BrainMap

Mrs. MARIA COROS

Dr. Ing.

Researcher - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Researcher

Web of Science ResearcherID: not public

Curriculum Vitae (20/06/2023)

Expertise & keywords

Innovative zeolite/graphene stone paper electrodes for pesticides detection in fruits and vegetables Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0358 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation:

Project website: https://www.itim-cj.ro/PNCDI/smartsens/

Abstract:

The major scope of this project is to develop and validate a laboratory technology for the detection of pesticides (glyphosate, cymoxanil) in fruits and vegetables samples using a new stone paper sensor based on composite material (zeolites/ graphene-Co nanoparticles) and a portable device coupled with a smartphone. The project proposes a revolutionary, fast and ecological method of obtaining graphene with the electric field created by plasma. The new sensor will be designed, characterized and validated by the young team. The experimental proof of concept will be demonstrated by testing the new flexible electrodes in laboratory solutions containing pesticides to evaluate the electro-analytical characteristics: sensitivity, limit of detection and linear range. The results obtained in real samples of fruits and vegetables will be compared with the results obtained with the chromatographic method. The feasibility of the project is demonstrated by the excellent experience of the Project leader in the area of electrochemical sensors. The main deliverers of the project will be: 3 ISI papers; 4 presentations at conferences; 1 laboratory technology for pesticides detection; 1 patent application. The impact of the present project is going to be high for scientific community and for food safety, public health and quality control of life due to this smart and portable testing device for monitoring the presence of pesticides in food stuffs.

Plasma Lab Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0661 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation:

Project website: https://www.itim-cj.ro/PNCDI/plasma-lab/

Abstract:

In this project we are assembling a team of skilled young researchers who together will form the first official plasma lab in our institute (INCDTIM) with the main objective to design and build innovative plasma systems / devices for microorganism inactivation / decontamination, which will serve humanity.

Cold plasma has entered this field as a novel, highly efficient and clean solution for virus inactivation.

Cold atmospheric plasma (also known as open-air nonthermal plasma) operating at atmospheric pressure and almost room temperature (T
Among its complex constituents, the emission of UV radiation and reactive oxygen and nitrogen species have the most important antimicrobial properties.

UV photons damage nucleic acids, whereas the highy reactive molecular species present in the plasma can oxidize the viral nucleic acids, proteins and lipids.

Graphene-based stochastic sensors for molecular diagnosis of upper gastro-intestinal cancer Call name: P 4 - Proiecte Complexe de Cercetare de Frontieră
PN-III-P4-ID-PCCF-2016-0006 2018 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA DE MEDICINA, FARMACIE, STIINTE SI TEHNOLOGIE DIN TARGU MURES (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.ralucavanstaden.ro/pdf/RAPORT%20FINAL.pdf

Abstract:

The main objective of the project is to design a new generation of stochastic sensors based on modified graphene materials for the fast screening of biological fluids (whole blood, saliva, urine) as well as of tissue samples, in order to diagnose faster the upper gastro-intestinal cancer. In this regard, a panel of biomarkers specific to this type of cancer was selected to be analyzed using stochastic sensors. In the final stage, statistic evaluation of correlation between the panel of biomarkers found in biological fluids and tissue samples using stochastic sensors will be performed, providing the information about the possibility of diagnosis of this cancer without performing the biopsy, all only based on screening tests of biological fluids and complementary imagistic noninvasive techniques. The panel of markers proposed to be analysed is the following: - the marker that is known to be supressed during gastric and gastro-esophageal carcinogenesis - p53, it will be used as a banchmark. The other biomarkers that will be used are the following: maspin, heparanase (an endoglycosidase that is a major component of the extracellular matrix), MMP-2 and MMP-9 (two matrix metaloproteinases), HER-2 and CD26/DPP4 (a surface T cell activation antigen). Graphene materials dopped with nitrogen and boron will be synthesized and use as paste unmodified or modified with fructans, ionic liquids or aptamers for the design of stochastic sensors. The stochastic sensors will be fully characterized electrochemically, and validated against a minimum of 200 real samples from confirmed patients: biological fluids and tumoral tissues will be used for validation, but also for developing of a faster, noninvasive method of screening for fast diagnosis, avoiding in this way the biopsy.

Interinstitutional program of developing advanced eco-nanotechnology solutions for multifunctional treatments of leather and textile materials Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0743 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.nipne.ro/proiecte/pn3/7-proiecte.html

Abstract:

Developing integrated functionalization eco nano technologies using physical techniques (gamma irradiation, plasma activation, electrodeposition) and nanocomposites with antibacterial, antistatic or hydrophobization properties will produce textile and leather materials with multifunctional advanced properties. Replacing and reducing volatile organic compounds that negatively impact the environment will set the premises of transferring advanced technologies to companies manufacturing medical articles, protection equipment, sports equipment or for other applications and creating thus new research services by PHYSforTeL consortium partners to the benefit of the traditional industrial sector of textile and leather industry.

NEW LUTING MATERIALS WITH GRAPHENE USED IN DENTISTRY Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1907 2017 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://lutgraf.granturi.ubbcluj.ro/index.htm

Abstract:

While dental cements development led to the emergence of new materials that meet the changing needs of dentists and together with innovations in delivery devices, have been cementing procedures faster, easier and more predictable. Functional these cements must withstand masticatory stress; maintain integrity in the oral and transferring occlusal forces from the fixed prosthetic restorations, dental and periodontal tissues.

Current resin cements are commonly used in dentistry commercially available inhibitors of their versatility, resistance and high compressive strength, low solubility and high aesthetic quality. Their main disadvantages are difficult removal of excess, working technique sensitive, high cost and difficult restoration cemented adhesive removal - most often sectioned into pieces before restoring be loosening. Graphene is considered to be the “thinnest and strongest material in the universe” and therefore it has remarkable physical and chemical properties, including superior Young’s modulus (1 TPa) and tensile strength (130 GPa). Recent studies have shown that graphene can be used as nanofiller and can dramatically improve the properties of polymer-based composites at a very low loading (0.1-5 wt. %). The aim of this project is to develop a technology for obtaining a cementing material, biocomposite, based on biocompatible polymers and graphene nanofillers of modern treatments and standardized bioglasses for cementing caries prevention effects.

Graphene-porphyrin supramolecular assemblies for chemical and electrochemical detection of hydrogen peroxide-an oxidative stress marker Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0305 2015 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/ru305/index.htm

Abstract:

The aim of the present project proposal is to develop innovative research in the field of graphene-based nanomaterials as advanced and functional materials. Additionally, the project will tackle aspects regarding the supramolecular behavior of graphene with porphyrin derivatives. The graphene-porphyrin assemblies will be formed by two different approaches – one that involves the oxidation of graphite and its reduction in the presence of nitrogen containing molecules and the other method involves the porphyrin mediated direct liquid-phase exfoliation of graphite. The two types of graphene-based nanomaterials are expected to present different electronic properties with direct implication on their application as chemical or electrochemical sensors of hydrogen peroxide – a known stable oxidative stress marker. In this respect, the peroxidase-like activity of the graphene-porphyrin assemblies will be assessed by the oxidation reaction of a peroxidase substrate. This project will also open new directions for exploring more of their possible applications.

Formic acid/carbon dioxide, a couple for renewable catalytic hydrogen storage Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-1326 2015 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/ru143/Home.htm

Abstract:

The growing need for energy requires development of new energy sources/carriers and more efficient utilization of energy. Hydrogen is the ideal energy carrier due to its natural abundance and non-polluting nature.

The development of hydrogen storage technologies for mobile applications still requires overcoming some technical barriers.

Different hydrogen storage paths have been envisaged: from the classical storage technologies, namely pressurization and cryogenic liquefaction, to the solid phase storage in metal hydrides, or physisorbed on a solid surface (metal-organic frameworks, covalent organic frameworks) and the organic liquid hydrogen carrier (LC) under ambient conditions.

Chemical hydrogen storage can became competitive if the storage material fulfils some requierements: high gravimetric and volumetric hydrogen content under ambient conditions, energy-efficient reversible charge and discharge, the absence of byproducts, long-term stability, low toxicity, easily available at a large scale and at a low price. The challenge is to find suitable organic carriers.

Formic acid is a promising candidate for reversible hydrogen storage. The aim of this project is to study formic acid decomposition/formation using a new type of catalysts: metallic nanoparticles confined in metal-organic frameworks, to exploit the nanoparticles confinement and the nanoscale properties for reactions of formic acid dehydrogenation and carbon dioxide reduction under mild conditions.

New nanocomposites based on biocompatible polymers and graphene for dental applications Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1282 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BABES BOLYAI (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); APEL LASER S.R.L. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/biograf/

Abstract:

In modern dentistry, both the early prevention of tooth decay and the development of new and efficient restorative materials are generally targeted. Although tremendous efforts have been made in promoting oral hygiene and fluoridation, the prevention of early caries lesions are still challenges for dental research and public health. Recent studies have indicated that nanotechnology might provide novel strategies in dentistry.

Graphene consists in a one-atom-thick planar sheet of sp2–bonded carbon atoms arranged in a hexagonal lattice. Graphene is considered to be the “thinnest and strongest material in the universe” and therefore it has remarkable physical and chemical properties, including superior Young’s modulus (1 TPa) and tensile strength (130 GPa). Recent studies have shown that graphene can be used as nanofiller and can dramatically improve the properties of polymer-based composites at a very low loading (0.1-5 wt.%).The results so far reported in the literature indicated that graphene/polymer composites are promising multifunctional materials with significantly improved tensile strength and elastic modulus, electrical and thermal conductivity. Despite some challenges and the fact that carbon nanotubes/polymer composites are sometimes better in some particular performance, graphene/polymer composites may have wide applications in dentistry due to their outstanding properties and the availability of graphene in a large quantity and at low cost.

Within the BIOGRAF project we plan to develop: ► a new nanocomposite material based on biocompatible polymers and graphene to be used in dental restorations ► new ex vivo tests to identify the host reaction to this material, in relationship with some biologic risk indicators. The final aim of the project is to develop modern and standardized therapies of caries lesions through the development of the novel nanocomposite material based on biocompatible polymers and graphene.

The present research project fits very well into the research domain 7. Materials, processes and innovative products since a new nanocomposite material with graphene will be manufactured which will fulfill the bio-safety criteria and have biocompatible properties with the local cellular environment. By its specific objectives BIOGRAF corresponds to the research thematic 7.1.6. Advanced materials and biomaterials for improving the quality of life (health, sport, education) because: ► a new nanocomposite material with graphene will be developed, for better medical treatments ► complex inter-/multidisciplinary studies will be performed, in order to elaborate and validate new standardized therapies based on advanced materials ►the development of a new perspective in dentistry, based on advanced theoretical and practical knowledge ► a research network will be developed which can ensure human resources for the top scientific research ► articles will be published in highly-ranked journals (ISI) ► research papers will be presented at international conferences ►valuable information will be disseminated among PhD/PostDoc students and researchers in the field of nanocomposite materials ►the equipments that will be purchased will develop the existing R&D infrastructure.

BIOGRAF project is aiming to deliver the following end-product(s)/ expected results:

► a new nanocomposite material with graphene, to be used in dental restoration therapy

► one laboratory technology for the synthesis of the nanocomposite material

►3 ISI papers, in highly ranked journals

►a patent.

Graphene-metal nanoparticles based electrodes for detection of pharmaceutical pollutants Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0125 2011 - 2016

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Tehnologii Izotopice si Moleculare

Project partners: Institutul National de Cercetare-Dezvoltare pentru Tehnologii Izotopice si Moleculare (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Tehnologii Izotopice si Moleculare (RO)

Project website: http://www.itim-cj.ro/PNCDI/idei125/index.htm

Abstract:

Graphene-based materials have recently attracted considerable interest both from the experimental and theoretical scientific communities. Graphene is a monolayer of sp2 hybridized carbon atoms which are packed into a honeycomb crystal structure. Due to their exceptional thermal and mechanical properties as well as high electrical conductivity, graphene sheets have a variety of applications in battery, field-effect transistors and electromechanical resonators. Their applicability as biosensors has now started to emerge, due to significant advantages over the classical electrodes, such as electrocatalytic effect, enhancement of mass transport and high effective surface area.

This project proposal brings up novelties through the original method used to obtain nanostructured material (graphene-metal nanoparticles composite) as well as through the way of its application (detection and degradation of pharmaceutical pollutants). This project has a multidisciplinary research area. The research activities within this project will provide: (a) new approaches for preparation of graphene-metal nanoparticles composite; (b) explanations about the intriguing properties associated with graphene-metal nanoparticles composite; (c) experimental solutions related to the assembly of metal nanoparticles on graphene platelets; (d) application of graphene-metal nanoparticles composite in electrocatalytic detection of two pharmaceutical pollutants: carbamazepine and captopril

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects