BrainMap

Mrs. Irina Fierascu (Dumitriu)

PhD, Habil.

Senior researcher (Ist degree), Emerging Nanotechnologies Group Leader - Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Other affiliations

PhD coordinator - UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (Romania)

Researcher | PhD supervisor

Curriculum Vitae (16/09/2024)

Expertise & keywords

Through nanotechnology towards the next generation dental restorative materials Call name: P 4 - Proiecte de cercetare exploratorie - PCE-2021
PN-III-P4-PCE-2021-0292 2022 - 2024

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation:

Project website: https://icechim.ro/project/nanodent_en/

Abstract:

The acidic attack from cariogenic bacteria found in dental plaque biofilm growth over the tooth is responsible for dental caries, also known as tooth decay, which is a biofilm-dependent infectious disease that damages teeth by minerals loss and presents a high incidence of clinical restorative polymeric fillings. The complexity of oral biofilms contributes to the difficulty in developing effective novel dental materials. Oral cavity represents an ideal environment for the microbial cell growth, persistence, and dental plaque establishment. When the complexity and volume of biofilms from the gingival crevice increase, chronic pathological conditions such as gingivitis and periodontitis can occur, predisposing to a wide range of complications. In this context, nanotechnology has potential to be explored in the development of bioactive dental materials to reduce or modulate the activities of caries-related bacteria. The project NanoDent proposes an original recipe based on nanometric phosphatic compounds enriched with phytosynthesized metallic nanoparticles and natural bioactive compounds, with simultaneous antibacterial and enhanced mechanical properties as a potential dental restorative material. The validation of the proposed technologies to obtain novel materials will be obtained via third-parties studies, performed through subcontracting.

Formulations of protective cosmetic products obtained by applying integrated and sustainable bioeconomy approaches Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-0273 2022 - 2024

Role in this project: Project coordinator

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO)

Affiliation:

Project website: https://icechim.ro/project/bioprotect_ro/

Abstract:

Fruit processing industries contribute more than 0.5 billion tons of

waste worldwide, and grape crops and its industrial products are one of

the main agro-economic activities in the world, with more than 60

million tons produced globally every year. The grape industry,

specifically the wine industry, is generating by-products rich in

nutrients, which are underutilized and often end up being polluters of

the environment. After grape juice extraction, the remaining materials

are currently not valued as highly profitable waste, being mainly

discarded in open areas, potentially causing environmental problems.

Chronic exposure of human skin to solar UV radiation is widely

recognized as the key factor responsible for photo-ageing. For these

reasons, the role of photoprotection is critical to avoid skin cancer and

others undesired effects.

In this context, the general objective of the project “Formulations of

protective cosmetic products obtained by applying integrated and

sustainable bioeconomy approaches - BioProtect” is to propose the use

of nanomaterials both as active ingredient and delivery system of

bioactive compounds (mixtures of phenolic compounds-rutin and

quercitin) recovered from grape by-products for development of UV

blocking cosmetic products. Target molecules obtained through green

technologies from grapes by-products can be used as potential active

UV blockers in cosmetic formulations being delivered by substituted

hydroxyapatite (with Fe - FeHAP). The use of FeHAP has a double role:

active ingredient with UV protection properties and delivery system for

the bioactive molecules.

The project starts from TRL 2 and aims to the validation at laboratory

scale of the technology (TRL 4). Validation of the proposed technical

solution will be performed by third parties.

Innovative multifunctional composites for the protection of cultural heritage objects Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-0627 2022 - 2024

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation:

Project website: https://icechim.ro/project/inheritage_ro/

Abstract:

In the last decades, new perspectives have emerged among both specialists, and the general public, regarding the preservation and enhancement of the cultural heritage. Conservation-restoration contribute to the safeguarding and understanding of the cultural property that benefits present and future generations, in its historical and aesthetic sense, in its physical integrity, its context and its uses. In the last years, the specialists in the field of materials science proposed a series of innovative materials and methodologies, applied in different areas, including the diagnosis and conservation state monitoring or preventive measures, implemented in order to reduce the need for interventions. However, as the degradation processes of cultural heritage objects remain inevitable, the continuous development of advanced materials able to counteract specific degradation processes is also necessary. Thus, are needed thorough scientific studies in order to develop tailored formulation, in order to protect, preserve, and restore cultural heritage objects, and this represents a continuous challenge for the scientists, aiming to replace the current rather serendipitous approaches in restoration. In this context, the project “Innovative multifunctional composites for the protection of cultural heritage objects” (INHERITAGE) aims to develop novel multi-layer composite materials with multiple functions (consolidation, self-cleaning and anti-microbial) applicable for the conservation of different inorganic substrates.

Antimicrobial PU foam nanocomposites designed for biomedical applications, synthesized by radiation-assisted technology Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-0423 2022 - 2024

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU INGINERIE ELECTRICA ICPE - CA BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU INGINERIE ELECTRICA ICPE - CA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation:

Project website: http://www.icpe-ca.ro/puma/; https://icechim.ro/project/puma_ro/

Abstract:

New technologies, based on nanoparticles are continuously introduced and developed in a large area of application fields, among them, biomedical and pharmaceutic products. The scope of the present project is to prepare some nanocomposite materials with intrinsic antimicrobial properties and to characterize their functionality. The new materials intended to be synthesized in this project are innovative metal nanoparticles (Silver and Copper-Gold nanoparticles) uniformly dispersed in polyurethane (PU) foam. The technology used for nanoparticle synthesis, recently developed at INCDIE ICPE-CA, based on radiation-induced chemical transformations, is environmentally friendly, because no chemical reagents (besides the nanoparticle precursors) are required and no chemical wastes emerge from the process. Another aim of the project is to exploit/ valorize the results recently obtained within earlier research projects by developing new functional models of materials with high antimicrobial activity and wide efficiency spectrum. This type of materials can be used in a wide area of applications, in particular in hospital environments (as for example structural elements of hospital mattresses and toppers, pillows, floor mats, cover materials for different surfaces or as components of various medical items, such as catheters, hydrogel support for bandages (dressings) a.s.o.). Given the current pandemic context caused by SARS CoV-2 and high percentage of nosocomial infections in hospitals, the project results will help to reduce the effects caused by such health crises, improving the health of patients and medical staff. On the other hand, given the multitude of practical applications of these polyurethane foams, the project results may open up new opportunities for the development of value-added antimicrobial PU based products (paints, footwear, dressings, etc.).

Due to its specificity, the project falls within the domain of public priority "Health".

Integrated Technology for the Advanced Removal of the Heavy Metals and of Arsenic from Complex Pollutants Matrices by Using Adsorbing Nanomaterials Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2021-0309 2022 - 2024

Role in this project: Key expert

Coordinating institution: I.C.P.E. BISTRITA S.A.

Project partners: I.C.P.E. BISTRITA S.A. (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA BUCURESTI (RO); AQUATIM S.A. (RO)

Affiliation:

Project website: https://icpebn.ro/uploads/cms/2022_OXYADS/Oxyads_RST_Etapa3.pdf

Abstract:

The project goal is to transfer (towards ICPE Bistrita S.A.) and develop an innovative technology for depolluting the waters coming from drinking sources containing heavy metals and As into a complex pollutants matrix. The technology will be developed at the TRL 6 technological level, and implemented as a pilot plant at the headquarters of an important regional operator in the field of water treatment and supply (Aquatim S.A.). Considering a complex water pollution both by metals (Fe, Mn) and nitrogen compounds (e.g.the ammonium ion NH4+) and in the presence of a natural organic matrix, the elimination of such pollutants simultaneously with the removal of arsenium is a task nearly impossible to carry out via the actual technologies under reasonable operational and energetic efficiency circumstances. It is proposed an innovative integrated technology using synergic stages of advanced oxidation (catalytic ozonation) with on-site produced oxidising agents, integrated with a filtering / biofiltering stage (for the removal of ammonium and the retention of the oxidising products) and of an adsorption step based of adsorbing nanomaterials for the targeted elimination of As. An additional element of novelty is represented by the utilisation of the nanomaterials based on modified apatite systems, with a nanowire-type morphology, as adsorbing material for the efficient inexpensive removal of the arsenic species. The technology on which the project is based depart from a technology developed and validated at the laboratory level by the ICECHIM team, ensued from a Research Project within the NUCLEU programme - Nanotechnologies with Applications for Monitoring and Protecting the Environment (PN.19.23.03.02), which is the subject of an invention patent request - CBI A00380/2019- (OSIM) 'An Adsorbing Agent with Magnetic Properties, Based on an Apatite Material, for Treating the Waters Impurified by Organic and Inorganic Compounds, and the Method for Obtaining the Same'.

High performance phytosynthesized nanostructures as biosensor platforms for detecting pathogenic microorganism from food matrixe Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-0042 2022 - 2024

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation:

Project website: http://nanobiopat.chimie.upb.ro

Abstract:

Present project proposal “High performance phytosynthesized

nanostructures as biosensor platforms for detecting pathogenic

microorganism from food matrixes” is based on a modern and “green ”

method of obtaining mono and bi metallic nanostructures (mono and

bimetallic gold, silver copper nanoparticles) with the help of natural

extracts from cruciferous vegetables, in order to obtain sensing

platforms with high selectivity and specificity able to detect microbial

pathogens from food matrixes. The absolute novelty of the proposed

solutions and the foreseen results allows us to hope that potential

stakeholders (identified during the project) will be eager to take over

and implement these technologies, leading to social and economic

benefits, together with an important contribution to the increase of life

quality. The formulated concept of the product (related to the obtaining

of mono and bimetallic phytosinthesized nanostructures) and the

technology (the development of the sensing platform for detecting

pathogenic microorganism from food matrixes) will be the basis of the

project development. In the project will take place the analytical and

experimental characterisation of the product and technology that will

be developed (referring to the obtaining of innovative nanostructures -

TRL 3), the project being finished with the validation of the proposed

technologies at laboratory scale, through analyses performed via

third-parties laboratories (TRL 4). After the project implementation

period and protection of the technologies through patents, the

consortium aims at large scale prototypes and demonstration of the

functionality of the proposed solutions in real-life systems (TRL 6).

TRANSDISCIPLINARY APPROACH FOR DEVELOPMENT OF TECHNOLOGICAL SOLUTIONS FOR TARGET COMPOUNDS RECOVERY FROM AGRO SIDE-STREAMS Call name: P 3 - SP 3.5 - Proiecte EUREKA Tradiţional (Network), EUREKA-Cluster, Eurostars
PN-III-P3-3.5-EUK-2019-0226 2020 - 2023

Role in this project: Key expert

Coordinating institution: HOFIGAL EXPORT IMPORT SA

Project partners: HOFIGAL EXPORT IMPORT SA (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO)

Affiliation:

Project website: https://hofigal.eu/content/26-proiect-tardis-hofigal

Abstract:

The project TARDIS is proposed in the context of closing chains in bioeconomy, in order to obtain extracts with increased target bioactive content, with potential pharmaceutical applications (Pharmacoidea) and/or nutraceutical products (HOFIGAL). Biowaste valorisation is an attractive approach in the framework of the EU Waste Management policies and the development of a circular economy. Wastes from biostreams and different bio-based sources are being under-utilized as potential resource of valuable compounds.

The general objective of the project is to underline, optimize and apply an integrate technology of sustainable and enhanced production of natural extracts with high content of biological active compounds from side streams of agricultural industries applicable for obtaining smart formulations for disorders of the 21st century, for which continuous research is carried out.

The main idea of the project is to process plants by-products rich in nutritional and bioactive compounds into formulations to be used in pharma industry with the following benefits: the use of obtained extracts and target compounds for the prevention / treatment of age-related neurodegenerative disorders such as Alzheimer's disease; minimizing the amount of plant waste by recovering the target compounds from the by-products; increasing the potential of the pharmaceutical and food market by designing new functional ingredients; increasing the quality of life.

The project will provide the necessary support for creating and developing a complementary research chain in bio-economy (industry, pharmacy, agriculture) that aims to achieve a high level of internationally recognized expertise. The project demonstrates an integrated cascading concept including pre-treatment, optimized extraction and separation technologies.

Evaluation of the exploatation potential Potential of Porous Materials in the tREatment of Microbiota-related dISeasEs - PREMISE Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-4018 2020 - 2022

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://www.micronanotech.ro/evaluarea-potentialului-de-exploatare-a-materialelor-poroase-in-tratarea-disbiozelor-microbiotei/

Abstract:

The scope of the current project proposal is to develop novel micro- and mesoporous materials (MMMs) using recent synthesis methods and to further functionalize these materials for developing better performances in order to be used as drug delivery systems (DDS), especially for microbiota-related diseases. These drug delivery systems are developed for oral administration and are expected to be protected within the stomach and maintain their activity until reach the desired site. Even if these drug delivery platforms are extensively exploited in the literature for several types of applications as DDS (hosting anticancer, anti-infectious or analgesic agents), the field of microbiota is only marginally treated. Nowadays, especially in the case of children, the awareness about the importance of the microbiota is well known, therefore after an antibiotic treatment, the prescription of probiotics is frequently needed. In the project’s boundaries, natural substances (polyphenols and vitamins) used as biological active agents will be loaded into the porous platforms, in order to assure a positive feedback to the microbiota due to the antioxidant, antimicrobial, anti-inflammatory and anticancer activities. In recent years, great emphasis has been placed on the development of micro and mesoporous materials loaded with biological active agents, but few research papers discuss the impact of functionalized MMMs on microbiota. In the current project, the main goal is to develop innovative MMMs with enhanced pore system able to host and deliver biological active agents (vitamins and polyphenols are expected to be used) for the treatment of the microbiota-related diseases. because most polyphenols have low solubility, two innovative delivery systems will be developed in order to assure triggering delivery / smart delivery.

Comprehensive Approach to support Precision Agriculture and environmental management through satellite technologies and classic methods of investigation Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3495 2020 - 2022

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO); UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://environment.inoe.ro/article/253/about-capa

Abstract:

The project ‘Comprehensive Approach to support Precision Agriculture and environmental management through satellite technologies and classic methods of investigation – CAPA’, addresses a major direction of the 21st century, namely, smart agriculture, bringing new insights into how the climate affects the phenological cycle of crops (through the occurrence of extreme events) and it also contributes to understanding the role of different air pollutants (such as greenhouse gases) in crop development. The project proposes the realization of synergies of the scientific activities integrating data on the complex eco-agro-system-culture relations, obtained by applying a conglomerate of methods and techniques (space technologies, the study of pollutants at the level of air, water, soil and plants), for a modern management of agricultural crops, in the context of intelligent agriculture. At the international level, smart agriculture is also based on the optimized management of the inputs according to the real needs of the crops, for their management and the reduction of the use of fertilizers, fungicides, pesticides and water resources. At the national level, the exploitation of satellite records in the field of agricultural management has not yet a significant spread, being used mainly in applications dedicated to environmental protection, forestry, territorial planning or in the military field. In this context, the project proposes the application and integration of spatial technologies together with in situ and ex situ analyses in the intelligent management of agriculture to monitor certain types of agricultural crops (from a pilot site), thus allowing the development of a successful model for better capitalization. of available resources.

Green technology for pharmaceuticals removal from water using eco-friendly oxidation catalysts Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3166 2020 - 2022

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); I.C.P.E. BISTRITA S.A. (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://www.avramescu-sorin-marius.eu/greencatox/#

Abstract:

Catalytic ozonation is a highly efficient process for removing most resistant organic pollutants from water and is a key process in wastewater treatment. Improving these technology in order to comply with green chemistry challenges is an important goal purification industry. Catalysts are the core of the process and, in the last decade, numerous studies and patents proposed a large range of materials for better ozone transformation into hydroxyl radicals and performing complete oxidation of the organic substrate. This project proposes a new and innovative class of ozonation catalysts with a morphology that assures an easy contact of ozone and pollutants with solid surface (thin-films) and green and cheaper technology for catalyst preparation using plant extracts instead of harmful chemical reagents (borohydride and organic solvents)

AI & EARTH OBSERVATION BASED SERVICES FOR CULTURAL HERITAGE MONITORING Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2019-0579 2020 - 2022

Role in this project: Key expert

Coordinating institution: GMV INNOVATING SOLUTIONS S.R.L.

Project partners: GMV INNOVATING SOLUTIONS S.R.L. (RO); UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://airfareproject.ro:49337/

Abstract:

Preservation of historic monuments and archaeological sites has a strategic importance for maintaining local cultural identity, encouraging a sustainable exploitation of cultural properties and creating new social opportunities. Cultural heritage objectives are often exposed to degradation due to natural and anthropogenic impacts. The AIRFARE project will implement, test and promote responsiveness solutions for effective resilience of cultural heritage against identified risks by exploiting the benefits of Earth Observation data wide availability and capabilities.

In this scope, specific EO data analysis tools will be used in order to construct a catalogue of services for cultural heritage monitoring, by integrating classical methodologies such as classification, change detection or multi-temporal interferometry with Artificial Intelligence/Machine Learning algorithms. These AI/ML processing algorithms are mature enough to be adapted to be implemented in the EO data processing pipelines in order to be used in the provision of services for cultural heritage monitoring.

A preliminary set of services that AIRFARE could deliver were identified in the proposal based on previous activities / pilot services performed by the university and the R&D institute partners: land-use maps, ground motion detection, archaeological sites, monitoring urban sprawl monitoring, illegal building near heritage sites, flood risk, local conditions, etc.

The AIRFARE project will extend this list, perform a trade-off analysis and further identify associated operational requirements for the services by involving relevant stakeholders such as ministries, institutes, administrators or owners of cultural heritage sites. Based on the outcomes, the algorithms will be selected, adapted and implemented. Lastly, the services will be implemented based on a GMV proprietary platform, tested and validated in an operational environment.

Water treatment from sources contaminated with nitrates and chlorinated organic compounds using integrated catalytic reduction / oxidation and biofiltration processes Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2019-0222 2020 - 2022

Role in this project: Key expert

Coordinating institution: I.C.P.E. BISTRITA S.A.

Project partners: I.C.P.E. BISTRITA S.A. (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); AKRO SRL (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://www.icpebn.ro/ro/pagini/75-proiect-pn-iii-p2-2-1-pte-2019-0222.html

Abstract:

The project goal is the transfer (to ICPE Bistrita S.A.) and the development of an innovative water treatment technology for drinking water from sources contaminated with nitrates and chlorinated organic compounds. The technology will be developed at the technological level TRL 6 and implemented in the industrial environment at pilot installation in a water treatment plant. Considering a complex pollution of water with both nitrates and chlorinated organic compounds in the presence of a natural organic water matrix, its treatment becomes particularly difficult with the existing industrial technologies, under under reasonable operational and energetic efficiency circumstances and without obtaining toxic by-products. The project proposes an innovative water treatment technology using integrated processes of catalytic reduction / oxidation (conversion of nitrates and organochlorinated compounds / ammonium oxidation) and biofiltration (biological conversion of ammonium) that act synergistically, without the use of chemical reagents, with oxidizing agents produced in site (ozone). For the catalytic stage, innovative catalysts, of bimetallic type, deposited on a styrene-divenylbenzene resin will be used. The technology underlying the project starts from a technology developed and validated at the laboratory scale (TRL4) by the partner groups: P1 - UB (PROTMED) and P2 - ICF "Ilie Murgulescu" resulting from a research project funded under the program PNII-PCCA no. 100/2012, (Integrated procedure for the elimination of nitrates and organochlorine pesticides from contaminated natural waters as a result of agricultural activities), being the subject of a patent application CBI A / 00872/2016.

Separation, fractionation and isolation of biologically active natural substances from corn oil and other side streams Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2020-0024 2020 - 2022

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation:

Project website: https://icechim.ro/project/premierea-participarii-la-orizont-2020/

Abstract:

The EXCornsEED project aims to exploit the convergence between science, chemistry, biology, engineering and biotechnology tools for the creation of new knowledge and innovative applications to develop and validate an integrated process of innovative and highly sustainable extraction, purification and concentration technologies to be applied to biorefineries side streams.

NEW DIAGNOSIS AND TREATMENT TECHNOLOGIES FOR THE CONSERVATION AND REVITALIZATION OF ARCHAEOLOGICAL COMPONENTS FROM NATIONAL CULTURAL HERITAGE Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0476 2018 - 2021

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA OVIDIUS (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIVERSITATEA "VALAHIA" TARGOVISTE (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://icechim.ro/project/tehnologii-noi-de-diagnoza-si-tratament-pentru-conservarea-si-revitalizarea-componentelor-arheologice-ale-patrimoniului-cultural-national-arheocons/

Abstract:

The cultural heritage, as a source of national historical and cultural authenticity, is subjected to deterioration, and for stopping it, some specific procedures are required: cleaning, replacement of old materials and application of new protective materials compatible with the original, and advanced monitoring with sustainability assessment. The consortium of the present project has a unique expertise in Romania, recognised in Europe, through the many published papers, essential projects in Romania (Basarabi Churches, Potlogi Palace, etc.), OSIM and EPO patents, technology transfer, nanomaterials in chemical and biological preservation for cultural heritage objects and objectives; the partner institutions complement each other on a regional basis in the working plan of the whole project.

The overall objective of the project is to develop new materials, new methods and technologies that obey the principles of authenticity, reversibility and value, with a strong impact on immobile cultural heritage objects (fresco, basreliefs and mosaic) and mobile (decorative artefacts from ceramics, glass, metal, bone, objects of art and archaeology). Specific objectives: Developing innovative technologies for protecting national cultural heritage, multidisciplinary cross-sectoral approach, encouraging young professionals as leaders in heritage preservation, exploitation of research results for new jobs, promoting heritage education, professional expertise among all factors involved in the patrimony protection system.

The project, with a high degree of innovation and originality, applies unique technologies in Romania based on new materials compatible with the original materials and develops new techniques practical applied to: Roman Mosaic and Hypogeum Tomb, Constanta, Adamclisi Museum (basreliefs), Constanta County, Corvin’s Castle (Fresca Loggia Mathia) and Archaeology Museum, Hunedoara.

Contingency of CBRN hazards and improvement of national security resources Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0395 2018 - 2021

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie (RO); Academia Tehnica Militara (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); Centrul de Cercetare Stiintifica pentru Fortele Navale Constanta (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=40&lang=ro si http://icechim-rezultate.ro/proiect.php?id=33&lang=en

Abstract:

SECURE-NET is a Complex Project designed to improve the institutional performance of the Consortium Research Partners (Institutions with Re-launch Capabilities in the Field of National Security). In this respect, the Complex Project proposes five research themes corresponding to the five Component Projects, which aim at: (i) contingency of chemical, biochemical, radiological and nuclear (CBRN) hazards by developing new decontamination products and by developing specific sensors for detecting chemical agents of combat, and (ii) improving national security by developing shock-absorbing composites, solid rocket fuel and multispectral camouflages. This Complex Project brings together institutions with tradition, having either similar specialisation or complementary specialisation, to strengthen scientific and technical competences in the field of National Security and Advanced Materials for military applications. The Project Consortium has a gender-balanced staff and promotes the involvement of a large number of teachers, researchers, doctoral students and post-doctoral students in all activities proposed by the Common Agenda. In addition, the project facilitates the transfer of scientific knowledge between participating institutions as well as the recruitment and training of new staff. The multitude of results generated by the implementation of SECURE-NET express the potential for significant influence upon (i) the scientific community through communication and dissemination of results (as a short- and medium-term impact), and (ii) the public and private environment by promoting new research services and new transferable products / technologies to the external environment of the Consortium, particularly to the national defence industry (as a long-term impact).

Closing the bioeconomy value chains by manufacturing market demanded innovative bioproducts Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0569 2018 - 2021

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA "DUNAREA DE JOS" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); UNIVERSITATEA AUREL VLAICU ARAD (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=51&lang=ro

Abstract:

Agriculture and food industry in Romania generates large amounts of co/by-products, which are not used and turn into wastes, with negative impacts. The approach of the project PRO-SPER is to develop integrated processes, flexible and interconnected, to transform a number of agro-food by-products in bio-products, with market demand. This approach facilitates the achievement of project goals, complex-coordination and linking of the research organizations that are members of the Consortium, INCDCP-ICMPP, UDJ, ICECHIM, INCDSB and UAV, for improving their institutional performance in the field of nano-and bio-technologies of their application into bioeconomy.

The overall objective of the project PRO-SPER is to increase the impact of research and development activities and innovation of the RDI institutions, by developing and harnessing innovative technological solutions for bio-nano-processing of several by-products from the bioeconomy value chains, for recovering and/or formation of value-added components and their use in order to obtain products with high added value.

Expected results through the implementation of the project (21 new jobs, 23 national patent applications and international patent applications 6 EPO/WIPO; 10 technologies/new products resulting from the project, at a level of technological maturity to enable taking over by the operators, 5 services research and technological research services 10 cheques, 10 experiments cheques services

80 internship of young researchers from and within partner institutions, 50 visits for developing new techniques for working jointly in the Consortium, 30 training internships for new employees, 28scientific papers, 1 joint program CDI, in line with the development plan of institutional partners) have a significant impact on the capacity-building of the partners in the Consortium.

Smart materials for medical applications Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0407 2018 - 2021

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://intelmatupb.wixsite.com/intelmat

Abstract:

INTELMAT project represents advanced research in the field of synthesis and application of smart materials for medical engineering in order to solve essential features of some acute/chronic diseases of large occurrence. 5 thematic directions are taking into consideration: 1. Developing of a controlled-release system of complex micro-colloidal architectures based on bacterial cellulose and hydrogels used for management of chronically wounds which aims to overcome the limitations of classical treatments; 2. Developing of new biomaterials specially designed with targeted action for treatment of inflammatory diseases of gastrointestinal segment; 3. Synthesis of new generation of composite membrane materials for artificial kidneys based on biocompatible polymers and derivative graphene; 4. Developing of some auto-assembly 3D platforms with controlled-released drugs based on polymeric nanoparticles and composite nanogels for the therapy of colon-rectal cancer; 5. Developing of innovative technologies for the synthesis of some 1D nano-architectures (nanowires) with controlled morphology, with applications in producing of non-enzimatic electrochemical biosensors.

Increasing the institutional bioeconomic research capacity for innovative exploitation of local plant resources to obtain horticultural products with high added value Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0332 2018 - 2021

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA PITESTI

Project partners: UNIVERSITATEA PITESTI (RO); INSTITUTUL DE CERCETARE-DEZVOLTARE PENTRU POMICULTURA MARACINENI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIOTEHNOLOGII IN HORTICULTURA STEFANESTI-ARGES (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); STATIUNEA DE CERCETARE-DEZVOLTARE PENTRU POMICULTURA CONSTANTA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE CRAIOVA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN SUDURA SI INCERCARI DE MATERIALE - ISIM TIMISOARA (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://www.upit.ro/ro/academia-reorganizata/facultatea-de-stiinte-educatie-fizica-si-informatica/departamente-la-nivelul-facultatii-de-stiinte-educatie-fizica-si-informatica/departamentul-stiinte-ale-naturii2/proiect-biohortinov

Abstract:

The complex project Increasing the institutional bioeconomic research capacity for innovative exploitation of local plant resources to obtain horticultural products with high added value comprises the following four projects:

Project 1."Complex electronic system with intelligent algorithms for data processing used for monitoring the developing conditions of water and biocenotic stresses, for warning about their presence and preventing them in horticulture"

Project 2."Multisensory quantification of water and biocenotic stress in horticulture through phytomonitoring and early warning in climate change conditions"

Project 3."Development of plant extracts and innovative phytosynthesized nanostructured mixtures with phytotherapeutical applications aimed at eliminating the biocenotic stress in horticultural crops"

Project 4."Innovative technologies for advanced processing of plant resources from pomiculture and viticulture"

The objectives of the project aim to develop the research capacity of the public organizations involved. Thus, upon the completion of the projects these organizations should meet the following outcome indicators: 1) employing new staff in research positions; 2)training the new and old employees through initial research training courses and specialist courses offered by each of the partners in their own field of competence (using the logistics of the learning resource centers); 3)obtaining new or significantly improved products/technologies/services; 4)structuring the offer for research and technological services and presenting it on the platform www.erris.gov.ro; 5)strengthening the capacity of the partner institutions through recovery strategies such as training programmes (research)/specialization programmes and visits (short-term); 6)offering and performing research services using the available research infrastructure; 7)creating a common programme for the learning resource centers, correlated with the institutional development plan of each partner

Multidisciplinary complex project for the monitoring, conservation, protection and promotion of the Romanian cultural heritage Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0413 2018 - 2021

Role in this project: Partner team leader

Coordinating institution: AGENTIA SPATIALA ROMANA

Project partners: AGENTIA SPATIALA ROMANA (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); MUZEUL NATIONAL AL UNIRII ALBA IULIA (RO); MUZEUL CIVILIZATIEI DACICE SI ROMANE (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://ro-cher.rosa.ro

Abstract:

The Cultural Heritage (CH) can represent one of the decisive factors for the standard of living and for the quality of life specific of different communities, can contribute to the prevention of cultural globalization, can support the cultural diversity and can positively influence the economic development. The protection of the CH represents a major concern for decision-makers, local communities and European citizens. At the European Union level, the year 2018 has been declared The European Year of Cultural Heritage. In the same time, Romania faces a very important historical celebration: The Centenary of the Great Union from 1918. The RO-CHER project proposes a multi-disciplinary innovative methodology that integrates high level scientific knowledge for safeguarding the cultural heritage and that targets the development of synergetic scientific activities in the framework of the 4 complementary component projects by: monitoring the CH objectives with the aid of space technologies; development of materials and innovative techniques based on soft nanomaterials for safeguarding the cultural heritage; recommendation of an integrated management system (conservation, restauration, protection) for mobile and immobile CH objectives; promoting CH by using state-of-the-art technologies of digital reconstruction. The specific results indicators, predicted since the pre-implementation phase, are: new jobs in research (7); patent requests (6); results validation and transfer to the economic environment; design and development of the services offer and the research infrastructure; mutual access of partners at equipments and technology; institutional capacity building by internships/training sessions and working visits; joint R&D&I programme, correlated with the development strategy of each partner, all of these leading to the creation of a knowledge cluster, being able to successfully access national and international funding.

Innovative technologies based on polymers for the obtaining of new advanced materials Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0428 2018 - 2021

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=41&lang=ro

Abstract:

The project is aimed at using the expertise that involved in consortium entities acquired in materials science. The consortium consists of three representative national institutes: INCD for Chemistry and Petrochemistry – ICECHIM Bucharest, INCD for Electrochemistry and Condensed Matter - INCEMC Timisoara and INCD of Chemical Pharmaceutical - ICCF Bucharest, and of two prestigious universities: University POLITEHNICA of Bucharest and the University of Bucharest and a remarkable institute of Romanian Academy: Institute of Macromolecular Chemistry – Petru Poni Iasi. Although having great tradition and noteworthy results, the first five institutions face a series of problems, from the lack of financial funds, equipment and the aging employees for ICCF and partly for INCEMC and ICECHIM, to the lack of highly qualified staff required for recent investments in equipment for all 5 institutions. In this respect, the project attempts relaunching the activity in the first 5 institutions of the consortium, by putting together the existing competencies, so as to develop new technologies in order to obtain new materials with high performance properties. Given that, 3 of the research teams are specialized in polymers (ICECHIM, Petru Poni and UPB) the developed technologies will use the polymers as intermediates or as a component in the finished product. To this end it is envisaged getting the titanium nitride for prosthetic coatings via inorganic-organic polymer nanocomposites, obtaining photocatalytic materials and antibacterial coatings by sol- gel reactions, obtaining of short-life or one-time use biomaterials from aliphatic polyesters and micro or nanocellulose and the development of new polyphase materials with medium or long life, based on biopolymers, through 3D printing. The project intends the full use of A1, A2, B and C checks in order to increase the institutional performance of partners.

Removal of hardly biodegradable organic compounds (Endocrine Disruptors) from water by using Advanced Oxidation Processes based on new innovative catalysts Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2016-0063 2016 - 2018

Role in this project: Key expert

Coordinating institution: I.C.P.E. BISTRITA S.A.

Project partners: I.C.P.E. BISTRITA S.A. (RO); UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.icpe-bn.ro/pagini/60-oxydep.html

Abstract:

Hardly biodegradable organic compounds, in particular endocrine disruptors, is an important component of pollution of the aquatic environment and water resources with a major impact on ecosystems and human health, which can not be addressed by conventional remediation technologies. These pollutants originate from chemical synthesis compounds resulting from the the various branches of the economy. An important source of these compounds consists of pharmaceutical, personal care products and pesticides. A laboratory validated technology for remediation of water containing hardly biodegradable organic compounds will be transferred to industrial partner, and as a result of the project, this technology will be validated in industrial environment. Also the functionality and the efficiency of this technology will be proved. The core of this technology is based on Advanced Oxidation Processes (AOP- in particular catalytic ozonation) using of innovative new catalysts previously developed by research organizations partners. The industrial research activities will result in the catalysts activity optimization and also in the development of a new advanced oxidation reactor. Based of this technology, a prototype of an new water remediation module will be developed with the industrial partner contribution. As a result of solid experience in the field of water treatment systems and production of specific equipment of the industrial partner, the prototype will be a fully automated operational one. The new developed technology, targeted to all organic pollutants, will be an environmentally friendly one and will display a high efficiency, a low energy consumption, with low operational costs. This technology is both addressed to wastewater treatment plants and to drinking water treatment plants.

Applied interdisciplinary implementation and toxicological evaluation of new pharmaceutical formulations of capsaicin. Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0443 2016 - 2018

Role in this project: Key expert

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); TIS FARMACEUTIC S.A. (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://carolinanegrei.wixsite.com/nanocaptox

Abstract:

The proposed project aims to develop a new technology and new products for the TIS FARMACEUTIC given the need to develop this technology in society and expand the range of products that use capsaicină.Vor be involved in the project team 12 high qualified persons UMF Carol Davila from 5 persons from ICECHIM. The project will involve young doctoral result of their participation will be materialized in the development of doctoral dissertations and theses postdoctoral research of high scientific level and experience gained through participation in competitive research at national and possibly in-ternational will lead their managerial skills development. Scheme embodiment comprises: 1.Sintezis, the characteristics, formulation of micro-size and nano-materials on the basis of capsaicin, 2.Obtaining a new pharmaceutical formulations which contain capsaicin new transportation system, and the active substance as such, 3. Testingboth in vitro capsaicin new transport system and the new pharmaceutical formulations with in vivo confocal microscopy 4.Studies of the vasodilatory capacity of the new formulation of capsaicin; studies on sensory nerve endings and Merkel cell concentration in patients with neuropathic diabet 5.Project Management 6.Scientific diseminatin and exploitation of results

Innovative ferrite/beta-cyclodextrin core-shell nanocomposites for removal of inorganic and organic pollutants from aqueous effluents Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0251 2017 - 2018

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.unibuc.ro/prof/avramescu_s_m/NanoFerDeX.php

Abstract:

Adsorption process is effective in removing certain organics but a large part of inorganic and organic pollutants cannot be removed using existing adsorbents Nanotechnology is an enabling technology that can help address key needs relating to energy, environment, health and agriculture all over the world.

This project proposes a new and innovative class of nanoadsorbents with core–shell morphology. These nanoadsorbents will be made from ferrite particles (core) and cyclodextrin moieties (shell) in order to benefit from outstanding properties of both materials: magnetic properties of ferrites nanoparticles and high adsorption capacity of cyclodextrin molecules. These nanoadsorbents will be used in treatment of wastewaters containing organic and inorganic pollutants. After thorough assessment of operational parameters at laboratory scale the prepared core-shell adsorbents will be tested at pilot scale in order to confirm, through their physical-structural and chemical properties the utility of these materials in water treatment processes.

Innovative apatitic materials with enhanced antimicrobial activity for building materials and cultural heritage conservation Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0198 2017 - 2018

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); CEPROCIM S.A. (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.icechim-rezultate.ro/proiect.php?id=27

Abstract:

The main goal of the project is the development of an innovative and versatile solution (consisting of hydroxyapatite derivatives), solution that could be applied either by incorporation into the building material (primary objective) or by surface spraying (secondary objective). From the project will emerge new solutions to an increasing problem, respectively the microbial loading of various buildings and stone. Either we are speaking of hospitals, where the antimicrobial property of the building itself will be a tremendous help in fighting hospital infections, or historical building belonging to our national or international heritage that needs consolidation and/or surface treatment or stone monuments that needs only surface treatment. The solutions developed in this project will represent not only an alignment to the international level of research, but also a very important technical solution, that will contribute to the project sustainability after the implementation period.

The project proposes the use of metal-substituted hydroxyapatite as antimicrobial component for building materials. This solution will be viable for multiple applications related to its use for new buildings with special requirements related to microbiological loading (such as hospital buildings) and for consolidation of cultural heritage constructions; also the use of substituted hydroxyapatites for protection of stone artefacts against environmental factors (acidic rain) and biodeterioration through spraying on their surface will also be evaluated. The validation of the proposed technologies will be obtained via third-parties studies.

The previous obtained results allows the consortium to define daring targets, while the experience of the researchers involved ensures their fulfilment; in the same time, the potential of the solutions offered at the end of the project will ensure the future development of the project idea towards higher technology readiness levels.

Innovative architectures of controlled drug released systems based on Hesperidin and Related Flavonoids for chronic leg ulcers wounds treatment Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1386 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" RA (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE DIABET, NUTRITIE SI BOLI METABOLICE''PROF.DR.N.PAULESCU''BUCURESTI (RO); CENTRUL MEDICAL CAROL SRL (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.ivb.ro/cercetare/PCCA%20ctr%20185_web%20data%202014.pdf

Abstract:

Chronic leg ulcers can have an arterial, venous, mixt or diabetes etiology. Is an invalidating disease that affects annually in SUA up to 2 million individuals and in Europe 1% form the population. Its incidence is rising with age, and over 2/3 from the patients have a history of ulcers more than 5 years. The co-morbidities are multiple, amputation and even death being frequent. The cost of the therapy can be in the developed countries up to 1-3% out of the total health care budget. The incidence of chronic leg ulcers is rising in Romania influenced by the arterial, venous or diabetes dysfunctions as well as by alcoholism, smoking and obesity.

The proposed project aims to obtain an innovative medical product as a dressing-patch embedding vasoactive and anti-oxidants compounds, (nano)hesperidin/flavonoids that have a controlled release. The innovative dressing is designed for topical application of chronic skin lesions developed in patients with leg ulcers. The final product formulated in this project matches the Priority Domain 6 Biotechnology (subdomain 6.1.1), thus improvement of healing process in post-surgery treatment chronic leg ulcer

The project is proposed by a consortium of 3 partners, “Victor Babeş” National Institute of Pathology, National Institute for Research in Chemistry - ICECHIM, „N. Paulescu” National Institute for Diabetes and Nutrition and a medical SME Medical Center Carol.

Among the flavonoids used in oral administration in chronic leg ulcer, hesperidin is a glucozid that is abundant in citrus fruits. Recently, formulating hesperidin in nanocristals, has provided its dermatological application, assessing its antioxidant effect. In vitro studies have shown its clear antioxidant properties, and using them as nutrients has shown its vaso-protective action.

The project proposes the following specific objectives:

• Obtaining and complex physical-chemical characterization of hesperidin/flavonoids compounds.

• In vitro testing of the obtained compounds in cellular systems for toxicological profile and regenerative capacity evaluation.

• In vivo testing of the formulated compounds in murine model for testing the efficacy of nanostructured hesperidin/flavonoids dressing-patches.

• Evaluation of the selected nanostructured hesperidin/flavonoids dressing-patches on adult human subjects diagnosed with chronic leg ulcers according to the national laws.

The project also intends to disseminate results in form of publications and scientific communications.

INNOVATIVE THERAPEUTIC PRODUCTS WITH PROPHILACTIC AND CURATIVE ACTION FOR ZOO-VETERINARY SECTOR Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0953 2014 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA

Project partners: UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); ASOCIATIA CENTRU DE CERCETARE STIINTIFICA IN DOMENIUL BIOCHIMIEI APLICATE SI BIOTEHNOLOGIEI (BIOTEHNOL) (RO); BIOING S.A. (RO); HOFIGAL EXPORT IMPORT SA (RO)

Affiliation: UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO)

Project website: http://sanovet.fifim.ro/

Abstract:

Title: „INNOVATIVE THERAPEUTIC PRODUCTS WITH PROPHILACTIC AND CURATIVE ACTION FOR ZOO-VETERINARY SECTOR”

Acronym: SANOVET

Program: PARTNERSHIPS

Subprogram: “ Applied Collaborative Research Projects”

Domain 5 - Agriculture, food safety and security

Research thematic: 5.1.4. Methods, techniques and technologies for growth and diversification of animal production and fisheries, veterinary protection insurance Animal health is a concern for all European citizens. This concern stems from the public health, food safety and food security aspects, which are related to animal health but also to economic costs that animal disease outbreaks can trigger. This project uses a very common and a high economical and ecologically impact disease model like inflammation, as a paradigm for a conceptual and practical approach aimed to capitalize inexpensive and available resources.

The project goal is to improve the level of veterinary protection by developing a semi - solid phytoproduct from indigenous flora with topical application.

Main objectives that will ensure the achievement of project aim are:

1. Obtaining crops to exploit the curative potential of Anthriscus sp.;

2. Obtaining the phytocomplex;

3. Evaluating extracts pharmacological viability;

4. Obtaining an innovative phytoproduct .

The results of this research project will be materialized through:

1. Development and characterization of a herbal extract enriched in active ingredients with a complex chemical structure, non-toxic, based on original recipe obtained from association of fractionated extract with volatile oil from Anethum sp properly processed,

2. Highlighting the biologic activity, which plays a role in sustaining and accelerating the healing process by in vivo testing of herbal extract,

3. Creating a new topic semisolid phytoproduct.

The project addresses to a major agricultural problem in an interdisciplinary aggregate approach in order to achieve high yields results with a low economical input and a great environmental safety.

TECHNIQUES AND INNOVATIVE MATERIALS FOR CONSERVATION/ RESTORATION OF STUCCO WORKS AND DECORATIVE MASONRY FROM HERITAGE BUILDINGS Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0831 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA "VALAHIA" TARGOVISTE

Project partners: UNIVERSITATEA "VALAHIA" TARGOVISTE (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); DANART IMPORT EXPORT SRL (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://fimmr.valahia.ro/STUCCO-MAT.html/

Abstract:

The stucco work façades of buildings, represent one of the most artistic expressions developed by the different cultures, are essential for the Cultural Heritage. During time, these have been exposed to outdoor adverse conditions being severe affected. That’s why, some conservation/restoration works are necessary, without reconstruction of the historical building, and without affecting the original aspect. The project will be focused on historical buildings study, architectural surfaces and stucco work decorations, and will aim: investigations of used materials, typical damage phenomena, identifying the degradation phenomena, evaluation of the conservative state and recommending the conservation and preservation possibilities by using some systems based on nanomaterials embedded into polymer matrixes (patch), for conservation/restoration market.

Firstly, an analysis of microclimatic and air quality data of the building’s surroundings will be performed to evaluate the environmental effects and the possible degradation causes. Then the stucco workes will be characterized in order to identify their composition and possible presence of organic additives, to determine their pore size distribution and to assess their conservation state. Will be analyzed and evaluated stucco work (gypsum/cement), with specific solutions for every one of them.

In this context, the general objective of our project aims at developing solutions for biological disinfection, cleaning, consolidation and conservative preservation with color revival of the stucco work monuments by nanomaterials-based methods, using innovative materials (nanomaterials embedded into polymers) and specific techniques (easier application in liquid state without any destructive intervention). Also, this project deals with the description of stucco with the historical inventory and classification (decorative plasterwork) and pigments used in some monuments from Romania.

To fulfil this aim, following specific objectives are formulated:

O1. Achievement of artistic, architectural, historical and cultural complex research studies on different stucco work’s Romanian buildings, and achievement a collection-catalog for stucco works in the period 1800-1945.

O2. Physical-chemical investigations and chemical composition of the samples prelevated from different buildings (with stucco works and their correlation with climate and environmental factors.

O3. Development of new solutions based on nanomaterials (hydroxyapatite, HAp) for biological disinfection of the investigated stucco works

O4. Development of new technical and scientific solutions for preventive conservation, providing long-term protection for indoor and outdoor stucco work decorations, as a nanocomposite system based on HAp, other minerals or clays nanoparticles embedded into carboxymethylcellulose (CMC) polymer, creating some patch-gels for cleaning stucco work decorations, by retention of organic contaminants and their consolidating.

O5. Complex studies of painting color revival by creating a new system based on HAp functionalized with fatty acids (FA) with or without pigments and stucco work techniques employed: from a simple palette of blue, red and black, to a more varied palette of red, blue, green, black and gold. There will be a portable kit containing: a HAp suspension for biological disinfection, a patch-gel based on CMC with inorganic nanostructures, for cleaning and restoration the microstructures of decorative stucco and new pasta based on HAp/FA with or without pigments, for the color revival of the stucco works restoration as close as possible to the original. The new materials will be tested on stone decorative dislocated fragments from Vacaresti church building (pieces without patrimony value) and similar pieces (without patrimony value, too) from other monuments.

An integrated approach for Reinforcement of historical chalk monuments by means of nano-materials-based treatment - a revolutionary concept Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1640 2012 - 2016

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA OVIDIUS (RO); INSTITUTUL DE CERCETARI PRODUSE AUXILIARE ORGANICE S.A. (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.icechim.ro/analize/proiecte/chalk-restore/

Abstract:

Modern civilization's inherited artworks have a powerful impact on society, from political, sociological, and anthropological points of view, so the conservation of our Cultural Heritage is fundamental for conveying to future generations our culture, traditions, and ways of behaving. In this context, the general objective of our project aims at developing solutions for preservation and restoration of patrimony chalk monuments both on site by nanotechnology and virtual by digitalization.

To fulfil this aim, following specific objectives are formulated:

1.Achievement of artistic, architectural, historical and cultural complex research studies on Basarabi chalk church. Physical-chemical investigations and correlations with climate and environment factors for this national patrimony monument.

2.Valuing the historical monument by scanning and digitization procedures, performing a valuable digitally archive; development of new technical and scientific solutions for restoration and preventive conservation based on nanomaterials providing long-term protection for indoor and outdoor chalk monuments.

3.Development of original non-destructive physical-chemical methods, based on colloidal science, nanomaterials and nanotechnology for chalk monuments restoration and preventive conservation.

4.Elaboration of technology based on nanomaterials adequate for restoration and preventive conservation of chalk church. Technological transfer of chalk church scanning and digitization archive, for a potential touristic virtual tour objective.

5.To create a start-up company, together with consortium partners, which can perform the technology transfer of the developed nanotechnology to other archaeological sites and monuments of architecture from Romania.

One can conclude that our project objectives and expected results could bring valuable contributions to National and European Cultural Heritage with the perspective of including the Basarabi chalk monument into UNESCO list.

DRUG DELIVERY HYBRIDS BASED ON POLYMERS AND POROUS CLAY HETEROSTRUCTURES Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1432 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO); METAV - CERCETARE DEZVOLTARE S.R.L. (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.tsocm.pub.ro/cercetare/DELPOCLAY

Abstract:

The research project is focused on the synthesis of new hybrid materials based on polymers and various organophylized porous clay heterostructures designed for controlled delivery of drugs which exhibit a low water solubility and high toxicity.

EXPLOITATION OF SPONTANEOUS FLORA RESOURCES BY NANOTECHNOLOGY FOR THE OBTAINING OF HIGH BIOACTIVE HYPERICIN CONCENTRATES Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-0548 2012 - 2016

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.icechim-pd.ro/en/pol_hitech/polimeri_hitech_spoflorahyp_en.html

Abstract:

The naphthodianthrones hypericin and pseudohypericin occur in the flowers and leaves of SJW. Hypericin act as an antibiotic and non-specific kinase inhibitor. Hypericin, is being clinically evaluated as an antiviral agent in the treatment of human immunodeficiency virus (HIV) infection. Hypericin was proven to be anti cholesterol and useful for blood circulation. In addition, hypericin is under research as an agent in photodynamic diagnosis (PDD) and therapy (PDT), of cancer.

The project target is to elaborate the production technologies for molecular imprinting of polymers with hypericin 1 enantiomer and for using these new materials in selective separations (MISPE), in order to obtain high bioactive concentrates of hypericin. This will allow the better exploitation of the resources of spontaneous flora and hereby to obtain by the “green chemistry” approaches dietary supplements able to prevent or to cure some diseases of the population. The main novelty of the project proposal is that it is intended to obtain molecularly imprinted polymer materials using as template the enantiomer 1 of hypericin, the materials being appropriate for preparative extraction of this enantiomer from primary SJW extracts. The second novelty of the project is the identification of technological parameters for MISPE separation of hypericin on the new materials. The third novelty of the project is the obtaining of high bioactive dietary supplements (concentrates) of hypericin. The many original idea involved in the project realization insures the deposition of at least 2 patent askings.

The hypericin concentrates that we intend to produce from St. John’s Wort are a world novelty. Such products are not yielded in Romania or abroad. Their enhanced bioactivity in preventing or curing some very dangerous diseases such as cancer, HIV, blood circulation disorders and depressions, will enable them to penetrate quickly on national and European markets.

SUPERABSORBENTS BIOPOLYMER MATERIALS FOR AGRICULTURE USES Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-0115 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.sabiom.ro

Abstract:

The aim of the SABIOM project is to obtain new superabsorbent materials which could be used in agriculture for water reserving and soil conditioning, starting from biopolymers and using especially green chemistry methods.The superabsorbent materials which will be prepared will also have the capacity of active agrochemicals delivery to the plants in order to protect them against different diseases or to enhance their growth. The novelty of this project is to use bacterial cellulose and other biopolymers in order to obtain superabsorbent hydrogels. This choice was determined by the fact that the majority of the superabsorbent polymers used as commercial products are synthetic polymers as crosslinked polyacrylates or polyacrylamide, and hydrolized cellulose polyacrylonitrile (PAN) or starch-PAN graft copolymers. This project is enrolled in the research efforts which are devoted to develop natural-based superabsorbent polymers starting from polysaccharides and polypeptides (proteins).

Eco-friendly food packaging from last generation multifunctional bioplastics Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1569 2012 - 2016

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); METAV - CERCETARE DEZVOLTARE S.R.L. (RO); INSTITUTUL DE CERCETARI PRODUSE AUXILIARE ORGANICE S.A. (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.bio-multi-pack.icechim.ro

Abstract:

The project proposes to carry out a technology for obtaining multifunctional materials based on last generation of biopolymers and bioadditives melt processable into catering food packaging. These packages will comply with the food safety conditions and will have physical – mechanical properties proper to the plastic products that are generally of commodity nature. The national and international novelty and added value of the project is determined by the originality of the propose new conceptual models for realising of new materials with improved thermal stability, small hygroscopicity, melt processable into catering food packaging. The elaboration of new solutions needs inter and transdisciplinary knowledge of chemistry, physics, physics and chemistry of polymers, mathematical statistics, process engineering, scale up and economics. The new technology has a great applicative potential and can be applied on the same industrial platform or on different platforms. All the novelty solutions will be disseminated and will be patented. At present on the Romanian market one can find only packaging made from imported oxobiodegradable pellets which has limited biodegradability. The realising according to the proposed new technology products which in nature will be totally destroyed in a very short time, would turn into the advantaje of beeing the only supplier, on the Romanian market for totally biodegradable products. The technology can be internationally applied by country with the same envoiroment problems as Ramania. The project consortium is formed from 4 partners: ICECHIM (CO), Politehnica University Bucharest (P1), SC Metav CD –SA (P2) and SC ICPAO SA (P3) with complementary expertise. The project manager is doctor and fulfill the eligibility conditions. P1 and P2 has project responsable that are doctors. Because of the great interest for the proposed subject P3 co–funded with 25 % from the entire project fund.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator
List of research grants as partner team leader
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects