BrainMap

Maria Suciu

- INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Other affiliations

Lecturer - UNIVERSITATEA BABES BOLYAI (Romania)

electron microscopy staff member - UNIVERSITATEA BABES BOLYAI (Romania)

Researcher | Teaching staff

Web of Science ResearcherID: not public

Curriculum Vitae (06/07/2021)

Expertise & keywords

A epitoxogenomic approach to cadmium hepatoxicity: a gastropod perspective Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0776 2015 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Project website: http://www.epicad.eu

Abstract:

Trace metal pollution is an urgent and future societal challenge worldwide. Cadmium is a high profile example of extremely toxic trace metal. The liver/hepatopancreas is the primary endpoint of Cd accumulation in higher bilaterians. Cadmium affects the subtle networks regulating gene expression (epigenome), including DNA methylation. However, we have surprisingly little information linking Cd and the variability or the intermediary steps of DNA methylation in liver. This high-quality research will use advanced epigenomic methods to unravel the mechanisms of Cd hepatotoxicity using the snail hepatopancreas as system study. It will assess the potential of hepatopancreas genome-wide (hydroxy)methylation levels for serving as subtle biomarkers of hepatotocixity induced by chronic low-level Cd exposure. Biomarkers of citotoxicity and genototoxicity will be used as benchmark biomarkers. This innovative, unconventional strategy will generate the primary know-how required for developing new ecotoxicological tools for environmental monitoring and risk assessment , as well as critical insights into the subtle effects of Cd on the liver/hepatopancreas epigenome. The proposed project will provide the principal investigator with a launching platform on which to reach scientific maturity and an outstanding opportunity to boost the profile of the science for all young researchers involved.

Characterization of the sub-cellular effects of functionalised magnetic nanoparticles in targeted anti-tumor therapy Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0608 2015 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website: http://poravpaul.wix.com/cellspion

Abstract:

Having unique magnetic properties, super-paramagnetic nanoparticles (SPIONs) are an efficient vector for anti-tumor targeted therapy, non-viral gene therapy, magnetic resonance imaging contrast agent, and thus personalized medicine. SPIONs are cheap and easy to synthesize, have determined dimensions, can be functionalized and loaded with various substances, and they can transport a certain drug to a certain area of the body in a targeted way, being conducted by magnet. They can be, this way, monitored in real time and at the area of interest SPIONs combine the chemical effect of the drug with the physical effect of the magnetic fluids induced hyperthermia, which generates selectively local overheating through an external magnetic field. In spite of all this promising features, there is still a certain holdback for using SPIONs as a nanotherapy method. This happens mostly because of the fact that nanomedicine is a new domain and because of the lack of coherence in all studies involving NPs in medical applications. Through our project we intend to integrate all aspects regarding cell-NPs interactions and to eliminate all dissonances that shows when passing from a certain study system to another (in vitro-2D-3D-in vivo), finally leading us to obtain coherent data. This is why this study is needed, a complete, integrating and complex study, which starts from NPs synthesis, bioavailability, cytostatic loading, fluorescent loading, in vitro and then in vivo, up to clearance.

The behavior of oral mesenchymal cells in relationship with a new resin composite material in modern regenerative periodontal therapy Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1474 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); UNIVERSITATEA BABES BOLYAI (RO); INSTITUTUL DE CERCETARI PRODUSE AUXILIARE ORGANICE S.A. (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Project website: http://bc.umfcluj.ro/stemdent/

Abstract:

Gingival recession is a common problem affecting a large number of individuals and the treatment is based on the use of periodontal plastic surgery procedures usually using palatal grafts and advanced flaps, which aim to cover the exposed roots. The clinical situation is furthermore complicated by the concomitant presence of non-carious cervical lesions (cervical abrasions), which demands parallel restorative/ periodontal surgical approaches. Periodontal tissue has a reduced intrinsic regenerative potential, mesenchymal stromal (stem) cells MSC(s) contained in the palatal grafts used in coverage surgeries could augment the local pool of MSCs. The use of autogenic MSCs may be an opportunity to increase periodontal regeneration since there are no safety standardized protocols for the use of the ex vivo manipulated MSCs. Resin composite materials used to restore cervical abrasions during root coverage treatment could have hazardous effects on local MSCs due to eluted components. The local microbial fingerprint, a particular genetic or inflammatory trait of the host could influence local MSCs' fate.

STEMDENT aims to develop a new application of modern regenerative periodontal therapies through investigation of the insights on oral MSC behaviour in relationship with environmental factors (new resin composite material), and some biologic characteristics of the host.

The objectives of STEMDENT are: ►to develop investigation sets for evaluating the oral MSCs' behaviour in relationship with some individual characteristics of the host; ►to develop/ characterize a new nanohybrid composite material; ►to develop standardised combined muco-gingival surgical/ restorative therapies for gingival recessions/cervical abrasions based on experimental evaluation of the behaviour of the oral MSCs in relationship with the new and other nanohybrid composites and the host individual characteristics; ►to upgrade the understanding and use of the research results; ► to develop an informational space in the domain of periodontics/ chemistry; ►to disseminate the results of the standardized treatment at European standards.

STEMDENT is conceived as a complex interdisciplinary / multidisciplinary project, with four partners with specific competencies in fields such as: periodontology, cytology and stem cell culture, histopathology, immunology, regeneration (neuronal tissue), veterinary medicine, chemical bio-components development and production, organic chemistry, marketing and project management. The innovative character of the project is given by the improvement of the biosafety of the new materias based on thoroughly evaluation of the biological responses including stem cells’ behaviour. The standardization of the clinical and laboratory research after the establishment of some associative arguments between the periodontal and restorative treatments and the evidence of some negative risk indicators on MSCs behaviour (local regeneration) has been demonstrated to be the new approach, in order to improve the therapy by increasing its predictability and the oral-quality-of-life.

STEMDENT major results will be: standardized clinical treatments for the patients with combined gingival recessions and cervical abrasions that will eliminate the aesthetic and functional deficits and a new direct radiopaque nanohybrid resin composite material for dental therapy, biologically and clinically tested. The results of the project will impact on the training of students and researchers from the partners’ institutions and on the market position of the firm.

Modeling and simulation of the dynamics of thymocyte populations and cells of the thymus medulla under normal and pathological situations Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0571 2012 - 2016

Role in this project:

Coordinating institution: Universitatea de Medicina si Farmacie "Victor Babes" Timisoara

Project partners: Universitatea de Medicina si Farmacie "Victor Babes" Timisoara (RO)

Affiliation: Universitatea de Medicina si Farmacie "Victor Babes" Timisoara (RO)

Project website: http://simtim.umft.ro

Abstract:

Thymus is the organ in which the positive and negative selection of thymocytes occurs, resulting in the production of mature T-cells that populate the peripheral tissues. In mouse thymocytes can be divided into four populations, based on the expression of CD and CD8 (developing in this sequence): CD4-CD8- double-negative, immature double-positive CD4+CD8+ and mature single-positive CD4+ and CD8+. From a mathematical standpoint these four thymocyte populations could be considered as four separate compartments connected with a one way flow of cells, with thymocytes from each compartment undergoing proliferation, cell death and inter-compartment transfer. We aim at developing a full mathematical model of the mouse thymus, based on a system of differential equations that would include all thymocyte populations, the medulla and the stromal component of the thymus with the purpose of describing the dynamics of thymocyte populations and the thymocyte-medulla interactions in normal and pathological situations. By investigating the the proliferation and death of each thymocyte population we aim at obtaining a precise expression of the proliferation, death and transfer rates during the investigation in order to optimize the mathematical model. Pathological conditions influence thymocyte dynamics by altering their death and proliferation. In a disease like diabetes that influences the proliferation and death of thymocytes we would like to be able to predict the evolution of the organ.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects