BrainMap

Mrs. Ioana Cătălina Gîfu

CSIII

Researcher - Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Researcher

Curriculum Vitae (28/05/2024)

Expertise & keywords

Design of new nanocellulose-based gas-carrier systems Call name: P 4 - Proiecte de cercetare exploratorie - PCE-2021
PN-III-P4-PCE-2021-0435 2022 - 2024

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation:

Project website: https://icechim.ro/celgas-en/

Abstract:

Severe oxygen deprivation can cause significant problems in chronic wounds, during organ preservation and implantation, or in cases of trauma, hemorrhagic shock, or viral pneumonia. Oxygen prevents wound infection, increases cell viability after implantation and could be an effective treatment in viral pneumonia. Currently, there is no viable solution to deliver oxygen to the grafts during the healing period and to administrate a large volume of oxygen to patients who suffered profound oxygen deprivation. The scope of the CELGAS project is to develop innovative oxygen-carrying systems capable of supplying oxygen in a controlled manner to injured tissue/ implants or intravenously. The innovative oxygen-carrying systems will ensure controlled release of oxygen for long periods of time, will have a high stability, biodegradability, will not be cytotoxic and will have a nanometric size, essential for intravenous administration to avoid vascular obstruction. In CELGAS, the problem will be addressed using nanocellulose and nanocellulose/biopolymer to encapsulate oxygen-generating species or to obtain oxygen-containing nanobubbles. The biopolymers to be used are selected from poly (3-hydroxybutyrate), medium chain length polyhydroxyalkanoates and polylactic acid. The design of the new systems will be based on improved methods and an efficient characterization that will allow the achievement of the objectives.

INNOVATIVE FULLERENOL - HYDROGELS BASED NANOMATERIALS FOR HEALTH DIAGNOSTIC AND CARE APPLICATIONS Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-M-ERANET-3-FULSENS-GEL 2022 - 2024

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); CHIMGRUP S.R.L. (RO); Ordu University (TR); Metrohm Dropsens, S.L. (ES)

Affiliation:

Project website: https://www.fulsens-gel.ro/

Abstract:

The project aims to develop an innovative nanomaterial with tunable network structures and improved electrochemical/ mechanical/ optical properties, with active surface for sensing applications. The innovative objectives aims to develop: a) new fullerenol(FL)-Hydrogel nanomaterials with better functionality and opto-electrochemical performances; b) (bio)sensitive FL-Hydrogels with higher stability, selectivity and sensitivity; c) flexible, wearable FL-Hydrogels multiplex patches for rapid and efficient health status screening.

BIOGENIC AMINES DETECTION IN FOOD BASED ON AN INNOVATIVE OPTO-ELECTROSENSITIVE PLATFORM Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1942 2022 - 2024

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); EPI-SISTEM S.R.L. (RO)

Affiliation:

Project website: https://ami-food.ro

Abstract:

The AMI-FOOD project aims to develop cost-effective and robust miniaturized opto-electrosensitive platforms based on an innovative fullerenol (FL) nanomaterial, with enhanced electrochemical, optical and mechanical properties, for specific and sensitive determination of biogenic amines (BAs) in food. The specific objectives of the project are: To develop a novel FL nanomaterial with tailored structure and enhanced functionality, electrochemical and optical properties; To develop bioselective layers based on FL and specific aptamers, with higher stability, selectivity and sensitivity for histamine and histidine determination; To develop miniaturized opto-electrosensitive bioanalytical tools for rapid and efficient screening of BAs in food. The integrated opto-electrosensitive platforms equipped with novel nanostructured FL material and specific aptamers will show higher sensitivity, specificity and stability comparing to existing commercial ones, responding to the urgent need of a tool for food quality monitoring and controlling of food spoilage/degradation in real time. The originality of this project consists in the design of new versatile (apta)sensors based on the synergistic combination of FL and luminescent based nanomaterials with specific aptamers. The outcomes of AMI-FOOD project are: (i) Innovative functionalized FL nanomaterials; (ii) highly sensitive and selective biosensing materials based on FL and aptamers; (iii) Prototype of opto-electrosensitive platforms based on FL and aptamers for BAs determination in food (TRL4) and (iv) Optimized method for BAs detection in food by using the developed FL-aptamer based bioanalytical tools. This project will have a high socio-economic impact on the safety food and health quality, contributing to reducing and eliminating the contaminated food from the market.

Biopolymer structures obtained by plasma treatment for wounds healing Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2559 2022 - 2024

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO)

Affiliation:

Project website: https://icechim.ro/project/biopolymer-structures-obtained-by-plasma-treatment-for-wounds-healing-bioplasm/

Abstract:

Chronic wounds, severe burns or infected wounds are among the most painful diseases that require long-term expensive treatment. Currently, the clinical management of chronic wounds is difficult due to the increasing risk of infection with antibiotic-resistant bacteria and the shortcomings of current therapies. A novel technology for the manufacture of bilayer wound dressings, based on nanocellulose and cold plasma processing, will be developed in BIOPLASM project. The scope of the project is to obtain effective dressings for the treatment of infected wounds by developing antibacterial nanocellulose nanocarriers deposited on an aliphatic polyester substrate.

The use of cold plasma for nanocellulose and biopolymers processing in view of medical application is an effervescent field, with important benefits related to eco-friendliness, lack of secondary or waste products, sterilization and large functionalization capabilities. Cold plasma treatment of liquid suspensions of nanocellulose is a concept developed by ICECHIM and INFLPR in a previous project. This will serve as a starting point together with the functionalization and processing of nanocellulose and aliphatic polyesters for building a new technological approach to fabricate bilayer wound dressings. The new technology will be validated by in vitro and in vivo studies. The project will be implemented by a skilled group of researchers from ICECHIM, INFLPR and Cantacuzino Institute.

Laccase immobilization onto CS-PAA microspheres and its application for textile dyes biodegradation Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0418 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation:

Project website: https://www.icf.ro/pr_2022/IMLAC.pdf

Abstract:

Surface water pollution, with textile dyes, is a serious environmental issue and constant efforts in its reduction are needed continuously. Studies show that the distribution in water bodies and bioavailability of textile dyes affects aquatic fauna and humans. Although enzymes can successfully biodegrade recalcitrant dyes from water, their cost and instability are prohibitive for real-life applications. Therefore, the young team of the IMLAC project aims to develop a practical treatment for the removal of indigo carmine, naphtol green, and methyl red from aqueous media, using immobilized laccase. In this integrated study, the production and use of immobilized enzymes will be investigated and calibrated according to environmental variables, including temperature and pH and, most importantly, cost reduction through recyclability of the product in the presence of dyes will be achieved. The work program of the IMLAC team, based at the "Ilie Murgulescu" Institute of Physical Chemistry, has three complementary components: 1- Production of new polymeric supports for enzymes immobilization. 2 - Development and optimization of a new enzyme immobilization technique. 3 - Application of new products with immobilized laccase in the removal of textile dyes in the aqueous medium. The results of this innovative project could fit into national and European programs facing the double challenge of water quality and water safety.

Advanced material based on push-pull extended π-conjugated azo-chromophores in functional matrices with enhanced NLO properties Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3009 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://unibuc.ro/cercetare/promovarea-rezultatelor-cercetarii/proiecte-de-cercetare/proiecte-cu-finantare-nationala/smart-nlo/?lang=en

Abstract:

Scope of the project SMART-NLO is to obtain, optimize and validate the technology of fabrication and the new product based on novel extended azo chromophores in organo-modified silica films, possesing superior NLO properties at TRL4, developed starting from the preliminary results related to other types of chromophores with nonlinear optical (NLO) properties, filmogenic modified silica films and nanocomposite clay-silica materials obtained at TRL2 already achieved by the team’s publications and the existing laboratory techniques. The method of fabrication of novel material consists in encapsulation of the novel chromophores with extended structures in a silica film rational designed to ensure enhanced nonlinear optical properties. Methods of preparation and composition of the silica filmogenic matrix will be adjust to render tunable and efficient advanced materials with suitable arrangement of chromophore molecules and improved stability, for the fabrication of hybrid materials with superior NLO properties. The methods of film formation are chemicals ones, selected to be energy saving and eco-friendly.

New Intelligent Anti-Corrosion Coatings for Active Protection of Metallic Surfaces, Enhanced with Stimuli - Responsive Mesoporous Silica Nanocontainers Loaded with Organic Inhibitors Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-2053 2020 - 2022

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://www.icechim-pd.ro/en/syst_heter/sisteme_heterogene_corrapel_en.html

Abstract:

The strategic objective of the project respond to the need to accomplish the estimated results of the RESEARCH PROJECTS FOR YOUNG INDEPENDENT TEAMS - PN-III-DCD-RU-TE-2019-2, entitled: „New Intelligent Anti-Corrosion Coatings for Active Protection of Metallic Surfaces, Enhanced with Stimuli - Responsive Mesoporous Silica Nanocontainers Loaded with Organic Inhibitors” are: to develop ability of the young researchers to lead teams and manage research projects and to increase their capacity to implement their own research program. Thus, the proposal aims to create an additional opportunity to strengthen a young research team and an independent research program for it, providing the financial and logistic support necessary for 2 young researchers, 2 postdoc students; 3 PhD students and 1 master’s student to carry out their own research activities and to enable them to achieve international high-level of scientific research. The scientific objective of the project consists in preparation of smart mesoporous silica nanocontainers capable of stimuli-responsive release of the encapsulated corrosion inhibitors (CIs). They will be used as key components for obtaining superhydrophobic silica hybrid coatings with enhanced anticorrosion active protection for metallic surfaces. Optimization of mesoporous silica nanoparticles as pH-triggered opening nanocontainers, Design and preparation of of superhydrophobic film forming silica matrices by a simple sol-gel route in the presence of different nanofillers with oxigen barrier and anticorrosion properties and Optimization of the anticorrosion coatings with integrated nanocontainers will be analyzed in terms of the efficiency of the corrosion resistance of the metal surfaces they cover.

INNOVATIVE 3D PRINTED NANOCOMPOSITE CONSTRUCTIONS OBTAINED FROM MARINE RESOURCES (ALGINATE, SALECAN) AND NATURAL CLAY WITH SPECIFIC APPLICATIONS IN BONE REGENERATION - 3D_ALSAC Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-4216 2020 - 2022

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); GENETIC LAB S.R.L. (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://www.icechim-pd.ro/en/syst_heter/sisteme_heterogene_3dalsac_en.html

Abstract:

The scope of 3D_ALSAC project is to develop and test demonstrative models for a new product and its associated technology, namely an efficient and improved printing formulation based on an innovative biomaterial, followed by the construction of a multifunctional 3D implant designed for bone tissue regeneration. Based on a solid foundation built from the theoretical and experimental results previously obtained by the partners of the Consortium, thus justifying TRL2, the objective of this project is to target TRL4, where an innovative 3D printed product based on biopolymer-clay nanocomposite will be developed, tested and validated. The concept of the 3D_ALSAC project resonates with the long-term vision of the research teams and especially that of the economic agent, of developing custom extracellular matrices for bone regeneration using the patient's stem cells. Thus, the 3D_ALSAC project opens new possibilities for collaboration with the economic environment in order to implement efficient and cost-effective solutions. The 3D_ALSAC project will lead to the evolution of the fields of materials science and regenerative medicine by repairing parts of the skeleton of the human body using innovative biomaterial based inks and 3D printing techniques and obtaining personalized implants, serving as the basis for new therapies used for bone tissue regeneration. The 3D_ALSAC project will closely monitor the improvement of the Romanian research performance internationally through an intensive and qualitative dissemination plan aimed at publishing at least 4 scientific papers in prestigious and open-access journals, with a cumulative impact factor greater than 15, at least 10 presentations at scientific events, 2 work-shops, 2 patent applications and, in addition, contributions to the development of 2 PhD/master/bachelor theses, according to the intellectual property agreement previously signed between the partners of the Consortium.

Advanced nanoparticle-based materials with synergistic effect on neuronal oxidative stress and beta-amyloid fibrillation for preventive treatment in Alzheimer's disease Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-4657 2020 - 2022

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://www.icechim-pd.ro/ro/syst_heter/sisteme_heterogene_nanonerves.html

Abstract:

This project aims to develop and to validate a new product and its technology with application in preventive treatment of Alzheimer's disease. This new product includes bioactive ingredients with effect on neuronal oxidative stress (curcumin) and beta-amyloid fibrillation (Ag and ZnO functionalized nanoparticles), and a nanocarrier (PEG-functionalized silica particles), that can act itself as a beta-amyloid fibrillation inhibitor. The main project novelty is related to: (i) study of the interaction of new formulations based on Ag or ZnO NPs and Curcumin encapsulated in functionalized silica NPs with beta amyloid fibrils and (ii) a sistematic and rational scientific approach to strike a balance between the effect of modifying the kinetics of amyloid beta fibril formation and the prevention of toxic effects (otherwise known) on neurons. Project objectives are: (i) to optimize product components and to improve their compatibility; (ii) to develop demonstration model, through components integration and (iii) to test and to validate the demonstration model, on laboratory conditions. Objectives are related to different TRLs: improved compatibility and optimal composition of new formulations based on Ag or ZnO NPs and Curcumin encapsulated in functionalized silica NPs (1st objective) allow properties analysis and improvement (TRL 3). Components integration (2nd objective) and product testing in laboratory conditions (3rd objective) permit technological development up to TRL 4.

Emerging technologies for the industrial capitalization of 2D structures (graphene and nongraphenic) Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0387 2018 - 2021

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA DIN CRAIOVA (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=49

Abstract:

EMERG2Ind is a complex solution that responds to the needs of Romanian research on one side through a institutional management and development mechanism, but at the same time it is a complex interface tool for the Romanian automotive industry as a development engine and integrator for the horizontal and vertical integration of the Romanian economic resources. International expertise is available in an attempt to develop concrete solutions in the country. Emerging technologies are being developed up to TRL4 and TRL5, through complementary harmonization of three strategic subprojects. The complex project approach is regional and institutional with cumulative indicators that fully meet the requirements and seeks to maximize the use of the funding instrument.

Closing the bioeconomy value chains by manufacturing market demanded innovative bioproducts Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0569 2018 - 2021

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA "DUNAREA DE JOS" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); UNIVERSITATEA AUREL VLAICU ARAD (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=51&lang=ro

Abstract:

Agriculture and food industry in Romania generates large amounts of co/by-products, which are not used and turn into wastes, with negative impacts. The approach of the project PRO-SPER is to develop integrated processes, flexible and interconnected, to transform a number of agro-food by-products in bio-products, with market demand. This approach facilitates the achievement of project goals, complex-coordination and linking of the research organizations that are members of the Consortium, INCDCP-ICMPP, UDJ, ICECHIM, INCDSB and UAV, for improving their institutional performance in the field of nano-and bio-technologies of their application into bioeconomy.

The overall objective of the project PRO-SPER is to increase the impact of research and development activities and innovation of the RDI institutions, by developing and harnessing innovative technological solutions for bio-nano-processing of several by-products from the bioeconomy value chains, for recovering and/or formation of value-added components and their use in order to obtain products with high added value.

Expected results through the implementation of the project (21 new jobs, 23 national patent applications and international patent applications 6 EPO/WIPO; 10 technologies/new products resulting from the project, at a level of technological maturity to enable taking over by the operators, 5 services research and technological research services 10 cheques, 10 experiments cheques services

80 internship of young researchers from and within partner institutions, 50 visits for developing new techniques for working jointly in the Consortium, 30 training internships for new employees, 28scientific papers, 1 joint program CDI, in line with the development plan of institutional partners) have a significant impact on the capacity-building of the partners in the Consortium.

Smart materials for medical applications Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0407 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://intelmatupb.wixsite.com/intelmat

Abstract:

INTELMAT project represents advanced research in the field of synthesis and application of smart materials for medical engineering in order to solve essential features of some acute/chronic diseases of large occurrence. 5 thematic directions are taking into consideration: 1. Developing of a controlled-release system of complex micro-colloidal architectures based on bacterial cellulose and hydrogels used for management of chronically wounds which aims to overcome the limitations of classical treatments; 2. Developing of new biomaterials specially designed with targeted action for treatment of inflammatory diseases of gastrointestinal segment; 3. Synthesis of new generation of composite membrane materials for artificial kidneys based on biocompatible polymers and derivative graphene; 4. Developing of some auto-assembly 3D platforms with controlled-released drugs based on polymeric nanoparticles and composite nanogels for the therapy of colon-rectal cancer; 5. Developing of innovative technologies for the synthesis of some 1D nano-architectures (nanowires) with controlled morphology, with applications in producing of non-enzimatic electrochemical biosensors.

Innovative technologies based on polymers for the obtaining of new advanced materials Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0428 2018 - 2021

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=41&lang=ro

Abstract:

The project is aimed at using the expertise that involved in consortium entities acquired in materials science. The consortium consists of three representative national institutes: INCD for Chemistry and Petrochemistry – ICECHIM Bucharest, INCD for Electrochemistry and Condensed Matter - INCEMC Timisoara and INCD of Chemical Pharmaceutical - ICCF Bucharest, and of two prestigious universities: University POLITEHNICA of Bucharest and the University of Bucharest and a remarkable institute of Romanian Academy: Institute of Macromolecular Chemistry – Petru Poni Iasi. Although having great tradition and noteworthy results, the first five institutions face a series of problems, from the lack of financial funds, equipment and the aging employees for ICCF and partly for INCEMC and ICECHIM, to the lack of highly qualified staff required for recent investments in equipment for all 5 institutions. In this respect, the project attempts relaunching the activity in the first 5 institutions of the consortium, by putting together the existing competencies, so as to develop new technologies in order to obtain new materials with high performance properties. Given that, 3 of the research teams are specialized in polymers (ICECHIM, Petru Poni and UPB) the developed technologies will use the polymers as intermediates or as a component in the finished product. To this end it is envisaged getting the titanium nitride for prosthetic coatings via inorganic-organic polymer nanocomposites, obtaining photocatalytic materials and antibacterial coatings by sol- gel reactions, obtaining of short-life or one-time use biomaterials from aliphatic polyesters and micro or nanocellulose and the development of new polyphase materials with medium or long life, based on biopolymers, through 3D printing. The project intends the full use of A1, A2, B and C checks in order to increase the institutional performance of partners.

A next generation plant biostimulant based on strigolactones included into stimuli responsive nanoformulation Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERANET-INCOMERA-BENDIS 2018 - 2019

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); ENPRO SOCTECH COM SRL (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=50&lang=ro

Abstract:

The BENDIS project aims to integrate technologies for the industrial production of a next generation plant biostimulant based on strigolactones (SL) analogs and/or mimics, included into a stimulus-controlled release nanoformulation. A better harnessing of exogenously applied SL analogues/mimics requires such formulations, which protect SL from rapid degradation and promote their steady release at the biologically active concentrations under controlled conditions – i.e. roots mediated pH changes in the soil. The nanoformulation includes mesoporous nanosilica, loaded with a hydrophobic "green" solvent with dissolved SL analogues/mimics. Mesoporous nanosilica particles are decorated with humic acids, wherein SL are embedded. Humic acids are immobilized on mesoporous silica through an aminopropyl bonding.

Contributions to enhancing the Sanimed SRL’s competitiveness by the knowledge assimilation and potential production implementation of some 3D collagen-polymer hybrid matrices intended to tissue repair Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0397 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.unibuc.ro/prof/micut_m/

Abstract:

The project proposal mainly aims at knowledge transfer to economic operator regarding the obtaining and development of 3D collagen-polymer hybrid biomaterials intended to biomedical applications. The practical implementation of the proposal should lead to enhancing competitiveness of private economic entity in order to develop itself in the near and middle-term future. In line with economic partner, the public entities University of Bucharest and ICECHIM (project partners) have identified aspects of scientific and technological existing at private partner, the weaknesses and strengths of these aspects, as a useful basis for designing new collagen-based hybrid biomaterials. In addition, the purpose that such kind of biomaterials be used in the process of tissue repair requires accounting a number of key characteristics against which it is possible to design, realize and develop this kind of hybrid collagen-polymer system: biocompatibility, bioresorbability, mechanical properties, internal and external morphology and manufacturing technology.

Increasing performance/competitiveness by improving the technology of smart products fabrication with superior biocompatibility and antibacterial properties for cosmeto-medical applications Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0142 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); SONNENKREUZ SRL (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.unibuc.ro/n/cercetare/94BG-2016.php

Abstract:

The purpose of this project is to increase the performance and the competitiveness of SC Sonnenkreuz SRL by using the expertise existing in the research organizations, University of Bucharest and INCDCP-ICECHIM, for developing and optimizing the modern technology for producing silver colloid dispersions, in order to obtain a product with higher biocompatibility and antimicrobial properties. To accomplish the purpose of the project, a full compliance between the requirements and the problems identified by the economic agent and the project objectives was followed. Two directions for innovating the final product and the manufacturing processes will be pursued: (i) obtaining of various colloid silver dispersions stabilized with polymers having intrinsic antibacterial activity, to achieve a synergistic effect and (ii) optimizing the production technology by electrochemical method by ensuring the control of nanoparticles growth. The knowledge transfer will include also the collaboration with the economic agent in order to identify the possibility of a subsequent development of other cosmeto-medical products based on the dispersions of silver nanoparticles with improved properties. For developing the quality assurance system at the economic agent, the collaboration between the partners UB and INCDCP-ICECHIM with SC Sonnenkreuz SRL will be intensified in order to accomplish the analyzes required for the characterization of the final products and to monitor the manufacturing process. Cooperation with the economic partner will be fulfilled by the activities of entrepreneurship knowledge transfer towards the researchers/PhD students/Master students involved in the project. Development of the new product and improvement of the technology will provide opportunities for practical training for master students, with a complex topic. The publishable scientific results will be widely disseminated in communications and articles in specialized journals.

Optimization and validation of an advanced material and technology default based on biopolymer-modified clay as carriers for controlled release of doxorubicin in gastrointestinal tract Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1896 2017 - 2018

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL DE BIOCHIMIE (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.icechim-pd.ro/ro/syst_heter/sisteme_heterogene_doxsaclay.html

Abstract:

The goal of the project DoxSaClay is to obtain, optimize and validate a new product and the associated technology reffering to the advanced material “biopolymer IPN hydrogel networks-modified clay-bioactive agent”. Preliminary results related to polymer-advanced modified clay nanocomposite materials are already demonstrated by the team’s publications. The consortium offers a high level of competencies in biomaterials domain, the Project Coordinating team having a great expertise in the synthesis of advanced materials while the competencies of Partner being related with in vitro testing on cell lines. The method will connect Salecan biopolymer with pH responsive (co)polymers to design new semi-interpenetrated networks (SIPN) with encapsulated amphiphilic nanoclays by free cross-linking radical co(polymerization) to render tunable and efficient advanced materials with enhanced mechanical strength, improved stability and adjustable responsive properties, for the controlled release of anti-cancer drug-doxorubicin in gastrointestinal tract. New delivery methods, particular delivery of doxorubicin, could make a dramatic impact to the medical community who administers the cancer treatment and the patient who endure the effects of the cancer treatment. The local, oral delivery of anti-cancer drugs to the colon maybe made possible by using designed technology, own modified clays and biopolymer semi-interpenetrated networks, by assembling them into novel structures and architectures that can exhibit properties appropriate for the application at hand. Validation of the results will be achieved by ISI publications in prestigious peer-reviewed scientific journals, conferences with international visibility and at least one patent request. Another priority of the present project is to increase the international visibility and competitiveness of Romanian research for successful integration in European Projects (Horizon 2020).

Investigating micro- and nanostructured colloidal systems by fluorescently labeled polymers and probes Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0916 2011 - 2016

Role in this project:

Coordinating institution: Institutul de Chimie Fizica "Ilie Murgulescu" al Academiei Romane

Project partners: Institutul de Chimie Fizica "Ilie Murgulescu" al Academiei Romane (RO)

Affiliation:

Project website: http://www.icf.ro/pr_2011/DFA/index.html

Abstract:

This project aims to synthesize and characterize hydrophobically modified and/or fluorescently labeled polymers, in order to apply them in probing the hydrophobic/hydrophilic interface of regular and reverse micelles and to investigate layer-by-layer polymer assemblies. To accomplish this goal the following parameters will be monitored: the alkyl chain length and amount grafted, the fluorophore content and its nature, the polymer molecular weight, the surfactant, pH, ionic strength, the organic solvent and the reverse micelle hydration degree. The techniques involved in this project are: UV spectroscopy, 1H-NMR, 13C-NMR, GPC and capillary electrophoresis, static and dynamic fluorescence, FTIR, rheometry, DLS, surface tension, goniometry. The acquired data will shed light and elucidate phenomena involved at nanometric scale in these systems. The importance of this study resides in obtaining new intelligent materials able to modify their molecular architecture in response to external stimuli. A particular attention will be payed to fluorescence resonance energy transfer (FRET) for getting insights into the interface of micellar nanocages and of thin films.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects