BrainMap

Mr. Florin Borcan

PhD Chem.

Associate Professor - UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Researcher | Teaching staff | Scientific reviewer

Web of Science ResearcherID: not public

Expertise & keywords

Study on Molecular Docking, Synthesis and Characterization of a Polyurethane Biomaterial used as a DNA Carrier Call name:
UMFT-5EXP/1244/ 30.01.2020 2020 - 2023

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Project website:

Abstract:

Climate change, junk food and stress lead to many diseases; rare diseases are those disorders that affect a very small

part of the population and the costs of drugs' discovery exceed the sums what might be recovered by selling to patients.

Gene therapy is a natural pathway of treating rare diseases and it is based on the delivery of genetic material to replace a

mutant gene. This project is about the obtaining and complete characterization of a polyurethane delivery system used

for DNA. Initially it will be computational studied the possibilities of structural modeling of the carrier so that the

encapsulation efficiency to be the highest. Based on the initial results, nanocarriers with different sizes will be

synthesized and they will be characterized by: studies of size and stability to agglomeration, electron microscopy, thermal

behavior, degradation studies in a degradation simulated medium, penetration of membranes, studies determining the

encapsulation efficiency, in vitro and in vivo toxicity studies and efficacy studies on animal models.

Advanced recovery of useful materials from used catalyst wastes Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0612 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE

Project partners: INSTITUTUL DE CHIMIE (RO); PRO AIR CLEAN ECOLOGIC S.A. (RO); INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Project website: http://acad-icht.tm.edu.ro/granturi/REMACAT.html

Abstract:

Responsible management of wastes coming from technological processes is a great priority highlighted by the internal and European legislation. According to the European legislation this means responsible management of chemical wastes by each member state, and also, of all the factors implied the life cycle of all products, and an important economical opportunity as well.

This project has, as main goal, the environment protection by recycling used complex catalysts having as support and flowing agent organic solvents in the purpose of reducing the emissions of heavy metals in environment and reducing pollution with aromatic organic materials. The second major objective, the economical one, deals with the valorisation of metallic compounds as advanced materials for the use in water cleaning systems and the advanced recycling of used solvents and water by means of green chemistry principles. The object of the project refers to the used complex catalyst CuAlCl4*toluene resulted from the COSORB processes, according to the following: separation and purification of toluene, recovery of copper as metallic powder, valorisation of aluminum(III) as flocculation agent in the cleaning water systems. The last objective also means the valorisation of the existent iron wastes at industrial partner, in order to obtain a complex flocculation agent Al(III)-Fe(III).

The objective of the project is placed in the research frame 3. Environment – 3.2.5. Theme Technologies for treating hazardous wastes. According to this theme, we accomplish:

- Chemical evaluation of the used complex catalyst – as waste;

- Establishing a unitary technology starting from the used complex catalyst and iron waste and providing reusable materials as an outcome.

The following steps are involved:

- setting up the separation and purification technology for the organic and inorganic components;

- elaborating the technology of metallic components valorisation as advanced materials;

- elaborating the technology of inorganic components valorisation as flocculation agents for water treatment;

- the design and making of the industrial plant;

- technological processes implementation;

- toxicological control and pollution impact on each step and products.

The novelty of the proposed solution refer to: (i) setting up a unitary technological flow; (ii) selection of the most adequate chemical methods for elaboration of economical and efficient technologies following the principles of green chemistry; (iii) obtaining high purity materials (toluene, copper, flocculation agents); (iv) obtaining a composite flocculation agent (also the technology) Al(III)-Fe(III) within the desired proportions and synergic effect;(v) the toxicological and pollution control of each technological step in order to control the ecological risk.

Participative management will be implemented in the partners’ relationship, the coordination of the activities and the relation with the Contractual Authority. Structured into 5 chapters, corresponding also to the 5 working packages, this proposal is the outcome of the project management activities to which all partner entities have contributed.

The impact of the project, generated by its results, is found in the environment protection (reducing the metal and hydrocarbon pollution risk), technical/scientific (elaboration of technologies and toxicological and chemical analysis systems), economical (efficiency/costs ratio) and social (eliminating the risk regarding people’s health and creating new work places) aspects.

Solving this multi-, inter- and transdisciplinary project implies activities specific to industrial research supported on fundamental knowledge and activities. The results obtained in the frame of this project is a unitary technological process and corresponding industrial plant implemented at the industrial partner and will be disseminated by two patents, communications, publications both on national and international levels and by organizing one workshop.

POLYETHER-URETHANE NANOCAPSULES USED AS TRANSDERMAL TRANSPORT VEHICLES FOR ACTIVE BIOLOGICAL SUBSTANCES Call name:
PN-II-RU-PD-2009 2010 - 2012

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Project website:

Abstract:

This project seeks to eliminate the disadvantages administration of biologically active substances by mouth or injection through the synthesis of polyether-urethane nanocapsules that can be used as transport vehicles patch. Synthesis involves a new technique of polycondensation at the interface of two phases combined with a spontaneous emulsion in three stages: preparation of a homogeneous organic layer consisting of isocyanate component, a lipophilic surfactant and solvent (organic phase) and an aqueous layer includes water, the hydroxyl component and surfactant hydrophilic (aqueous phase); injecting the organic phase in the aqueous phase under magnetic stirring at which point precipitate the nanocapsules instantly, and the primary membrane is formed immediately; remove the solvent by evaporation at low pressure. Cytotoxicity of polyether-urethane material is tested by testing AMES, LDH and Trypan blue. The amount of biologically active substances are embedded in nanocapsules is optimize by the use of polyols with different molecular weights. The efficiency tests that are determined by fluorescence microscopy depth to which penetrate the skin and during nanocapsulele are bioavailable.

NANOTEHNOLOGIES OF POLYURETHANES COATED BY ANTIMICROBIAN LAYER Call name:
CNCSIS TD 137 / 2007 2007 - 2008

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE VEST TIMISOARA

Project partners: UNIVERSITATEA DE VEST TIMISOARA ()

Affiliation: UNIVERSITATEA DE VEST TIMISOARA ()

Project website:

Abstract:

THE GLOBAL POLYURETHANES PRODUCTION IS IN A CONTINUOUSLY INCREASE IN THE LAST DECADE AND THIS IS BECAUSE THE DIVERSITY OF THE POLYURETHANES MATERIALS APPLICATIONS: FURNITURE INDUSTRY (CUSHIONS, QUILTS, MATTRESSES, FURNITURE), THE AUTOMOTIVE INDUSTRY (CHAIRS, ANTISHOCK BARS, AUTOMOTIVE FRONT PANEL), BUILDINGS INDUSTRY (ORNAMENTAL COLUMNS, HIGH THERMAL ISOLATING BRICKS), THE MEDICAL INDUSTRY (PROSTHESES, PREORDAINED PERMEABILITY MEMBRAINS, MEDICAL DEVICES) ETC.THE SYNTHESIS OF POLYURETHANE MATERIAL WITH ANTIMICROBIAL PROPERTIES IS AN ACTUAL THEME FROM THIS DOMAIN, ITS IMEDIATELY APPLICATIONS ARE IN A BIG NUMBER: THE ELIMINATION OF THE CONTAMINATION POSIBILITIES OF HUMAN BODY AND THE BACTERIA COLONIZATION DEVELOPING POSIBILITIES AT THE CONTACT BETWEEN A PERSON WITH THE CHAIRS OF MASS TRANSIT AUTOMOTIVES, OR BETWEEN A PERSON AND A CUSHION, QUILT AND MATTRESS FROM POLYMER MATERIAL, THE ELIMINATION OF BACTERIA DEVELOPMENT INSIDE THE SHOES AND THE PREVENTION OF THE INFECTIONS DUE TO THE CENTRAL VASCULAR CATHETERS. THIS RESEARCH PROJECT WANT TO STUDY THE BINDING POSIBILITIES OF SOME ANTIMICROBIAL SUBSTANCES LIKE ANTIBIOTICS, ANTISEPTICS ETC. IN THE POLYURETHANE MATRIX, AND WHILE THE USAGE, IT WILL BE DESORBED PREVENTING THE DEVELOPING OF MICROBIAL CULTURES. IN ORDER TO OBTAIN SUCH AS POLYURETHANES, I WILL START THE SYNTHESIS WITH SOME STANDARD STRUCTURE WITH ACIDIC OR BASIC PROPERTIES AND I WILL BIND OF THESE ANTIMICROBIAL SUBSTANCES MOLECULES. THE STUDY WILL CONTAIN THE DEVELOPMENT OF NEW METHODS AND TECHNIQUES TO INCREASE THE ANTIMICORBIAL SUBSTANCES QUANTITY, AND I WILL TEST THE RESULTS USING BACTERIA.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects