Ecology - ECOIND Bucuresti (P2) and a SMED - SC Marnews Consulting SRL (P3) which produces feeding crops.

The general objectives of the project are:

 Development and homologation of innovative feeding solutions for laying hens, which to allow the production of low cholesterol eggs, within the context of the Romanian market

 Production, on the basis of in-depth interdisciplinary researches, of a functional food available for a broad category of consumers, with a role in maintaining the health state of the consumers and in preventing the onset of nutrition-related diseases (obesity, cardiovascular diseases, etc.). This will likely decrease the social costs for human health care by promoting a natural consumer food

 Production of eggs using friendly feeding solutions, while ensuring animal welfare, consumer safety and environmental protection.

 Promoting a partnership in them field of scientific research between two economic units and two national research institutes interested to diversify their production on the basis of sound scientific studies and as a means to penetrate and remain on the Romanian market.

With this view, the project will run interdisciplinary research activities going deep into the research topic, with the purpose to find solutions applicable to the problem of interest.

By its purpose, objectives and structure of the consortium, the project fits the requirements of the Program INNOVATION (PN-II-IN-DPST-2012-1), field of Agriculture, food safety and security, having an innovative character, market potential and social usefulness.

Hazardous chemicals aquatic risk assessment according to REACH Regulation. Acute toxicity effects of some anilines and aromatic nitroderivates Call name:
PN 09 – 13 01 02 2012 - 2013

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Project website:

Abstract:

Monitoring system of the quality of water intended for human consumption, produced and distributed by Romanian Company Call name:
EEA GRANTS Projects, RO-0016 Application 2009 - 2011

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Project website:

Abstract:

Ecological products for metal manufacturing obtained from generable material Call name:
PN II 2007, INOVATION Program – MODUL I 2007 - 2009

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Project website:

Abstract:

Researches concerning eco-engineering of protection anticorrosive products Call name:
Program CEEX – Module I (AMCSIT-RELANSIN) Contract 142/2006, Ad. 2006 - 2008

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND

Project partners: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND ()

Project website:

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects