BrainMap

Mrs. MIRELA-FERNANDA ZALTARIOV

Scientific Researcher III

Scientific Researcher III - INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Researcher | Scientific reviewer

Web of Science ResearcherID: https://www.webofscience.com/wos/woscc/summary/c0e0d26f-499a-460a-af55-ac1b3139cb59-78c2fab3/relevance/1?state=%7B%7D

Curriculum Vitae (06/06/2024)

Expertise & keywords

Emerging 2D materials based on two-dimensional permethylated metal-organic networks Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2000 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://2dpermosil.ro/

Abstract:

After the discovery of graphene with the set of properties that essentially distinguish it from other allotropes of carbon, ultra-thin layered materials, classified as 2D nanomaterials, enjoy a growing interest due to their unique properties. In this context, very recently become of interest 2D MOFs. But in the crystallization process, 2D layers stack on the basis of intermolecular interactions, leading to higher dimensional materials. To manifest behavioral particularities specific to a 2D material, they must be isolated individually or in multilayers with thickness/surface aspect ratio as small, which is a challenge that seek solutions through different approaches (top-down or bottom-up). The project idea is to design and synthesize two-dimensional metal-organic networks with extremely weak intermolecular interactions, which facilitate delamination in nanosheets. The originality and the key to success in this approach is the use of ligands containing permethylated silicon units which by their natural exposure shield the structure and prevent the establishment of noticeable interactions. New ligands and combinations thereof will be prepared and used to coordinate various metal ions or clusters. Nanosheets formed will be evaluated as such, but also the effect of their incorporation in silicone matrices for the development of materials responsive to stimuli. Their common nature creates the premises for a better compatibility and forming advanced composites.

Mimicking living matter mechanisms by five-dimensional chemistry approaches Call name: P 4 - Proiecte Complexe de Cercetare de Frontieră
PN-III-P4-ID-PCCF-2016-0050 2018 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.intelcentru.ro/5D-nanoP/

Abstract:

Mimicking the living matter mechanism of cooperation by complementarity represents one of the most challenging tasks of supramolecular chemistry. For now the solution consists in using particularly designed molecular unimers, endowed with the necessary amount of chemical information.

The 5D-nanoP project is dedicated to interfacing the fundamental research area of constitutional dynamic chemistry with the practical approaches of medicinal chemistry and biomedical applications. In the spirit of a metaphor of Jean-Marie Lehn (Nobel Prize in Chemistry, 1987), the project aims to materialize the concept of 5D chemistry in designing, synthesizing, characterizing, and using molecules with conditional affinity, to build versatile supramolecular nanoplatforms able to vectorize compounds of pharmaceutical or biochemical relevance, and genetic actuators, all of them involved in physiologic and pathologic processes at cell- and tissue-level.

The project will add the layer of 5D chemistry over the backgrounds of molecular assembling line techniques to produce particulate nanoplatforms, self-assemblable in the virtue of the chemical information stored by the designed unimer molecules. Two modern techniques of building dynamic chemical structures will be considered: (i) the use of self-immolative linkers, and (ii) the space stepwise and time phased (microfluidic) assisted synthesis. To prove the applicability of the produced nanoplatforms, an ex vivo cell cultivation system will be developed to emulate tissue/tumor niches.

Eight teams will be involved in the 5D-nanoP project to cover the main addressed research areas: (i) the in silico molecular design, (ii) the development of a unimers chemical library, (iii) the development of a molecular assembling line, (iv) the conjugation of the developed platforms with chemical species of biomedical interest, (v) the build of ex vivo emulating niches, and (vi) the bio-oriented assessment of nanoconstructs efficacy.

Eco-innovative technologies for recovering of the platinum group metals from scrap catalytic convertors Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0185 2018 - 2021

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE "CORIOLAN DRĂGULESCU" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE BIOLOGIE (RO); INOE 2000 - FILIALA INSTITUTUL DE CERCETARI PENTRU HIDRAULICA SI PNEUMATICA BUCURESTI RA (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.3nanosae.org/ecotech-gmp/

Abstract:

Autocatalysts are used to convert vehicle exhaust (carbon monoxide, nitrogen oxides, hydrocarbons, etc.) into less harmful products, such as: carbon dioxide and nitrogen. Platinum group metals (PGMs) are the active component in autocatalysts and consequently the auto industry is the largest PGM consumer. Limited PGM resources demands recycling to support an expanding auto market. Traditional recycling methods are using high temperatures and highly oxidative agents (e.g. aqua regia) making them large energy consumers and environmental pollutants. As a result, there is a need to develop alternative ways to recycle PGMs with a significant decrease in energy consumption and a reduced impact on the environment. ECOTECH-GMP project at hand draws from the knowledge, skills and competences of top leading Romanian research institutions in materials science, physics, chemistry and engineering for creating the know-how to develop the eco-technologies required to recycle PGM with zero emissions. There is currently no such technology available in the world. Four sub-projects are proposed to solve the issue of PGM eco-recycling, encompassing electrochemistry, coordination chemistry, hydrodynamics and bioelectrochemistry. The sub-projects are intertwined and function in synergy to deliver several solutions to the issue at hand. The potential of this project is mesmerizing for any interested company: small initial capital, low energy consumption and high throughput. The benefits for the society at large are thrilling: improved public health because of decreased toxic pollutants (chlorides, nitrates, nitrides, etc.) and creating new jobs owing to the potential of this technology to transform into an industry.

New scaffolds for extension of structure-activity relationship studies of metal-based anticancer drugs Call name: P 1 - SP 1.1 - Proiecte de cercetare Postdoctorală
PN-III-P1-1.1-PD-2016-1027 2018 - 2020

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.icmpp.ro/metdrug

Abstract:

The present proposal is concerned with the development of new metal complexes based on a library of specifically modified indolo[2,3-c]quinolines and new indolo[3,2-d]benzazepines to be evaluated as anticancer drugs. We propose to extend our studies on structure-activity relationships on these frameworks and to elucidate the effects of location of the lactam group in azepine ring, and orientation of indole basic unit with respect to quinolone-2-(1H)-one entity. The rationale behind our proposal is to design new metal complexes which can allow their application at very low doses due to the highly cytotoxicity, at nanomolar concentrations. Thus the enormous potential impact of these new classes of metal-based drugs relies in their possible site-specific delivery in localized tumors, strongly improving their cellular uptake and minimizing unwanted side-effects, which could offer a significant advantage over platinum-based chemotherapeutics.

Metal-organic frameworks with hydrophobicity fine-tunned by using silicones chemistry Call name: P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0642 2017 - 2019

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.silmofs.icmpp.ro

Abstract:

The project is devoted to design, synthesis and structural characterization of metal-organic frameworks (MOFs) with controlled hydrophobicity required for certain applications such as gas storage, drug delivery systems, self-compatibilizing fillers for special energy composites, supercapacitors, etc. Different from the approaches reported in literature consisting in attaching hydrophobic groups near coordination sites, or post-synthetic grafting of such groups onto linkers, here will be used mainly ligands with siloxane spacers having attached to the silicon atoms one of the highest hydrophobic group, methyl, but also some derivatives inserting more longer (octyl), more rigid (phenyl, diphenyl), more polar (chloropropyl) or more hydrophobe (trifluoropropyl) groups in order to fine tune moisture stability of the resulted MOFs but also their lipophilicity and crystallinity. The high flexibility of the siloxane backbone allows the organic groups to be arranged and presented to their best effect. In addition, metals in high oxidation state will be used. The key steps in achieving the project objectives consist in engineering the spacer by using new approaches in silicones chemistry (i.e., Piers-Rubinsztajn reaction), attaching coordination groups (by thiol-ene addition or nucleophilic substitution), construction of MOF's and their isolation in a form accessible to characterize accurately. Thus original polydentate ligands mainly consisting in polycarboxylic acids and N-donor heterocycles with controlled diorganosiloxane or silane spacers will be obtained and used to built MOFs. The rare examples of assembling using the flexible linker, apart from those published by the authors of this proposal, and limited investigation in the field opens the innovative perspective for new knowledge and unique properties of MOFs.

Luminescent organometallic complexes with self-assembling properties Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1536 2017 - 2018

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.icmpp.ro/ro/projects.html

Abstract:

In the field of silicon-containing organometallic complexes the design and fabrication of supramolecular architectures with specific target applications is a narrow scientific domain. These compounds display several drawbacks, such as a limited solubility and a high hydrophobicity, which limit their applicative potential. The high-resolution structural details and some fluorescence parameters, such as the emission intensity or decay time, depend on the crystalline structure. In this respect, fluorescent single crystals of silicon-containing metal complexes are less encountered. The fluorescent properties of Schiff bases used as ligands in obtaining luminescent coordination compounds are well known, but their potential in developing emissive silicon-containing metal complexes is yet to be explored. The project goal is to validate a demonstration technology for obtaining luminescent organometallic complexes with a well defined architecture, created by supramolecular non-covalent interactions, using silicon-containing Schiff bases ligands and different metal ions. The proposed project aims to create a new class of luminescent metal complexes based on Schiff bases containing flexible siloxane and silane units. The difficulties in obtaining the metal complexes as single crystals are resolved by a specific strategy, and the complexes are highly organized in solid state. The starting experimental model is based on several homonuclear Zn(II) and Cu(II) complexes based on Schiff bases containing tetradimethylsiloxane and trimethylsilyl units, whose single crystals are strongly emissive. The potential use as photoluminescent materials will be testes under UV irradiation. The validated technology will be applied in fabrication of new luminescent supramolecular self-assemblies of homo/heteronuclear (3d, 3d/4f and 4f) metal complexes based on siloxane/silane-containing Schiff bases ligands.

New coordination networks containing polyfunctional flexible bridges Call name: Exploratory Research Projects - PCE-2012 call
PN-II-ID-PCE-2012-4-0261 2013 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.icmpp.ro/cazacu0261/pce_2012_4_0261_en_2016.ppt; http://www.icmpp.ro/cazacu0261/pce_2012_4_0261_ro_2016.ppt

Abstract:

The project aim is to bring developments in the metal-containing materials field by the preparation of new metal-organic networks using ligands with high flexible siloxane spacer between the complexing groups. Networks having single metal ions or polynuclear clusters as nodes will be prepared. The later will be obtained and subsequently used as secondary building units (SBUs) or generated in situ concomitantly with the network formation. Original di- tetra- and polycarboxylic acids as well as amine ligands containing siloxane moieties will be used as SBUs for the metal-organic structures infinitely extended into one, two or three dimensions (1D, 2D or 3D, respectively) via more or less covalent metal-ligand bonding. The siloxane moieties confer flexibility to the networks, thus structural adjustment through rotations and twists of structural units are expected, leading to better uptake of different guest molecules. Both building blocks (siloxane ligands and metal clusters) and networks prepared on their basis will be fully characterized from structural point of view by using adequate techniques (elemental, spectroscopic, X-ray diffraction). The specific properties (as for example: sorbtion behavior, magnetic, catalytic, biological, etc.) will be evaluated in order to identify possible applications of the new materials.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader	Download (14.83 kb) 09/01/2019
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects