BrainMap

Mrs. Ioana-Cristina Marinas

PhD

Researcher - DELTAROM SRL

Other affiliations

Scientific researcher - SANIMED INTERNATIONAL IMPEX S.R.L. (Romania)

Researcher - UNIVERSITATEA BUCURESTI (Romania)

Researcher | Scientific reviewer

Web of Science ResearcherID: not public

Curriculum Vitae (10/09/2021)

Expertise & keywords

Innovative multifunctional, bioactive topical formulation for the management of malignant wounds Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2193 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://bios.unibuc.ro/Proiecte/proiect-pn-iii-p2-2-1-ped-2021-2193.html

Abstract:

Malignant fungating wounds (MFW) are incurable, severe, and debilitating conditions normally occurring in the last (six) months of oncologic patient’ life, affecting the overall quality of life and requiring appropriate palliative care to alleviate pain and suffering. MFW’s microbiome may influence the development and severity of wound symptoms, causing foul odors, peri-wound skin damage, inflammation, and ultimately, delays in the healing proliferative phase. ARGOS project is implemented by a consortium of two research institutions and one company with previous experience in developing collagen-based pharmaco-cosmeceutic products and is aiming to develop an innovative multi-purpose, bioactive topical formulation to assist the physical management of malignant fungating wounds, by addressing the microbiome-related symptoms such as pain, odor, and exudate. The proposed solution is based on collagen and inorganic - gold, silver and magnetic – nanoparticles functionalized with plant-derived bioactive compounds (such as polyphenols contained in Chelidonium majus L. and Tamarix gallica extracts, with previously demonstrated antioxidant, antimicrobial, antiproliferative, antiviral and immunomodulatory activity). Therefore, the main novelty of the proposed solution is that it provides not only a wide antimicrobial effect, but also anti-cancer activity and pro-healing properties on the site of malignant wounds. The physico-chemical, mechanical and biological properties of the collagen-based optimized product will be validated by standard protocols and the technological scaling documentation and argumentation of the investments required for in vivo tests will be elaborated (TRL4).

Installation for the automated control of the reproducibility of collagen gel batches for biomedical and cosmeceutical applications Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2021-0429 2022 - 2024

Role in this project:

Coordinating institution: SANIMED INTERNATIONAL IMPEX S.R.L.

Project partners: SANIMED INTERNATIONAL IMPEX S.R.L. (RO); INOE 2000 - FILIALA INSTITUTUL DE CERCETARI PENTRU HIDRAULICA SI PNEUMATICA BUCURESTI RA (RO)

Affiliation:

Project website: https://www.sanimed.ro/proiect-remedial_37.html

Abstract:

The project aims to significantly improve the performance of the pilot plant for the production of highly purified fluid, semi-solid and solid collagen forms, which operates in the company S.C. Sanimed International Impex S.R.L., using elements of technological process quality engineering. In concrete terms, the improvement will aim at ensuring the reproducibility of the batches and the traceability of the processing of the material being processed, by developing an automated control system of the technological and operating parameters of the pilot plant. Reproducibility will be improved by replacing the manual control with the automated one, and the traceability of the operation will be implemented by sampling in real time and storing in integrum and ad tempus indefinitum the numerical data provided by the sensors which will be added to the installation, as well as their subsequent processing.

The overall objective of the REMEDIAL project is to (i) bring the pilot plant to the functional parameters required by the GMP (Good Manufacturing Practices) provisions in the field of production of biomaterials and medical devices of IIb and III classes, (ii) to prepare the plant for production certification, according to European regulations for the CE mark and (iii) increase the productivity of the installation, by eliminating unproductive times, repeated processing and fraction of tissue debris and residues resulting from incomplete processing of the raw material (horse or cattle tendons).

The project will ensure the transfer of know-how and constructive-applicative solutions from the National Institute of Hydraulics and Pneumatics Bucharest, to the Sanimed company. The object of the transfer is the concrete realization of the system for the control and automation of the operation of the pilot installation for obtaining the highly purified collagen forms, in operation in the productive spaces of the company.

SYNERGICSTIC ACTIVES SYSTEMS FOR REGENERATIVE COSMETICS Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2021-0303 2022 - 2024

Role in this project:

Coordinating institution: SANIMED INTERNATIONAL IMPEX S.R.L.

Project partners: SANIMED INTERNATIONAL IMPEX S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation:

Project website: https://www.sanimed.ro/proiect-grace_36.html

Abstract:

The GRACE project aims to obtain and characterize a range of integrative products, designed to regenerate the epidermis affected by superficial lesions, solar radiation, radiation therapy, or bedsores, using specifically functionalized hydrogels with complexes of inclusion of active ingredients in host molecules. These supramolecular complexes will represent the innovative component in the formulation of a new range of products with applications in the field of regenerative cosmetics. In concrete terms, the GRACE project aims to obtain a range of 3 products: single-dose hydrogel (for superficial lesions), cream gel (for skin affected by radiation) and cleansing gel (for gentle debris removal and cleaning of superficial lesions). In this sense, the project will stimulate the investment in research - technological development from the beneficiary company, as well as the consolidation of the company's potential actor on the domestic and international market, highly competitive, of dermato-cosmetic products. In the alternative, the project will develop the company's traditional partnerships with scientific research institutions, in order to connect Romanian applied research to the requirements of the national and European socio-economic environment.

Integrated use of the next generation plant biostimulants for an enhanced sustainability of field vegetable high residue farming systems Call name: EEA Grants - Proiecte Colaborative de Cercetare
RO-NO-2019-0540 2020 - 2024

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); Norwegian Institute for Water Research (NO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); Norgenotech AS (NO); ENPRO SOCTECH COM SRL (RO); AMIA INTERNATIONAL IMPORT EXPORT S.R.L. (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://icechim.ro/project/stim4plus-en/

Abstract:

The project addresses mainly the thematic area of Biotechnology, more exactly the key topic Biotechnology for agriculture, aquaculture, forestry and biomass production. The biotechnological solutions which STIM4+ project proposes to develop are intended to compensate the negative effects of the low-input, high-residue sustainable vegetable production systems. These proposed biotechnological solutions are related to the use of the next generation plant biostimulants. Plant biostimulants represent an emerging class of agricultural input, which protect plants against abiotic stress, enhance / benefits nutrients uptake and improve yield quality . The proposed plant biostimulants to be used for an enhanced sustainability of field vegetables grown in a high residue system are including into all classes / subclasses mentioned in the new EU Regulation 1009/2019. The multi-functional Trichoderma strains-based plant biostimulants (a microbial plant biostimulants) will be included into a glycodinameric, chitosan based bioactive (micro)hydrogel formulation. Decoration of microgels with anchor peptides will be used as a (micro)hydrogel tackifier on the plant residues. The bioactive hydrogel is based on an organic plant biostimulants (chitosan), which will be used to generate a biocompatible 3D porous structure, thermo- and pH-responsive and with a hydrophilic – hydrophobic segregation feature. This hydrophilic – hydrophobic segregation (micro)hydrogels will be used for embedding hydrophobic mimetic strigolactones. Propper application technologies of such smart formulated hydrophobic molecules will be developed, to exploit strigolactones both functions, as exo-signals for a better harnessing of beneficial microbiome and as cue for deleterious organisms (e.g. to induce suicidal germination of parasitic plants). The smart formulated bioproducts / agricultural inputs and the agricultural practices intended to exploit their specific features of such bioproducts are an example of biotechnologies for agriculture. The natural strigolactones mimics will be a part of the microbial standardized extract, which we intend to produce from microalgae culture and which is another example of organic plant biostimulant. This microbial standardized extract will include natural strigolactones, polyamines and betaines. Both strigolactones and polyamines are exo- and endo-signals. As exo-signals, both strigolactones and polyamines have been demonstrated to enhance mycorrhizae hyphal branching and root colonization. As endo-signals, both strigolactones and polyamines are involved in plant stress responses. Betaine also supports plant response to stress, especially to drought. Strigolactone mimics used for laboratory screening will be synthetized based on a rational bio-design. The inorganic plant biostimulants are represented by selenium, as zerovalent nano-selenium. A large body of evidence demonstrates that selenium acts as a plant biostimulant. Selenium protects plants against abiotic stress, especially drought, enhances / benefits nutrient uptake and improves edible yield quality. Nanoselenium (zerovalent) particles show a much lower environmental impact and an improved efficiency compared to other selenium species. Application of selenium nanoparticles reduces the risk of accumulation of polyamines in the edible yield. From a food safety point-of-view, accumulation of polyamines in vegetables grown into HV mulch could have some carcinogenic effects, because polyamines were found to support proliferation of various tumor cells.

The project is an interdisciplinary one and address also other key topics as Environmental impact and risk assessment of the modern, new and emerging technologies and products. Safety and environmental impact of the new developed products will be determined by a state-of-art 3R techniques, by Norway partners. The project contributes to the objectives and the priorities of the call. It supports research cooperation between Romania and Norway and consolidate a strategic partnership.

Impact of gamma radiation sterilization on wet collagen properties according to quality standards for Class IIB medical devices Call name:
POC-A1-A1.2.3-G-2015 2023 - 2023

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (); DELTAROM SRL ()

Affiliation: DELTAROM SRL ()

Project website:

Abstract:

Obtaining wet collagen forms according to quality and functionality standards for medical devices. Impact of gamma radiation sterilization on product characteristics

FOODSAFETY4EU - MULTI-STAKEHOLDER PLATFORM FOR FOOD SAFETY IN EUROPE Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2020-0014 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE - IBA BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE - IBA BUCURESTI (RO)

Affiliation:

Project website: https://bioresurse.ro/blogs/proiecte/tagged/proiecte-nationale

Abstract:

FOODSAFETY4EU is a European project that aims to design, develop and launch a European Food Safety System (ESF) platform for food chain actors in this system, by structuring a participatory process which will support a system of their reaction and adaptation.

The platform will allow FSS actors to efficiently access resources and data, to synchronize research on food safety, strategies, etc. to exchange scientific knowledge, good practices and beneficial contributions for the future EU ESF. This will increase interactive cooperation within the system as well as with civil society, in order to increase public confidence in the food system, through dedicated tools.

Given the size of the FOODSAFETY4EU consortium, 22 partners, participation in such a project favours the development of institutional relations with other research institutions, which will contribute to the possibility of creating new consortia to participate in other European and international competitions for future calls. The main objective pursued by this funding application is to increase the visibility and international involvement of IBA Bucharest by participating in scientific events in order to promote the research activity of the institute.

PRotein and biOmolecules sources for nutritional security and biodiVersity of bakery products in a cIrcular fooD system Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERANET-COREORGANIC&SUSFOOD-PROVIDE-1 2020 - 2023

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE - IBA BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE - IBA BUCURESTI (RO); Technical University of Munich (DE); National Agency for New Technologies, Energy and Sustainable Economic Development (IT); Norwegian University of Science and Technology (NO); Chouaib Doukkali University (MA)

Affiliation:

Project website: https://bioresurse.ro/blogs/media/surse-de-proteine-%C8%99i-biomolecule-pentru-securitatea-nutri%C8%9Bionala-%C8%99i-biodiversitatea-produselor-de-panifica%C8%9Bie-intr-un-sistem-alimentar-circular-provide

Abstract:

The project focuses on valorisation of food transformation industry by-products for use in bakery production. This will be based on “green” innovation processes, which will use also material from organic products and the resulting new products can be marketed “organic”. With the aim to promote circularity in the agrifood systems, 4 specific objectives have been identified: identify by-products rich in nutrients and bioactives, valorise wastes and by-products, promote circular Food Systems, define strategies to put the new products into the market. After having mapped sources of proteins and bioactive compounds from agrifood processes by-products, byproducts from different food production chains (e.g.: dairy, oilseeds, brewery, meat, prickly pear cactus) will be valorised treating them with innovative “clean technologies” in pilot facilities to extract bioactive compounds (e.g. oils, waxes, fatty acids, carotenoids, polyphenols, tocopherols) and obtain defatted protein cakes to be used for producing new bakery products. 3 case studies will be implemented. Quality & safety of sources, intermediate-, end- and by-products, as well as the health enhancing properties of plant and by products extracts, will be assessed. The new products will be tested for consumers’ perception and acceptance and the technologies implemented at industrial scale.

Environmental and socio-economic sustainability will be assessed, and integrated traceability systems and innovative processes for human health and well-being developed. PROVIDE is designed to achieve a multi-sector impact (public authorities, market system, consumers/society, healthcare, environment, sustainability&circular economy), thus reflecting its multidisciplinary (anal. chemistry, (micro)biology and biotechnol., environm., food technologies, etc.), multi-actor and Pan-European (Scandinavia – Norway; Central Europe - Germany; South-East Europe – Romania; Southern Europe - Italy) & Northern African (Morocco) approach.

Biogenic nano-system for targeted delivery of bioactive ingredients on dysbiosis biofilm involved in gingivitis and periodontitis Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-4527 2020 - 2022

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://icechim.ro/project/bionanogum-en/

Abstract:

BioNanoGum project proposal aims to develop an innovative biogenic nano-system for resolution of dysbiosis oral biofilms and inflammation involved in gingivitis and periodontitis, based on an innovative bacterial nanocellulose - fungal (nano)chitosan stimuli-responsive hydrogel, biogenic selenium nanoparticles (bioSeNPs), and hollow pollen shells filled with biogenic silica nanoparticles (bioSiOxNPs). Gingivitis and periodontitis affect more than 30% of globe population and can lead to teeth loss, but also other complications and severe diseases (Alzheimer, diabetes, autoimmune diseases). SeNPs, silicic acid released from SiOxNPs, and chitosan nano-structures determine (frank) resolution of dysbiosis biofilms and inflammation. However, there are also several drawbacks such as a very narrow physiological window (in the case of Se), or induced inflammation through a MAMPs similar mechanism, mediated by the Toll-like receptors (in the case of SiOxNPs). New formulations are needed in order to reduce risks of negative effects and to optimize the beneficial effects. BioNanoGum will use compounds acting complementary to SeNPs, which will lead to the reduction of Se dose. The pollen shells, obtained by Kombucha fermentation, will be used as encapsulation carriers for SiOxNPs, which allows bearing benefits from the anti-inflammatory, anti-bacterial and wound-healing effects of the silicic acid slowly released from bioSiOxNPs. The biogenic nano-system will deliver different components into a complementary manner and will act both on the resolution of pathogenic biofilms and on that of inflammation. BioNanoGum involves the niche between biotechnology and nanotechnology with health applications. This niche market has a significant growing potential, because it addresses several of the main health problems in the European Union and worldwide, from the beginning of the 21st century : an ageing population, with an increased incidence of non-communicable / chronic disease.

Innovative medical device for emergency and operational medicine Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3396 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Affiliation:

Project website: http://www.incdtp.ro/cellmatrix.html

Abstract:

Wound healing is a multiphase and multifactorial physiological process. The complexity of this phenomenon makes the healing process very difficult and painful due to several abnormalities. As a response to this problematic issue, as primary or secondary dressing, a complex composite matrix for hemostasis and connective tissue regeneration will be design, developed and validated. The demonstrative model will consist in three layers, namely semi-adherent or a non-adherent layer, absorptive layer and bacterial barrier layer. For the first layer, different textile structures based on conventional and non-conventional technology will be developed. The textile structures will be made from synthetic, artificial and/or bioresorbable polymers (PGA, PLA) and will be design so that to ensure a pore diameter of 50 µm, considering as being enough to permit the free passage of exudates into the secondary absorbent layer but too small to allow the ingress of granulation tissue. The perforated structure prevents the dressing from adhering to the surface of the wound while the holes allow the passage of exudates to the absorbent layer. The second layer will comprise an absorbent material for absorbing exudates, blood, moisture and other fluid materials from the inner layer and maintains the wound in moist environment. A collagen or collagen cellulosic matrix containing a super-absorbent, e.g., carboxymethyl cellulose/ sodium polyacrylate etc., by electrospinning technologies deposition will be used for absorbent layer in the composite dressing. The third or outer layer comprises a bacterium-impermeable and air-permeable cover film. The cover film also consists of a layer of pressure-sensitive adhesive in its peripheral. The bacterial barrier layer will comprise a flexible, waterproof and breathable material (e.g. polyurethane film of approximately 0.5–1.5 mm thickness, polypropylene or polyethylene such as a low-density, opaque polyethylene film).

New Amine based DES’s SOlvent development for CO2 capture in a demonstrative pilot Installation by Chemical Absorption Technology Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-4387 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.energ.pub.ro/proiecte_cercetare/asociat/index.html

Abstract:

The purpose of this project is to develop the post-combustion chemical absorption of carbon dioxide by testing new physico-chemical solvents hybrid amine-deep eutectic solvents (DES). In this project, at least three types of amine eutectic hybrid solvents, (ChCl-MEA), (ChCl-DEA) and (ChCl-MDEA) will be used. Through experimental and modeling-simulation studies, the validation of the CO2 capture post-combustion technology in the case of its integration in the circulating fluidized bed combustion (CFBC) technology using fossil fuels such as lignite will be conducted. At the same time, it is desired to identify CO2 sequestration solutions by developing algae culture that are characterized by an absorption capacity of 15-20 times higher than the usual plants. The overall objective of the project is to develop the technological maturity level (from TRL 3 to TRL 4) up to the laboratory scale of the CFBC plant provided with post-combustion CO2 capture through chemical absorption belonging to the „CO2 Capture Technologies” laboratory from the Power Engineering Faculty from University Polytechnic of Bucharest. Optimization and validation of CO2 chemical absorption technology will focus on: reducing the energy penalty; solvent flow minimization (L/G ratio); increasing the absorption capacity of the hybrid amine-DES solvent; diminish of solvent losses in the absorption-desorption columns; evaluation of economic indicators CAPEX, OPEX, the levelised cost of electricity as well as the cost avoided with CO2 emission. Together with the coordinator of the Polytechnic University of Bucharest, the consortium also includes the partner ICECHIM - the National Research and Development Institute for Chemistry and Petrochemistry recognized for its experience in the development of chemical, physical solvents and respectively the development of algae cultures for CO2 sequestration.

METROFOOD-RI Preparatory Phase Project Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2020-0011 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE - IBA BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE - IBA BUCURESTI (RO)

Affiliation:

Project website: https://bioresurse.ro/blogs/proiecte/metrofood-ri-faza-pregatitoare

Abstract:

METROFOOD-RI – Infrastructure for Promoting Metrology in Food and Nutrition - is a pan-European Research Infrastructure (RI) aimed to promote scientific excellence in the field of food quality and safety. It provides high-quality metrology services in food and nutrition, comprising an important cross-section of highly interdisciplinary and interconnected fields throughout the food value chain, including agrifood, sustainable development, food safety, quality, traceability and authenticity, environmental safety, and human health.

Given the size of the METROFOOD-PP consortium, participation in such a project favors the development of institutional relations with other European research institutions, which will

contributes to the possibility of creating new consortia to participate in other European and international competitions for future calls.

Cresterea competitivitatii prin inovare si imbunatatirea proceselor de fabricatie cu iradieri gamma tehnologice Call name: Parteneriat pentru transfer de cunostinte (Apel reconstituit pentru pastrarea pistei de Audit - Anul 2015)
107514 2016 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); SANIMED INTERNATIONAL IMPEX SRL (RO); DDS DIAGNOSTIC SRL (RO); DENTIX MILLENNIUM SRL (RO)

Affiliation: SANIMED INTERNATIONAL IMPEX SRL (RO)

Project website:

Abstract:

CREȘTEREA CAPACITĂȚII DE TRANSFER TEHNOLOGIC și DE CUNOȘTINȚE A INCDTIM CLUJ ÎN DOMENIUL BIOECONOMIEI Call name: Parteneriat pentru transfer de cunostinte (Apel reconstituit pentru pastrarea pistei de Audit - Anul 2015)
105533 2016 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE (RO); TEODENT SRL (RO); INSPRESSO SRL (RO); EVOLO CPV S.R.L. (RO); FARMEC SA (RO); I.C.P.E. BISTRITA SA (RO); TERACRYSTAL SRL (RO); PARAPHARM SRL (RO); ETERA PROD S.R.L. (RO); SANIMED INTERNATIONAL IMPEX SRL (RO); AGRO COSM FAN SRL (RO); S.C. ROSEAL S.A. (RO)

Affiliation: SANIMED INTERNATIONAL IMPEX SRL (RO)

Project website:

Abstract:

New textiles for parietal defects Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-ERANET MANUNET III-PariTex 2019 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Affiliation: SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Project website: http://www.paritex.ro

Abstract:

The role of medical devices is essential to the healthcare of citizens. The diversity and innovativeness of this sector contributes significantly to enhancing the safety, quality and efficacy of healthcare in the EU. The challenges related to R&D, emerging technologies and the green economy, as well as issues related to the EU’s trade and regulatory cooperation globally have became more intensive in recent years. SMEs in particular face challenges in this regard. The medical devices sector faces many challenges at national, European and international level, which may have an impact on their innovation capacity and overall competitiveness: Public Health Systems, Finding the balance between patient’s needs and financial sustainability, Competitiveness and innovation. The medical devices with high added value made from resorbable and nonresorbable biopolimers, processed by modern technology (knitting and electrospinning) with linear and spatial structure, functionalized with active agents will be obtained in PariTex project will be a contribution of R&D activity to give an answer for sustainable medical textile device sector. The PariTex project will develop new textiles materials for healing of the parietal abdominal defects, based fibers/ yarns made of nonabsorbable and resorbable polymers (biopolymers) obtained by classical and unconventional (electrospinning) technologies. Knitted and nonwoven fabrics characterized by mass, thickness, porosity,density, dimensions etc. are functionalized by incorporating or coating with substances that have the goal of: reducing adherence to human tissue, reducing the risk of infection, monitoring healing time by using controlled release systems based on natural polymers, reducing abdominal discomfort and associated pain. Will be assessed the level of biological performance, by the test of the mutagenic potential by using the micronucleus test on the hematogenic marrow of mice to determine the sensitizing potential, acute local tolerance, cytotoxicity and subacute toxicity.

The project will contribute to the initiation and consolidation of a value chain for the realization of functional textile structures based on partners' competencies, but also by attracting clusters of textiles and medicine for the application of the results.

Production of ferulic acid, 2,3 Butanediole and microbial plant biostimulants from lignocellulosic biomass by a two-step cascading process Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERANET-FACCE-SURPLUS-DEBUT 2018 - 2020

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); ENPRO SOCTECH COM SRL (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=46&lang=ro

Abstract:

The DEBUT project aims to develop a small biorefinery process, with two steps: 1) biomass pre-treatment with natural deep eutectic solvents (NaDES); and 2) one pot production of a versatile chemical, 2,3 butanediol (2,3-BD), from NaDES pre-treated lignocellulose biomass, by simultaneous saccarification and fermentation (SSF), performed by a plant biostimulant microbial consortia. The main biochemicals resulting from the biorefinery process are phenolic acids, specially ferulic acid, and 2,3-BD. Phenolic acids address mainly health and wellness-related industries, whereas 2,3-BD is a versatile chemical, with a fast-growing market. The proposed biorefinery process produces also agricultural inputs such as lignin, minerals and microbial plant biostimulants. A first project novelty is related to the use of a plant biostimulant microbial consortium for simultaneous saccarification and fermentation of lignocellulose. According to our knowledge such approach has not been done yet. On such process there are no by-products – recalcitrant lignocellulose, not converted to 2-3 BD, together with embedded microbial biostimulants biomass, is a useful agricultural input - a microbial plant biostimulant. Process up-scale to TRL5 is done also in an innovative manner, through adaptation of the already known equipment to newly developed technology. For NaDES extraction we propose to use the continuous operated reconfigurable columns systems, applied for decades for various types of extraction (e.g. for extraction of soluble from coffee). For SSF with microbial plant biostimulant consortium we propose the use of vacuum operated ploughshare mixer. This approach will ensure not only a better recovery of volatile 2,3 BD, but also a higher specificity of the fermentation medium, due to micro-aerobic conditions. The DEBUT project proposes a new approach of small scale biorefinery, compatible with a farm facility, which valorises agricultural side streams, with recovery of minerals and lignin (main precursor of soil organic matter) for agricultural use, and production of an innovative agricultural input, a microbial plant biostimulant. The project proposes a biotechnological two step cascading process, which converts excess lignocellulosic biomass into biochemicals (phenolic acids, 2,3 B-D), with added-value and fast-growing market. The main innovative solutions, NaDES and microbial plant biostimulant, are investigated for their potential adverse effects by a battery of state-of-the art techniques, in an trans-national partnership, to ensure that they do not affect natural ecosystem productivity.

Innovative green technologies for valorisation of lignocellulose Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2016-2518 2018 - 2020

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=29&lang=en

Abstract:

The scientific scope of the INTELIGRENCE project is to develop an innovative green technology, based on natural deep eutectic solvents (NADESs) and enzymatic processes, for multi-stage cascading use and valorisation of lignocellulosic biomass. The following interrelated specific objectives will be addressed: (1) to elaborate NADESs with high feruloyl esterase (FAE) compatibility and ability to extract ferulic acid (FA) from biomass; (2) to develop NADESs for cellulose valorisation into nanocelullose and the subsequent saccharification of the polysaccharides; (3) to investigate and optimize the use of selected NADESs in a multi-stage cascading processing of a lignocellulosic substrate. The project brings several innovative elements: the first time use of a high-throughput experimentation (HTE) approach for characterization and optimization of NADESs-based formulations for lignocellulose processing; in-situ lipophilisation of FA and generation of secondary (hydrophobic) NADESs from FA; the use of NADESs in association with enzymatic cocktails incorporating the recently discovered lytic polysaccharide monooxygenases (LPMOs) during the second step of the multi-stage cascading approach. The applied direction is related to the high added value of the main products (ferulic acid and nano-cellulose) intended to be obtained from lignocellulose by the proposed cascading NADES-enzymes treatment approach. Ferulic acid is an ideal precursor for the production of bio-vanillin and it exhibits a wide variety of biological activities, having a market which will exceed $100 million (US), mainly due to the increased demand for anti-aging serum based on ferulic acid. Nanocellulose market will exceed $250 million (US) in 2023, due to applications related to composites, packaging, coatings, biomedicine and automotive. The new scientific data will be relevant also for the biological significance of NADESs that are formed from components which are normally present in biological systems.

Composite hydrogels based on inorganic nanoparticles and collagen with prolonged antimicrobial activity for the prevention of wound infections Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2016-0177 2016 - 2018

Role in this project: Key expert

Coordinating institution: SANIMED INTERNATIONAL IMPEX S.R.L.

Project partners: SANIMED INTERNATIONAL IMPEX S.R.L. (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO)

Affiliation: SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Project website: http://nanocolagel.sanimed.ro/

Abstract:

Chronic wounds represent a good niche for biofilm development because the impaired immune response promotes infection susceptibility whilst necrotic tissue and debris favor bacterial attachment. Collagen hydrogels represent one of the most efficient treatments in case of both chronic and acute wounds due to their ability to maintain optimal humidity and aeration parameters. Currently, at a national level there is no production of collagen hydrogels aimed for the treatment of chronic wounds, hence these types of products are being imported. In this context, the present project proposal aims to design and obtain new types of multifunctional collagen hydrogels harboring antimicrobial properties in order to favor the healing process of chronic wounds. As a novelty element in comparison to products currently available on the international market, we will design and produce collagen hydrogels containing nanoparticles. Thus, Sanimed International Impex S.R.L will develop a simple and rapid technology to obtain hydrogels functionalized with metalic and oxidic nanoparticles (collagen hydrogels with Ag nanoparticles, collagen hydrogels with ZnO hydrogels and collagen hydrogels with SiO2@ZnO nanoparticles). The novel hydrogels will be tested for their antimicrobial and antibiofilm properties using in vitro and in vivo methods and also for the host response after hydrogel treatment on wounded cells and in vivo lesion murine models, for achieving market preparation.

Technology and equipment for producing collagen-based nanofibrillary structures for resorbable wound dressings Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2016-0174 2016 - 2018

Role in this project: Key expert

Coordinating institution: SANIMED INTERNATIONAL IMPEX S.R.L.

Project partners: SANIMED INTERNATIONAL IMPEX S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO)

Affiliation: SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Project website: http://nano-ecol.sanimed.ro

Abstract:

The nano-ECol project proposal aims to develop an innovative technology and to implement a demonstrative prototype at the Technology Readiness Level TRL5, for the production of micro- and nano-fibrillar substrata usable as absorbable dressings for wounds and burns. The micro- and nano-fibers will be obtained by electrospinning, starting from colloidal solutions of atelocollagen currently manufactured at S.C. Sanimed International Impex S.R.L. In this respect, the project aims at shifting/promoting the INFIM SPIN 1.0 prototype, developed through a previous project by the National Institute of Materials Physics (INCDFM), and preliminary tested for its atelocollagen electrospinning capacity, from the TRL4 to the TRL5.

The main technological challenges faced by the nano-Ecol project are: (i) preserving atelocollagen macromolecule in a quasi-native state, (ii) providing the products reproducibility, (iii) producing substrates with an area of tens of square dm and thickness of 3 ... 12 mm, (iv) providing a prototype able to work at micropilot scale, with at demand-formulated electrospun compositions, (v) providing rapid structural and dimensional prototyping, (vi) scaling-up the prototype and related technology to industrial level.

The project will benefit from the facilities and logistics of five research centers, of which two belong to Sanimed, and three to INCDFM. Services and facilities provided by all mentioned centers are detailed on the ERRIS platform.

The Sanimed co-funding represents 67.63% of the sum allocated to the company from the public budget, i.e. 25.27% of total buget, and 39.04% of the total payroll.

The expected outcomes of the project meet the Sanimed interest in expanding the range of products and addressability, by manufacturing resorbable dressings with tailored shape, structure and density, obtained from compositions formulated at physician’s request, in order to satisfy specific pacient needs.

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List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
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