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Marcela-Corina Roșu

- INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Researcher

Marcela-Corina Rosu is currently senior research scientist at the National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania. She studied chemistry at the Babes-Bolyai University, Cluj-Napoca, Romania. She received her MSc degree in Quality Analysis and Environment Monitoring and PhD degree in Chemistry from the same university. Her research is multidisciplinary and mainly concerns the development of advanced nanomaterials (mostly based on TiO2) with application in various fields, such as environmental (photocatalysts for degradation of organic pollutants from water), biomedical (nanocomposites for dental applications, nanocomposites with antibacterial and anticancer potential) and textile-leather sector (functional nano-coatings for textile/leather materials).

Web of Science ResearcherID: not public

Expertise & keywords

TiO2 nanotubes/graphene-based nanomaterials to address the emerging contaminants pollution Call name: EEA Grants - Proiecte Colaborative de Cercetare
RO-NO-2019-0616 2020 - 2024

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); University of South-Eastern Norway (NO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/graftid/

Abstract:

For the past century, the environment suffers from rapid deterioration due to the explosive development of chemical and pharmaceutical industries. Large quantities of drugs, personal care products, detergents, pesticides, food additives have been released in the aquatic system. The pollutants of emerging concern are not yet monitored and well regulated by authorities while there is an increased awareness of their impact on human health. The United Nations World Water Development Report 2018 states that “An estimated 80% of all industrial and municipal wastewater is released to the environment without any prior treatment, resulting in a growing deterioration of overall water quality with detrimental impacts on human health and ecosystems”. Advanced Oxidation Processes (AOPs) based on photocatalysis are the most powerful and viable alternative to the conventional wastewater treatment technologies that still have some limitations (e.g., high operation costs, energy consumption, or reduce efficiency due to the chemical stability of pollutants and/or the complexity of their degradation). Thus, the development of solar-driven catalysts with improved photocatalytic activity for the environment-friendly and facile treatment of aquatic systems remains an important target to environment remediation.

Interinstitutional program of developing advanced eco-nanotechnology solutions for multifunctional treatments of leather and textile materials Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0743 2018 - 2021

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.nipne.ro/proiecte/pn3/7-proiecte.html

Abstract:

Developing integrated functionalization eco nano technologies using physical techniques (gamma irradiation, plasma activation, electrodeposition) and nanocomposites with antibacterial, antistatic or hydrophobization properties will produce textile and leather materials with multifunctional advanced properties. Replacing and reducing volatile organic compounds that negatively impact the environment will set the premises of transferring advanced technologies to companies manufacturing medical articles, protection equipment, sports equipment or for other applications and creating thus new research services by PHYSforTeL consortium partners to the benefit of the traditional industrial sector of textile and leather industry.

CarBon quANtum Dots/graPhene hybrids with broAd photoreSponSivity Call name:
ATTRACT 2019 - 2020

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (); UNIVERSITATEA BABES BOLYAI (); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU INGINERIE ELECTRICA ICPE - CA BUCURESTI ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD ()

Project website:

Abstract:

NEW LUTING MATERIALS WITH GRAPHENE USED IN DENTISTRY Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1907 2017 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://lutgraf.granturi.ubbcluj.ro/index.htm

Abstract:

While dental cements development led to the emergence of new materials that meet the changing needs of dentists and together with innovations in delivery devices, have been cementing procedures faster, easier and more predictable. Functional these cements must withstand masticatory stress; maintain integrity in the oral and transferring occlusal forces from the fixed prosthetic restorations, dental and periodontal tissues.

Current resin cements are commonly used in dentistry commercially available inhibitors of their versatility, resistance and high compressive strength, low solubility and high aesthetic quality. Their main disadvantages are difficult removal of excess, working technique sensitive, high cost and difficult restoration cemented adhesive removal - most often sectioned into pieces before restoring be loosening. Graphene is considered to be the “thinnest and strongest material in the universe” and therefore it has remarkable physical and chemical properties, including superior Young’s modulus (1 TPa) and tensile strength (130 GPa). Recent studies have shown that graphene can be used as nanofiller and can dramatically improve the properties of polymer-based composites at a very low loading (0.1-5 wt. %). The aim of this project is to develop a technology for obtaining a cementing material, biocomposite, based on biocompatible polymers and graphene nanofillers of modern treatments and standardized bioglasses for cementing caries prevention effects.

Laboratory technology for detection of leukemia biomarkers using new graphene-based materials Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0392 2017 - 2018

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/pncdi/bioleuk/

Abstract:

The major scope of this project is to develop and validate a laboratory technology for the detection of two leukemia biomarkers: 8-hydroxy-2’-deoxyguanosine and 8-nitroguanine, in blood and urine samples. In order to achieve this, we will design, implement and test a demonstrative model of stochastic sensor, which can provide improved services in the area of public health. Other important achievements of the project will be: (i) cost-efficient and reproducible graphene synthesis; (ii) full characterization of graphene properties, as sensing layer on different substrates; (iii) studies of detection mechanisms and effect of grafene surface modifications. This will enable to develop sensors with ultra-low detection limits for biomarkers relevant to human health, in laboratory conditions. In this way, we will use the knowledge generated by basic research in the sensor area, for developing a higher level of technological maturity.

Stochastic sensing creates a totally new approach, allowing the same systems to be used in vitro and in vivo. Advantages over current capabilities: (i) single-molecule resolution; (ii) detection in real-time with broad spectrum detection; (iii) such technology eliminates the need for microarrays and multi-step labeling assays. Market size: vast applicability in biomarkers, metabolomics, proteomics, genomics.

Biomarkers are diverse in their conformations, requiring higher design complexity of receptors and sensors for successful sensing. In order to achieve these, two major objectives are proposed:

O1: Developing of lab-validated technology for the detection of two leukemia biomarkers;

O2: Increase the capacity of the two Research Institutes to generate new lab technologies and to provide them to economic agents.

Major expected result: technology validated in the lab for two leukemia biomarkers.

Electrochemical platform for selective lead ion detection Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0415 2017 - 2018

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); SITEX 45 SRL (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/pncdi/respond/index.htm

Abstract:

Altering living environment (through air, water and soil pollution) is one of the most complex problems of mankind due to its repercussions, in most cases irreversible and chronic, with negative impact on the most precious attribute of man: its health. As a result of anthropoid activities, some metal ion (like copper, nickel, cadmium, chromium, lead, mercury, zinc and others) reach water sources. These items are considered particularly dangerous pollutants, due to the imbalances and diseases they can cause (even at low concentrations) and because of their cumulative effect in different organs, since the body is unable to eliminate them by conventional methods. The current project proposal is motivated by the increase threat of heavy metal pollution and due to the requirements for the development of new, cheap and sensitive detection devices. The major objective targets the development and validation of a laboratory technology for the fabrication of a low cost sensing electrochemical platform for selective detection of lead ions concentration from aqueous solutions. Our main goal is to take a nanocomposite graphene based material from a state of raw potential up to a point where we can exploit the graphene unique electrical and optical properties, by integration of modified electrodes in novel electronic systems that can revolutionize multiple industries, especially the sensor applications, with direct beneficial impact in health and life sciences. The research team targets to take use of the high sensitivity and selectivity of an already existing modified electrode obtained in our group (from the surface area modification of a metallic, gold electrode with a new type of nanocomposite material based on chitosan and N-doped graphenes) in order to build a selective electrochemical detection platform for lead ion concentration from different water sources.

Graphene-porphyrin supramolecular assemblies for chemical and electrochemical detection of hydrogen peroxide-an oxidative stress marker Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0305 2015 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/ru305/index.htm

Abstract:

The aim of the present project proposal is to develop innovative research in the field of graphene-based nanomaterials as advanced and functional materials. Additionally, the project will tackle aspects regarding the supramolecular behavior of graphene with porphyrin derivatives. The graphene-porphyrin assemblies will be formed by two different approaches – one that involves the oxidation of graphite and its reduction in the presence of nitrogen containing molecules and the other method involves the porphyrin mediated direct liquid-phase exfoliation of graphite. The two types of graphene-based nanomaterials are expected to present different electronic properties with direct implication on their application as chemical or electrochemical sensors of hydrogen peroxide – a known stable oxidative stress marker. In this respect, the peroxidase-like activity of the graphene-porphyrin assemblies will be assessed by the oxidation reaction of a peroxidase substrate. This project will also open new directions for exploring more of their possible applications.

New nanocomposites based on biocompatible polymers and graphene for dental applications Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1282 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BABES BOLYAI (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); APEL LASER S.R.L. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/biograf/

Abstract:

In modern dentistry, both the early prevention of tooth decay and the development of new and efficient restorative materials are generally targeted. Although tremendous efforts have been made in promoting oral hygiene and fluoridation, the prevention of early caries lesions are still challenges for dental research and public health. Recent studies have indicated that nanotechnology might provide novel strategies in dentistry.

Graphene consists in a one-atom-thick planar sheet of sp2–bonded carbon atoms arranged in a hexagonal lattice. Graphene is considered to be the “thinnest and strongest material in the universe” and therefore it has remarkable physical and chemical properties, including superior Young’s modulus (1 TPa) and tensile strength (130 GPa). Recent studies have shown that graphene can be used as nanofiller and can dramatically improve the properties of polymer-based composites at a very low loading (0.1-5 wt.%).The results so far reported in the literature indicated that graphene/polymer composites are promising multifunctional materials with significantly improved tensile strength and elastic modulus, electrical and thermal conductivity. Despite some challenges and the fact that carbon nanotubes/polymer composites are sometimes better in some particular performance, graphene/polymer composites may have wide applications in dentistry due to their outstanding properties and the availability of graphene in a large quantity and at low cost.

Within the BIOGRAF project we plan to develop: ► a new nanocomposite material based on biocompatible polymers and graphene to be used in dental restorations ► new ex vivo tests to identify the host reaction to this material, in relationship with some biologic risk indicators. The final aim of the project is to develop modern and standardized therapies of caries lesions through the development of the novel nanocomposite material based on biocompatible polymers and graphene.

The present research project fits very well into the research domain 7. Materials, processes and innovative products since a new nanocomposite material with graphene will be manufactured which will fulfill the bio-safety criteria and have biocompatible properties with the local cellular environment. By its specific objectives BIOGRAF corresponds to the research thematic 7.1.6. Advanced materials and biomaterials for improving the quality of life (health, sport, education) because: ► a new nanocomposite material with graphene will be developed, for better medical treatments ► complex inter-/multidisciplinary studies will be performed, in order to elaborate and validate new standardized therapies based on advanced materials ►the development of a new perspective in dentistry, based on advanced theoretical and practical knowledge ► a research network will be developed which can ensure human resources for the top scientific research ► articles will be published in highly-ranked journals (ISI) ► research papers will be presented at international conferences ►valuable information will be disseminated among PhD/PostDoc students and researchers in the field of nanocomposite materials ►the equipments that will be purchased will develop the existing R&D infrastructure.

BIOGRAF project is aiming to deliver the following end-product(s)/ expected results:

► a new nanocomposite material with graphene, to be used in dental restoration therapy

► one laboratory technology for the synthesis of the nanocomposite material

►3 ISI papers, in highly ranked journals

►a patent.

Photocatalytic production of hydrogen from industrial sulphurous waste using solar energy Call name:
PNCDI II 22 124/2008 -

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA

Project partners:

Affiliation:

Project website:

Abstract:

Modern methods of investigation, authentication, conservation and enhancement of the icons in the Ethnographic Museum of Transylvania Call name:
PNCDI 2 2008 - 2011

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website:

Abstract:

Micro and nanostructured oxide materials with luminescent chromatic for lighting devices– MAMINAL Call name:
PN2- PARTENERSHIPS 71-122/2007 2007 - 2010

Role in this project:

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI ()

Affiliation: UNIVERSITATEA BABES BOLYAI ()

Project website:

Abstract:

Hydrogen production on photo-electroliytic route Call name:
Cex 710/P4/24.07/ 2006 2006 - 2009

Role in this project:

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website:

Abstract:

Obiectivul principal al proiectului de cercetare HIDROSOL este de a dezvolta dispozitive PEC cu fotoelectrozi ieftini pe baza de semiconductori de eficienta ridicata pentru producerea directa a hidrogenului din apa folosind lumina solara ca sursa de energie. Pentru atingerea acestui obiectiv abordarea noastra include eforturi de cercetare paralela pe mai multe directii:

Modelare de diverse configuratii de dispozitive PEC pentru a compara diverse tipuri de materiale si diverse configuratii de sisteme PEC;

Experimente diversificate privind sinteza materialelor si testarea acestora pentru a identifica un potential critic de utilitate (ex. stabilitate, activitate fotocatalitica);

Fabricarea de fotoelectrozi si testarea acestora pentru a identifica si a obtine un nivel critic de performanta al nivelului operational al fotoelectroziolor;

Identificarea sistemelor de materiale cele mai potrivite pentru a atinge performantele optime pe durata lunga in ce priveste eficienta, stabilitatea, sclabilitatea si costurile;

Realizarea unor modele de dispozitive PEC avansate in configuratia de sistem Monolitica Multi-jonctiune si in configuratia de sistem de Tandem cu doi Fononi.

Biocomposites with porphirins with applicability in the photodynamic therapy of malignant cutaneous tumors Call name:
CEEX 102/2006 -

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners:

Affiliation:

Project website: http://www.itim-cj.ro/~dsilipas/viasan/index.htm

Abstract:

Cunoasterea si intelegerea compozitelor avansate pe baza de chitosan cu aplicatii in medicina cu diferiti fotosensibilizatori, metodele de caracterizare fizico-chimica a materialelor biocompozite cu chitosan, substante fotosensibilizante si� vehicole si dezvoltarea unei metode terapeutice eficiente.

Elaborarea conceptelor si strategiei de sinteza a compozitelor biocompatibile pe baza de hidrogeluri de chitosan si acid delta-amino-levulinic si a compozitelor cu chitosan si porfirine Obtinerea si caracterizarea hidrogelurilor biocompozite cu chitosan, cu substante de fotosensibilizare pentru PDT, studii in vitro si in vivo. Diseminarea rezultatelor � realizarea unui workshop la nivel national pentru sporirea vizibilitatii partenerilor participanti in proiect. Stabilirea normelor si formularilor optime pentru metoda de terapie fotodinamica a cancerului cu hidrogeluri compozite chiosan/materiale celulozice cu porfirine in afectiuni tumorale cutanate, elaborarea rapoartelor de experimentare si diseminarea rezultatelor, pentru deschiderea posibilitatii omologarilor ulterioare.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects