BrainMap

Magdalena Aflori

PhD

- INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Researcher | Scientific reviewer | PhD supervisor

Web of Science ResearcherID: C-4305-2011

Expertise & keywords

Advanced composite hydrogels with antibacterial and anti-inflammatory properties for the treatment of periodontosis Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-1780 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA "APOLLONIA" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: https://icmpp.ro/projects/l5/about.php?id=12

Abstract:

As considerable efforts are being made to find new therapeutic strategies in the treatment of periodontitis in order to reduce the side effects associated with the topical administration of drugs and to improve patient comfort, the present project aims to design, optimise and validate a new product and the associated technology. The new product is an advanced composite hydrogel with embedded silver nanoparticles and an anti-inflammatory drug for targeted periodontitis treatment. The consortium involved in this project has a high level of knowledge in biomaterials field, the coordinator team having expertize in synthesis and characterization of advanced biomaterials, while the partner has great competences in biological testing of biomaterials.

The method combine the small silver nanoparticles prepared by a "green" method with a hydrogel based on Chitosan/Poly(vinyl alcohol) obtained by a double crosslinking. Consequently, advanced biocompatible materials will be obtained with adjustable physico-chemical properties, good chemical and mechanical stability, strong and persistent antibacterial activity, and with response properties to the controlled release of anti-inflammatory drug in the local gingival treatment of periodontitis. The correlation between the structure and the properties of the composite hydrogel will be followed in order to establish the optimal preparation method, the optimum loading ratio with silver nanoparticles and crosslinking degree so as to achieve a good antimicrobial activity and a sustained drug delivery.

The new biomaterials, used as they are or integrated into other structures/architectures, could have a major impact in the medical field by administering the antibiotic and anti-inflammatory treatment of periodontitis, and also on the patient who will support this treatment.

Partnerships for knowledge transfer in the field of polymer materials used in biomedical engineering Call name:
ID P_40_443 2016 - 2021

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://poingbio.icmpp.ro/index.php

Abstract:

Flexible white OLED for lighting applications Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1861 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA "ŞTEFAN CEL MARE" DIN SUCEAVA (RO); APEL LASER S.R.L. (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://danielaailincai.wix.com/flexwol

Abstract:

The present consortium (“Petru Poni” Institute of Macromolecular Chemistry – PPIMC Iasi, Stefan cel Mare” University – USV, Suceava and APEL LASER SRL) aims to work together on a multidisciplinary joint project around a very hot topic regarding optoelectronics: white organic light emitting diodes (WOLED). In the context of the global warming, several governments took measures to promote better energy efficiency through advanced lighting technologies. Within this context, European Union set new energy efficient requirements for the lamps produced starting with September 2009, the traditional incandescent and halogen bulbs being gradually eliminated from the market. WOLED lamps are recommended as alternatives to the conventional incandescent bulbs. This is the reason why, in the last years, the thermally activated delayed fluorescence emitters consisting of strong donor-acceptor organic molecules have become highly attractive, in particular due to their applicability for low energy consuming electro-luminescent devices such as WOLEDs. The aim of this project is to obtain an OLED configuration able to be competitive on the Romanian market and not only. To achieve this target, WOLED configuration is thought according with the hottest researches within WOLEDs field and comprises original elements designed to improve the commercially WOLED performances. This includes combined efforts in chemistry, physics and engineering towards the obtaining of new materials, new device concepts, and new technological approaches and to a deeper understanding of the involved basic processes that are determining the devices performance, reliability and durability. The general aim is to reduce the cost, increase the performance and improve configurability, scalability, adaptability, reliability and self-adjusting capabilities of the integrated electronic, optoelectronic and photonic components. To realize a WOLED with increased performances, we propose the obtaining of a new hybrid material as emissive layer, being composed of two thermally activated delayed fluorescence compounds, e.g., green and red emitters, respectively, dispersed as nanometric droplets/nanocrystals into a fluorescent, blue emitting matrix. After varying the molar ratio between the three components, a white light emission will be achieved. To assure the best purity of the hybrid material components, the low molecular weight compounds will be obtained in form of single crystals, while the polymers will be synthesized through electropolymerization. The hybrid material and its components will be structurally confirmed and the film forming ability, electrochemical, optical, electro-optical, mechanical and morphological properties will be determined with the aim to choose the most appropriate material for WOLED configuration. The materials with optimal balance of properties, i.e., good flexibility, white emitting and good quantum efficiency will be selected, and a simulation of the WOLED configuration will be done based on their electrochemical characteristics (HOMO/LUMO levels, band gap, and reversibility of oxidation and reduction processes). The results of simulation process will allow us to choose an optimal configuration to determine the WOLED maximum performances. The electrodes and the substrate with the proper characteristics will be obtained in our laboratories, thus avoiding the eventually inadequacies caused by the use of commercial products. An original element of the proposed configuration is the creation of a new substrate with a refraction index close to air by dispersing liquid crystals in a polymer matrix.

Phosphorus-containing polymers for high performance materials used in advanced technologies and/or biomedical applications Call name: Projects for Young Research Teams - TE-2012 call
PN-II-RU-TE-2012-3-0123 2013 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://proiect0123.wix.com/serbezeanu

Abstract:

The present research will develop the field of phosphorus-containing macromolecular compounds, the main goals being the design, synthesis and characterization of novel polymers containing phosphorus in the main and/or the side chain and the investigation of potential applications of these materials in high ranked fields of the modern technology and/or in biomedicine. The targeted polymers will be designed in such manner to possess good solubility and processability, flame retardancy, high thermal stability, biocompatibility and biodegradability. The structure of monomers and polymers will be verified by means of Fourier transform infrared (FTIR) spectroscopy and NMR spectroscopy. The liquid crystalline behavior will be investigated by polarized light microscopy, differential scanning calorimetry, and X-ray diffraction. The effect of the phosphorus content on the thermal properties and the flame retardancy will be evaluated by means of thermogravimetric analysis (TGA), TGA-FTIR, and scanning electron microscopy. The physical properties of the poly(organophosphazene)-doxorubicin nanoparticles and the release profile of doxorubicin from the micelles will be determined, and the in vivo antitumor activity of the poly(organophosphazene)-doxorubicin will be monitored to assess the efficacy of using the polymer-drug nanoparticles as a drug delivery system.

Promoting Equal Opportunities in. University and Academic Career for Women in Romania Call name:
POSDRU/144/6.3/S/127928 2014 - 2015

Role in this project: Key expert

Coordinating institution: ACADEMIA ROMÂNĂ - FILIALA IAŞI

Project partners: ACADEMIA ROMÂNĂ - FILIALA IAŞI (RO); UNIVERSITATEA "APOLLONIA" (RO); ACADEMIA ROMANA FILIALA CLUJ (RO); UNIVERSITATEA LUCIAN BLAGA (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA TEHNICA DIN CLUJ - NAPOCA - CENTRUL UNIVERSITAR NORD DIN BAIA MARE (RO)

Affiliation: ACADEMIA ROMÂNĂ - FILIALA IAŞI (RO)

Project website: http://proiectpecafrom.acadiasi.ro/

Abstract:

Obiectivul general al proiectului:

Cresterea oportunitatilor de angajare si acces la construirea unei cariere profesionale, in perioada 2013-2015, pentru 550 de femei cu studii universitare sau postuniversitare care doresc sa profeseze in invatamantul superior si cercetare in Romania.

Obiectivele specific ale proiectului sunt:

1. Cresterea nivelului de competenta in accesarea pietei muncii in perioada 2013-2015, pentru dezvoltarea unei cariere pentru 550 de femei cu studii universitare sau postuniversitare care doresc sa profeseze in invatamantul superior si cercetare in Romania.

2. Cresterea gradului de informare asupra oportunitatilor de ocupare si dezvoltare a carierei profesionale in perioada 2013-2015 pentru 550 de femei cu studii universitare sau postuniversitare care doresc sa profeseze in invatamantul superior si cercetare in Romania.

3. Cresterea gradului de acces la programe de dezvoltare si suport in carierea in perioada 2013-2015 pentru 550 de femei cu studii universitare sau postuniversitare care doresc sa profeseze in invatamantul superior si cercetare in Romania.

4. Cresterea nivelului de constientizare pentru cel putin 60 de experti sau operatori mass-media sau personal al autoritatilor publice centrale si locale, asupra problematicii egalitatii de sanse pentru femei cu studii universitare sau postuniversitare care doresc sa profeseze in invatamantul superior si cercetare in Romania.

5. Dezvoltarea componentei de cercetare a problematicii egalitatii de sanse in dezvoltarea profesionala a femeilor cu studii universitare sau postuniversitare pentru consolidarea principiului accesului egal pentru toţi pe piaţa muncii in societatea romaneasca.

Obiectivul general al proiectului va genera un efect pozitiv pe termen lung la nivel national aducand o contributie semnificativa la recomandarile din Rezolutia Parlamentului European privind femeile si stiinta, prin reducerea ratei reduse, comparativ cu barbatii, a femeilor cu studii superioare, care au acces la dezvoltarea unei cariere universitare sau de cercetare,in urma crearii si aplicarii unui model inovator si eficient de program integrat de suport in cariera, model perfectionat in urma participarii partenerilor in alte proiecte anterioare POSDRU in cadrul DMI 1.5, unde au fost observate problemele cu care se confrunta femeile doctorande sau participante la programe postdoctorale, sub aspectul evolutiei lor profesionale. Proiectul propus propune un program ce vizeaza atat diversificarea pregatirii profesionale a femeilor cu studii superioare ce vizeaza dezvoltarea unei cariere in cercetare sau invatamantul superior conform cerintelor pietei muncii,cat si formarea de competente antrepenoriale,concomitent cu asistarea lor pentru dezvoltare personala,evaluare aptitudinala si consiliere ocupationala pentru o decizie responsabila de a accepta un loc de munca si a pastra acest loc de munca pe o perioada indelungata sau de a demara o afacere viabila.

EUROPEAN SOCIAL FUND - Post-doctoral scholarship program "Cristofor I. Simionescu" Call name:
POSDRU I/89 /1.5/S/55216 2010 - 2013

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://postdoc.icmpp.ro/intranet.html

Abstract:

Study of some tunable molecular switches hydrosoluble and conducting polymer – based Call name:
CNCSIS A 1149/2006 2006 - 2008

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Affiliation: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Project website:

Abstract:

Polyamide nanocomposites with electro and thermoconductive properties, obtained in situ via anionic polymerization of lactams in the presence of conductive nanoparticles Call name:
CNCSIS 307 2006 - 2008

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" ()

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" ()

Project website:

Abstract:

Complex space charge structures in plasma. Physical models. Applications Call name:
CEEX ET 69 -

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners:

Affiliation:

Project website:

Abstract:

The aim of this project is the intensive experimental study of the complex space charge structures in plasma (sheaths, double layers, multiple double layers, solitons, plasma vortexes, etc.), the elaboration of physical models for the appearance and dynamics of these structures and the identification and elaboration of applications. These structures appears in almost all plasma devices, from simple ones, like plasma diodes, to complex ones, like tokamaks, as well as in some natural phenomena, like aurora or ball lightning. Their appearance in plasma is often related with strong nonlinear effects, like the appearance of bistability, hysteresis, negative differential resistance or flicker noise. Their nonlinear dynamics was linked with the onset of some low-frequency instabilities in plasma. Such structures were proposed as candidate for many applications, like nano-engines, medium sensors, ultra-fast switches, high-frequency generators, etc. Our research will be focused on the identification of the physical processes at the origin of the generation and dynamics of complex space charge structures in plasma. For this, we will use a large area of diagnosis methods, starting with simple ones (use of Langmuir probes) and ending with complex ones (laser induced fluorescence and Thomson scattering diagnostics). The obtained experimental data will be analyzed with the modern methods of time series analysis provided by the nonlinear dynamics. In parallel, we will develop computer simulations of the phenomena. The identification of the involved physical processes, will permit us to develop physical models for this structures, that will be experimentally and numerically checked. Having now a whole image of these phenomena, we can start to identify the potential applications of these structures. We will focus on the applications in nano-technologies (nano-engines) and medium protection (very sensitive sensors) and on finding new fields of applications for these structures.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects