BrainMap

Maria-Olimpia Miclaus

Dr.

- INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Researcher

Web of Science ResearcherID: I-4245-2016

Curriculum Vitae (18/07/2023)

Expertise & keywords

SYNERGICSTIC ACTIVES SYSTEMS FOR REGENERATIVE COSMETICS Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2021-0303 2022 - 2024

Role in this project: Key expert

Coordinating institution: SANIMED INTERNATIONAL IMPEX S.R.L.

Project partners: SANIMED INTERNATIONAL IMPEX S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Project website: https://www.sanimed.ro/proiect-grace_36.html

Abstract:

The GRACE project aims to obtain and characterize a range of integrative products, designed to regenerate the epidermis affected by superficial lesions, solar radiation, radiation therapy, or bedsores, using specifically functionalized hydrogels with complexes of inclusion of active ingredients in host molecules. These supramolecular complexes will represent the innovative component in the formulation of a new range of products with applications in the field of regenerative cosmetics. In concrete terms, the GRACE project aims to obtain a range of 3 products: single-dose hydrogel (for superficial lesions), cream gel (for skin affected by radiation) and cleansing gel (for gentle debris removal and cleaning of superficial lesions). In this sense, the project will stimulate the investment in research - technological development from the beneficiary company, as well as the consolidation of the company's potential actor on the domestic and international market, highly competitive, of dermato-cosmetic products. In the alternative, the project will develop the company's traditional partnerships with scientific research institutions, in order to connect Romanian applied research to the requirements of the national and European socio-economic environment.

Ketoconazole: from fundamentals to new antifungal formulations based on PAMAM dendrimers with improved biodisponibility Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0244 2022 - 2024

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/ket-in-pamam/

Abstract:

The goal of the proposed project is to create a young, multidisciplinary research team capable to promote new solid forms/formulations of active pharmaceutical ingredient (API) Ketoconazole with market potential. My research experience in APIs new solid forms development will be expanded with the knowledge about API-dendrimer encapsulation, antifungal activity and biocompatibility studies. The team consist of five young researcher (project leader - chemical engineer, 2 chemists, 1 biotehnologist, 1 dermatologist), one SR dermatologist and one postdoc.

Finding new solid forms/formulations of Ketoconazole with enhanced solubility and bioavailability can be the basis of a better product in order to maximize its therapeutic efficacy. For two new co-crystals, KTZ-Adipic Acid and KTZ-Sorbic Acid, with 100 and 40-fold increased solubility compared to commercial KTZ and for an KTZ-PAMAM complex, as APIs in optimized antifungal products with oral/topical administration, the research team will strengthen their market potential.

For the co-crystals we will complete the preliminary preformulation information with specific studies/assessment: compatibility with pharmaceutical excipients, in vitro and in vivo biocompatibility tests, a protocol for co-crystallization process at grams scale necessary in pharmaceutical industry for developing a successful industrial co-crystallization process.

From amorphous to crystalline: in the quest for new pharmaceutical formulation, with improved stability of representative statin drugs Call name: P 1 - SP 1.1 - Proiecte de cercetare Postdoctorală
PN-III-P1-1.1-PD-2019-0701 2021 - 2023

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/crystatin

Abstract:

Statins are the most commonly used group of drugs for lowering cholesterol. They belong to class II of the biopharmaceutical classification system (BCS), which means that they are poorly soluble, but permeate biological membranes well. Even if, in the literature there are reported also crystalline forms (polymorphs and salts) of statins, the pharmaceutical companies, prefer the amorphous salts forms for the formulation of the drug. The reason is that the solubility of the reported new crystalline forms is generally still less than that of the amorphous salt form. Amorphous forms are known to have low stability, witch creates problems at the formulation stage: they mix less and have worse rheological properties than crystalline systems.

In this context the main objective of the proposal is to obtain crystalline forms - co-crystals. Co-crystal formation with a suitable co-former offers the potential of improved solubility via modification of the underlying crystal structure.

For the two selected statins - Pravastatin and Pitavastatin - will be applied advanced crystal engineering and characterization techniques. For obtaining pharmaceutical co-crystals high-throughput crystallization methods will be used, whereas to increase accuracy / reliability in crystal structure determination a recently new methodology that combine X-ray diffraction with complementary techniques like Solid State NMR and molecular modeling, NMR crystallography, will be employed.

Taking into account the fact that the patent of Pravastatin sodium (market as Pravachol) has expired in 2016, and the patent of Pitavastatin calcium (markt as Livalo) will expire in 2021, new crystalline solid forms of the tow statins will give the possibility to the pharmaceutical companies to release a generic drug with improved pharmaceutical properties. The complete characterization of the new crystalline forms will be described in papers published in prestigious ISI journals.

Increasing technological and knowledge transfer capacity of INCDTIM Cluj in the field of bioeconomics Call name:
POC 18/2016 2016 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/poc/ttc/

Abstract:

MATERIALE ACTIVE UNICOMPONENTE PENTRU CELULE SOLARE ORGANICE BAZATE PE COMPUŞI PI-CONJUGATI AUTOASAMBLAŢI (SMOSCs) / SELF-ORGANIZED PI-CONJUGATED SYSTEMS AS ACTIVE CONSTITUENTS FOR SINGLE-MATERIAL ORGANIC SOLAR CELLS (SMOSCs) Call name: Atragerea de personal cu competențe avansate din străinătate pentru consolidarea capacității de cercetare-dezvoltare (Apel reconstiuit pentru păstrarea pistei de audit - Anul 2015)
103509 2016 - 2020

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA "BABES-BOLYAI"

Project partners: UNIVERSITATEA "BABES-BOLYAI" (RO)

Affiliation: UNIVERSITATEA "BABES-BOLYAI" (RO)

Project website:

Abstract:

Design of some spin-crossover supramolecular structures controlled by ultrashort laser pulses Call name: P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0208 2017 - 2019

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/pncdi/lascro/index.html

Abstract:

The present project proposes to elaborate a detailed theoretical framework for laying out different supramolecular complexes with well-defined properties based on the spin crossover effects. To achieve this goal, the density functional theory (DFT) and its linear response time-dependent (TDDFT) version will be considered as the theoretical framework to describe different electronic excited states in “low” and “high” total spin configuration. In the first period of the project implementation, the validation of the used theoretical model will be carried out through the comparison with already existing experimental measurements. This investigation will be followed by a detailed description of the physical phenomena of the laser induced spin transition in organometallic complexes which mainly includes: theoretical characterization of the molecular electronic excited states; description of the radiation decay pathways and localization of the intersystem crossing points; calculation of the spin-orbit couplings. After the successful validation and development of the theoretical framework, several metal-ligand structures will be investigated in order to design metal-coordinated macrocycles with efficient spin transitions driven by the external laser field in a controlled manner. Each case of metal-coordinated macrocycles will be characterized in detail and the most promising candidates will be selected for chemical synthesis. After the successful synthesis, the macrocycle compounds will be investigated using different spectroscopy techniques, like UV-Vis, transient absorption or Raman in order to characterize their spin crossover properties. Based on these analyses the most important feature of the spin crossover complexes, namely the ligand bond length variation driven by an external laser field in a controlled manner, will be applied in case of sulfonated coordination polymer networks to build molecular materials with special properties.

Revival of an old drug by crystal engineering: development of improved ketoconazole based antifungal products Call name:
2016 - 2018

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Project website:

Abstract:

Innovative platforms for applications in emerging areas: neural network based computing techniques, development of new pharmaceutical formulations, molecular diagnosis, biomedicine. Call name:
PN18-03 02 01 2018 - 2018

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/index.php?menu=2&submenu=302P3

Abstract:

General Objective

Developing innovative platforms and applications in emerging areas: neural network based computing techniques, new pharmaceutical formulations

with increased efficacy, molecular diagnosis, biomedicine.

Specific Goals

A. Physical-chemical models based on neural networks: applications to describe and predict the generation of higher harmonics and pulsations of attoseconds.

We propose designing a process of generating higher harmonics using artificial back-propagation networks;

B. Obtaining complex supramolecular systems with applications in the development of new, highly efficacious pharmaceutical formulations and separating

natural bioactive compounds from plant extracts. We aim to obtain new pharmaceutical formulations of synthetic and natural bioactive compounds;

C. Developing innovative molecular diagnostics platforms for biomedical applications based on ultrasensitive spectroscopic techniques, nanostructured interfaces and high accuracy analysis algorithms.

Revival of an old drug by crystal engineering: development of improved ketoconazole based antifungal products Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1521 2017 - 2018

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/pncdi/ketcrys/index.htm

Abstract:

The goal of the proposed project is to assess the market potential of two co-crystal solid forms of ketoconazole (KET) with fumaric acid (FUM) and p-aminobenzoic acid (PABA) coformers, as APIs with improved properties in terms of solubility / antifungal activity. The 100-fold increased solubility of KET-FUM compared with commercial KET indicates his pharmaceutical potential for oral drug therapy by reducing the administered dose. On the other hand, KET-PABA with only 10-fold increase solubility, increase antifungal activity and due to its sunscreen coformer has pharmaceutical potential for topical use, especially during summer time. The project results will complete the preliminary preformulation information of KET-FUM and KET-PABA already reported by our research group (protocol for co-crystallization process at small scale – milligrams, solubility and dissolution rate, thermal analysis, FT-IR and antifungal activity for both solid forms and structural characterization of KET-FUM) with common and specific studies/assessment (compatibility with pharmaceutical excipients for KET-FUM – oral therapy; crystal structure characterization for KET-PABA, in vitro and in vivo biocompatibility assessment for both crystalline forms). We will also develop protocol for co-crystallization process at large scale (grams) necessary in pharmaceutical industry for developing a successful industrial co-crystallization process. This research will raise the technology readiness level from TRL2 to TRL4 for KET-FUM and KET-PABA crystalline forms. For KET-PABA (targeted for topical therapy) we will initiate a patenting strategy.

Development of active thermal-wave methodologies for non-destructive evaluation and thermophotonic imaging of teeth Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-1507 2015 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation:

Project website: http://www.itim-cj.ro/PNCDI/ru136/index.htm

Abstract:

The main objective of the project is to improve the performance in dental diagnosis and to show that using different types of modulation sources (lasers, LEDs), modulation schemes, and complex image processing algorithms, one can construct high resolution images of defective zones of teeth.

The main investigation technique will be infrared lock-in thermography, which is a non-contact and non-invasive tool.

In order to evaluate the adaptation between restorative materials and tooth, an automatic defect detection methodology will be implemented.The method will allow the assessment of both marginal and internal microgaps located at the interface between tooth and filling. The progression of demineralization of enamel with time, for specimens undergoing different treatment demineralization periods, will also be analyzed. 2D maps of the demineralized zones of dental tissue and of the interfaces will be obtained, highlighting the areas with defects .

The method will be validated by complementary techniques: SEM and X-ray diffraction.

Universal Multiscale Simulations for Hydrogen Storage in Novel Materials Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-1309 2015 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation:

Project website: http://www.itim-cj.ro/PNCDI/ru194/index.html

Abstract:

The realization of efficient hydrogen storage in materials will have a tremendous impact on the fields of renewable energy and clean transportation. The most promising high uptake materials are based on the physisorbtion of the hydrogen which offers fast, reversible, energetically cheap storage. However, materials synthesized so far have poor ambient conditions performance due to the weak forces binding the molecular hydrogen. We will develop a universal multiscale simulation tool to aid the design of better hydrogen storage materials that will improve upon the state of the art simulations as follows. i) The polarization effects in electric fields will be included both at microscopic and macroscopic scales. ii) The weak interactions involved in the physisorbtion will be correctly treated at the ab initio level, thus revealing the most favorable microscopic features of the materials for hydrogen storage and ensuring the transferability of the code. iii) The simulation will be precise and transferable allowing in silico screening on a large class or materials, thus greatly reducing the experimental overhead. We aim to open the new research direction of electrically controlled hydrogen storage. We will design and then synthesize in the lab polarizable nanoporous materials with electrically tunable hydrogen storage properties based on covalent organic frameworks. We will assess the potential of these materials for industrial applications.

Multidisciplinary evaluation of imperial gates of churches from the 15th to the 19th century for conservation and restoration using classical and digital methods, for ensuring community viability Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1882 2014 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO); UNIVERSITATEA TEHNICA DIN CLUJ - NAPOCA (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA DE ARTA SI DESIGN CLUJ-NAPOCA (RO); DANART IMPORT EXPORT SRL (RO)

Affiliation:

Project website: http://usiimparatesti.granturi.ubbcluj.ro/index.html

Abstract:

ASTERCRIG project proposes an interdisciplinary approach of classical and digital conservation - restoration of an important symbol of our cultural heritage, namely the Imperial Gates belonging to iconostasis from Transylvanian wooden churches dating back to 15th-19th century. From two counties from Transylvania: Cluj and Salaj, the wooden churches will be investigated in order to establish the conservation status of the imperial gates. One of the selected counties (Salaj) have large parts of their territory declared as “disadvantaged areas”. The best preserved ones are those which are still in use. The depopulation of the rural area reduces their number year after year. Some of the inactive churches were saved by including them in open air village museums. Also valuable artistic artifacts were saved by moving them to such museums. After a theological, artistical and historical evaluation protocole, two imperial gates from each county will be selected and investigated. Several analytical methods (non-destructive and/or destructive) will be used complementary for the investigation of wooden support, painting layer and varnish. The digital reconstruction method will be based upon accurate scientific analysis (Raman, FTIR, chromatography methods, XRD, etc.) as well as modern engineering tools specific for reverse engineering. Based on this digital restoration, a virtual 3D museum will be realized that will include the imperial woods, classically and digitally restored. The scientific and technical results will be presented during an international symposium dedicated to cultural patrimony conservation and restoration. A printed catalogue containing the imperial doors, classically and digitally restored will be edited.

The improvement of the manufacturing technology of lead-acid batteries to be used for start-and-stop automobiles Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1226 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BABES BOLYAI (RO); ROMBAT S.A. (RO)

Affiliation:

Project website: http://www.itim-cj.ro/PNCDI/rombss/

Abstract:

We propose a methodology for the improvement of fabrication technology for the positive electrodes used as components in the lead-acid batteries produced at sc rombat sa . The final goal of our consortium is to improve the current technology used by industrial partner for fabrication of the batteries to be used for start-and-stop automobiles (i.e . To satisfy the j240 – sae and en 50342-6 quality tests) . The proposed approach is designed for the optimization of the scientific and technological steps involved in the fabrication of positive electrodes . It integrates the fundamental knowledge obtained from ab initio calculations, synthesis of new chemical compounds, fabrication of new alloys and structural characterization of the materials used to fabricate the electrode, at both nanoscopic and mesoscopic scale . The key element for the integration of all these activities is the fabrication and characterization of functional prototypes by the industrial partner.

The main problem to be solved is to control the corrosion of the positive electrode during the charge-discharge cycles, imposed by the requests of the start-and-stop technology . The solutions proposed by our consortium are: (i) fabrication of new alloys to be used for the production of the metallic grid that support for the active mass of the electrode (ii) improving the fabrication technology of the metallic grid (iii) improving the electrochemical properties of the active mass by new fabrication technology and by the use of new additives to the active mass. We note here that for the negative electrode as well as for the electrolyte the standard products fabricated by sc rombat sa will be used . The project’s goal will be achieved by using a feed-back loop: the design of materials and the fabrication steps involved by each prototype will be refined by successive fabrication of the prototypes that will gradually incorporate the information produced by each partner . At each step of our methodology the full characterization of the electrochemical and structural properties of the materials and prototypes already fabricated will be used as starting point for further refinement of the fabrication technology . A continuous exchange of data between the research Institutes and the industrial partner is foreseen for the whole duration of the project . This will allow us to tune the results obtained in the laboratory with those produced in industrial conditions . At project’s term we will discuss the technological steps needed for the implementation of the results by using the infrastructure available at sc rombat sa.

Novel advanced smart biomaterials of giomer type with applications in dentistry Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1419 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); REMED PRODIMPEX SRL (RO)

Affiliation:

Project website: http://granturi.ubbcluj.ro/giodent

Abstract:

The present research project proposed the elaboration, achievement and experimentation of novel, advanced, smart biomaterial formulations belonging to the giomers class with low polymerization shrinkage, continuous release of fluoride in time, improved adhesion to tooth tissues, high mechanical properties and good biocompatibility to be used in different applications in dentistry.

Given the ample and varied activities to be undertaken, the project requires a consortium to be constituted from five partners, two Universities, one National Research Institute, one Institute of the Romanian Academy and one commercial entity, forming an interdisciplinary team of specialists with experience in chemistry, engineering, physics, materials science, biology and medicine .

The planed results of the research activities are the following: 3 products of giomer type for the restoration of the anterior and posterior teeth, for the prophylaxis of caries with children and as liner/base material; 1 dentin adhesive with improved adhesion to tooth structure, 4 laboratory technologies, 3 Feasibility studies, 3 marketing studies, 4 technical specifications, 6 ISI articles and 2 registered patents.

By achieving the proposed project, contribution is brought to the sustaining of the national policy in the field, by creating the transfer and capitalization opportunities which will lead to the development of a Romanian industry of performing dental products, at

European standards level, having in view the specialized human potential with experience in the field.

Rational design and generation of synthetic, short antimicrobial peptides. Linking structure to function Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0595 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); UNIVERSITATEA BABES BOLYAI (RO)

Affiliation:

Project website: http://www.science.research.uaic.ro/biopep/

Abstract:

Antimicrobial peptides (AMPs) are an integral part of the immune system and protect a host from invading pathogenic bacteria. To overcome the problem of antimicrobial resistance, AMPs are being considered as potential alternatives for antibiotics. Although over 1000 AMPs have been isolated and characterized from various hosts, only limited successes have so far been achieved in clinical trials. The major hurdles for converting them into drugs lie in the high cost of production, toxicity to host cells, and susceptibility to proteolytic degradation. Therefore, a better understanding of the structure–activity relationships of AMPs is required to facilitate the design of novel antimicrobial agents. Herein we plan to focus our effort on designing and optimizing novel short, cationic amphiphilic peptides. We will undertake rational design, synthesis, and extensive testing of a series of short cationic peptides, we envision proteolityc and salt resistant. They will be made of a limited set of L- and D-aminoacids based on an elementary amphipathic templates of up to to 11 aminoacids, searching for the minimum number of aminoacids and optimal architecture able to confer the peptide optimal lytic activity and specificity against various pathogens. In order to enhance antimicrobial activity with no additional hemolytic activity, peptide synthesis will be considered by using non-natural amino acid analogs that will substitute hydrophobic residues leucine, isoleucine and phenylalanine. This group of peptides will be designed and synthesized with shorter sequence and simpler molecular structure and could be easily modified upon a particular requirement. The structural simplicity also offer technological advantages for mass production and purification.

Modern high-troughput methodologies for obtaining and characterizing new solid forms of pharmaceutical compounds Call name:
POSCCE ID 536 2010 - 2014

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/pos/htpharma/

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects