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Romania
Citizenship:
Ph.D. degree award:
1999
Mrs.
Lorelei Irina
Brasoveanu
Senior researcher, PhD
Senior Researcher
-
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU"
Researcher | Scientific reviewer | Other | PhD supervisor
Web of Science ResearcherID:
E-7146-2019
Personal public profile link.
Curriculum Vitae (06/10/2021)
Expertise & keywords
Tumor biomarkers
Multidrug resistance
Flow cytometry
Tumor immunology/immunotherapy
organometallic compounds
Apoptosis
Cell culture
Oxidative stress
Nanomedicine
Cell signalling
Angiogenesis
cell adhesion molecules
Carcinogenesis
Complement system
Bioactive compounds
Projects
Publications & Patents
Entrepreneurship
Reviewer section
Molecular markers as predictors of treatment outcome and global prognosis in the management of differentiated thyroid carcinoma.
Call name:
Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1337
2012
-
2016
Role in this project:
Coordinating institution:
INSTITUTUL NATIONAL DE ENDOCRINOLOGIE "C.I.PARHON" BUCURESTI
Project partners:
INSTITUTUL NATIONAL DE ENDOCRINOLOGIE "C.I.PARHON" BUCURESTI (RO); INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); AGILROM SCIENTIFIC SRL (RO)
Affiliation:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO)
Project website:
http://www.parhon.ro
Abstract:
Thyroid cancer, the most frequent endocrine malignancy, is a treatable disease if properly diagnosed. However, some cases develop aggressive disease by severe mutations or dedifferentiation, while others are diagnosed incidentally while being operated for a multinodular goiter, with microcarcinomas surrounded by non-neoplastic thyroid tissue. Risk factors, environment, family history and oncogenetic events favor or trigger this transformation. The present study will evaluate the prevalence of thyroid cancer in a prospective observational approach, involving the National Institute of Endocrinology as well as other three partners: Institute of Virology Stefan S. Nicolau, Institute of Cell Biology and Pathology Nicolae Simionescu and Agilrom Scientific SRL.
Major objective of the project: Improvement of the diagnostic and follow-up protocols for thyroid differentiated carcinoma with new markers for a better treatment outcome, prognosis and quality of life
The patients will be evaluated according to current guidelines of care. In an attempt to improve the diagnostic and treatment protocols after a detailed genomic/epigenetic approach of the cases the most significant markers will be selected. A total of 300 new cases of differentiated thyroid cancer, as well as multinodular goiter controls will be followed in a 3 years cohort, being evaluated by clinical, biochemical, pathology and advanced imaging (ultrasound and I131 gamma camera) technology, as well as routine and immunohistochemistry pathology. Genetic (genomic and tumor DNA), epigenetic and proteic markers will be evaluated on biological samples (blood and tumor tissue), and compared between the groups with different tumor pathology and expected/encountered evolution. A final practical target will be the design of a microarray chip for genetic diagnosis of thyroid cancer susceptibility. Another result will be the nucleus of thyroid cancer registry in Romania and the improvement of current diagnosis and treatment
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Design and development of transport and delivery systems for new ruthenium compunds with antitumor activity
Call name:
Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1454
2012
-
2016
Role in this project:
Coordinating institution:
UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA
Project partners:
UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); INSTITUTUL ONCOLOGIC PROF.DR.ALEXANDRU TRESTIOREANU BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO); PHARMA SERV INTERNATIONAL SRL (RO)
Affiliation:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO)
Project website:
http://cercetare-umf.ro/uploads_ro/592/Pagina_web_136_2012-actualizata_2016.pdf
Abstract:
The proposed cooperative study is a complex interdisciplinary approach aimed at developing pharmaceutical product models with significant antitumor action and minimal side effects. During the project, three pharmaceutical systems that include some ruthenium complexes will be studied regarding solubility, capacity to transport and deliver the active substance at the final site of action, the antitumor activity and the side effects. The final scope of the project is to select the system (or systems) who best meet the requirements regarding bioavailability and pharmaco-toxicological properties for a possible inclusion in the clinical trials of the studied ruthenium complexes.
The proposed project has least three main goals. First, we want to develop pharmaceutical systems for improve the solubility of some ruthenium compounds in order to achieve a better pharmacokinetic profile for these compounds. Second, we intend to evaluate the antitumor activity of the developed systems using various cell lines from solid tumors and in vivo, comparing to cisplatin as reference substance. Third, we intend to evaluate the general toxicity of the developed systems, comparing to cisplatin. Additionally, we want to explore the possibility of development of these products as oral drugs and to establish what kind of cancer can be treated with these agents.
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Identification and characterization of a subpopulation of cells with tumor stem cell properties in hepatoma and esophageal cancers correlate with the mechanisms of resistance to treatment
Call name:
PNCDI II Grant 420144/2008
2008
-
2011
Role in this project:
Partner team leader
Coordinating institution:
INSTITUTUL ONCOLOGIC PROF.DR.ALEXANDRU TRESTIOREANU BUCURESTI
Project partners:
INSTITUTUL ONCOLOGIC PROF.DR.ALEXANDRU TRESTIOREANU BUCURESTI (); INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" ()
Affiliation:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" ()
Project website:
Abstract:
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“Immunogenomical study of expression and functional role of some cell adhesion molecules (CAM) associated to colorectal cancer”
Call name:
PNCDI II Grant 420173 /2008
2008
-
2011
Role in this project:
Project coordinator
Coordinating institution:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU"
Project partners:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" ()
Affiliation:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" ()
Project website:
Abstract:
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Modulation of expression of several biological markers of tumor progression and correlation with resistance to chemotherapy in breast and ovarian cancers
Call name:
P-CD 123/2006 CEEX Program (Biomedical)
2006
-
2008
Role in this project:
Project coordinator
Coordinating institution:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU"
Project partners:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" ()
Affiliation:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" ()
Project website:
Abstract:
Read more
Radiolabelled biomolecules for targeted therapy of cancer and angiogenesis inhibition
Call name:
P-CD 26/2005 CEEX Program (Biomedical)
2005
-
2008
Role in this project:
Partner team leader
Coordinating institution:
INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH
Project partners:
INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (); INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (); INSTITUTUL ONCOLOGIC PROF.DR.ALEXANDRU TRESTIOREANU BUCURESTI ()
Affiliation:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" ()
Project website:
Abstract:
Read more
Studies in cellular and molecular level of biological activity of curcumin in order to evaluate potential therapeutic
Call name:
P-CD 77/2006 CEEX Program (Biomedical)
2006
-
2008
Role in this project:
Partner team leader
Coordinating institution:
UNIVERSITATEA BUCURESTI
Project partners:
UNIVERSITATEA BUCURESTI (); INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (); INSTITUTUL ONCOLOGIC PROF.DR.ALEXANDRU TRESTIOREANU BUCURESTI ()
Affiliation:
INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" ()
Project website:
Abstract:
Read more
FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
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