BrainMap

Mrs. GEORGIANA-ILEANA BADEA

PhD

Researcher - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Researcher

Web of Science ResearcherID: J-2512-2014

Curriculum Vitae (26/02/2024)

Expertise & keywords

The development of an innovative product based on increasing the therapeutic potential of some extracts obtained within CROMATEC PLUS SRL Call name:
Proiect tehnologic inovativ - Apel 202, MySmis 156316 2023 - 2023

Role in this project: Key expert

Coordinating institution: CROMATEC PLUS SRL

Project partners: CROMATEC PLUS SRL (); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE ()

Project website:

Abstract:

Development of New PHYTo-formulations with enhanced BIOACTive potential based on polyphenols complexes from plants and vegetal by-products Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3945 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); UNIVERSITATEA BUCURESTI (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: https://www.incdsb.ro/p/nphytbioact/Rezultate.html

Abstract:

NPHYTBIOACT project intends to demonstrate the feasibility of using innovative technologies to improve natural resources (plants and vegetal by-products) use and to increase the efficiency of phyto-products formulation. The core objective of the project: to settle a complete solution for development and lab-scale validation of new phyto-formulations with enhanced bioactivity. Achieving the NPHYTBIOACT major goal implies the following technological downstream: 1.Validation of the innovative technologies of extraction existing at the consortium level (TRL 3) for silymarin extraction from milk thistle and polyphenols/flavonoids extraction from rosehip; 2.Development and characterization of phytosomes (phyto-phospholipids complexes) based on complexes “active compound –phospholipids” to be further used in phyto-products formulation. In our case active compound are silymarin, respectively polyphenols/flavonoids while phospholipids are phosphatidylcholine, phosphatidylethanolamine phosphatidylserine; 3. Lab-scale new phyto-formulations based on the developed phytosomes & validation of the new-formulations

At the project completion the following outcomes will be provided: two validated extraction technologies (microwave assisted extraction), for silymarin from milk thistle (plant, by products) and polyphenols/flavonoids from rosehip (plant, young branches, by-products) and selective concentration and standardization in rutin, quercitrin and kaempherol will be performed; lab-scale validated procedures for phytosomes synthesis, silymarin-phytosomes, respectively flavonoids-phytosomes; validated formula for new highly bioactive phyto-products including synthesized phytosomes.

NPHYTBIOACT, aims to perform a step forward from the results existing at the consortium level, targeting to improve the existing know-how in order to obtain new phyto-products with enhanced bioactivity and increased solubility characteristics in physiological relevant fluids.

Fast analysis method of aspartame from foods using an amperometric enzymatic biosensor Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0503 2017 - 2018

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/Aspsense/PED-180-ASPSENSE.htm

Abstract:

This demonstrative project aims to develop and validate in laboratory a fast analytical method for detection of aspartame from food samples based on a combination of an amperometric enzymatic biosensor and a Low-noise potentiostat. The growing use of aspartame in the food industry requires the development of rapid and effective methods for its determination. The project aims to provide a cost effective and easy to use analytical method of aspartame. The detection principle of the biosensor is based on enzymatic oxidation of aspartame catalyzed by carboxyl esterase (CaE) and alcohol oxidize (AOX), with the production of hydrogen peroxide that is electrochemically quantified. The developed potentiostat used for the quantification of the biosensors’ amperometric signals has two building blocks: (i) a potentiostat circuit that provides constant continuous voltage and (ii) current sensing circuit to quantify the current solution ICELL related with the concentration of aspartame. Low-pass filter will be added to the current sensing circuit’s feedback loop to diminish the induced electromagnetic noise effects. The consortium combines the vast experience in the field of biosensors and enzymology of National Institute of R&D for Biological Sciences with the know-how in electronic potentiostat design of the University Politehnica of Bucharest.

Pencil˗based sensor array for naringenin like compounds analysis from beverages Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0477 2017 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.chimie.unibuc.ro/cercetare/analitica/PED_2017_David_Iulia.pdf

Abstract:

The health benefits of phenolic antioxidants from food and beverages is well known. At present, there are no specific legislative or regulatory requirements with respect to antioxidant capacity of a compound nor a standard method for naringenine (NG) and derivatives quantification. Flavonoid antioxidants of NG and derivatives type exist in different concentrations in largely consumed beverages (beer, juice, tea) worldwide. Therefore, there is a great demand on cheap and non-polluting methods for rapid, routine determination of the composition of complex samples with implications on human health. The aim of the present project is the development and validation of a method for NG and derivatives determination and of a dual sensors array based on disposable pencil graphite electrode (PGE) which has good electrode characteristics, is non-toxic, cheap, easy to procure, being largely commercially available. The device intended to be developed and validated consists of a bare PGE for the content and a DPPH-modified –PGE for the antioxidant efficacy assessment of NG and derivatives from beverages, using methods already developed by project team members (coordinator-UB has experience in voltammetric methods development based on PGE; partner P1- NIRDBS has expertise in methods and sensors development pot the assessment of antioxidant efficacy of compounds from different matrixes). According to the existing team members’ publications, this proposal starts from TRL2 and reaches TRL4 after the development and validation of the dual sensors array. The proposed device could be used as a reliable and rapid tool for beverages process control in order to replace tedious and time-consuming analysis, if yes/no decisions should be taken.

High Valorisation of Press Cake Resulted in Processing of Milk Thistle Oil by Cold Pressing Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0119 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); HOFIGAL EXPORT IMPORT SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: https://www.chimie.unibuc.ro/cercetare/analitica/VALSUSA.pdf/

Abstract:

The project is targeting two main objectives: a) development of efficient extraction technologies to support the higher valorisation of byproduct resulted from milk thistle processing to obtain oil; b) strenghtening the collaboration between academic research and industrial end-users and enhancing the human resource expertize. Achieving the first objective involves the following subsidiary objectives: characterization of by-product from the production of oil thistle in terms of profile composition and initial efficacy; development and optimization of extraction technologies; formulation and characterization of extracts with high content of sylimarin; demonstration/testing/validation of realised extraction technologies for the trader. At the end the obtained product have to have a silymarin concentration of at least 50%. The second objective consists of training internships of master students at the trader facilities, to enhance their entrepreneurial capabilities, and the training of specialized HOFIGAL staff in academic laboratories.

The assessment of composition profile will be performed by HPLC – DAD- MS, capillary electrophoresis, fluorimetric methods, chemiluminescent method etc. Silymarin extraction will be accomplished using: ethyl alcohol, methyl alcohol, ethyl acetate, dioxane, water or various mixtures solvent/water. It will be performed the study of the temperature influence and the influence of the extraction technique used: percolation / maceration, Soxhlet, and accelerated extraction based on the use of cavitation phenomena (ultrasound or microwave assisted) on sylimarin extraction yield. The aim is to settled extraction technologies based on the use of non-flammable solvent (or with reduced flammability) and mild working conditions, as technology agreed by trader. The extracts antioxidant capacity and their antitumoral effects will be assessed. The obtained silymarin concentrate will be used by HOFIGAL in phyto-drugs formulation and food supplements.

Integrated system for monitoring and bioremediation of metal/radionuclides - contaminated area Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0608 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); CP MED LABORATORY SRL (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU METALE SI RESURSE RADIOACTIVE - I.C.P.M.R.R. BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/Imonbio/Proiect.html

Abstract:

The core objective of the proposal consists in the development of new integrated system for monitoring and bioremediation of metal/radionuclides from contaminated areas, this meaning the complex approach of the subject from the following points: development of new analytical methods/devices applicable to fast assessment/monitoring of heavy metals and radionuclides from contaminated areas; development of a bio-remediation strategy based on micro-organisms effective against the two classes of contaminants. The project proposes as monitoring devices an array of electrochemical (enzymatic and micro-organism based) biosensors, selective and sensitive for heavy metals and radionuclides. Envisaged heavy metals are copper, lead, mercury, cadmium, zinc, while envisaged radionuclides are uranium, radon, and thorium.

The following subsidiary objectives are envisaged:

 Design of a microorganisms based bio-remediation strategy and development of the experimental model on lab-scale;

 The versatile use of Pseudomonas and Clostridium strains, both in bio-remediation strategy (as biocatalysts) and in biosensors construction (as pollutants bio-recognition element).

 Design, construction and validation of the new analytical device: biosensor platform based on microorganisms and enzymes immobilization.

 Design of a demonstrator model to support the bio-remediation strategy

Sustained dissemination actions (ISI papers, Conferences) and patent request are also planned.

Higher Valorisation of Vegetal By-Products and Wastes to Support Sustainable Use of Natural Resources Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0361 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/HIVEGRES/index_ro.html

Abstract:

The project Higher Valorisation of Vegetal By-Products and Wastes to Support Sustainable Use of Natural Resources - HIVEGRES- proposes, in general terms, new technologies able to improve the natural resources use (wastes and by-products) and to increase the efficiency of bio-products formulation in terms of process control and formulation technology. The project frames in the general field of Industrial Green Technology aiming to acquire, by safe methods, an enhanced content of high quality natural nutraceutics to be used as supplements and additives in obtaining efficient functional phyto-products.

HIVEGRES project aims to provide industrial innovative solutions (sustained by a strong scientific basis) to cover the industrial activities which are supporting the base for launching new healthy products, conforming to EU regulations and claims, with lower processing and production costs while enhancing the natural resources sustainable use; the project is focusing mainly on the phyto-pharmaceutical products sector.

In the frame of present project the practical addressed issues are:

1) Improved, sustainable use of natural resources by recycling vegetal wastes and by-products, improving the production yields and, consequently saving material from disposal while improving the whole process

2) Introducing new tools to control and monitor the production process and to assess the products quality: nano-sized biosensors array and flow injection analysis (FIA) methods and device

3) To create new opportunities for functional phyto-products diversification and opening new prospects in the market segment for the involved Small and Medium Enterprises (SMEs).

To achieve the main goals of the project within the proposed 24 months project, the following main active principles are envisaged: the most efficient xanthophylls (Lutein and Zeaxanthin), carotenoids and anthocyanins from vegetal by-products, respectively wastes. For each active principle a specific vegetal source will be addressed, accordingly to the existing by-products and wastes and to the expected content of compounds occurring in each source.

Targeted vegetal materials are: by-products resulted from Vaccinium vitis-idaea, (cowberry), Myrtilli fructus and leaves (bilberry), Cynosbati fructus and leaves (rosehip), Hippopheas fructus (sea-buckthorns) and leaves (wild and cultivated in Romania, mainly Northern part) and vegetables wastes resulted from cultivars (all over the country) of tomatoes, carrots and egg plants.

Two important innovative approaches are proposed by HIVEGRES: in the products quality control (raw material and final products) by introducing nano-sized sensors able to provide information which comply to EU claims, and in natural resources processing technology, by proposing an improved extraction technology able to lead to higher extraction yield of active principles.

3th International Conference and Innovation in Art Research and Technology Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2017-2093 2017 -

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website:

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects