BrainMap

Mrs. Madalina Georgiana Albu Kaya

First degree researcher

First degee researcher - INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI

Researcher | Scientific reviewer

Dr. Madalina Georgiana ALBUKAYA has been working since February 2001 for INCDTP - Leather and Footwear Research Institute and leads the Collagen Department. She is a First Degree Researcher who obtained her diploma degree, master and PhD at the University of Bucharest, Faculty of Chemistry and two Postdoctoral studies, one in Biotechnology at University Politehnica of Bucharest and one in solid state NMR at Osaka University, Institute for Protein Research. Her research activity is in the field of collagen processing, characterization and application especially as biomaterials for medicine, dentistry, pharmacy and cosmetics.

Curriculum Vitae (13/01/2024)

Expertise & keywords

Design, modeling and validation of novel biohybrid for wound healing applications by tissue engineering Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2917 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)

Affiliation:

Project website: https://sorinadinescu.wixsite.com/622pedhealskin

Abstract:

Chronic wounds affect patients’ life quality, as they require repetitive treatments and incur considerable medical costs. Some are incredibly dangerous – e.g. diabetic ulcers, which precede 85% of amputations, while some can take decades to heal, thus contributing to secondary conditions such as depression. Thus, much effort has been focused on developing novel therapeutic approaches for these types of wounds. In this regard, an improved method of treatment would be the topical application of therapeutic agents with multiple properties (anti-inflammatory, antioxidant, antimicrobial, pro-angiogenic, pro-regenerative) that could facilitate the impaired healing process of such lesions. In this context, the aim of HEALSKIN project is to develop and validate at lab scale an innovative biohybrid with multiple therapeutic properties for chronic wound healing applications, based on natural components (collagen, sericin) and improved with two flavonoids (curcumin and quercetin). We plan to develop and evaluate the biocompatibility of HEALSKIN, cellular adhesion and cytoskeleton development, anti-inflammatory effect and pro-regenerative potential on normal skin cells (fibroblasts/keratinocytes), and investigate the efficiency of HEALSKIN in simulated oxidative stress conditions, as well as test its pro-angiogenic potential on endothelial cells and its antimicrobial effect on several bacterial strains. By the end of the project we expect to obtain a biocompatible material, capable of promoting cell viability, adhesion and proliferation, combat excess inflammation, oxidative stress and bacterial infection, favor regeneration and angiogenesis, in order to validate HEALSKIN as a potential candidate for skin regeneration. HEALSKIN could have an extraordinary impact on the improvement of therapeutic possibilities, contributing to faster recovery, better emotional outcome, and in general an increase in life quality level for the patients.

OPTIMIZATION OF THE MODERN TECHNOLOGY FOR PROCESSING BREWING SPENT YEAST AND OBTAINING OF DERIVED PRODUCTS Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0308 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA

Project partners: UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO); UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); PHARMACORP INNOVATION S.R.L. (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); AGSIRA SRL (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO)

Project website: http://www.usamv.ro/dgpcsa-cdi/optimizarea-tehnologiei-moderne-de-procesare-drojdiei-uzate-de-bere-si-de-obtinere-produselor-derivate-biodryyeast/

Abstract:

The consortium consists of five research organizations that aim to obtain new products through optimization and validation of technologies, as well as to provide recommendation for the modernization of the existing production lines. The main objective of the industrial producer AGSIRA is to provide at least one new product to existing customers.

The research organizations will tackle together with AGSIRA the following issues established based on the needs identified at the industrial producer:

-design of a new production line to produce brewing yeast as feed through a new biotechnological process;

-obtaining a new product, having superior quality in comparison with the existing product in terms of composition, by optimizing the mixture between the yeast produced by the new technology with current processed spent brewing yeast;

-obtaining active brewing yeast (by freeze-drying and atomization);

-obtaining of derived products based on brewing yeast.

DESIGN, EVALUATION AND MODELING OF DRUG RELEASE MECHANISM FOR NOVEL TOPICAL MULTIPARTICULATE DELIVERY SYSTEMS Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0813 2017 - 2018

Role in this project:

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO)

Project website: https://umfcd.ro/cercetare-si-dezvoltare/proiecte/proiecte-nationale/proectarea-evaluarea-si-modelarea-mecanismului-de-eliberare-a-medicamentului-pentru-noi-sisteme-multiparticulate-de-cedare-topica/

Abstract:

TOPMULTINOV project is a new and modern concept for the development of smart biomaterial supports usable in burned skin repair. Efficient regeneration of burned skin is still a clinical challenge, obtaining of an adequate drug release support being a top approach in the field of biomaterials. The general objective of this project consists of the design, evaluation and modeling of an anti-inflammatory drug release mechanism from topical multiparticulate systems that will ensure a controlled release for burns healing. As a novelty element of the project, ensuring a proper anti-inflammatory drug delivery from spongious collagen-based supports using different techniques that allow a gradual degradation of collagen support and a slow release of drug is mentioned. The vehicle formulation in the drug delivery sciences is a critical quality attribute which needs special attention for tailor made design to rationalize the system development. Thus, the project presents a new approach concerning the preparation of release supports like collagen-based spongious matrices with an anti-inflammatory drug incorporated in free form, in free and encapsulated form, and in encapsulated form respectively, to model and control its release rate. The results generated by the preparation, physico-chemical and morphological characterization as well as the in vitro studies of drug release and testing of the designed topical systems on animal model will be disseminated at conferences, in specialty articles, and by patent application. The pluridisciplinarity and complementarity of both teams provide high level of scientific/technical experiences to ensure a successful project achievement. TOPMULTINOV is perfectly integrated in the national and European strategies with respect to the impact on human health for improved health and life quality.

RECONSTRUCTION OF THE LIGAMENTS USING ADVANCED STRUCTURED MATERIALS BASED ON LIGASINT NATURAL AND SYNTHETIC POLYMERS Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0270 2014 - 2017

Role in this project:

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU MECATRONICA SI TEHNICA MASURARII (RO); MEDICAL ORTOVIT S.R.L. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)

Project website: http://www.ligasint.ro

Abstract:

The crossed anterior ligament is a central support structure of the knee (is part of the “main pivot”), intracapsular, extra synovial, with a back and lateral trajectory, that lays between the anterior distal insertion, at the level of the tibia spines and the proximal insertion on the lateral femoral condyle, posterior at the level of the intercondylar fossa.

As any other ligament, the anterior crossed ligament stabilizes the knee joint.

It is already known that the lesion of the crossed ligament is one of the most frequent knee pathology especially for professional sportsmen, but also for the active average age population. The consequence of the lesion of the crossed ligament is the appearance of an anterior-posterior laxity, and its result is an unstable knee, predisposed to the appearance of associated lesions and a much faster degradation to a degenerative disease. That is why in case of complete anterior crossed ligament lesions, the chose therapeutic attitude is the surgical intervention and the reconstruction of the ligament, re-establishing the stability of the knee. The reconstruction can be performed using a biological graft (allograft or auto graft), or an artificial implant (substitution or strengthening – augmentation). Each graft is characterised by advantages and disadvantages related to the manner in which is taken, resistance, fixing, reliability, complications and sequelae. The future perspective is represented by biological material: natural or synthetic collagen matrixes and fibres close to the histologic structure of the ligament. The objective of the research project is included in this perspective by researching the possibility to obtain an inert collagen implant that can be colonized by different types of cells (osteocytes in the bone, fibroblasts in the articulation), allowing to obtain a “neo – ligament” that is as close as possible to the structure and mechanic properties of the native ligament. Despite the effort of the various famous research centres, until presently we did not obtain replacements for tendons and ligaments with properties similar to the natural ones. Moreover, until now, no functional model was created that, once implanted, lead to the complete recovery. In terms of material there are two main graft categories: natural and synthetic, both with obvious advantages and disadvantages. A third category of grafts is being substantiated, and that is the category of mixed replacements, category expected to maintain the advantages of the two categories and limit their disadvantages to the maximum. Starting with the fact that the ligaments and dense conjunctive tissues composed especially of collagen fibres orderly compacted and with the shortcomings mentioned we propose to decrease or even eliminate these secondary reactions by including the aligned collagen fibres type I (characteristic for ligaments) in the fibrilary structure of these grafts, in an amount that shall be experimentally determined. The project wants to create ligament replacements that combine the beneficial properties of the two established classes and specifically the positive properties of the natural and synthetic ligaments. The objective is to create an heterogeneous experimental model.

Green Tannery – Methods for energetic recovery of biodegradable wastes Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1017 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); ACADEMIA DE STUDII ECONOMICE (RO); ACADEMIA DE POLITIE "ALEXANDRU IOAN CUZA" (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO); TARO COMIMPEX S.R.L. (RO); I.C.P.E. BISTRITA S.A. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)

Project website: http://spms.energ.pub.ro/TanGreen/index.html

Abstract:

The proposed research topic is considering the environmental aspects resulting from the leather and fur processing industry. Thus, the project focus is on the treatment and recovery of the resulting products from the processing of hides and pelts, such as: crude fats derived from skin to be extracted, modified, and recovered from its use as biofuel used in the training of an auto engine, either by digestion with sludge from wastewater treatment in a tank for the production of biogas, used as a heat source. The protein also results will be treated and recovered from its use as a fertilizer in agriculture.

Chemical processing of hides and fur is an important source of environmental pollution through wastewater due to the great diversity of chemical products used in fabrication (salts, acids, caustics, dyes, grease products, degreasing, etc.), but due to the removal of the skin, during processing of the organic compounds in an appreciable proportion (from gross skin lies only 60% in the final product). The amount of wastewater from tannery is great, if it is proposed that for getting a ton of finished leather is consumed an average of 70m3 of water. The concentration of production in high-yield tannery involves special problems of environment protection, given that virtually all of the technologies of processing of hides and pelts are sources of pollution. Waste waters have a complex chemical load, made up of proteins and fats from the skin, and the gross excess chemicals used in various phases of processing.

Through multidisciplinary implications of the project, the implementation of the project consortium consists of academic institutions and private companies from different domain activities. In concordance, the project coordinator is University Politehnica of Bucharest, the project implementation team includes teachers, doctoral students and young researchers from Power Engineer Faculty and Mechanical Faculty who will investigate the methods to exploit the useful components of the waste from tanneries in the energy field that make up the project research novelty, also a team with rich experience in the tanneries processes and technologies from the National R&D Institute for Leather will work to find new methods to separate grease and proteins from the crude hide, the economic and social impact of the project results will be analysed by a research team within The Bucharest University of Economic Studies, a research team from the Police Academy "A.I. Cuza", Fire Officers Faculty will identify the risk situations at explosion that may occur in biogas reactor.

The beneficiary of the project results is SC TARO COMIMPEX SRL BUCURESTI, a company with tradition in leather processing. The separation of fats and protein from the waste of skin will be performed using an installation made by SC BERIMEX SRL BUCURESTI. For pipeline networks, the biogas reactor and automation installations the SC ICPE Bistrita will be involve, a company with tradition in the design and implementation of treatment plants and wastewater treatment plants gained through work carried out under the programmes of the national R&D and applications deployed in more than 20 years of activities.

The general objective of the proposed project is the design and implementation of modern waste treatment facilities and the recovery of waste from leather and fur processing industry with the use of components useful novelty in the energetic field. Research results will be through the publications and patents, so it will make a significant contribution to increasing the visibility and impact of the Romanian research to international level.

Rational design and synthesis of smart bioactive scaffolds for personalized treatment of acute and chronic cutaneous wounds (ZETTAskin) Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0816 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); LMS PLASTIC SURGERY CLINIQUE SRL (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)

Project website: http://www.clinicazetta.ro/presa/cercetare-stiintifica/

Abstract:

ZETTAskin proposes a novel personalized wound healing treatment developed by Romanian plastic and aesthetic surgeons and healthcare providers with the support of biologists and materials scientists: full protocol for wound healing using skin constructs and personalized surgical acts for wound initial treatment, harvesting of autologous cellular material and its loading in personalized scaffolds, followed by application and follow-up of wound healing. The scaffolds and the preparative protocols for predefined personalized needs (e.g. shape, dimension) will be also delivered. The driving force behind the high performance of the novel skin grafts comes from the innovative strategy based on synergistic effects of (i) scaffolds with predefined chemical, physical and mechanical properties providing initial structural support to guide tissue formation and (ii) use of autologous cellular content to provide the best possible healing outcome. Additionally, these bioengineered products will be cost efficient, easy to produce, to sterilize, and to handle by the surgeon. In addition to the novelty of the approach, ZETTAskin has major claims to exclusivity in Romania since this research has not been yet developed by other Romanian scientists. The polymer scaffolds will be based on multicomponent systems including collagen, alginate and hyaluronan; the matrices will be processed as loose networks with progressive porosity, decreasing from bottom (larger pores) to top (denser layer) to mimic the natural architecture. The scaffolds design will cover aspects at macro-, micro- and molecular level, for optimum hosting of autologous cells and fat tissue. Control of the concerted effect of the synthesis and processing parameters on the overall functionality and architecture of the scaffold is recognized as a challenge with managed risks. ZETTAskin delivers 3D scaffolds as solid sheets with thickness-progressive porosity and functionality. The main advance of ZETTAskin products is the induction of optimum healing of wounds impossible to manage through existing or conventional therapies, due to the use of patients' own cells and fat tissue. Personalization of the bioengineered constructs simultaneously comes from: 1) predefined size, thickness and controlled properties of the scaffold to suit each clinical need and 2) loading with patient's own cells. Our strategy surpass existing products/therapies due to significantly lower cost, large availability, improved performances. Zettaskin offers hope for clinical situations nowadays without solution. The pluridisciplinarity and complementarity of the Consortium provide necessary scientific/technical experiences to ensure a successful achievement. This will lead to important progress in skingineering. This action will not duplicate efforts supported by other funding bodies and will complement existing projects. ZETTAskin will strengthen the collaboration between Romanian teams significantly contributing to a more structured and coherent intra-EU research arena with all derived benefits: competitive high-skilled multi- and inter-disciplinary scientists, transfer of knowledge, high-level science transferred into academic curricula. Our strategic objectives relate directly to this call, which aims the consolidation of R&D through the development of solutions for socio-economic relevant problems leading to innovative technologies/products, to increase the competitiveness of the Romanian economy. The proposal is perfectly integrated in the national and European strategies with respect to Biotechnology for improved health and life quality.

Technologies and smart products for prevention and treatment of mastitis in productive ruminants, based on green chemistry of the composites for veterinary public health (GREENVET) Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0415 2014 - 2017

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); ROMVAC COMPANY S.A. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)

Project website: http://www.icechim.ro/polimeri/proiecte/greenvet/

Abstract:

GREENVET project is a multidisciplinary answer for mastitis treatment in productive ruminants by integrating scientific research from outside discipline, inside the veterinary public health. The solution consists in innovative composites using green chemistry, supramolecular structures and intelligent materials using natural sources for one of the most expensive and health risky disease in livestock production. A final treatment will be developed as product, for internal market but with high export potential. The product consists in an integrated complex system with natural bioactive components (essential oils) as cure for sustaining or alternative to classical antibiotics, anti-inflammatories and cicatrizants with high impact on quality of life: problems of food supplies and quality, health and sustainable resources. GREENVET assumes a consortium (2 unique and large national research institutes, the largest technical university from Romania and the largest producer in Romania for veterinary products) with both experienced and young researchers. The management consist in the classical: planning, organizing and controlling in order to attain a minimum risk for project implementation (specific risk in multidisciplinary research), but is based on latest trend in the field -less graphs and more people- concept, by motivational approach and a proven background history of the collaboration between partners. GREENVET consortium experience in biomedical solutions is focused on the project working plan and provides outputs in terms of experimental models, prototype set, innovative technology, patent claim, dissemination in ISI journals and scientific events, documentation for product registration/or product notification. The budget breakdown and plan is well balanced to the resources to be committed in work complexity and less in time length of the task for people with different skills in multidisciplinary research.

Interdisciplinary research about using of collagen based products with elastic characteristics on rape crop for yield increasing, reducing of losses of harvest and sustainable of agriculture productio Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0589 2014 - 2017

Role in this project:

Coordinating institution: PROBSTDORFER SAATZUCHT ROMANIA SRL

Project partners: PROBSTDORFER SAATZUCHT ROMANIA SRL (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO); UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); DANUBE RESEARCH-CONSULTING SRL (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)

Project website: http://www.probstdorfer.ro/proiect_rapestick/

Abstract:

The project offers a technical solution for treating the rape crops in order to reduce the losses caused by the dehiscence of the silicva before harvesting.

The solution proposed have to use solution based on polymerisable collagen extracts, resulted from the processing of subproducts from aquaculture and from the fishing industry, which have: adhesive properties and elasticity characteristics, resistance to UV radiations, and a high contents of amino acids. At this moment these subproducts from aquaculture and fishing industry are thrown, being a polluting factor with organic matter of the residual industrial waters.

The novelty of the project consists in the use of polymerized substances for the protection of the rape silicva, which are based on the collagen extracts from fish, having beside the antidehiscence effect, also a foliar fertiliser and a fungicide effects. Compared with antidehiscence products used at this moment, which are synthesis products, and which have exclusively the adhesive function, the new proposed products by the triple effect characteristics, - adhesive, fertilizer and fungicide, will have an impact on increasing of crop production at quantitative and qualitative level, by increasing the vegetation period (prolonging the grain filling period), increasing the TKW (weight of 1000 kernels), and reducing the water evapotranspiration at the rape crop field level. The antidehiscent effect will be given by the elastic feature of the fish collagen, the fertilizer feature will be given by the amino acid content of collagen, and the fungicide feature will be given by the film-forming effect and by the semipermeable membrane of the product polymerized from fish collagen extract, resistant to the UV radiation. By reducing losses from rape grain, pollution (weeding) with rape plants in successive crops after rape crop is reduced, reducing the quantity use of herbicides on succeeding crops. Into project are involves five partners, two research institutes, one university and two SMEs that will exploit the results of the research each in its own economic development.

MINIMIZATION AND INTEGRATED MONITORING OF POLLUTANTS IN THE LEATHER INDUSTRY TOWARD SUSTAINABLE PRODUCTION Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1575 2012 - 2016

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I.

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO); INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO); PIELOREX S.A. (RO); MUSETTE EXIM S.R.L. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)

Project website: http://www.icpi.ro/ICPI/index.php?option=com_content&task=view&id=165&Itemid=26

Abstract:

Sustainable development means that the needs of the present generation should be met without compromising the ability of future generations to meet their own needs. It is an overarching objective of the EU set out in the Treaty, governing all the Union’s policies and activities.

Leather production recovers the hides/skins that result from the production of meat and transform them into a noble material that finds applications in a myriad of consumer goods. Leather industry is, however, an environmentally intensive activity that can carry adverse effects to water, air and soil if the plant does not apply pollution prevention techniques. The general objective of the project is the development and validation of the innovative minimization techniques and of an integrated, computer aided, monitoring system for pollutants to aid a sustainable production in the leather industry. It classifies the project within the 3. Environment/3.1 Means and mechanisms for decreasing environmental pollution research direction.

The complex consortium which includes 2 R&D institutes - one specialised in leather & footwear research, the 2nd acting in environmental protection - and 2 SMEs - a tannery and a footwear company - will collaborate to reach the 3 major S&T objectives: (i) identification of the significant environmental aspects for each activity by monitoring emitted pollutants; (ii) implementation of new ecological techniques for minimizing pollutants in the 2 SMEs; (iii) optimisation of pollutant control/analysis methods by designing and implementation of an innovative monitoring system. The new innovative complex (technological & monitoring) system resulted in the project will catalytically act for: improving the quality of the working environment, reducing/eliminating the pollutants, facilitating the implementation of the environmental management systems and ecolabelling in the Romanian leather sector, contributing directly to its competitiveness and sustainable development.

Interdisciplinary research on seed treatment with collagen hydrolysates for quality indicators increasing, pesticide reduction and sustainable development of agriculture production. Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1805 2012 - 2016

Role in this project:

Coordinating institution: PROBSTDORFER SAATZUCHT ROMANIA SRL

Project partners: PROBSTDORFER SAATZUCHT ROMANIA SRL (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU MASINI SI INSTALATII DESTINATE AGRICULTURII SI INDUSTRIEI ALIMENTARE - INMA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)

Project website: http://www.icpi.ro/ICPI/index.php?option=com_content&task=view&id=170&Itemid=26

Abstract:

The project theme falls within the actual trends to create new and complex materials having a higher ecological impact than the current products as well as added value, by using advanced processes for chemical processes and bio-refinement of renewable natural resources.

The main objective of the project „GERMOSTIM” is to develop new and advanced materials and technologies, having a bio-stimulating effect for plant growth and an insecto-fungicide effects onto seeds, by using the valuable organic nitrogen resource from the leather industry and from the leather by-products – which are currently treated as residues.

The originality of the project is given by the following: the techniques used for processing proteic by-products to obtain a bio-compatible component with insecto-fungicide and phyto-regulatory growth functions; use of an original mathematical model to optimise the proteic component separation process; elaboration of advanced and complex materials to be used for establishment of recipes of pesticide mixes – protein hydrolysate.

The use of collagen resources in the leather industry to create organic materials, the ingredient and bio-stimulators for seed crops will allow for an innovative valorisation of a natural resource and for an increase in the sustainability of certain traditional economic sectors for our country which are currently in full ascension, such as: agriculture, chemical industry and leather industry.

This project aims at creating a technology for cereal seeds treatment, which generates an increase of the quality indicators for treated seeds, guarantees an increased percentage of sprung plants, an early and effective protection of plantlets against pathogen and harmful agents through a disinfection of the seeds surface, by destroying the pathogen agents present on the grain, ensuring the protection of roots and hypocotyls against the attack of pests and pathogen agents, ensuring a rapid springing of the crops, with an optimum density, as a

Natural bioactive compounds for therapeutically textiles Call name: EUREKA 2012
PN-II-IN-EUK-2011-E-7214 2013 - 2015

Role in this project:

Coordinating institution: MAGNUM SX S.R.L.

Project partners: MAGNUM SX S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)

Project website: http://www.magsx.ro/docs/texbiocoll/prezentare.html

Abstract:

Technical textiles are defined as comprising all those textile based products which are used principally due to their performance or functional characteristics. Creation of new features and functionalities of textile products through developing of new materials and technologies is the main objective of the project. The products with added value resulting from the cooperation between the partners of this consortium will contribute to the increase of the competitiveness of textiles SME and consolidation of their market position based on the access of companies to R&D infrastructure from each country.

The specific objectives of the project consist of the followings:

- highlighting of current and future national and European / international potential of textile products to improve quality of life and the achievement of specific technologies,

- design, obtaining of cosmetic / medical formulations as bioactive microcapsules;

- obtaining of products with optimized and functionalized potential by using of some specific technologies for textile processing,

- design, development of different knitted products with high added value through functionalisation of textile materials with bio-active compounds based on collagen hydrolisates - experimental models,

- testing of the functionalized textiles in vitro and in vivo before their omologation;

- establishing, testing, validation and elaboration of technical documentation for prototypes and introducing them in manufacturing,

- presentation and demonstration of functionality and utility of the new products.

NEW CONCEPTS AND STRATEGIES FOR THE DEVELOPMENT OF KNOWLEDGE OF NEW BIOCOMPATIBLE STRUCTURES IN BIOENGINEERING Call name: Complex Exploratory Research Projects - PCCE-2008 call
PN-II-ID-PCCE-2008-0248 2010 - 2013

Role in this project:

Coordinating institution: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA

Project partners: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA NICOLAE SIMIONESCU-LABORATORUL DE CELULE STEM SI TERAPIE CELULARA (RO); UNIVERSITATEA POLITEHNICA BUCURESTI-FACULTATEA DE CHIMIE APLICATA SI STIINTA MATERIALELOR (RO); UNIVERSITATEA POLITEHNICA BUCURESTI-CENTRUL NATIONAL DE CONSULTANTA PENTRU PROTECTIA MEDIULUI (RO); INSTITUTUL DE CHIMIE FIZICA ILIE MURGULESCU (RO); UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, CENTRUL DE BIOMATERIALE, INSTITUTUL DE CERCETARI EXPERIMENTALE SI INTERDISCIPLINARE (RO); INSTITUTUL DE CERCETARE-DEZVOLTARE PENTRU CHIMIE SI PETROCHIMIE BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA BUCURESTI-FACULTATEA DE CHIMIE APLICATA SI STIINTA MATERIALELOR (RO)

Project website: http://www.pcce248.weebly.com

Abstract:

IN TISSUE ENGINEERING (TE) THE COMBINED KNOWLEDGE FROM BIOLOGY AND ENGINEERING

IS DIRECTED TOWARDS THE POSSIBILITY TO RESTORE LOST OR DAMAGED TISSUE. THE

GENERAL AIM OF THIS PROJECT IS TO CONSOLIDATE A CROSS-DISCIPLINARY TEAM OF

COLLABORATING INVESTIGATORS TO CARRY OUT SOME CELL-SUPPORT CONSTRUCTS (CSC)

WITH POSSIBLE APPLICATIONS IN REGENERATION/REPAIR OF SOFT AND HARD TISSUES AND IT

DOES NOT ASSUME PRE-CLINICAL AND CLINICAL TRIALS. THIS APPLICATION CONTAINS THREE

SPECIFIC OBJECTIVES: 1- OBTAINMENT OF NEW SUPPORT 3-D STRUCTURES DESIGNED TO

CULTIVATE OSTEOBLASTS AND HUMAN MESENCHYMAL STEM CELLS (HMSC) TO OBTAIN CSCS

WITH CHARACTERIZED ARCHITECTURE AND MECHANICAL PROPERTIES, USEFUL IN BONE TISSUE

ENGINEERING; 2 - DEVELOPMENT OF REGENERATION STRATEGIES OF ADIPOSE TISSUE BY

IMPLANTATION OF PREADIPOCYTES IN 3-D HYDROGEL SCAFFOLDS, THAT MIMIC

EXTRACELLULAR MATRIX, DESTINED TO THE RECONSTRUCTION OF SOFT TISSUE DEFECTS

(SEVERE TRAUMAS, DEEP BURNS OR TUMOR RESECTIONS) AND 3 - STUDY OF THE EFFECTS OF 3-

D CULTURE AND GROWTH FACTORS ON THE CHONDROGENIC DIFFERENTIATION OF HMSC CELLS

TO OBTAIN SOME INVESTIGATION MODELS OF THEIR POTENTIAL IN CARTILAGE TISSUE

REGENERATION. THE PROJECT PRESENTS VIABILITY, INNOVATION, COMPLEXITY AND

INTERDISCIPLINARY EXCHANGE BECAUSE: 1 - IT IS A CONSORTIUM WHICH CONSISTS FROM

PARTNERS WITH COMPLEMENTALLY COMPETENCES WHO ENGAGE TO ACT AS A UNITY IN THE

FOLLOWING FIELDS: CELLULAR AND MOLECULAR BIOLOGY, CHEMISTRY AND PHYSICS OF

MATERIALS, ENGINEERING SCIENCES – IN ORDER TO GET ALL OBJECTIVES; 2 - THE PARTNERS

ARE STAFFS WITH A GOOD, STRONG REPUTATION ON THEIR FIELD, AND THEY HAVE THE

NECESSARY MANAGERIAL EXPERIENCE AS WELL AS THE HUMAN RESOURCES AND PERFORMING

EQUIPMENTS AND 3 - THE PARTNERSHIP WAS PARTIALLY CONSOLIDATED DURING PREVIOUS

COLLABORATIONS AND WHICH SUSTAIN IT. ACCOMPLISHMENT OF THE OBJECTIVES OF THIS

PROJECT CONSTITUTES A SCIENTIFIC CHALLENGE FOR ANY SCIENTIFIC TEAM AROUND THE

WORLD.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator
List of research grants as partner team leader
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects