BrainMap

Mrs. Monica-Cornelia Sardaru

Research Assistant

Research Assistant - INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Researcher

Curriculum Vitae (26/08/2021)

Expertise & keywords

Innovative multifunctional, bioactive topical formulation for the management of malignant wounds Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2193 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://bios.unibuc.ro/Proiecte/proiect-pn-iii-p2-2-1-ped-2021-2193.html

Abstract:

Malignant fungating wounds (MFW) are incurable, severe, and debilitating conditions normally occurring in the last (six) months of oncologic patient’ life, affecting the overall quality of life and requiring appropriate palliative care to alleviate pain and suffering. MFW’s microbiome may influence the development and severity of wound symptoms, causing foul odors, peri-wound skin damage, inflammation, and ultimately, delays in the healing proliferative phase. ARGOS project is implemented by a consortium of two research institutions and one company with previous experience in developing collagen-based pharmaco-cosmeceutic products and is aiming to develop an innovative multi-purpose, bioactive topical formulation to assist the physical management of malignant fungating wounds, by addressing the microbiome-related symptoms such as pain, odor, and exudate. The proposed solution is based on collagen and inorganic - gold, silver and magnetic – nanoparticles functionalized with plant-derived bioactive compounds (such as polyphenols contained in Chelidonium majus L. and Tamarix gallica extracts, with previously demonstrated antioxidant, antimicrobial, antiproliferative, antiviral and immunomodulatory activity). Therefore, the main novelty of the proposed solution is that it provides not only a wide antimicrobial effect, but also anti-cancer activity and pro-healing properties on the site of malignant wounds. The physico-chemical, mechanical and biological properties of the collagen-based optimized product will be validated by standard protocols and the technological scaling documentation and argumentation of the investments required for in vivo tests will be elaborated (TRL4).

Versatile molecular vectors with tailored carrying and actuating abilities, dedicated to gene and drug delivery in fight against cancer Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1523 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://www.intelcentru.ro/tm-vector/index.php

Abstract:

Gene therapy represents nowadays one of the most challenging promises for the cure of cancer, rare, and severe diseases. The speed of the steps toward it strongly depends on the efficacy and reliability of the molecular tools involved in the manipulation (isolation, reconfiguration, multiplication) and vehiculation (native state preservation, dense packaging, targeted and “stealth” delivery, local protection) of the nucleic acids.

The main objective of TM-Vector project is to develop a highly reproducible macromolecular edifice capable to function as a cooperative carrier for nucleic acids, characterized by the ability to be post-decorated with biochemical and / or pharmacologic active molecules, by virtue of dynamic processes of selective affinity of host-guest type. The particular architecture of the carrying vector will offer three unique functional properties, representing our original contribution to the practice of nucleic acid vectorization: (i) the ability to target various cell receptors; (ii) the possibility to concomitantly vectorize several types of active molecules (e.g. nucleic acid molecules and pro-drug molecules); (iii) the capacity to selectively attach molecules having neat different volumes and conformations.

TM-Vector project could have societal impact, contributing to the improvement of the quality of life of sufferers. The applied research directions could also contribute to the technology of gene and drugs carriers produced at biopharmaceutical scale.

New Polyfunctional Azasteroids Mimics: fluorescent and biologically active compounds Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2016-1205 2018 - 2020

Role in this project:

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Affiliation: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Project website: https://teclu.chem.uaic.ro/npamfb/

Abstract:

The research project is primarily aimed at the synthesis of new azasteroids derivatives through conventional and unconventional methods, using microwave and ultrasound technology. It will be obtained new azasteroids which demonstrates potential applications for medicine. Thus, it will be studied the biological activity (anticancer, antibacterial and antifungal activity) of the new obtained compounds. Also, will be obtained new materials with azaheterocyclic skeleton of interest for optoelectronics (OLED) through various reactions. It will be elaborated environmentally friendly methods using microwave and ultrasound energy. The synthesis of new azasteroids structures containing azaheterocyclic skeleton by Heck, Suzuki and Sonogashira cross coupling reactions, will be done. Structural characterization of newly compounds using modern and specific techniques: elemental analysis, chemical and spectral analysis: IR, UV-Vis, NMR, MS, X-ray, will be done.

The proposal has several elements of originality, having in view obtaining of new compounds/materials, elaboration of new experimental setup methods (using microwave and ultrasound technology) and/or adaptation of the existing one, new contribution to the already existing approaches / theories, bringing thus significant contribution to the fundamental research. Also, the results of research could have potential applications: in the field of optoelectronic and in the field of pharmaceutical industry.

„22nd International Conference on Organic Synthesis”, (22-ICOS) Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2018-0672 2018 -

Role in this project:

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Affiliation: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Project website:

Abstract:

Chemistry Conference for Young Scientists, ChemCYS 2018 Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2017-1104 2017 -

Role in this project:

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Affiliation: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Project website:

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects