BrainMap

Ioan Turcu

Dr

Research Team Leader - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Researcher | Scientific reviewer

Web of Science ResearcherID: not public

Curriculum Vitae (22/02/2024)

Expertise & keywords

Strengthening the institutional performance of INCDTIM Cluj-Napoca Call name:
C1.2.PFE-CDI.2021 / 532 2022 - 2024

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Project website: https://www.itim-cj.ro/pncdi/consol-itim/index_files/home.htm

Abstract:

The main activities to be implemented within the project focus on: i) increasing INCDTIM's involvement in major international projects as well as its international visibility; ii) stimulating activities dedicated to accessing European RDI funds and technology transfer; iii) supporting the mobility of research staff, especially young researchers; iv) upgrading and maintaining the research infrastructure; v) supporting patenting and open access publishing; vi) intensifying and diversifying communication and promotion activities on three distinct levels: the scientific community, the business environment and the general public.

Development of a highly sensitive and selective SERS aptasensor for medical diagnosis Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1998 2022 - 2024

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO); CENTRUL INTERNATIONAL DE BIODINAMICA (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website: https://sites.google.com/view/nanoaptadia/home

Abstract:

Biomarkers are currently used for detection of diseases and monitoring therapeutic progresses in diagnostics. The accurate measurement of biomarkers in human patient samples is exceedingly important requirement for any analytical method. This project aims to develop an experimental demonstrator designed to provide pertinent solutions to three unmet medical needs in diagnostics: (1) high sensitivity; (2) high specificity and (3) label-free detection of disease biomarkers. Specifically, a novel biosensing nanotechnology will be implemented by coupling a new class of high affinity biorecognition elements called aptamers at the surface of plasmonic nanoplatforms recently developed in our laboratory. While the aptamers attached onto the metallic surface can specifically recognize the target molecules (biomarkers), the signal transduction will be based on ultrasensitive Surface Enhanced Raman Scattering (SERS). SERS has previously demonstrated its analytical performance toward “single-molecule sensitivity” and ability to identify and discern biomolecules by their spectral “Raman fingerprint” signature. By exploiting the complementary expertise of three research centers in SERS spectroscopy, chemistry and surface engineering, and fabrication and characterization of plasmonic nanoplatforms we expect to provide the feasibility of aptamer-modified SERS nanosensor for high sensitivity, high specificity and label-free detection of some relevant disease biomarkers. The as-fabricated “microchip” inserted in a Raman spectrometer to collect the SERS signal from the targeted biomarkers can offer unique characteristics, competitive advantages compared to other detection systems in the market and real potential for technology transfer.

Eco-friendly nanocomposites based on bio-PA and bio-fillers for injected auto parts Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-0795 2022 - 2024

Role in this project: Partner team leader

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://icechim.ro/project/econano4auto/

Abstract:

The ECONANO4AUTO project offers an innovative and efficient solution for the field of smart specialization - Energy, environment and climate changes, namely reducing the CO2 footprint and accumulations of polymeric waste, by developing of new and innovative technology for obtaining of new polymer bio-nanocomposites based on bio-PA and keratin/ nanoparticle hybrids, lightweight and with improved thermal and mechanical properties. Starting from high-performances bio-PA10,10 and a natural waste (chicken feathers) the project will provide at the end a viable, low cost and eco-friendly solution for effective using of chicken feathers and reducing of impact on environmental pollution. The developed technology will be validated in laboratory conditions to obtain parts by injection moulding. A toxicological study will be carried out regarding the nanomaterials action on the epidermal and pulmonary cells and a methodological guide will be elaborated regarding the prevention of the risks related to the work with nanoparticles. The partnership for this project involves 2 R&D National Institutes, well known in Romania and abroad, competent in the project field and with scientific and technical potential for development and characterization the new technology for obtaining bio-polymer nanocomposites.

Ready-to-use flexible wound dressing with synergistic photothermal and antimicrobial capabilities Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-3342 2022 - 2024

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); UNIVERSITATEA BABES BOLYAI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO)

Project website: https://www.nipne.ro/proiecte/pn3/66-proiecte.html

Abstract:

The increasing costs of treatment of chronic wounds has urged the scientific community to look for more efficient wound-dressings. When addressing a chronic wound one should consider the diverse microbial environment that needs to be targeted, but also supporting wound healing. Biocompatible materials support the healing of the wound while antimicrobial agents (i.e., iodine, honey and silver, etc) can be easily incorporated if needed. Due to the rise of antibiotic resistance treatment of chronic wounds has become extremely complicated because of the lack of adequate dressing systems. Recently there is a growing interest towards the use of natural products with antimicrobial features, such as antimicrobial peptides (AMPs). Therefore, we plan to design AuBPs-based flexible PDMS patches functionalized with antimicrobial peptides used as a new alternative for chronic wounds treatment. We plan to combine the effect of photo-thermal disinfection generated by gold nanobipyramids activated with white light (e.g. smartphone torch light) with the one obtained by AMP release. To our knowledge, this is the first study that envisages flexible wound dressing with synergistic photo-thermal and antimicrobial capabilities.

MICRO / NANO-BIO systems which can be integrated into innovative platforms for emerging technologies Call name:
PN19 35 02 01 2019 - 2022

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Project website: http://ro.itim-cj.ro/micro-nano-bio-sisteme-pentru-platforme-inovative-destinate-tehnologiilor-emergente/

Abstract:

General Objective

Development of MICRO / NANO-BIO systems that can be integrated into innovative platforms for applications in emerging technologies.

Specific Objectives

A. Design and MICRO / NANO-manufacturing of structures with controlled geometries and properties for the development of smart optical labels,

laser field amplifiyng surfaces and biomimetic systems with targeted properties.

B. Development of innovative platforms based on MOF-protein / biomolecule biohybrid systems, anticancer / antifungal molecular biostructures and exosomes with potential for diagnosis and treatment of neurodegenerative diseases

Emerging technologies for the industrial capitalization of 2D structures (graphene and nongraphenic) Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0387 2018 - 2021

Role in this project: Partner team leader

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA DIN CRAIOVA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=49

Abstract:

EMERG2Ind is a complex solution that responds to the needs of Romanian research on one side through a institutional management and development mechanism, but at the same time it is a complex interface tool for the Romanian automotive industry as a development engine and integrator for the horizontal and vertical integration of the Romanian economic resources. International expertise is available in an attempt to develop concrete solutions in the country. Emerging technologies are being developed up to TRL4 and TRL5, through complementary harmonization of three strategic subprojects. The complex project approach is regional and institutional with cumulative indicators that fully meet the requirements and seeks to maximize the use of the funding instrument.

Underwater geological structures prone to the generation and accumulation of biogases - associated geo-biogeochemical processes Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0178 2018 - 2021

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU GEOLOGIE SI GEOECOLOGIE MARINA - GEOECOMAR

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU GEOLOGIE SI GEOECOLOGIE MARINA - GEOECOMAR (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE MARINĂ "GRIGORE ANTIPA"-I.N.C.D.M. CONSTANŢA (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://sites.google.com/view/ubiogas

Abstract:

In comparison with the accumulations of thermogenic methane, the accumulations of biogenic ones are formed in more predictable geological settings. At global level it has been assessed that more than 20% of the total methane reserves are biogenic. In the last decade in Romania the interest for the biogenic methane has increased constantly and the most important discovery, with reserves that can cover the entire needs for methane of Romania for 6-8 years, is methane of biogenic origin. This finding of biogenic methane is in the Domino geological structure, offshore Black Sea, in the Romanian economic exclusive zone.

The present research program, uBioGas, by its 3 projects: (10 Plio-Quaternary geological structures favorable to the generation and accumulation of biogenic methane in the Romanian zone at the Black Sea; (2) Determination of bio-geochemical parameters associated to the geological structures evidenced in the project (1), requested for 1D modelling of the methane generation processes and development of analogies regarding the generation and accumulation processes that take place in the Plio-Quaternary pile of sediments.

(3) Paleogeographic evolution of the studied region, in the framework of nowadays and Quaternary environment - climate changes, their influence against the processes of generation and accumulation of methane.

According with the project’s topic and with the structure of the consortium that performs the research program, the project is an interdisciplinary one, with researchers from geosciences (geologists, geophysicists, geochemists), natural sciences (chemistry, physics, biology), from almost all Romanian regions.

The projects valorize the available Romanian research infrastructure, but will also contributes to the further development of it, by adding new equipments and updates to the ones needed to perform the researches, in accordance with the global developments, including the training of researchers in using the new technologies.

Emerging molecular technologies based on micro and nano-structured systems with biomedical applications Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0010 2018 - 2021

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO); UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/tehnobiomed/

Abstract:

The TehnoBioMed project aims to increase the institutional performance of 6 partners with a rich tradition in research, development and innovation (RDI) joined in a consortium with a strong interdisciplinary character designed to develop emerging molecular technologies based on micro- and nanostructured systems and dedicated to biomedical applications.

The project consortium consists of 6 partners distributed in 3 university centers with a tradition in the RDI activity: Cluj-Napoca, Bucharest, Iasi, and consists of 3 national institutes and 3 prestigious universities. The consortium partners are distributed in three different development regions of Romania.

The specific objectives of the project can be synthesized by: i) Manufacturing and testing of surfaces with antimicrobial properties obtained by micro- and nano-fabrication techniques and functionalized with antimicrobial peptides; ii) Development of molecular targeting drug systems by encapsulation in supramolecular structures of the dendrimeric type; iii) Carrying out, calibrating and testing a complex diagnostic equipment based on the principles of coherent optics and dedicated to obtaining high-resolution images in medicine and material science; iv) Development of new technologies for the detection and analysis of molecular biomarkers; v) Development of the technological potential of phycobiliproteins for the production of photosensitive materials with applications in new solar cells and new immunological sensors.

The project aims to develop new or significantly improved products / technologies / services of which we mention the following: Developing a high-resolution OCT imaging equipment with applications in biomedicine and material science; Designing, manufacturing and testing of a nano-ELISA technology; Making new systems with improved antimicrobial activity and increased efficiency against bacterial biofilm formation; Obtaining compounds/materials with impact in the prevention and control of infections.

Innovative platforms for applications in emerging areas: neural network based computing techniques, development of new pharmaceutical formulations, molecular diagnosis, biomedicine. Call name:
PN18-03 02 01 2018 - 2018

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/index.php?menu=2&submenu=302P3

Abstract:

General Objective

Developing innovative platforms and applications in emerging areas: neural network based computing techniques, new pharmaceutical formulations

with increased efficacy, molecular diagnosis, biomedicine.

Specific Goals

A. Physical-chemical models based on neural networks: applications to describe and predict the generation of higher harmonics and pulsations of attoseconds.

We propose designing a process of generating higher harmonics using artificial back-propagation networks;

B. Obtaining complex supramolecular systems with applications in the development of new, highly efficacious pharmaceutical formulations and separating

natural bioactive compounds from plant extracts. We aim to obtain new pharmaceutical formulations of synthetic and natural bioactive compounds;

C. Developing innovative molecular diagnostics platforms for biomedical applications based on ultrasensitive spectroscopic techniques, nanostructured interfaces and high accuracy analysis algorithms.

Micro- and nanotechnology techniques dedicated to the development of molecular and thermoelectric devices and graphene-based sensors Call name:
PN16-30 02 01 2016 - 2017

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/index.php?menu=2&submenu=301P5

Abstract:

Objectives

A. Obtaining micro / nano-structured materials and surfaces through the development / use of state-of-the-art manufacturing techniques.

Development of applications in the field of molecular and thermoelectric devices and graphene sensors.

B. Design and characterization of materials / surfaces by numerical, spectroscopic and high resolution microscopy.

The improvement of the manufacturing technology of lead-acid batteries to be used for start-and-stop automobiles Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1226 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BABES BOLYAI (RO); ROMBAT S.A. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/rombss/

Abstract:

We propose a methodology for the improvement of fabrication technology for the positive electrodes used as components in the lead-acid batteries produced at sc rombat sa . The final goal of our consortium is to improve the current technology used by industrial partner for fabrication of the batteries to be used for start-and-stop automobiles (i.e . To satisfy the j240 – sae and en 50342-6 quality tests) . The proposed approach is designed for the optimization of the scientific and technological steps involved in the fabrication of positive electrodes . It integrates the fundamental knowledge obtained from ab initio calculations, synthesis of new chemical compounds, fabrication of new alloys and structural characterization of the materials used to fabricate the electrode, at both nanoscopic and mesoscopic scale . The key element for the integration of all these activities is the fabrication and characterization of functional prototypes by the industrial partner.

The main problem to be solved is to control the corrosion of the positive electrode during the charge-discharge cycles, imposed by the requests of the start-and-stop technology . The solutions proposed by our consortium are: (i) fabrication of new alloys to be used for the production of the metallic grid that support for the active mass of the electrode (ii) improving the fabrication technology of the metallic grid (iii) improving the electrochemical properties of the active mass by new fabrication technology and by the use of new additives to the active mass. We note here that for the negative electrode as well as for the electrolyte the standard products fabricated by sc rombat sa will be used . The project’s goal will be achieved by using a feed-back loop: the design of materials and the fabrication steps involved by each prototype will be refined by successive fabrication of the prototypes that will gradually incorporate the information produced by each partner . At each step of our methodology the full characterization of the electrochemical and structural properties of the materials and prototypes already fabricated will be used as starting point for further refinement of the fabrication technology . A continuous exchange of data between the research Institutes and the industrial partner is foreseen for the whole duration of the project . This will allow us to tune the results obtained in the laboratory with those produced in industrial conditions . At project’s term we will discuss the technological steps needed for the implementation of the results by using the infrastructure available at sc rombat sa.

Homogenous immunoassay technique based on functionalized nanoparticles. Application to detection of pesticide contaminant 2,4-dichlorophenoxyacetic acid from alimentary and environmental samples Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0402 2012 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://proiecte.nipne.ro/pn2/138-proiecte.html

Abstract:

Immunological methods such as enzyme linked immunosorbent assay (ELISA) are increasingly becoming important for pesticides residual analysis due to the high specificity of detecting molecules like antibodies. These immunoassay methods are highly specific, sensitive (nanogram or picogram) and accuracy for the detection of low molecular weight contaminants presents in our environment. ELISA is a technique based on the ability of non-labeled antigen (e.g. pesticide) in a specific volume of standard solution or in an unknown sample to compete with a fixed of amount of enzymatic labeled antigen for a limited number of binding sites of a specific binding antibody protein. The objective of the project is to develop a new and innovative immunochemical technique based on functionalized nanoparticles, homogenous enzyme linked immunosorbent assay (HnELISA) technique for detection of pesticide contaminant 2,4-dichlorophenoxyacetic acid (2,4D) from alimentary and environmental samples. 2,4D is one of the most used herbicide in agriculture to control and destroy of the weeds that can affect agricultural crops. The remanence of this organochlorurate compound in alimentary products, transfer and contamination of ground water in the areas where this pesticide is used require the analysis of this chemical in order to establish the contamination level of the alimentary products and the environmental factors (water, soil).

The objective of the project is to develop an immunoassay technique with improved qualities in comparison with traditionally ELISA technique existed on the market for detection of pesticide contaminants from alimentary and environmental factors. Qualitative characteristics as sensitivity, accuracy, stability of the nanoimmunosorbent and low cost per assay are finally taken in account. Development of HnELISA technique would have practical application in monitoring of the pesticide contaminant 2,4D from alimentary and environmental samples.

Rational design and generation of synthetic, short antimicrobial peptides. Linking structure to function Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0595 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.science.research.uaic.ro/biopep/

Abstract:

Antimicrobial peptides (AMPs) are an integral part of the immune system and protect a host from invading pathogenic bacteria. To overcome the problem of antimicrobial resistance, AMPs are being considered as potential alternatives for antibiotics. Although over 1000 AMPs have been isolated and characterized from various hosts, only limited successes have so far been achieved in clinical trials. The major hurdles for converting them into drugs lie in the high cost of production, toxicity to host cells, and susceptibility to proteolytic degradation. Therefore, a better understanding of the structure–activity relationships of AMPs is required to facilitate the design of novel antimicrobial agents. Herein we plan to focus our effort on designing and optimizing novel short, cationic amphiphilic peptides. We will undertake rational design, synthesis, and extensive testing of a series of short cationic peptides, we envision proteolityc and salt resistant. They will be made of a limited set of L- and D-aminoacids based on an elementary amphipathic templates of up to to 11 aminoacids, searching for the minimum number of aminoacids and optimal architecture able to confer the peptide optimal lytic activity and specificity against various pathogens. In order to enhance antimicrobial activity with no additional hemolytic activity, peptide synthesis will be considered by using non-natural amino acid analogs that will substitute hydrophobic residues leucine, isoleucine and phenylalanine. This group of peptides will be designed and synthesized with shorter sequence and simpler molecular structure and could be easily modified upon a particular requirement. The structural simplicity also offer technological advantages for mass production and purification.

Bioligand - macromolecule intermolecular interactions as probed by spectroscopic and microcalorimetric techniques Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0032 2011 - 2016

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Tehnologii Izotopice si Moleculare, Cluj-Napoca

Project partners: Institutul National de Cercetare-Dezvoltare pentru Tehnologii Izotopice si Moleculare, Cluj-Napoca (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Tehnologii Izotopice si Moleculare, Cluj-Napoca (RO)

Project website: http://itim-cj.ro/PNCDI/idei8/

Abstract:

The study of intermolecular interactions in solutions is of central importance to most chemical and biochemical disciplines. The solution behaviour of bio and macromolecules, their aggregation or intermolecular interactions is relevant for their biological activity. The binding affinity and the molecular recognition capacity can be described by the dissociation constant and the number of binding sites on the macromolecule. Any interaction that interferes with the binding of a bio-molecule to its receptor, such as competitive binding, may affect the pharmacological activity. The purpose of this project consist in the characterization of the molecular binding process between bio-ligands and receptors, using a variety of spectroscopic (nmr, uv/vis and fluorescence) and calorimetric techniques (ITC). Moreover, we intend to investigate the competitive binding process of two ligands to a macromolecular receptor and of two receptors to a bio-ligand. NMR is the major technique used to analyze the interaction between a bio-ligand and a receptor giving useful information about the, stoichiometry, stability, specific and non-specific binding sites. ITC is one of the most powerful and precise technique currently available to characterize the energetics of intermolecular interactions. It allows the binding functions ΔG, ΔH and ΔS to be determined within a single experiment and an accurate determination of the reaction stoichiometry and the dissociation constant.

Ion sensing and separation through modified cyclic peptides, cyclodextrins and protein pores Call name: Complex Exploratory Research Projects - PCCE-2011 call
PN-II-ID-PCCE-2011-2-0027 2012 - 2016

Role in this project: Partner team leader

Coordinating institution: “Alexandru Ioan Cuza” University

Project partners: “Alexandru Ioan Cuza” University (RO); National Research and Development Institute of Isotopic and Molecular Technologies (RO); “Babes-Bolyai” University (RO); “Horia Hulubei” National Institute for Physics and Nuclear Engineering (RO); “Carol Davila” University of Medicine and Pharmacy (RO)

Affiliation: National Research and Development Institute of Isotopic and Molecular Technologies (RO)

Project website: http://science.research.uaic.ro/biosens/

Abstract:

Development of nanostructures capable of detecting and separating individual molecules and ions has become an important field of research. Particularly, protein-based nanostructures are attractive due to their ability for tunable molecular recognition and ease of chemical modification, which are extremely important factors on various applications. In this project, self-assembly functionalization will be approached, aimed at providing an efficient design for molecular recognition, ion sensing and separation, through new host-guest chemical methodologies, bio-nanofabrication and physicochemical manipulations methods. New crown ether type macrocycles, functionalized cyclodextrins and cyclic peptides will be engineered to work as specific molecular adaptors for the -hemolysin protein, giving rise to hybrid molecular superstructures possessing ion sensing and selectivity properties. The size and functionality of the macrocycles are targeted to ensure the anchorage in the pores and the selectivity of specific host-guest complexation processes. A surface detector array device suitable for use with a biosensor is envisioned, through ink printing nanotechnologies. The device architecture will be formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. Custom designed nanoscale bilayers containing selected receptors through cyclodextrins derivatives and macrocyclic peptides, self-assembled on different micro-nano arrays surfaces (polymers, Au or Si) will be fabricated. Further engineering of such functionalized nanomaterials based on molecular recognition and host-guest methodologies, in conjunction with flexible and mechanically robust enough substrate platforms, have the great potential for applications such as separation of nanoparticles, sensors, drug delivery, removal of heavy metals from aqueous solutions and chiral separation.

Surface and Interface Science: Physics, chemistry, biology, applications. Call name: Complex Exploratory Research Projects - PCCE-2008 call
PN-II-ID-PCCE-2008-0076 2010 - 2013

Role in this project: Key expert

Coordinating institution: INSATITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA MATERIALELOR

Project partners: INSATITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA MATERIALELOR (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU INGINERIE ELECTRICA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE CAROL DAVILA DIN BUCURESTI (RO); UNIVERSITATEA ALEXANDRU IOAN CUZA DIN IASI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA TEHNICA DIN IASI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE DIN CLUJ-NAPOCA (RO); UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA (RO); ACADEMIA ROMANA FILIALA TIMISOARA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE VICTOR BABES TIMISOARA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE DIN CLUJ-NAPOCA (RO)

Project website: http://www.infim.ro/projects/siinta-suprafetelor-si-interfetelor-fizica-chimie-biologie-aplicatii

Abstract:

This project intends to provide a financial background for developing the community of Surface Science in Romania. Thematics from physics and chemistry of surfaces will be tackled together with applications of surface science in biology and in technology; also new standards will be proposed for consistent data interpretation. The Project clusterizes the most important Romanian teams with preoccupations in surface science, namely all X-ray photoelectron spectroscopy teams with most of the community of thin film deposition, cluster and nanoparticle physics, surface reactivity, surface chemistry and photochemistry, multilayer physics and applications, magnetic fluids, functionalization of surfaces, cell attachment, studies of cellular membrane. The research teams belong to highly prominent Universities and Research Institutes from practically all geographical areas of the country. The Consortium disposes of infrastructure exceeding 10 million euros, of more than one hundreed highly qualified scientists which have generated during the past years more than 3 % of the national scientific visibility. The research will concentrate into four main areas: (i) magnetic properties of surfaces and low-dimensional systems; (ii) electrical properties of surfaces and heterostructures; (iii) surface chemistry; (iv) application of surface science in functionalized systems and in biology, together with (v) an area concentrating on standardization in X-ray photoelectron spectroscopy, Auger electron spectroscopy and related techniques. Each area is divided into several thematics; each thematic has at least one in-charge scientist. This Project will foster the surface science community in Romania and will contribute strongly to the development of high-technological industrial preoccupation in all geographical areas concerned. Several cutting-edge applications are also foreseen by pursuing the fundamental research proposed.

Molecular and Biomolecular Physics Department Upgrading Call name:
2 PM/I/07.10.2008 2008 - 2012

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/mdfmolbio/en/index.html

Abstract:

General objective:

Molecular And Biomolecular Physics Department Upgrading through the acquisition of ultramodern research infrastructure.

Specific objectives:

The diversification of research topics, related equipment and research competencies from the molecular and biomolecular physics and technology area.

The significant increase in the quality of the research and development (R&D) activity.

The stimulation of the technological transfer to beneficiaries and establishment of productive entities using innovative technologies.

The establishment of a high performance center of molecular physics and technology able to:

coagulate the cooperation with specialists from abroad;

offer cutting edge conditions of training and specialization for masters, PhD students and young researchers;

attract young graduates toward research;

stimulate the return of researchers who are currently working abroad;

provide the premises for research teams in NIRDIMT to be able to participate in complex European research projects, especially in the EU's FP7 projects.

Organisation of the coding sequence of the microbian genome; autoregresive modelation Call name:
PN II ID_32 2008 - 2010

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/id32/pagina-engleza.html

Abstract:

Objective: Supramolecular organization of coding sequences in bacterial genome. Simulation is done with autoregressive models.

It is shown that DNA organization is based on weak interaction between terms (the lengths of coding sequences).

This type of organization is one of short-distance and not long-distance (or fractal).

New ideas brought by the project are the following:

- The type of DNA organization (length of coding sequences) is characterization by correlation proprieties at short distance.

- Pointing out the confusion at a big scale in literature by which structures and phenomena with spatial and temporal organization at short distance

are confused with fractal structures, and also the best method to be used to avoid this confusion.

- Organization of bacterial genome is described by first and higher order autoregressive models, where the fundamental parameter is the interaction

factor among the series terms.

- Phenomena can be categorized in structures (phenomena) with weak interaction (the case of microbial DNA), with strong interaction (proteins)

or with medium interaction (other systems outside of the project interest).

- MATLAB programs are used to describe some structures and phenomena with autoregressive models.

Self-assembled bidimensional supramolecular structures based on functionalized organic molecules Call name:
2-CEX-06-11-93/2006 2006 - 2008

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BABES BOLYAI (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/ssba/index.html

Abstract:

The goals of this research project are the design, synthesis and characterization of functionalized bidimensional supramolecular structures with applications

in nanoscience and nanotechnologies. The functionalized organic molecules design needs structural analysis and organic syntheses know-how,

simulations and molecular modelling, identification and investigation of intermolecular interactions.

We intend to obtain and characterize Self-assembled Bidimensional Supramolecular Structures (SBSS) of podands and thiophene-phenothiazine macrocycles

on gold surfaces and gold nanoparticles respectively.

The project has multi- and inter-disciplinary features, focusing on complex problems from fundamental sciences: molecular and atomic physics,

organic chemistry and computational physics.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects