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Romania
Citizenship:
Ph.D. degree award:
Mariana
Ionita
-
UNIVERSITATEA NAȚIONALĂ DE ȘTIINȚĂ ȘI TEHNOLOGIE POLITEHNICA BUCUREȘTI
Researcher | Teaching staff | Scientific reviewer | Manager
Personal public profile link.
Expertise & keywords
Biomaterials
Graphene
Bone regeneration
nano-carbon
Nanocomposites
nanooxides
Sol-gel
Nanocomposites
Molecular modeling
Projects
Publications & Patents
Entrepreneurship
Reviewer section
Toolbox for personalized bone regeneration; tailoring solutions for tomorrow
Call name:
P 4 - Proiecte de cercetare exploratorie - PCE-2021
PN-III-P4-PCE-2021-0244
2022
-
2024
Role in this project:
Coordinating institution:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Project partners:
UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO)
Affiliation:
Project website:
https://reosteokit.chimie.upb.ro/
Abstract:
The overall objective of the REOSTEOKIT project is to improve health in society by introducing unique approaches to bone regenerative medicine that not only improve implementation of existing cell / bone substitute therapy for the serious complication of non-union bone fractures, but provide holistic transition from conventional regenerative medicine to integrative, personalized regenerative medicine. REOSTEOKIT aim is to provide bone reconstruction kit which merges cost-effective therapy with much improved regenerative efficiency than current treatment options used in the restoration of non-healing bone defects and a reliable a portable device monitoring in real time the osteogenic potential of human mesenchymal stem cells i.e. quantitative measure of bone formation.
Success in the main technical objectives will generated publications in high-profile peer-reviewed journals, presentations at international events aiming to raise awareness, inform, make sustainable via Intellectual Property, and increase international visibility of Romanian scientific research.
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Hemodialysis combined with stimuli responsive drug delivery - a new generation of polymeric membranes for advanced biomedical applications
Call name:
P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1154
2021
-
2024
Role in this project:
Coordinating institution:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Project partners:
UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO)
Affiliation:
Project website:
https://hemdelstim.wixsite.com/hemdelstim/research
Abstract:
The HemDelStim project sets as its main scientific goal the development of a new approach and a new scientific direction for the treatment of patients with chronic kidney dysfunction and liver cancer. Unlike the therapeutic approach so far, which involves performing hemodialysis (to replace kidney function) in parallel with chemotherapy, the project aims to combine these two processes, in an intelligent way, with a minimal impact on the body. The drug used to treat liver cancer – doxorubicin, will be encapsulated in supramolecular or polymeric architectures, the release being made strictly on the basis of a stimulus - alpha-fetoprotein, the tumor marker for this type of cancer. For this intelligent release, the concept of “stimuli responsive drug delivery” will be used. The supramolecular or polymeric architectures containing doxorubicin will also include a monoclonal antibody for alpha-fetoprotein. The presence of alpha-fetoprotein in the blood subjected to dialysis will cause the encapsulation to break down and release doxorubicin in a controlled manner. The supramolecular or polymeric architectures containing alpha-fetoprotein monoclonal antibody on the surface and encapsulated doxorubicin will be immobilized on polysulfone hemodialysis membranes (membranes containing anticoagulants on the surface). The combination of these two therapeutic procedures, hemodialysis and stimuli responsive drug delivery, is the main novelty of the project.
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Super carbonaceous materials for selective separation; multi-scale computer-aided molecular design and engineering
Call name:
PN-III-P1-1.1-TE-2016-2402
2018
-
2020
Role in this project:
Project coordinator
Coordinating institution:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Project partners:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Affiliation:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Project website:
http://te_success.chimie.upb.ro
Abstract:
The project main ambition is to merge together the knowledge and skills established in the predecessor project, TE-17/2013 GRAPHPERM, towards the design of efficient solution for selective separation. SUCCESS project aims to an enhanced understanding and the knowledge-based design of novel selective separation membranes based on super carbonaceous materials. Super carbonaceous materials are envisaged to combine a much improved trade-off between permeabilities and selectivities with various other properties needed to ensure processability and durability for high performance separation membranes. The project goal will be achieved by developing and extensive application of complex multi-scale computer-aided design (CAMD) complemented with computer-assisted evaluation (mainly atomistic-, quantitative structure property relationship (QSPR)- and mesoscale- tools) to generate different super carbonaceous complex structures and super carbonaceous material / polymer composites potentially attractive for selective separation. Subsequently, the in silico outputs will constitute the doorstep toward the actual design/synthesis and advanced characterization of the super carbonaceous materials and super carbonaceous material / polymer composites and are also anticipated to reduce the amount of poor design cycle paths. Due to the high novelty of both, materials and approach, SUCCESS project will contribute to the exploration of the frontiers of knowledge, will support long-term innovation in the field and generate high standard publications. The main result of SUCCESS project will be a novel, innovative selective separation system with much improved effectiveness that will constitute an alternative for separation membranes currently in use. The ultimate aim of the present project is to sustain the research team (1 ESR and 2 Master’s student) to expertise and conduct research in a multidisciplinary topic with strategic potential but unluckily still not enough exploited in Romania.
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Super carbonaceous materials for selective separation; multi-scale computer-aided molecular design and engineering
Call name:
P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2016-2402
2018
-
2020
Role in this project:
Coordinating institution:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Project partners:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Affiliation:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Project website:
http://tesuccess.chimie.upb.ro
Abstract:
The project main ambition is to merge together the knowledge and skills established in the predecessor project, TE-17/2013 GRAPHPERM, towards the design of efficient solution for selective separation. SUCCESS project aims to an enhanced understanding and the knowledge-based design of novel selective separation membranes based on super carbonaceous materials. Super carbonaceous materials are envisaged to combine a much improved trade-off between permeabilities and selectivities with various other properties needed to ensure processability and durability for high performance separation membranes. The project goal will be achieved by developing and extensive application of complex multi-scale computer-aided design (CAMD) complemented with computer-assisted evaluation (mainly atomistic-, quantitative structure property relationship (QSPR)- and mesoscale- tools) to generate different super carbonaceous complex structures and super carbonaceous material / polymer composites potentially attractive for selective separation. Subsequently, the in silico outputs will constitute the doorstep toward the actual design/synthesis and advanced characterization of the super carbonaceous materials and super carbonaceous material / polymer composites and are also anticipated to reduce the amount of poor design cycle paths. Due to the high novelty of both, materials and approach, SUCCESS project will contribute to the exploration of the frontiers of knowledge, will support long-term innovation in the field and generate high standard publications. The main result of SUCCESS project will be a novel, innovative selective separation system with much improved effectiveness that will constitute an alternative for separation membranes currently in use. The ultimate aim of the present project is to sustain the research team (1 ESR and 2 Master’s student) to expertise and conduct research in a multidisciplinary topic with strategic potential but unluckily still not enough exploited in Romania.
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Developing new graphene-polymer composites biomaterials for scaffold fabrication with applicability in bone repair by coupling multiscale molecular modelling and experiments
Call name:
Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-1538
2012
-
2016
Role in this project:
Coordinating institution:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Project partners:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA "DUNAREA DE JOS" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA DE VEST "VASILE GOLDIŞ" ARAD (RO)
Affiliation:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Project website:
http://www.tsocm.pub.ro/cercetare/POLYGRAPH/
Abstract:
The main aims of this project are interdisciplinary efforts using complex computational tools of materials modelling and advanced experimental techniques for the knowledge-based design of novel, improved biopolymer-graphene scaffolds for bone repair. The key functionality of these materials is both physical and chemical cues to direct cells organization, growth, and differentiation in the process of forming functional tissue. The aim is pursued by developing and extensive application of multiscale computer-aided molecular design complemented with computer-assisted evaluation of the end-use performance of the materials in question. The resulting outputs will constitute the doorstep toward the fabrication of the biopolymer-graphene biomaterials of potential commercial values. This goal is achieved by the development of a complex protocol based on advanced experimental techniques. A method for graphene synthesis and modification by plasma treatment in order to introduce different chemical groups on the surface and graft peptides or proteins capable to facilitated cells adhesion, growth, and tissue remodelling will be establish. The end-use performance of these materials depends on several crucial factors such as graphene surface properties, polymer nature, and the methods used for biomaterial synthesis. On the frame of the experimental activity the research will be focus on modulating synthesis parameters in order to obtain a material suitable for bone repair scaffold. Extensive characterisation of biomaterials surface and bulk by physical-chemical techniques will be employed. The ultimate aim of present project should be the in vitro assessment of biocompatibility in terms of cellular morphology, adhesion, viability and proliferation, and the evaluation of differentiation potential of the new elaborated scaffolds. These studies will be complemented with in vivo assay regarding bone reconstruction with biopolymer-graphene scaffolds.
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Multi-scale computational approach and experiments towards knowledge-based design of polymer-graphene membrane materials for selective gas separation
Call name:
Projects for Young Research Teams - TE-2012 call
PN-II-RU-TE-2012-3-0478
2013
-
2016
Role in this project:
Coordinating institution:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Project partners:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Affiliation:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Project website:
http://graphperm.blogspot.ro/
Abstract:
This project aims at an enhanced understanding and the knowledge-based design of novel polymer-graphene materials which combine a much improved trade-off between permeabilities and selectivities with various other properties needed to ensure processability and durability for high performance membranes for selective gas separation. The aim is pursued by first developing and extensive application of multiscale computer-aided molecular modeling (CAMM) and design (CAMD) complemented with computer-assisted evaluation (mainly atomistic-, quantitative structure property relationship (QSPR)- and mesoscale- tools) to be utilized to help to develop polymer (polysulfones, polyimides)-graphene membrane materials potentially attractive for air separation (O2/N2) and natural gas purification (CO2/CH4). The resulting outputs from computational approach will constitute the doorstep toward the actual design/synthesis and characterization of the polymer-graphene materials which may lead to further design cycles contribution. The research project will thus contribute to the exploration of the frontiers of knowledge and will support long-term innovation in the field. The ultimate aim of present project should be the formation of new research team (2 post-docs and 2 PhD students) specialized in a topic with strategic potential but unluckily not enough exploited in Romania.
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ELECTROCHEMICALLY FUNCTIONALIZED CARBON NANOTUBES FOR THE ASSEMBLING OF MODIFIED ELECTRODES APPLIED IN SENSORS FIELD
Call name:
Projects for Young Research Teams - TE-2010 call
PN-II-RU-TE-2010-0153
2010
-
2013
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Project partners:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Affiliation:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Project website:
http://te.chfiz.pub.ro/
Abstract:
CARBON NANOTUBES (CNTS) HAVE BECOME THE SUBJECT OF INTENSE RESEARCHES IN THE LAST DECADES BECAUSE OF THEIR UNIQUE PROPERTIES AND THE PROMISING APPLICATIONS IN ANY ASPECT OF NANOTECHNOLOGY. BECAUSE OF THEIR UNIQUE ONE-DIMENSIONAL NANOSTRUCTURES, CNTS DISPLAY FASCINATING ELECTRONIC PROPERTIES THAT ARE DISTINCT FROM OTHER CARBONACEOUS MATERIALS. PARTICULARLY, THE PROPERTIES OF SMALL DIMENSIONS, FUNCTIONAL SURFACES, GOOD CONDUCTIVITY, EXCELLENT BIOCOMPATIBILITY, MODIFIABLE SIDEWALL, AND HIGH REACTIVITY MAKE CNTS IDEAL CANDIDATES FOR CONSTRUCTING SENSORS WITH HIGH PERFORMANCES.
THE OVERALL OBJECTIVE OF THIS PROJECT IS TO DEVELOP SOME SIMPLE AND REPRODUCIBLE PROCEDURES OF ELECTROCHEMICAL FUNCTIONALISATION OF CNTS IN ORDER TO OBTAIN NEW ELECTRODE MATERIALS FOR APPLICATION IN OBTAINING ELECTROCHEMICAL SENSORS WITH HIGH SENSITIVITY AND SPECIFICITY.
BECAUSE SEVERAL CRUCIAL FACTORS, AS THE SURFACE PROPERTIES OF CNTS, THE METHODS FOR CONSTRUCTING CARBON NANOTUBE ELECTRODES AND THE MANNERS FOR ELECTROCHEMICAL SENSING APPLICATIONS PREDOMINATE THE ANALYTICAL PERFORMANCES OF CNTS ELECTRODES, A SYSTEMATICAL COMPREHENSION OF THE RELATED KNOWLEDGE IS ESSENTIAL TO THE ACQUAINTANCE, MASTERY AND DEVELOPMENT OF CNTS-BASED ELECTROCHEMICAL SENSORS.
IN THE FRAME OF THIS PROJECT, WE WILL ACHIEVE A COMPREHENSIVE RESEARCH WORK ON SOME IMPORTANT ASPECTS OF THE APPLICATIONS OF FUNCTIONALIZED CNTS IN ELECTROCHEMICAL SENSORS, INCLUDING THE ELECTROCHEMICAL METHODS OF FUNCTIONALIZATION OF CNTS, THE APPROACHES TO THE IMMOBILIZATION OF FUNCTIONAL CNTS SENSING FILMS ON ELECTRODES, AND THE METHODS TO IMPLEMENT SPECIFIC SENSOR FUNCTION TO THE CNTS-BASED ELECTROCHEMICAL SENSORS FOR DIFFERENT APPLICATIONS. IN THE LAST PART OF THE PROJECT, WE WILL MAINLY FOCUS ON THE APPLICATIONS OF CNTS-BASED ELECTROCHEMICAL SENSORS IN THE ANALYSIS OF VARIOUS ANALYTES AND BIOLOGICAL SUBSTANCES.
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FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator
List of research grants as partner team leader
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
[T: 0.4178, O: 221]