BrainMap

Ioan Cristian Tivig

Dr.

Assistant Professor - UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Researcher

Curious about the bounderies between technology and biology. Worked in a broad spectrum of domains, from biochemestry and biophysics to biotechnology and bio-microfabrication. My main field of research is electric field applications (Dielectrophoresis, Electroporation etc.) and optical trapping (Optical Tweezers). My other skills include programing (Python and C ++), 3D printing (FDM and resin), 3d modeling and simulations (mainly on electric fields). Currently working as a full-time lecturer and researcher in Bucharest, Romania. Looking forward to speaking with anybody who shares my passions!

Web of Science ResearcherID: C-1415-2019

Curriculum Vitae (20/02/2024)

Expertise & keywords

Optoelectric microfluidic system for tumor cells characterization and separation according to their malignancy grade Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-0451 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO)

Affiliation:

Project website: https://cetal.inflpr.ro/newsite/ped_596

Abstract:

In the present project we shall fabricate and validate a microfluidic device based on dielectrophoresis and optical tweezers capable to characterize and separate cancer cells according to their malignancy potency. Specifically, using a novel fabrication approach, we will develop a compact glass based optoelectric biochip for efficient cell trapping followed by microfluidic separation. The device will provide a complete label-free method of cell separation and consists in creating a double trap due to gradients of electric field amplitude and laser light intensity. The sorted cells can be further used for downstream applications (such as, precision medicine diagnostic by providing specific cell subsets or obtaining specific cell cultures for selection of chemotherapy drugs). The device has the perspective to be integrated into an automated theranostic technology or system to evaluate specific cancer cells types and to sort them in designated groups.

Nanoplatform for natural and synthetic compounds with synergistic cytotoxic effect Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-2553 2020 - 2022

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Project website: https://www.researchgate.net/project/Nanoplatform-for-natural-and-synthetic-compounds-with-synergistic-cytotoxic-effect

Abstract:

This project is an interdisciplinary research that integrates the expertise of chemists, physicists and physicians, involving three research groups, two from UPB and the other from UMF that have already collaborated. The scope of this project is the development and testing at laboratory scale of a new complex targeted nanoplatform containing functionalized mesoporous silica nanoparticles (MSN) coated by fucoidan, a natural sulfated polysaccharide with anticancer and immunotherapeutic activity, for Irinotecan that integrates at least 3 functionalities (TRL4): carrier, targeting and intracellular delivery. The development of the new platform is based on the concept that an oral administration of the Irinotecan, a cytostatic agent, commonly used for colon cancer, combined with fucoidan, could increase its therapeutic efficiency and reduce side effects and its gathers the most advanced scientific results for the encapsulation, targeting and controlled intracellular release of the cytostatic agent (TRL3). All these components were proved to be valuable for the drug delivery systems, but all of them were never assembled in a single advanced delivery system with expected synergistic effect, and this is the step forward in our research and the novelty of this proposal for a laboratory demonstration. Based on our knowledge, it is for the first time that Irinotecan-loaded MSN is combined with fucoidan for a synergistic anticancer effect. Another novel aspect of this proposal consists in identification of membrane/intracellular localization of nanoplatform used for cytostatic agent delivery by using hyperspectral microscopy. Modulation of Irinotecan-nanoplatform cytotoxic activity will highlights the main endocytotic mechanisms involved in nanoplatforms uptake.

Current challenges and dielectric-based techniques to characterize MSCs and their differentiated progeny Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-Franța (bilaterale)
PN-III-P3-3.1-PM-RO-FR-2019-0237 2019 - 2021

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); CNRS - UMR 8203 Gustave Roussy - PR2 (FR)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Project website: https://umfcd.ro/

Abstract:

Separation of stem cells and their derivatives in varying degrees of differentiation plays an important role in stem cell therapies and the possibility of selecting the most differentiated cells would significantly increase the effectiveness of these regenerative medicine procedures. The aim of the project is to characterize and separate human MS (MSCs) as well as differentiated cells from them through dielectrophoresis (DEP). Within the project, MSCs will be differentiated into osteoblasts, adipocytes and neurons, and the DEP spectra characteristic of each cell line will be measured and characterized. This will be done for several differentiation steps to assess whether it is possible to determine the degree of differentiation by DEP method. DEP chambers integrated into microfluidic chips will be designed and their ability to separate the cells according to the degree of differentiation will be tested.

NEW METHODS OF DIAGNOSIS AND TREATMENT: CURRENT CHALLENGES AND TECHNOLOGIC SOLUTIONS BASED ON NANOMATERIALS AND BIOMATERIALS Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0062 2018 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA TRANSILVANIA BRASOV (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Project website: http://infim.ro/en/project/sanomat/

Abstract:

The project will develop novel conceptual and functional solutions of biomedical devices for treatment, reinforcement/repair/replacement (of human tissues) and diagnosis based on nanostructured and/or biocompatible materials, with high attractivity and certain potential for technology transfer to industry. The experience of the interdisciplinary consortium will allow a passage from concepts of nanomaterials and biomaterials with extended and/or complementary functional features to implementation to new biomedical applications of great interest: (i) antitumoral therapeutic systems (by localized magnetic hyperthermia, photodynamic therapy and drug delivery); (ii) biocompatible compounds with enhanced antimicrobial efficacy; (iii) stent or vein/arterial filters implants based on ferromagnetic shape-memory alloys (with the advantage of repositioning without the need of new invasive interventions); (iv) personalized bone regenerative implants (i.e. porous ceramic scaffolds for bone tissue engineering; dental implants with rapid osseointegration); (v) (bio)sensors for monitoring the bioavailability of pharmaceutical compounds and detecting the reactive oxygen species and their biologic effect; and (vi) correlation of physico-chemical properties with clinical investigations for two types of aerosols (salt particles and essential oils), and their prospective coupling with possible synergistic effects. The synergic development of the institutional capacity of the project partners will be achieved by: creating new jobs and purchasing new equipment and software, providing technical/scientific assistance to the emerging institutions, initiating and fostering collaborations with partners from industry in view of technology transfer, and increasing the international visibility of the involved institutions by capitalizing on the obtained research results. The project will create the core of the first national cluster in the field of healthcare technologies.

Integrated and innovative key actions for mycotoxin management in the food and feed chain Call name: EC - H2020
H2020-200216-678781 2016 - 2020

Role in this project: Key expert

Coordinating institution: CONSIGLIO NAZIONALE DELLE RICERCHE

Project partners: CONSIGLIO NAZIONALE DELLE RICERCHE (IT); INSTITUTE OF PLANT PROTECTION CHINESE ACADEMY OF AGRICULTURE SCIENCES (CN); LIMITED LIABILITY COMPANY STREAMOZONE (UA); LIAONING ACADEMY OF AGRICULTURAL SCIENCES (CN); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE (RO); EIDGENOESSISCHES DEPARTEMENT FUER WIRTSCHAFT, BILDUNG UND FORSCHUNG (CH); BOORTMALT NV (BE); INTERNATIONAL INSTITUTE OF TROPICAL AGRICULTURE (NG); SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES (CN); LAVIOSA CHIMICA MINERARIA SPA (IT); CONFEDERATION EUROPEENNE DE LA PRODUCTION DE MAIS (FR); UNIVERSITEIT GENT (BE); SHANGHAI JIAO TONG UNIVERSITY (CN); TEKNOLOGIAN TUTKIMUSKESKUS VTT OY (FI); LESAFFRE INTERNATIONAL SARL (FR); TURKIYE BILIMSEL VE TEKNOLOJIK ARASTIRMA KURUMU (TR); JIANGSU ACADEMY OF AGRICULTURAL SCIENCES*JAAS (CN); BUHLER AG (CH); UNIVERSITAT DE VALENCIA (ES); AUSTEP-AUSTEAM ENVIRONMENTAL PROTECTION SPA (IT); Zhejiang University (CN); Huazhong Agricultural University (CN); HUBEI PROVINCIAL ACADEMY OF AGRICULTURE (CN); Institute of Medicinal Plant Development , Chinese Academy of Medical Sciences (CN); SYNGENTA ITALIA S.P.A. (IT); UNIVERSIDAD NACIONAL DE RIO CUARTO (AR); ANHUI AGRICULTURAL UNIVERSITY (CN); FACULTY OF AGRICULTURE - UNIVERSITY OF BELGRADE (RS); Chinese Academy of Agricultural Sciences (CN); UNISENSOR SA (BE); UNIVERSITA CATTOLICA DEL SACRO CUORE (IT); STICHTING WAGENINGEN RESEARCH (NL); ASSOCIATION GENERALE DES PRODUCTEURS DE MAIS (FR)

Affiliation: INSTITUTE OF PLANT PROTECTION CHINESE ACADEMY OF AGRICULTURE SCIENCES (CN)

Project website: http://www.mycokey.eu

Abstract:

Prim - Performance and innovation in management Call name:
POCU 227/3/8/117868 2018 - 2019

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE - IBA BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE - IBA BUCURESTI ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU BIORESURSE ALIMENTARE - IBA BUCURESTI ()

Project website: https://bioresurse.ro/en/blogs/proiecte/prim-performan%C8%9Ba-%C8%99i-inovare-in-management

Abstract:

The objective of the project: improvement of managerial, entrepreneurial and human resource management skills, as well as the ability to use and promote current and innovative management tools, methods, practices and standards for 510 managers, entrepreneurs and employees of the human resources departments in the potential sectors Competitive and high specialization: Tourism and ecotourism, Food and beverage processing and Textiles and leather, from the Central Region and supporting 48 SMEs in order to review / develop long-term strategic plans.

Specific objectives:

Raising the awareness level regarding the importance and the need for continuous professional training among companies from competitive and highly specialized economic sectors - Tourism and ecotourism, Food and beverage processing and Textiles and leather goods in the Central Region through an awareness campaign aimed at at least 600 people (managers, entrepreneurs and employees from human resources departments) from at least 50 companies in the area, for 12 months;

professional development of 510 managers, entrepreneurs and employees from human resources departments from at least 50 companies active in Tourism and ecotourism, Food and beverage processing and Textile and leather - economic sectors with competitive potential and intelligent specialization, from the Central Region;

developing and testing a sustainable strategic planning framework among at least 48 SMEs in the sectors with competitive potential and intelligent specialization: Tourism and ecotourism, Food and beverage processing and Textiles and leather goods in the Center Region, over 10 months.;

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects