BrainMap

Ioan Andrei Dascalu

- INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Researcher

Expertise & keywords

BIOMAT4CAST - PETRU PONI INSTITUTE OF MACROMOLECULAR CHEMISTRY MULTI-SCALE IN SILICO LABORATORY FOR COMPLEX AND SMART BIOMATERIALS Call name: P 5.8 - SP 5.8.1 - Premiere Orizont Europa - Instituții - Competiția 2023
PN-IV-P8-8.1-PRE-HE-ORG-2023-0048 2023 - 2027

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://icmpp.ro/projects/l1/about.php?id=69

Abstract:

The aim of the BioMAt4CAST - Support project is to strengthen the institutional capacity of ICMPP, through the institutional award given to organizations that successfully apply and implement projects financed by the European Commission's Innovation Research Framework Program. The funding allocated through the BioMAt4CAST – Support project supports the project signed with the European Commission, BioMat4CAST (GA 101086667), by creating new support activities. The funding obtained through the European project is mainly focused on the molecular modeling and simulation team and less on the experimental team. For this reason, BioMat4CAST - Support will be directed to the priority financing of experimental research activities that are not provided in the already signed project with the European Commission, procurement activities for the development of the research infrastructure and those for disseminating the results. Thus, the proposed activities will lead to the strengthening of the institutional capacity to sustainably participate in new competitions organized in the Innovation Research Framework Program of the European Commission.

Versatile molecular vectors with tailored carrying and actuating abilities, dedicated to gene and drug delivery in fight against cancer Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1523 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://www.intelcentru.ro/tm-vector/index.php

Abstract:

Gene therapy represents nowadays one of the most challenging promises for the cure of cancer, rare, and severe diseases. The speed of the steps toward it strongly depends on the efficacy and reliability of the molecular tools involved in the manipulation (isolation, reconfiguration, multiplication) and vehiculation (native state preservation, dense packaging, targeted and “stealth” delivery, local protection) of the nucleic acids.

The main objective of TM-Vector project is to develop a highly reproducible macromolecular edifice capable to function as a cooperative carrier for nucleic acids, characterized by the ability to be post-decorated with biochemical and / or pharmacologic active molecules, by virtue of dynamic processes of selective affinity of host-guest type. The particular architecture of the carrying vector will offer three unique functional properties, representing our original contribution to the practice of nucleic acid vectorization: (i) the ability to target various cell receptors; (ii) the possibility to concomitantly vectorize several types of active molecules (e.g. nucleic acid molecules and pro-drug molecules); (iii) the capacity to selectively attach molecules having neat different volumes and conformations.

TM-Vector project could have societal impact, contributing to the improvement of the quality of life of sufferers. The applied research directions could also contribute to the technology of gene and drugs carriers produced at biopharmaceutical scale.

Metal-organic frameworks based on fluorinated therphenilic ligands for gas storage and separation Call name: P 1 - SP 1.1 - Proiecte de cercetare Postdoctorală
PN-III-P1-1.1-PD-2019-1303 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: https://icmpp.ro/projects/l1/about.php?id=19

Abstract:

Proiectarea si izolarea a trei acizi dicarboxilici cu o catena terfenilica partial fluorurata sunt prezentate si explicate tinand cont de doua aspecte. Dimensiunea, mai exact lungimea acizilor dicarboxilici are drept scop formarea porilor de dimensiuni mari in cadrul retelei de coordinare. Functionalitatea care in acest caz este datorata prezentei atomilor de fluor va asigura stabilitatea si hidrofobicitatea retelei de coordinare precum si interactia cu gazul ce urmeaza a fi stocat sau separat. Retelele hibride izolate vor fi evaluate din punct de vedere al suprafetei specifice si al cristalinitatii, iar sinteza lor va fi permanent modificata pentru a obtine proprietatile optime ale retelei metal-organice.

Mimicking living matter mechanisms by five-dimensional chemistry approaches Call name: P 4 - Proiecte Complexe de Cercetare de Frontieră
PN-III-P4-ID-PCCF-2016-0050 2018 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.intelcentru.ro/5D-nanoP/

Abstract:

Mimicking the living matter mechanism of cooperation by complementarity represents one of the most challenging tasks of supramolecular chemistry. For now the solution consists in using particularly designed molecular unimers, endowed with the necessary amount of chemical information.

The 5D-nanoP project is dedicated to interfacing the fundamental research area of constitutional dynamic chemistry with the practical approaches of medicinal chemistry and biomedical applications. In the spirit of a metaphor of Jean-Marie Lehn (Nobel Prize in Chemistry, 1987), the project aims to materialize the concept of 5D chemistry in designing, synthesizing, characterizing, and using molecules with conditional affinity, to build versatile supramolecular nanoplatforms able to vectorize compounds of pharmaceutical or biochemical relevance, and genetic actuators, all of them involved in physiologic and pathologic processes at cell- and tissue-level.

The project will add the layer of 5D chemistry over the backgrounds of molecular assembling line techniques to produce particulate nanoplatforms, self-assemblable in the virtue of the chemical information stored by the designed unimer molecules. Two modern techniques of building dynamic chemical structures will be considered: (i) the use of self-immolative linkers, and (ii) the space stepwise and time phased (microfluidic) assisted synthesis. To prove the applicability of the produced nanoplatforms, an ex vivo cell cultivation system will be developed to emulate tissue/tumor niches.

Eight teams will be involved in the 5D-nanoP project to cover the main addressed research areas: (i) the in silico molecular design, (ii) the development of a unimers chemical library, (iii) the development of a molecular assembling line, (iv) the conjugation of the developed platforms with chemical species of biomedical interest, (v) the build of ex vivo emulating niches, and (vi) the bio-oriented assessment of nanoconstructs efficacy.

New coordinated porous polymers with variable sized organic ligands for gas storage Call name:
2016 - 2020

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" ()

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" ()

Project website: http://pocpolig.icmpp.ro/

Abstract:

SupraChem Lab - Laboratory of Supramolecular Chemistry for Adaptive Delivery Systems - ERA Chair initiative Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2016-0011 2016 - 2020

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.intelcentru.ro/suprachem_lab/PNIII/

Abstract:

The SupraChem Lab - Support Project aaims to complements the European funding for the WIDESPREAD 2-2014 project: ERA CHAIR, no. 667387: SupraChem Lab - Laboratory of Supramolecular Chemistry for Adaptive Delivery Systems ERA Chair initiative Project.

The Orizont 2020 project started in July 2015 and aims to create a team to conduct advanced research on supramolecular chemistry. The SupraChem Lab project benefits from the scientific support of several high-level chemists, including Nobel Prize-winning Professor Jean-Marie Lehn in 1987 and is considered the founder of the global supramolecular chemistry school.

Functional DNA nanostructures-gold nanoparticles for targeted gene therapy purposes Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-1444 2015 - 2017

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: http://rotarualexandru.wix.com/dnananogold

Abstract:

The new and emerging field of DNA nanotechnology centres around the unique self-assembly properties of DNA and other nucleotide derivatives to form nanoscale structures with predictable geometry and/or function. It includes studies of the basic self-assembly properties of single bases to large assemblies of hundreds of DNA strands. Chemical synthesis of short DNA sequences makes it possible to insert non-natural chemical modifications at specific positions in DNA strands. Such modifications include fluorophores, biotin and in particular reactive chemical linkers that in turn make it possible to covalently attach other molecules or nano-objects to DNA. In consequence, DNA Nanotechnology has the potential to solve one of the major challenges of Nanotechnology - the precise assembly of nano-scale materials for different applications. In this regard, DNAnanoGold project proposes to explore the potential of precisely assembled DNA nanostructures to be decorated with functionalized gold nanoparticles with the ultimate goal of creating functionalized nano-carrier for targeted gene therapy. The proposed system possesses biocompatibility and a very precise shape and size control. It takes advantage over other functionalized nanostructures by multiple active and recognition sites and by controlled fluorescent labeling. Besides the scientific value of the proposal, DNAnanoGold intends to create a unique young interdisciplinary research team in the emerging field of DNA Nanotechnology.

Biologically inspired systems for engineered structural and functional entities Call name: Complex Exploratory Research Projects - PCCE-2011 call
PN-II-ID-PCCE-2011-2-0028 2012 - 2016

Role in this project:

Coordinating institution: "Petru Poni" Institute of Macromolecular Chemistry

Project partners: "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "N. Simionescu" Institute of Cellular Biology and Pathology (RO); " Gheorghe Asachi" Technical University of Iasi (RO); " Costin D. Nenitescu" Institute of Organic Chemistry (RO)

Affiliation:

Project website: http://www.intelcentru.ro/Biomimetics_PCCE

Abstract:

The project aims to study, to develop and to preliminary test biomimetic structural and functional entities, able to act as gene transfection vehicles of non-viral type, and having a DNA packaging capacity of about 2  5 kilobases. The main features of these entities are: (i) the general structure of a polyplex, (ii) the functionality of a cargo-complex that chemomimic the histones, morphomimic the nucleosome and biomimic a virus like gene vector, (iii) the ability to include or to reversibly bind and transport (bio)chemical species necessary to assist the DNA vehiculation and trafficking, (iv) are based on fullerene-rich polymers and / or dendrimers, (v) the capacity to associate to artificial extracellular matrices, in order to generate gene delivery systems with transfection ability, for ex vivo applications. The developed entities will represent effective tools in genetic and tissue engineering, useful in health restoration, life quality enhancement, and to cure tissue and human organism deficiencies. The envisioned engineering strategy to build biomimetic entities may sustain a spin-off type transfer of knowledge towards hi-tech application areas, with a clear echo in clinics and, finally, in human health. The project involves seven complementary teams hosted by four research and academic institutions. In equilibrated ratios, senior, young and junior researchers will collaborate inside the project frame.

Bionanoconjugates formation by laser ablation in liquid Call name: Projects for Young Research Teams - TE-2011 call
PN-II-RU-TE-2011-3-0174 2011 - 2014

Role in this project:

Coordinating institution: Institutul de Chimie Macromoleculara "Petru Poni" Iasi

Project partners: Institutul de Chimie Macromoleculara "Petru Poni" Iasi (RO)

Affiliation:

Project website: http://www.intelcentru.ro/BioNP/index.html

Abstract:

The object of this proposal is the formation of metallic or metal oxide bionanoconjugates. Bionanoconjugates are functionalized nanoparticles, attached to biomolecules. The formation method we propose is based on laser ablation of the metal or metal oxide immersed in an appropriate liquid medium (solution). The biomolecules (or other species that will subsequently react with the biomolecules) are present in the solution and will act as capping agent, preventing the agglomeration of the formed nanoparticles and stabilizing the obtained colloid. The bionanoconjugates thus formed suitable for biological applications.

We will produce and characterize cysteine – gold nanoconjugates in aqueous solution and oleic acid coated magnetite (Fe3O4) nanoconjugates that will be used afterwards to form bionanoconjugates of interest.

Synthesis and in vitro/in vivo assessmnet of new conjugates with antimicrobial activity Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-Moldova (bilaterale)
PN-III-P3-3.1-PM-RO-MD-2016-0110 2016 -

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); Institutul de Chimie al Academiei de Științe a Moldovei (MD)

Affiliation:

Project website:

Abstract:

Propunerea de proiect se axeaza pe o cercetare interdisciplinara prioritara a nanomedicinei: nanosisteme de transport cu eliberare controlata de medicamente, incadrandu-se in prioritatile tematice ale programelor PN III si Orizont 2020. Obiectivul strategic al acestui proiect este de a dezvolta o colaborare stiintifica intre parteneri din diferite tari cu competente complementare, care sa creeze premisele recunoasterii si integrarii colectivelor in proiecte internationale. Proiectul isi propune instruirea si perfectionarea tinerilor cercetatori, eficientizarea schimbului de experienta intre parteneri, cresterea transparentei si credibilitatii in fata partenerilor internationali prin implicare in propunerile de proiecte europene. Prezentul proiect are trei obiective stiintifice majore: (i) sinteza, caracterizarea fizico-chimica si testarea in vitro si in vivo de noi compusi mic moleculari cu activitate antimicrobiana (derivaţi ai oxindolului, oxadiazolului, triazolului, tiazolidinelor); (ii) sinteza, caracterizarea fizico-chimica si testarea in vitro si in vivo a complecsilor de incluziune pe baza de ciclodextrine adecvat functionalizate si compusi mic moleculari sinteti in cadrul obiectivului (i), pentru a obtine sisteme de transport si eliberare controlata de medicamente; (iii) valorificarea rezultatelor prin prezentarea la manifestari stiintifice,vpublicarea in reviste cotate ISI si pregatirea de proiecte stiintifice pentru competitii lansate in Programul Orizont 2020.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects