BrainMap

Mr. Marius Andrei Avram

PhD

Researcher - INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Researcher | Manager

Web of Science ResearcherID: AAH-9342-2020

Curriculum Vitae (20/09/2024)

Expertise & keywords

Nano meta components for electronic smart wireless systems Call name: P 5.8 - SP 5.8.1 - Premiere Orizont Europa - Instituții - Competiția 2023
PN-IV-P8-8.1-PRE-HE-ORG-2023-0033 2023 - 2026

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website:

Abstract:

New communications and radar systems require small and tunable high-frequency devices, since their backbone is the Internet-of-Things (IoT). The need for ultrafast, low-energy-consumption information processing of an exponentially increasing data volume will lead to a global mobile traffic reaching 4394 EB by 2030, thus starting the 6G era (data rate up to 1 Tb/s) of an “ubiquitous virtual existence”. In today’s wireless applications, radar sensors play one of the major roles. Due to the increased need for higher sensitivity and non-destructive inspection systems, radar sensors with operating frequency in the microwave spectrum have been gaining increasing attention for smart home, non-destructive material classification, monitoring vital signals, and all the IoT application that need micro-motion detection. The market penetration for these sensors is now hampered by (i) the limited antenna performance and (ii) the frequency selectivity and tunability. SMARTWAY proposes novel architectures based on new paradigms that exhibit a significant decrease in energy consumption while improving speed/performance and miniaturization. The disruptive nature of the targeted approach relies on progress towards the wafer-scale integration of two-dimensional (2D) materials and metamaterials (MMs) into radar sensor suitable for IoT sensing applications. The final outcome of this support activity will be a band-pass filter in the 1–5 GHz range based on nanoscale ferroelectric and carbon-based materials, thus providing brand-new designs of nanoelectronics components with emphasis on compatibility and integration of different materials/technologies.

Beam-steering antenna arrays based on nanostructured graphene/graphite for advanced microwave communications Call name: P 4 - Proiecte de cercetare exploratorie - PCE-2021
PN-III-P4-PCE-2021-0223 2022 - 2024

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation:

Project website: https://www.imt.ro/steering-graph/

Abstract:

The goal of STEERING-GRAPH is to integrate nanostructured graphene/graphite into CMOS-compatible beam-steering antenna arrays, in which the radiating elements will be made of a carbon-like material that ensures gain tunability (as well as frequency and matching reconfiguration), whereas the modulation of the phase needed to steer the beam of the array will be obtained using memristors/memtransistors integrating graphene/graphite layers and doped/undoped hafnium oxides. This way, the outcome of STEERING-GRAPH will be a carbon-based phased antenna array with non-volatile memristor-like switches, providing good RF performance and low-power consumption, since the non-volatility state entails that the controlling signals do not need to be applied continuously, thus minimizing power consumption (i.e., in the range 10–100 mW) and reducing antenna’s sensitivity to power outages.

The concrete objectives of STEERING-GRAPH are: (1) design, fabrication, and experimental characterisation of nanocrystalline graphite-based antennas and antenna arrays; (2) design, fabrication, and experimental characterisation of two- or three-terminal memristors based on dielectric/ferroelectric hafnium oxides and graphene/graphite; (3) hybrid and, then monolithic integration of antenna arrays and memristors/memtransistors for CMOS-compatible „non-volatile and low-power beamforming applications”.

Fabrication by Photolithography of Optical Components with Large Apertures and Complex Aspherical Surfaces Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1233 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation:

Project website: http://www.imt.ro/LACAS

Abstract:

The project titled Fabrication by photolithography of Optical Elements with Large Apertures and Complex Aspherical Surfaces (LACAS) will development of technology based on microfabrication methods for realizing large aperture optical elements with complex aspherical optical surfaces for generating helical wavefront beam carrying orbital angular momentum (OAM) for high power lasers and Bessel beams of zeroth and higher order for free space optical communications. Also, in the framework of this project, free form optical components with the functionality of sorting beams with helical wavefronts as a function of their OAM and with applications in quantum information will be fabricated. The proper functionality of the fabricated components and a high quality of their optical surface will validate the technology

Graphene based spintronic structures for sensing applications and signal processing Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-3112 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA TRANSILVANIA BRASOV

Project partners: UNIVERSITATEA TRANSILVANIA BRASOV (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation:

Project website: https://graphenespin.unitbv.ro/

Abstract:

The project scope consists in development and testing of a graphene based spintronic demonstration chip which has the flexibility to be configured for various applications like: magnetic field detection, magnetic nanoparticles detection and demonstration of a two/three terminal device functionality – diode/spin valve transistor. By using magnetic electrodes, e.g. Co, deposited on graphene, one can manipulate not only the charge but also the spin of the electron. Such that, using an innovative setup with nonmagnetic and magnetic electrodes on graphene we propose a demonstration chip on which many applications like described above can be developed. To microfabricate this chip, numerical simulations and experimental activities will be done in order to increase the spin injection/detection efficiency through the optimization of the graphene/electrodes interfaces, the structure of the magnetic layers, the deposition processes and the layout of the chip.

Impedimetric biosensor based on vertical graphene, integrated with a microfluidic system for monitoring the plasma levels of anti-tumoral agents. Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2021-0444 2022 - 2024

Role in this project:

Coordinating institution: DDS DIAGNOSTIC S.R.L.

Project partners: DDS DIAGNOSTIC S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation:

Project website: https://ddsdiagnostic.com/neoplacip/

Abstract:

The treatment of patients diagnosed with different types of malignant tumors with antineoplastic drugs is difficult, due to the considerable variability of the pharmacokinetic parameters of these drugs, but also due to a plethora of adverse and secondary effects. The project proposes development of a sensor for simultaneous detection from human plasma of three antitumoral compunds commonly used in cancer therapy in Romania: etoposide, cisplatin and bleomycin. They are often used in combination therapy, in an attempt to minimize side effects and maximize the therapeutic effect. The NEOPLACIP project proposes the development of a microfluidic system, based on detection by electrochemical impedance, for the prognosis and personalization of antitumor therapy by determining the concentration of the antineoplastic agents in the biological fluids of patients undergoing treatment. The microfluidic system will be presented with integrated electrochemical sensors whose working electrodes are functionalized with vertical graphene and will specifically bind the therapeutic compunds through a set of immunoglobulins. This type of sensor is able to provide information on the concentration of antineoplastics in the human plasma, through a fast and sensitive analysis, in real-time. The information obtained will lead to the personalization of the administration method, with benefits first and foremost for the patient, and subsequently economic benefits through low consumption of reagents, low costs, cheap and easy-to-handle equipment and instruments and implicitly, very low risk of contamination. So far, in Romania, no microfluidic platforms have been developed presented with electrochemical sensors based on graphene for the detection of biomolecules, hence the market potential for the sensor. In addition, the project will stimulate Research-Development-Innovation investments by the beneficiary company and will strengthen its position on the market.

Nanocarbon-based resistive sensors for IoT applications – from material synthesis to versatile readout circuitry Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-4158 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO)

Affiliation:

Project website: https://www.imt.ro/caress

Abstract:

CARESS - is a multidisciplinary research project which aims to realize a versatile, low-cost sensing system employing resistive sensors The execution of the activities will bring together the expertise of researchers in the field of materials science, chemistry, physics, and microelectronics technology (IMT Bucharest) and the experts in the field of electronic devices and circuits, electrical measurements (Polytechnica University of Bucharest). The team comprise experienced researchers, post-doctoral researchers, as well as 2 PhD students. We aim to demonstrate how resistive sensors (with a well-established position on the sensor’s market) can be integrated into various applications (wearables, environmental monitoring) through a versatile, low-cost readout circuit, ready for integration in IoT applications. Its main objectives are a) realization of novel sensing materials, based on fluorinated nanocarbon materials (subject of two Romanian patent applications) and b) the design, realization and testing of a versatile readout circuit, ready for various applications (incl. IoT architectures). The process of obtaining fluorinated nanocarbon materials will be carried out in a RF plasma environment, following a well prepared “design of experiments” plan; these will be thoroughly characterized. Specific designs for the interdigitated transducers, including Wheatstone bridges, will be developed and realized on flexible substrates. The envisaged improved electronic architecture concept, based on the Wheatstone half-bridge monolithic sensing element is meant to sequentially acquire signal from multiple types of resistive sensor-structures. A microcontroller included in the electronic circuit architecture, will control the biasing of the bridge and the overall power consumption of the system. The integrated system – bridges, resistive sensor, readout circuit- will be thoroughly characterized and tested, employing dedicated instruments, available at the partners.

Nano-crystalline graphite disposable electrodes for polycyclic aromatic hydrocarbons sensing Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-0768 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO)

Affiliation:

Project website: https://www.imt.ro/NCGHySe/

Abstract:

This project has the objective to develop electrochemical sensors for polycyclic aromatic hydrocarbons (PAHs), based on nano-crystalline graphite (NCG) films deposited via plasma-enhanced chemical vapor deposition (PECVD) on different insulating substrates. The design of these electrochemical sensors includes the growth of the NCG material in a 3D nanoarchitecture as graphite nanowalls (GNW) onto the substrates of choice, increasing the active surface area in order to enhance the sensitivity towards PAHs. Carbon-based electrodes have already been employed in applications as electrochemical sensors as they allow wider working potential windows and lower noise, compared to those of metal electrodes (e.g., Au, Pt). Using PECVD as the preparation method of the NCG films, we aim to obtain 3D doped nano-crystalline graphite films with excellent electrochemical performance for the detection of PAHs.

Nanocrystalline Graphene e-Tongue for Extra-Virgin Olive Oils Testing Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2256 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation:

Project website: https://www.imt.ro/NAGET/rezultate.php

Abstract:

Olive oil is one of the most valuable foods due to its unique organoleptic properties, its high content of monounsaturated fatty acids (70-80%) and its antioxidant properties given by the presence of lipophilic phenols (tocopherols) and hydrophilic phenols (hydroxytyrosol, tyrosol, oleacein, vanillic acid) in the composition of olive oil. Extra virgin olive oil (EVOO) is traded at higher prices than other vegetable oils due to its exceptional properties such as nutritional value, aroma and excellent taste and is therefore subject to fraudulent activities. Therefore, the present project proposal aims to develop an electrochemical tongue sensor paired with chemometrics targeting the adulteration of extra-virgin olive oils. The proposed analytical approach being developed will be validated in relation to a standardised method used to determine the authenticity of extra virgin olive oils. The electrochemical tool will benefit from the knowledge already acquired by the consortium members. The e-tongue will consist of a suitable conductive material as the sensing interface (i.e. nanocrystalline graphene (NCG) based electrodes), the surface of the transducers will be modified with graphene quantum dots (GQDs) to chemically tailor the surface, increase the electroactive area and improve the sensitivity. The electrochemically recorded data will be processed and analysed using established and new chemometrics tools to train and validate a method for classifying olive and vegetable oils and another for predicting the concentrations of selected markers associated with olive oil adulteration.

New semiconductor ferroelectric material for digital applications Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-3183 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation:

Project website: https://www.imt.ro/ferromemolog/index.html

Abstract:

The project proposes to develop a new semiconductor ferroelectric at the wafer scale NiO:N (NiO doped with N) and based on it to develop switchable rectification devices, logic gates and transistors with memories where the logic operation and memory are in the same place. We have obtained the demonstration of the ferroelectricity in atomically-thin NiO doped with N. The advantages of a NiO:N ferroelectric semiconductor films are very important since on a single chip we can combine various functions of semiconductors, such as amplification and digital processing, with those specific of ferroelectrics, such as memory. Therefore, on a single chip, it could be possible to assemble all electronic functions for in-memory computing, going thus beyond the von Neumann computing architecture used today, in which the memory and the digital processing unit (ALU) are separated and the computer consumes the largest part of its electric power to transfer data between these two units.

The main outcome of this project will be the foundation of a technological platform for the ferroelectric field-effect-transistor memory devices, logic gates with memories, and for memory diodes devices with logic gates.

First demonstrator (designed to be realized from TRL 2 up to TRL 4) is a CMOS compatible device in which several layers are used forming an MFM (metal–ferroelectric–metal) diode in which, it is used, in frist time, as a ferroelectric material, a NiO:N film, then with HfO2:Zr. The Ferroelectric films layer will have thicknesses between a few nanometers and 30 nm.

Second demonstrator (designed to be realized from TRL 2 up to TRL 4) is a ferroelectric FET (Fe-FET) having as channel a graphene monolayer transferred at the wafer scale.

Both demonstrators are advanced devices at the wafer scale in the area of neuromorphic computation since the logic and memory operations are taking in the same place as in the case of neurons.

Waterproof deformable hybrid solar cells Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1691 2021 - 2023

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO)

Affiliation:

Project website: https://infim.ro/en/project/waterproof-deformable-hybrid-solar-cells/

Abstract:

Combinând problemele majore legate de încălzirea globală datorită gazelor cu efect de seră ce implică găsirea de noi metode de producere de energie curată, regenerabilă cu cele legate de progresul în domeniul electronicii, direcțiile recente urmăresc dezvoltarea de noi metode și materiale care pot: oferi a sursă alternativă fezabilă pentru energie regenerabilă bazată pe radiația solară, (ii) oferi performanțe ridicate ale dispozitivelor și (iii) susține deformarea mecanică. Prezentul proiect propune un nou tip de celulă organică hibridă flexibilă, care combină proprietățile materialelor organice cu cele ale siliciului. Structura propusă constă într-o celulă solară elastomerică bazată pe nanopaterni de Si sub formă de trunchi de con incorporați într-un amestec de donor/acceptor de material organic, plasat între doi electrozi metalici transparenți și flexibili. Obiectivele principale sunt: (i) realizarea trunchiurilor de con inversate de Si; (ii) depunerea de material organic peste nanopaternii de Si; (iii) incorporarea structurii într-o membrane elastomerică; (iv) depunerea electrozilor metalici și caracterizarea structurilor. Principalele tehnologii folosite în realizarea obiectivelor sunt: tehnica de nano-imprimare folosind radiația ultravioletă- pentru realizarea paternilor, evaporare laser pulsate asistată de o matrice-pentru depunerea stratului organic; spinare pentru depunerea PEDOT:PSS-ului și tehnica de electrospinare pentru realizarea electrozilor metalici.

Elastomeric tuneable metasurfaces for efficient spectroscopic sensors for plastic detection Call name: EEA Grants - Proiecte Colaborative de Cercetare
EEA-RO-NO-2018-0438 2019 - 2023

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); SINTEF AS (NO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: https://elastometa.ro

Abstract:

If current production and waste management trends continue, it is projected that roughly 12 billion metric tons of plastic waste will be in landfills or in the natural environment by 2050. Plastics represent a significant environmental problem: They are for the most part not biodegradable, cause problems for terrestrial and aquatic life, and enter the food chain in the form of microplastics. A shift towards a circular economy has been proposed to meet these challenges, in which production, circulation and consumption do not leave behind negative footprints and do not deplete natural resources. An essential component in the transition to a circular economy involves turning waste into value, thereby giving incentives to reduce, reuse and recycle. Simplified and low-cost methods of sorting materials are currently making a great impact on the environment: It is estimated that the reverse vending machines of the company TOMRA alone capture 35 billion beverage containers every year, and thereby reduce greenhouse gas emissions by an equivalent of 2 million cars driving 10'000km annually.

Photonic sensors are ideally suited for material sorting due to the spectroscopy technique, which allows for discrimination between different polymer types by illuminating with near infrared electromagnetic fields and measuring absorption. An important development goal is to make such spectroscopy simple, affordable and energy efficient. The ElastoMETA project aims to design and fabricate functional nanostructured surfaces, known as metasurfaces, to meet these goals. These surfaces contain simple subwavelength nano-structures that can shape light which is transmitted through them. Despite their simplicity, they offer a new paradigm for advanced field manipulation due to unprecedented control of phase, polarization, amplitude and dispersion of the electromagnetic fields. The versatility of this approach is evident by the short time during which numerous realizations have been made: e.g. micro-lenses, filters, couplers, emitters and even holograms. With further development, metasurfaces are expected to have several advantages over existing optical sensor technologies for recycling applications (e.g. diffractive optics), in terms of (i) increased efficiency, (ii) relative ease of fabrication, and (iii) enhanced functionality.

The ElastoMETA project aims to develop designs and cost-effective nanostructuring processes for (a) tuneable, filtering and efficient lens designs, and (b) directional infrared emitters, for plastic detection. These developments are central to improving the efficiency and functionality of a spectroscopic microsensor for a circular economy. To this end ElastoMETA combines Romanian expertise in UV-nanoimprint and electron beam lithography from the National R&D Institute of Materials Physics (INCDFM) and the National R&D Institute in Microtechnology (IMT), and in theoretical photonics at University of Bucharest (UB) with Norwegian expertise at SINTEF Microsystems and Nanotechnology (SINTEF MiNaLab) in developing micro-optical sensor devices for industrial plastic and gas detection. This new long-term strategic partnership aims to bring developments at the forefront of photonics and nanotechnology towards commercial sensor applications for a competitive Romanian and Norwegian industry within the circular economy.

ElastoMETA demands close collaboration of the Romanian and Norwegian partners on interdisciplinary and interrelated work, related to i) design and simulation of functional structures acting as tunable, filtering lenses and directional sources, 2) process development using electron beam lithography for design verification, 3) UV nanoimprint lithography for cost effective nanostructuring of large area lenses, 4) embedding structures in elastomeric substrates to allow for mechanical tuneability 5) optical characterization and testing of the manufactured structures and 6) dissemination and evaluation of the project.

Piezoelectric Energy Source for Smart Factory Applications Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERANET-M-SmartEnergy 2021 - 2023

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); RENAULT TECHNOLOGIE ROUMANIE SRL (RO); Łukasiewicz Instytut Technologii Elektronowej (PL); École Polytechnique Fédérale de Lausanne (CH); Center for Corporate Responsibility and Sustainability @ University of Zürich (CH); Medbryt sp. z o.o. (PL)

Affiliation:

Project website: https://www.imt.ro/smartenergy

Abstract:

SmartEnergy aims to develop an integrated, miniaturized, highly energy efficient, maintenance-free and environmentally-friendly energy source, with extensive scalability and re-configurability. The system integrates a MEMS piezoelectric energy harvester, a rectifier circuit and a supercapacitor, and shows a great promise to replace conventional energy sources and significantly reduce the environmental impact.

The proposal covers a new technology based on advanced multifunctional materials, including highly efficient piezoelectric materials and arrays of decorated carbon nanotubes electrodes.

The project will start from TRL 3 and will reach TRL 5. The development is largely industry-driven, with Renault as the end-user looking to upgrade factory processes monitoring through autonomous sensor nodes. Thus our SmartEnergy source has a great potential to drive down cost, while making smart factory and IoT applications greener and smarter.

NANOMATERIALS ENABLING SMART ENERGY HARVESTING FOR NEXTGENERATION INTERNET-OF-THINGS Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2020-0072 2021 - 2023

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation:

Project website: https://www.imt.ro/NANO-EH_24.2021/

Abstract:

The 4th Industrial Revolution (4IR) builds on the Internet-of-Things (IoT) paradigm, as it relies upon the scenario of having billions of interconnected autonomous mobile devices, with unprecedented processing power, storage capacity and access to knowledge. At the same time, the 4IR should be increasingly eco-friendly, by exploiting technological breakthroughs in everyday life (such us artificial intelligence, wireless communication and quantum computing). The biggest bottleneck for 4IR is that in most situations, IoT devices/networks will be remotely deployed, so that maintenance may be either inconvenient or impossible. This implies that IoT devices either have to embed energy sources consistent with their operative lifespan or that clean and renewable energy convertors must sit on board. The significant broadening of the wireless communication spectrum in Europe makes the Radio frequency (RF) energy scavenging a highly desirable way forward for clean powering of the next generation IoT. NANO-EH has the ambitious vision of creating a pathway for translating forefront knowledge of unique high frequency properties of emerging classes of nanomaterials into advanced device engineering for scalable miniaturized energy harvesting/storage submodules. This target will be reached by developing non-toxic and rare earth/lead-free materials exhibiting CMOS-compatibility and scalability for low cost and large-scale manufacturing.

Senzori magnetorezistivi optimizati pentru detecția pe cip a nanoparticulelor magnetice Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3514 2020 - 2022

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA TRANSILVANIA BRASOV

Project partners: UNIVERSITATEA TRANSILVANIA BRASOV (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://magsensonchip.unitbv.ro/

Abstract:

The project scope consists in development and testing of a demonstration model with on chip integrated spintronic magnetic sensors, optimized for capture and detection of magnetic nanoparticles (MNPs) in a simple microfluidic cell, the core of a lab on chip device. A main goal related with this scope is to propose a more efficient detection scheme by: (i) choosing the adequate multilayer structure and sensor’s layout and (ii) by exploiting specific properties of spintronic structures related with magnetic domain walls and their dynamics in well-defined magnetic fields. The spintronic sensors, used for this demonstrator, are based on Planar Hall Effect (PHE) in exchange-biased magnetic thin films. The core of our demonstration model is a demonstration chip, which will host 2 identical rows with spintronic sensors, with different geometries on each row. This setup is used to have the pairs “measurement sensor-reference sensor” for each particular geometry that, in turn, will be finally established during the project implementation through micromagnetic simulations and experimental tests. The demonstration model will be tested and validated in laboratory conditions, TRL4, for MNPs detection, fluid flow through microfluidic channels, surface and volume detection of different magnetically labelled biomolecules using both DC magnetometry and AC magnetorelaxometry. Will be tested and validated the detection limit, the methods reliability and signal stability. Through these researches, the project aims to achieve practical and original results with potential market application because of the demanding of new, reliable and cheap techniques for detection of magnetically-labelled biomolecules.

Innovative probe system for electrophysiological guidance in functional neurosurgery Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3775 2020 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); TERMOBIT PROD SRL (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: https://www.imt.ro/brain-guide

Abstract:

The overall goal of the joint BRAIN-GUIDE project is to demonstrate and validate in laboratory - starting from TRL-2 level - a new generation of brain electrode probes that significantly enhance the functional capabilities of the probes that are currently used intraoperatively in the acute stage of the functional neurosurgery (DBS) protocol for accurate determination of the anatomical target. The acute probe system to be developed is designed to allow intraoperative wireless electrophysiological guidance through recording of bioelectrical activity from deep brain structures and selective electrical stimulation using a set of segmented macroelectrodes realized from conductive carbon.

In the context of the slow innovation pace related to the electrophysiological guidance probes our new “segmented carbon + wireless headstage” design brings several advantageous features for the DBS surgical procedure, enabling multichannel recording of high-quality local field potentials and more efficient and directionally selective stimulation, while avoiding the need for connection cables that clutter the surgical theatre, pick up motion artifacts and attenuate the signal. The proposed solution is cost-effective and relies on a pre-submitted patent application authored by members of two project partners (CO and P1).

The project leverages both the ideal complementary expertise and starting grounds, available in the consortium. Project coordination and electrode probe realization is ensured by the IMT Bucharest team (CO) specialized in R&D for functional materials and micro-nano technologies. The wireless headstage system will be developed by the Termobit Prod SRL team (P1), that has a proved expertise in electrophysiology and development of electrophysiological equipment. The project will benefit from the rich, specific, expertise of the UMF-CD team (P2) for optimal starting specifications and in-vivo evaluation of the planned prototype.

RANGE OF IMAGE OPTICAL SYSTEMS WITH ZOOM FOR MWIR SPECTRAL FIELD WITH SECURITY APPLICATIONS Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2019-0465 2020 - 2022

Role in this project: Key expert

Coordinating institution: PRO OPTICA SA

Project partners: PRO OPTICA SA (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: https://prooptica.ro/mwiro/

Abstract:

The idea of this project, to create an optical imaging system with diffractive elements in the MWIR field, appeared as a good opportunity to capitalize on the experience and know-how accumulated for the realization of an optical imaging system with diffractive elements in the LWIR field. . The diffractive elements were made lithographically, in a previous partnership PRO OPTICA- IMT, financed from European funds., The results obtained previously and those expected to be obtained in the present project, are in line with the directions of interest of Pro Optica to design and realize high performance imaging optical systems, continuous improvement of the technical performances and of the constructive solutions of the observation systems as well as in keeping with the evolution and market requirements. The project has emerged as a necessity to diversify the portfolio of products offered on the national and international market and to develop new products and competitive achievement technologies, with improved performances. Each of the four spectral domains currently used for observation, VIS, SWIR, MWIR and LWIR (the last 3 listed domains are included in the IR domain), has advantages and disadvantages and a perfect system should contain working capabilities for all these areas. Each of these areas has its own specific characteristics, but the use of IR technologies for different applications (car technique, surveillance, medicine, etc.) is very dynamic and in these areas the problems are mainly related to the increase of the performances and the realization of low prices.

6. Innovative approaches in the treatment and control of patients infected with SARS-CoV-2 virus Call name: P 2 - SP 2.1 - Soluţii - 2020 - 1
PN-III-P2-2.1-SOL-2020-0061 2020 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); SPITALUL CLINIC DE BOLI INFECŢIOASE "SF. PARASCHEVA" IAŞI (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO); SPITALUL CLINIC DE PNEUMOFTIZIOLOGIE (RO); DDS DIAGNOSTIC S.R.L. (RO)

Affiliation:

Project website: https://www.imt.ro/AITC-SARS-CoV-2/

Abstract:

The aim of the project is to develop and test an innovative and effective “lab-on-a-chip” microfluidic system with a role in controlling SARS-CoV-2 infection in patients with moderate and severe forms. The project proposes the development of a "lab-on-a-chip" microfluidic device, "Point-of-care", for the detection of SARS-CoV-2 from samples of nasopharyngeal exudate, cheap, mass-produced, which integrates both modern nanoplasmonic amplification methods as well as methods for detecting amplified material, capable of performing detections with increased sensitivity and specificity in a much shorter time compared to conventional diagnostic methods. We will test and evaluate two modern nanoplasmonic methods for viral RNA amplification: chip nanoplasmonic PCR and loop-mediated isothermal amplification (LAMP). In order to identify and quantify the amplified target molecules, the efficiency of an electrochemical and an impedimetric detection principle will be tested and evaluated. After evaluating the sensitivity and specificity of the amplification and detection methods, the final optimized device consisting of an amplification module and another molecular detection module will be performed. Thus, the innovative device developed will allow infection control in patients with different forms of severity and can be used to increase population testing capacity and prevent the spread of SARS-CoV-2 infection in Romania.

NANO components for electronic SMART wireless systems Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2020-0073 2021 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation:

Project website: https://www.imt.ro/NANOSMART_suport/

Abstract:

In the modern world everything goes wireless and everyone goes mobile. To sustain this trend, higher frequency, smaller, more complex analogue electronics with beam steering capabilities are needed. The objective of NANOSMART is to develop technology for future generation, smart monolithic Transmit / Receive front-end ICs capable of RF switching, power management, high efficiency, at a fraction of the footprint and cost of current solutions. NANOSMART addresses this need by developing a new technological platform based on CNT and 2D material electronics (the two most promising technologies to replace Silicon electronics in the future). NANOSMART develops unique concepts already proven by the consortium such as deep sub-wavelength antennae, CNT NEMS for RF switching, CNT-based nano-electromechanical reconfigurable filters and multiple FET technologies. Monolithic integration of all technologies mentioned above will provide a compact platform including new amplifier architecture, power management, RF switching and antennae on one monolithically integrated chip. Within the front-end IC, three sensor types (temperature, humidity and RF radiation built from novel technology) will also be integrated to provide smart, autonomous system reaction and thus improve accuracy, power efficiency and real-time system health monitoring and on-the-fly response to ambient conditions.

Microfluidic platform for circulating tumour cells (CTCs) concentration through dielectrophoresis-magnetophoresis and analyzed via broadband dielectric spectroscopy and electrochemical impedance Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0214 2018 - 2021

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Project partners: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO); UNIVERSITATEA TRANSILVANIA BRASOV (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.ucelldetect.ro

Abstract:

The overall objective (GO) of uCellDetect is assuming the development of a microfluidic platform which is to integrate electromanipulation (DEP dielectrophoresis) technologies combined with magnetomanipulation (MPA – magnetophoresis) allowing the improvement of sorting and trapping capacity of circulating tumour cells (CTCs) harvested and purified from surgically excised tumors. Simultaneously with the sorting and trapping, on the basis of CTCs’ specific properties (electrical magnetic, electrochemical and spin), at the level of microfluidic platform the characterization of CTCs through broadband dielectric spectroscopy, electrochemical impedance and spintronic detection will be possible, fact which will ensure the precocious diagnosis, minimally invasive, tumours stabilization, monitoring and assessment of therapeutical interventions. The innovative device which is to be developed within 24 months will represent a fast and cheap technology allowing patients to appeal to an affordable diagnosis technology in comparison with the conventional costly and laborious technologies. The Consortium is encompassing 4 partners (two universities, one nationa R&D center and a revival R&D center) which agreed to share expertise, scientific, human and material resources (R&D infrastructure) grant integral complimentary approaches within the Bionanotechnology domain with immediate application in biomedicine.

Nanostructured carbon based materials for advanced industrial applications Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0619 2018 - 2021

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA TRANSILVANIA BRASOV (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/nanocarbon+/

Abstract:

Our proposal (NANOCARBON+) is focused on a highly technologically relevant unifying topic: the exploitation of the recently demonstrated extreme properties of a specific class of carbon nanomaterials - nanostructured graphene, used in specific morphologies and compositional categories - towards the development of innovative technologies for essential eco-industrial areas (failure monitoring, pollutant detection/decontamination in air/water, green energy). The proposal is split in four composing projects, all of them aiming at exploring the use of these unique nanomaterials for the development of innovative and/or improved sensing devices in a range of applications with strong industrial impact.

The consortium behind this proposal has a good regional coverage and suitable research and development resources, both in terms of researchers and appropriate equipment. The consortium comprises of four National R&D Institutes and two Universities, distributed in three adminstrative regions.

The central objective of this complex proposal is an efficient integration of the scientific expertise and experimental capabilities, complementarities and synergies of the six consortium member organizations, towards augmenting their overall organizational performance.

The objectives of the proposal go well beyond the academic research; from the very begining of the execution, we aim at achieving a very good connection with SMEs and other industrial partners in order to understand market requirements and to be able to transfer suitable innovatibe technologies and further support the development of new products. Developing new technologies and services is one part of the expected output, contributing to the development of the partner's capabilities by opening new research areas; in addition, a special attention is devoted to the increase and development of the human resources involved in research. In this respect, the consortium does commit to creating 11 new research positions.

Sensors and Integrated Electronic and Photonic Systems for people and Infrastructures Security Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0419 2018 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA PITESTI (RO); Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.sensis-ict.ro

Abstract:

The Complex Project “Sensors and Integrated Electronic and Photonic Systems for people and Infrastructures Security” aims to develop new sensors, new integrated electronic and photonic systems for detection of explosives used in terrorist attacks or accidentally released in military bases or industrial sites.

The Complex Project is developed through four distinct projects, called “components” which are converging to the Project goals by detection of explosive substances and increasing the security of people and infrastructures, as follows:

1) Design and development of a portable microsystem, based on TF BAR sensors arrays, for multiple detection of explosives (TATP, HMTD, TNT, RDX, NG, EGDN) used in terrorist attacks; 2) SiC-based hydrocarbons sensors for measuring the hydrogen and hydrocarbons in hostile industrial environments; 3) Infrared sensors for dangerous gases detection, such as explosive gases (methane) or pollutants (carbon dioxide / monoxide); 4) Design and development of a piezoelectric energy micro-harvester, able to generate electric power in the 100µW range, used for powering up sensors and portable microsystems used in explosive gases and substances detection.

The complex project description includes the novelty elements, detailed activities description, the working procedures within the consortium, expected results and deliverables. The deliverables has an average TRL 5, which means all four component projects will have a high technological level and the result’s maturity will reach at least successful laboratory testing.

The project will deliver the sensors and integrated systems along with the energy micro-harvester as physical objects and technologies, functional and laboratory- and real conditions tested, scientific papers and patents. The project’s high impact on the participants and also the social impact are detailed.

Developing quantum information and quantum technologies in Romania Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0338 2018 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: https://roqnet.ro/qutech-ro/

Abstract:

Quantum information and quantum technologies are at the forefront of the second quantum revolution: quantum computers, quantum cryptography, quantum communication, quantum imaging/sensing etc. Quantum technologies are strategically important for the economic development -- the European Union recently announced a 1 Billion Euro Quantum Technologies Flagship (QT Flagship) program. Compared to other European countries, unfortunately these fields are seriously underdeveloped in Romania.

The project aims to develop quantum information and quantum technologies in Romania, such that the Romanian community will actively participate in the QT Flagship. The project director (R.I.) is National Quantum Coordinator for Romania in the coordination and support action preparing the European QT Flagship.

The project has three strategic objectives:

(i) research: developing the research capacity in quantum information and quantum technologies;

(ii) education: teaching and training PhD students, postdocs and researchers to work in these fields;

(iii) dissemination: disseminate and transfer the results to society in order to stimulate scientific and economic progress.

Each partner will be responsible for a project from the common research agenda:

1. IFIN-HH: developing theoretical and computational methods for quantum information and quantum technologies (Q-INFO)

2. INFLPR: developing the integrated quantum photonics platform (Q-CHIP)

3. IMT: quantum information with optical vortices (Q-VORTEX)

4. UPB: developing two research laboratories and a quantum source (Q-LAB)

(a) quantum computation lab: cloud programming the IBM-Q quantum computer;

(b) applied quantum information lab.

5. INCDTIM: developing theoretical models for quantum computation with Majorana fermions (Q-FERMI)

The project will result in the formation of the Romanian Quantum Network and the participation of Romania to the European QT Flagship.

Technologic paradigms in synthesis and characterization of variable dimensionality systems Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0152 2018 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEHNOLOGII CRIOGENICE SI IZOTOPICE - I.C.S.I. RAMNICU VALCEA (RO); UNIVERSITATEA DE VEST TIMISOARA (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU FIZICA TEHNICA-IFT IASI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://infim.ro/project/vardimtech/, http://infim.ro/project/vardimtech-en

Abstract:

Last decades brought a considerable development of technologies based on ordered systems. Starting with semiconductor physics and photovoltaics, technologies soon evolved towards the utilisation on large scale of thin films and of surface / interface properties. Example go nowadays from data storage and readout (electrostatic or magnetic memories, giant magnetoresistance) to catalysis, gas sensors or photocatalysis (surface phenomena), and towards interfaces with biological matter (biosensors, templates for tissue reconstruction, interfaces between biological electrical signals and microelectronics). In Romania, crystal growth is performed since half a century; nevertheless, during the last years these activities fade out and need to be seriously reinforced, especially with the advent of new laser and detector technologies required by the Extreme Light Infrastructure facilities. Also, surface science started to be developped seriously only during the last decade, together with techniques involving self-organized nanoparticles, nanoparticle production etc. The main goal of this Project is to gather the relevant experience from the five partners, namely the experience in crystal growth from the University of Timișoara, with the surface science, nanoparticle and nanowire technologies developped by NI of Materials Physics, the cryogenic and ultrahigh vacuum techniques provided by the NI for Cryogenic and Isotopic Technologie, and the experience in ordered 2D systems (graphene and the like) owned by the NI for Microtechnologies (IMT). This common agenda will result in a coherent fostering of technologies relying on ordered systems of variable dimensionalities: 0D i.e. clusters or nanoparticles, including quantum dots; 1D i.e. free and supported nanowires and nanofibers; 2D: surfaces, interfaces and graphene-like systems; and 3D crystals of actual technological interest, together with setting up new ultrahigh vacuum, surface science and electron spectroscopy techniques.

Technological transfer to increase the quality and security level of holographic labels Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2016-0072 2016 - 2018

Role in this project: Key expert

Coordinating institution: OPTOELECTRONICA - 2001 S.A.

Project partners: OPTOELECTRONICA - 2001 S.A. (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://optoel.ro/index.php/projects/national/TSCEH/ro/acasa

Abstract:

In this context, the economic agent, Optoelectronica 2001, through the TSCEH project, decided to increase the security level and the quality of their holographic labels, following a strategy based on technological transfer:

1. from the Microtechnology Institute of Bucharest, to include a new security element in the shape of submicrometric structures

2. from Politehnica University of Bucharest, to improve the optical and morphological properties, by iterative optimization of the characterization processes.

The results will be at TRL6:

obtaining a prototype of holographic label with a new security element, of submicrometric structure type (EHS), fabricated using a modified technology, demonstrated in industrial environment.

OPTOEL produces holographic labels using a technology based on a mask obtained with modulated laser beam. These labels contain many security elements as optical effects. The challenge of this project is to find the technological solutions to include in a free zone from this mask of the submicrometric structures made starting from electron beam lithography.

The innovative character of the TSCEH project is proven by:

1. Changes in the technological steps by finding the optimal solution to include the submicrometric structures

2. Improving the optical and morphological properties by setting the optimal values of the parameters involved in the technological processes.

Portable Microfluidic Biochip for T Lymphocyte Counter Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2016-0145 2016 - 2018

Role in this project: Key expert

Coordinating institution: DDS DIAGNOSTIC S.R.L.

Project partners: DDS DIAGNOSTIC S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: https://ddsdiagnostic.com/biolimf/

Abstract:

This project will develop a biochip microfluidic prototype for determining the number of Total lymphocytes (CD3+), helper T lymphocytes (CD3+, CD4+), lymphocytes T suppressor/cytotoxic (CD3+, CD8+), lymphocytes immature T (CD3+, CD4+, CD8+ ) from human blood. The device will be made of biocompatible polymers (PDMS) and will include a micro channels system with three compartments (one for sample and two for reagents), a reaction chamber in which the anti-CD3+, anti-CD4+, anti-CD8+ will be immobilized. The counting of the immune complexes formed will be realized directly in the reaction chamber using an electrochemical sensor. Using the Nyquist diagram by processing and data normalization, the number of T lymphocytes CD3+, CD4+, CD8+, will be realized and the development of a software will permit the data processing. This project also aims to connect the Romanian applied research and technological progress to the national and international socio-economic development and requirements. Particularly important is the development of partnerships between research institutions and the private sector, cooperation which will increase the investments of the DDS Diagnostic company for research and development activities. This project will determine the strengthening of the company's innovation capacity and will enhance its contribution to the creation of new products/technologies with great potential for commercial exploitation in national and international medical markets.

Graphene synthesized by Thermal Chemical Vapor Deposition and integrated in microfluidic devices for biomedical applications Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0123 2017 - 2018

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/integraph

Abstract:

The present project proposal aims to explore possible applications of CVD grown graphene in biomedical devices by investigating possible developments of microfluidic systems with integrated graphene layers, and test their feasibility for biomedical applications. We target three possible applications of graphene: antibacterial function; electro-mechanical sensor for microfluidic flows; electric sensor for non-specific particle detection. Our aim is to implement a fabrication process for integrating single layer graphene in microfluidic devices, in order to fabricate microfluidic systems with an integrated antibacterial function, a pressure sensing function, and non-specific single cell detection function

Integrated Crossbar of Microelectromechanical Selectors and Non-Volatile Memory Devices for Neuromorphic Computing Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2016-0026 2016 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/selectX/

Abstract:

The goal of the SelectX project is to propose a technologic alternative for the hardware implementation of the artificial neural networks in a flexible and energy efficient manner. The biological neural networks, although slow, have an extraordinary performance for certain types of problems, such as visual recognition, natural language processing, etc.

Trying to mimic in a rudimentary way the organization of biological neural networks, the artificial neural networks are becoming widely used in software (Google Machine Intelligence, Facebook Artificial Intelligence Research). Unfortunately, this approach is power intensive (kW of power) and requires a large amount of computational resources (hundreds of traditional multi-core processors).

The memristor is a passive two-terminal device which has an analog resistance, tunable through voltage pulses. This makes it attractive for use as artificial synapse. A hybrid system made of dense memristor synaptic matrices (“crossbars”), fabricated directly on the surface of a transistor (CMOS) neural chip could implement very complex artificial neural circuits.

A fundamental problem with the memristor passive matrix matrices is the existence of leakage currents which prevents the correct reading of the value of the memristor resistance and, consequently, the produces the incorrect operation of the circuit. These leakage currents can be reduced to insignificant values if the matrix contains components with high non-linearity.

Microgrippers as end-effectors with integrated sensors for microrobotic applications Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERA-MANUNET-II-Robogrip 2016 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); SITEX 45 SRL (RO); UNIVERSITATEA TEHNICA DIN CLUJ - NAPOCA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/robogrip/

Abstract:

The main purpose of the project is to develop a robotic micromanipulation system with MEMS micro-grippers integrated with microsensors for position/force feedback control for cell manipulation. This will be achieved by developing a set of electro-thermally actuated end-effFectors with different functions (pick and place, pushing-pulling, gripping), in different configurations to be integrated in a robotic micromanipulation system. The end-effector and the integrated sensors will be designed and build at the system level, due to their interdependence not only at functional level but also considering the fabrication technology and component materials. Our implementations will integrate a micro-gripper with different sensing functionalities (force, displacement), the maximum attempt being the full instrumentation of the system. The demonstrator will be used for tailored functionalization of medical devices with cells, in demanded regions.

Compact spectrometer in infrared Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1988 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); OPTOELECTRONICA - 2001 S.A. (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU INGINERIE ELECTRICA ICPE - CA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/cospir/

Abstract:

The proposed project aims the validation of new “proof of concept” for a compact spectrometer working in middle and long infrared. This spectrometer will retain the advantages of the current gas sensor optimized for the detection of one or a few gas species as the low cost, small volume but in the same time will offer the flexibility of the bulky, costly spectrometers. The previous research on such compact spectrometers considered dispersive devices based on MEMS – micro-electro-mechanical systems technology with movable small parts actuated electrostatically or thermally and nondispersive devices based on filters at fixed wavelengths. The nondispersive spectrometer employs either large movable parts as wheel filter or the beam splitting before entering the filter arrray. This project has as the main objective the design and fabrication of a compact spectrometer based on an array of filters without any movable parts which will eliminate the need for power splitting by using a configuration based on a sequential approach (all radiation enters the first filter and the rest of the radiation not transmitted is reflected and further used to enter the second filter, etc).

In order to obtain a spectrometer with good working characteristics it is necessary to design and fabricate high quality components both active (infrared thermal emitters and detectors) and passive (filters and Fresnel lenses). Since the research field on the infrared emitters and detectors is still open, the secondary objective of this project is to obtain original results regarding both infrared emitters and sources which will be published in ISI ranked journals and presented at conferences.

The consortium is made up from IMT-Bucharest as project coordinator, Optoelectronica-2001 as SME, and two other research organizations, ICPE-CA and INFLPR. There are four work packages in this project, the first ones deal with the design and fabrication of the active and passive components for spectrometer and the last two work packages will include the studies on the design and fabrication of the spectrometer.

The task of the design and fabrication of the active and passive components will be the assigned to IMT due to the high expertise of the research staff and also due to the availability of the equipments suitable for microfabrication technologies. There are also available dedicated software packages for electro-thermal-mechanical simulations for active components and optical simulations for passive components. The sensitive layers for the pyroelectric detectors will be deposited by ICPE-CA with RF sputtering or sol-gel method and INFLPR with Pulsed Laser Deposition. The fabrication of high quality infrared thermal detectors is critical for the successful end of the project, that is why the option to consider more deposition method for various sensitive layers has been considered. The characterization of the components will be made by Optoelectronica due the high expertise and equipments available ((sources, camera, FTIR spectrometer working in infrared)

The task of the spectrometer fabrication is assigned to Optoelectronica due to the team members experience in fabrication of optical devices and equipments integrated with control and command circuits. The testing procedure for the spectrometer validation and calibration will be performed by Optoelectronica with IMT.

The intellectual properties rights will be protected by filling patents and the results obtained in this project may be used by SME partner of the consortium – Optoelectronica for development into an product, or as a base of development into a product in cooperation with another company.

Micro-electro-fluidic system for biological cells separation and electroporation Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1141 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); SPITAL LOTUS SRL (RO); DDS DIAGNOSTIC S.R.L. (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/mefsys/

Abstract:

The objective of the project is design, fabrication and testing a micro-electro-fluidic system for biological cells separation and for membrane permeabilization by electroporation to release cellular content for laboratory or research analysis. Functionality of such system is based on separation by dielectrophoresis of cells in fluid media, on membrane electroporation by applying an electric field and on evaluation of electroporation efficiency by electrical and optical methods, using functionalized ferromagnetic nanoparticles for cell capture. At the present, the separation technique by dielectrophoresis is performed by using structures with channels where the electrodes are placed on the surface in contact to substrate. Electroporation is realized by permeabilization of the membrane as effect of electrical pulses, and its scope is either transfection or releasing cellular content. Microfluidic systems that use both techniques are rarely, and, related to those that are developed until now, the electrodes used for electroporation are distinct from the electrodes used for dielectrophoresis due to difference in applications, despite the fact that this approach needs complex fabrication methods. Still, implementing both techniques on a chip is a requirement of such systems, while reducing the number of electrodes shall contribute to simplify fabrication methods, reducing costs and facilitate the use of dielectrophoresis in selective manipulation of cells, in order to evaluate permeabilization efficiency.

In this context, the general objectives of the project are: - Design, simulation and optimization of an experimental model of micro-electro-fluidic system with multifunctional electrodes that ensure both manipulation / separation and electroporation; - Masks design and realization; - Technological design and fabrication of optimized microsystems using MEMS technologies; - Microphysical characterization; developing methods for electroporated cells quantification and for determination of dielectric and optical properties after electroporation; - Synthesis, characterization and functionalization of ferromagnetic nanoparticles with specific antibodies for cells capture; - Cells preparation and characterization of dielectric and biophysical properties before and after electroporation; - Testing micro-electro-fluidic system, electroporated cells quantification by alternate methods (electrical, optical) and correlation of results.

The project requests integration of multi-disciplinary theoretical and technical knowledge: microfluidics, electric field effects, mathematical and numerical modelling, microtechnologies for microsystems fabrication, biology, biochemistry, biophysics, nanoparticles syntetization and characterization, optics. By comparison to conventional devices, the microsystem proposed for fabrication and testing offers advantages such as reduced fabrication costs due to simplified electrodes, low power consumption, reduction of heating effects, better control on electrical parameters, implying increased efficiency and precision. The microsystem can be integrated in lab-on-chip devices or sensors for biochemical analysis, diagnosis of cellular properties and content or therapy by transfection. Last, but not least, the research can give answers to questions related to dielectric properties variation of electroporated cells or to selective separation means of electroporated versus unmodified cells.

Lab-on-a-chip for label free detection of cancer cells Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0366 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); SPITAL LOTUS SRL (RO); DDS DIAGNOSTIC S.R.L. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/cancellab

Abstract:

By implementing this project, realized in partnership between a research & development institute with the main activity the integration of micro-nano-info-biotechnologies and two industrial partners with activities in the applicative research and development of biomedical systems, we are proposing to capitalize the expertise and synergy complementarity for the development of portable technologies that can diagnose cancer in an early stage. The main idea of this project consists in the development, fabrication and testing up to an integrated biochip proof of concept for monitoring the melanoma cells and biomarkers activity associated to the different development stages of the malign melanoma.

The novelty of the device consists in the integration on the same chip of two biosensors, one electrochemical and the other plasmonic resonance, with signal acquiring and modulation from both sensors. The electrochemical biosensor is represented by an inter-digitated nano-electrodes network realised on silicon substrate, and the plasmon one by a periodic gold nano-cylinders network with a diameter of ~ 200 nm, height of ~ 300 nm and network constant of ~ 800 nm. The proposed methods in this project for the biological interactions monitoring at tumour cells level imply the use of real time modern characterization techniques of the processes that occur at the sensor interface with the bio-cells: electrochemical impedance spectroscopy (EIS) and surface plasmon resonance (SPR). The analyte molecules from the liquid sample in contact with the electrochemical sensor determine the increase of double-layer capacitance and of charge transfer resistance at high frequencies, the increase of mass molecular transport (diffusion) at low frequencies. Also in contact with the plasmon sensor it determines the refraction index increase, the superficial plasmon propagation constant modification which by altering the coupling conditions it alters the wave characteristic coupled with the superficial plasmons, e.g. coupling angle, coupling wave length, wave’s intensity and phase.

By integrating the biochip with the signal amplification and processing module, a new miniaturised technique is developed, with a high degree of automating and the possibility of replacing the current laborious methods of individual quantification of the tumour biomarkers (ELISA, immunoturbidimetry, chemi-luminescence, immune detection techniques in laminar flux), with the purpose of monitoring the malign melanoma in different disease stages (I,II,II,IV). For this we develop a new lab-on-a-chip device (~0.5x0,25 mm2), connected to computer by a USB connector. The active area of the device will be ~1 mm2. The functioning principle of the device is the following: on the active areas of the device (inter-digitised nano-electrodes and plasmon nano-cylinders) the functionalized NPs are immobilized with the anti-tumour antibodies; the cells will recognise the specific antibodies, the direct detection methods becoming very sensible, which allows the detection limit drop to very low concentrations of tumour cells.

This technique allows the simultaneous and fast detection of 5 important biomarkers for monitoring and investigating the malign melanoma: TA-90 (Tumour-associated glycoprotein Antigen) , S100B protein, VEGF-A growth factor, Immunosuppressive Cytokine IL-10, IL-6 and C-Reactive protein (CRP). The detection of these 5 biomarkers is correlated in the first stage with the impedance, dielectric constants and refraction index variation for establishing the melanoma stage. Later on, the detection will be performed exclusively by determining the variation of the electrochemical and optical parameters.

In conclusion, this device allows the realization of a diagnose system with increased sensibility, high specificity and reliability, that ensures an efficient and qualitative medical assistance.

Immunoassay Lab-on-a-chip for cellular apoptosis study Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0052 2012 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA TRANSILVANIA BRASOV (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/cellimmunochip

Abstract:

The ambitious goal of this project is to combine fundamental research with complex applicative research in order to bring important scientific contributions both on the theoretical level and on the experimental one, in a high-end field: bio-nano-engineering, a new field in Romania and in expansion stage worldwide. Bio-nano-engineering assumes the integration of the physico-chemical processes with the biological ones by involving complex systems realized on the micro or nano scale, the applications of these systems being found in biomedicine The aim of this project is the development (design, fabrication and characterisation) of a versatile lab-on-a-chip integrated system, which is composed of a microfluidic platform, an interdigitated micro/nano-electrodes electrochemical biosensor and an array of spin valves for superparamagnetic nanoparticles - based immunoassay, and will be applied to the study of cellular apoptosis and detection of specific antigens as clinical diagnostics application. The screening reaction is based on a competitive immunoassay, enhanced by using functionalized superparamagnetic nanoparticles, prepared through a simple and reliable surface modification and protein conjugation process. The main advantage of this system is its re-usability. Also, its configuration can be changed easily so the user can try several electrode configurations with the same holder. Moreover, because the functionalized nanoparticles are magnetically trapped above the electrodes, the user can adjust the fluid flow rate to the kinetic parameters of chemical reactions under study to optimize detection. The superparamagnetic nanoparticles can be trapped by polarization of the spin valve array and can be released by blocking the magnetic field. We shall demonstrate how to take further advantage of the microfluidic system to determine enzyme activities or concentrations, as flow velocity can be adjusted to the rate of the reactions under study.

Efficient electrochemical catalysis and regeneration of nicotinamide adenine dinucleotide at layer-by-layer self-assembled doped membranes Call name: Projects for Young Research Teams - TE-2010 call
PN-II-RU-TE-2010-0044 2010 - 2013

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU MICROTEHNOLOGIE DIN BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU MICROTEHNOLOGIE DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU MICROTEHNOLOGIE DIN BUCURESTI (RO)

Project website: http://www.imt.ro/NADH/

Abstract:

The need for an efficient catalysis and regeneration process involving the nicotinamide adenine dinucleotide is justified, by its economical weight as well as by its valuable applications in the biotechnology field. Nanostructured materials exhibit interesting properties which favour the electrochemical detection of NADH. Obstacles for the effective use of nicotinamide adenine dinucleotide include the need of high overpotentials for direct oxidation or reduction of the cofactor, electrode fouling, dimerization of the cofactor, etc. Nevertheless, to promote economically efficient processes, the regeneration of the pyridine cofactor remains a key problem to solve. A platform for various dehydrogenase based bioassays should be obtained by developing an electrochemical probe based on layer-by-layer self-assembled doped metallic nanoparticles membranes. When using nanoparticles for catalysis two main issues are raising: the stabilization the particles while retaining sufficient catalytic activity and the problematic separation of the catalytic particles from the reaction product and unused reactants at the end of the reaction. One solution may be the immobilization of the nanoparticles in thin membranes, minimizing the mass transfer limitations. A generic platform offering a fast regeneration and an efficient catalysis of coenzyme is the goal of this proposal. The motivation, the goals, the team and the methodology are fully described in this research proposal.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects