BrainMap

Oana Alexandra Hosu-Stancioiu

- UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Researcher | Teaching staff

Curriculum Vitae (15/10/2019)

Expertise & keywords

Design sensing platforms for detection and quantification of biomarkers involved in neurological disorders Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0460 2015 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO)

Project website: http://www.granturi.umfcluj.ro/BIO-NEURO-SENS

Abstract:

Neurological disorders are numerous, diverse, frequently severe, affecting a large portion of the world’s population, with challenges in their diagnosis and treatment. The current project proposes the development of a global strategy for designing (bio)sensors, involving an ultrasensitive electrochemical setup based on a specific and selective nanoplatform capable of simultaneous detection of some biomarkers involved in neurological disorders. The originality of the proposed project resides from the use of electroanalytical methods involving electrodes modified in a controlled and optimized way with a novel association of nanomaterials with bioelements. Various strategies are envisaged for the functionalization of different types of electrodes and the use of various nanomaterials, design of new and innovative way that will allow their immobilization. The obtainment of the completely functional nanoplatforms will be followed by the optimum immobilization of the bioelements (enzyme, antibody, aptamer) will be determined, assuring highly specific detection. After the complete characterization of the elaborated sensors in terms of properties and performances, their application for real samples analyses will be tested, as a first step in development of point-of-care devices.

The success of the project could assure an early diagnosis of neurological disorders with improvement in the health of the population.

project title Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2017-0506 2017 -

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation:

Project website:

Abstract:

Innovative electrochemical sensors for sensitive and selective detection of some biogenic amines Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-Franța (bilaterale)
PN-III-P3-3.1-PM-RO-FR-2016-0003 2016 -

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); Université Rennes 1, Campus de Beaulieu, nstitut des Sciences Chimiques de Rennes (ISCR), UMR CNRS 6226, "Matière Condensée et Systèmes Electroactifs" (MaCSE) (FR)

Affiliation:

Project website:

Abstract:

Aminele biogene (dopamina, serotonina) prezintă un rol important în controlul și reglarea principalelor funcții neuronale, fiind incriminate de apariţia unor patologii psihologice și neurologice. Acești compuși pot fi consideraţi atât biomarkeri în apariția și monitorizarea evoluţiei unor boli neurodegenerative cât și ținte pentru noi metode terapeutice. În vederea diagnosticării și monitorizării eficacității terapiei propuse, se impune dezvoltarea unor metode de detecție și cuantificare rapide ale acestor amine. Proiectul propus urmărește obținerea unor platforme selective pentru detecția specifică a aminelor biogene cum sunt dopamina sau serotonina. Astfel, posibilitatea implementării unor metode și dispozitive care să permită identificarea și cuantificarea acestor compuși rapid, cu costuri scăzute și fără a necesita separarea în cazul determinărilor efectuate pe matrici complexe, este de mare interes pentru lumea medicală. Originalitatea acestui studiu constă în implementarea unor platforme pe bază de nanoparticule de aur si polipirol care să permită analiza calitativă și cantitativă a unor amine biogene prin intermediul tehnicilor electrochimice precum si a unor catalizatori biomimetici pe baza de cupru. Tehnicile abordate permit sintetizarea unor nanostucturi care prezintă densitate crescuta de centrii activi disponibili pentru legarea analitului de interes pe o suprafaţă geometrică relativ redusă și posibilităţi de miniaturizare cu creşterea spectrului de aplicaţii.

project title Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori cu experienta din diaspora
PN-III-P1-1.1-MCD-2016-0101 2016 -

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO)

Affiliation:

Project website:

Abstract:

Call name: Premierea obtinerii atestatului de abilitare - Competitia 2015
PN-II-RU-ABIL-2015-2-0008 2015 -

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO)

Affiliation:

Project website:

Abstract:

FUNCTIONALIZED NANOMATERIALS WITH CHROMO AND FLUOROPHORES AND NANOSTRUCTURED PLATFORMS FOR BIOSENSORS APPLIED IN PHARMACEUTICAL AND BIOMEDICAL FIELDS Call name: Programul de actiuni Integrate Romania-Franta (bilaterale)
PN-II-CT-RO-FR-2014-2-0008 2014 -

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); Universite Joseph Fourier (FR)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO)

Project website:

Abstract:

The aim of this project is to obtain supramolecular nanomaterials functionalized with chromophores and fluorescent compounds and nanostructured platform for the development of biosensors with possible applications in the detection of biomedical and pharmaceutical compounds. For this purpose new nanostructured surfaces with photoelectrochemical properties will be develop by combining chromophores or fluorophores with new nanomaterials. Several molecules are taken into account: photosensitive transition metal complexes such as complexes of Ru(II) with pyridine having photoelectrochemical and electrochemiluminescence properties, and tetrazine derivatives, due to their fluorescent properties. Another objective of the project is to obtain nanostructured platforms by nanospheric lithography for the controlled immobilization of biomolecules and rational design of biosensors, with possible applications in biomedical analysis. Modified electrodes with graphene, cyclodextrins and polymer films for detection and simultaneous determination of ascorbic acid, uric acid and dopamine in pharmaceutical and biological samples will also develop. This collaboration will enable the development of new research directions on the topic of biosensors using the scientific skills of each team.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects