BrainMap

Mr. Marius Stefan

Prof. PhD. habil.

Professor - UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Researcher | Teaching staff | Scientific reviewer | PhD supervisor

Web of Science ResearcherID: not public

Curriculum Vitae (26/04/2024)

Expertise & keywords

Study of Zea mays and Vigna unguiculata rhizosphere diversity – premises for potential applications in bioeconomy Call name:
PN III-P3-119 2016 - 2017

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (); North-West University, Mafikeng ()

Affiliation: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI ()

Project website:

Abstract:

Effects of 6-hydroxy-nicotine on chlorisondamine-induced oxidative stress and neurotoxicity: relevance for Alzheimer’s disease Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0106 2015 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Affiliation: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Project website: http://www.bio.uaic.ro/cercetare/grupuri/bioactive/content/grants/te2015.html

Abstract:

The search for neuroprotective therapeutics for Alzheimer’s disease (AD) has been recently geared toward the identification of modulators for nicotinic acetylcholine receptors (nAChR). Using computational methods, the Arthrobacter nicotinovorans metabolic intermediate 6-hidroxy-nicotine (6HNic) have been identified as a putative nAChR ligand. The cognitive-functions tests performed on normal rats showed that chemically synthesized 6HNic has positive effects on spatial memory, mainly by decreasing brain oxidative stress.The current research funding application aims to form a young team with the goal to isolate 6HNic and to evaluate its potential of improving the cognitive and non-cognitive functions in a rodent model of AD. For this, the Arthrobacter nicotinovorans enzyme responsible for 6HNic production will be cloned, expressed, purified and further used to produce the compound in an in-vitro reaction. After its isolation by HPLC from the reaction mixture, 6HNic will be injected in chlorisondamine-treated rats and its neuroprotective and anti-oxidant properties will be assessed using a combination of behavioral tests, flow-cytometry and biochemistry techniques. Also, the systemic toxicity as well as pro-apoptotic properties will be investigated, in an attempt to fully characterize the compound and to conclude its applicability in the field of AD.

Applications of biomolecules with antifungal properties in plant protection Call name:
2015 - 2016

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (); Lille University ()

Affiliation: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI ()

Project website:

Abstract:

THE IMPACT OF SOME RHIZOBACTERIA STRAINS ON SOYBEAN (GLYCINE MAX L. MERR.) PLANTS GROWTH AND DEVELOPMENT Call name:
PN II -ID-PCE -

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners:

Affiliation:

Project website:

Abstract:

Impact of rhizospheric microorganisms (PGPR) on growth and development of food crops Call name:
2006 - 2007

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI ()

Affiliation: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI ()

Project website:

Abstract:

Applications of some biomolecules with antifungal properties in plant protection Call name: Programul de actiuni Integrate Romania-Franta (bilaterale)
PN-II-CT-RO-FR-2014-2-0033 2014 -

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); Université Lille 1 (FR)

Affiliation: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Project website:

Abstract:

Phytopathogenic microorganisms represent a major threat worldwide for both agricultural production and ecosystem stability. For this reason, farmers became dependent on the use of chemicals as a method of pest control. Excessive use of plant protection products has however negative consequences: soil and atmosphere pollution, water quality degradation, biodiversity loss in the agricultural ecosystems, threatening human health. In this context, the project proposes as an alternative to traditional chemical fungicides the use of lipopeptide (iturine, surfactin and fengicine) produced by species of the genus Bacillus for the biocontrol of the phytopathogenic fungus Fusarium oxysporum. Using purified biomolecules, characterized and tested by French researchers from the University of Science and Technology of Lille 1, we intend to test the biocontrol potential of the lipopeptides within the specific pathosystem of ornamental plants grown in the Botanical Garden of Iasi: Narcissus and Iris. The results of these investigations will be later extended to other plant species with economic value.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects