BrainMap

Florentina Gatea

Dr

Researcher - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Researcher | Scientific reviewer

Web of Science ResearcherID: https://publons.com/researcher/2777265/florentina-gatea/

Curriculum Vitae (27/10/2019)

Expertise & keywords

Development of New PHYTo-formulations with enhanced BIOACTive potential based on polyphenols complexes from plants and vegetal by-products Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3945 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); UNIVERSITATEA BUCURESTI (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: https://www.incdsb.ro/p/nphytbioact/Rezultate.html

Abstract:

NPHYTBIOACT project intends to demonstrate the feasibility of using innovative technologies to improve natural resources (plants and vegetal by-products) use and to increase the efficiency of phyto-products formulation. The core objective of the project: to settle a complete solution for development and lab-scale validation of new phyto-formulations with enhanced bioactivity. Achieving the NPHYTBIOACT major goal implies the following technological downstream: 1.Validation of the innovative technologies of extraction existing at the consortium level (TRL 3) for silymarin extraction from milk thistle and polyphenols/flavonoids extraction from rosehip; 2.Development and characterization of phytosomes (phyto-phospholipids complexes) based on complexes “active compound –phospholipids” to be further used in phyto-products formulation. In our case active compound are silymarin, respectively polyphenols/flavonoids while phospholipids are phosphatidylcholine, phosphatidylethanolamine phosphatidylserine; 3. Lab-scale new phyto-formulations based on the developed phytosomes & validation of the new-formulations

At the project completion the following outcomes will be provided: two validated extraction technologies (microwave assisted extraction), for silymarin from milk thistle (plant, by products) and polyphenols/flavonoids from rosehip (plant, young branches, by-products) and selective concentration and standardization in rutin, quercitrin and kaempherol will be performed; lab-scale validated procedures for phytosomes synthesis, silymarin-phytosomes, respectively flavonoids-phytosomes; validated formula for new highly bioactive phyto-products including synthesized phytosomes.

NPHYTBIOACT, aims to perform a step forward from the results existing at the consortium level, targeting to improve the existing know-how in order to obtain new phyto-products with enhanced bioactivity and increased solubility characteristics in physiological relevant fluids.

Obtaining new vector types for their phytotherapeutical principles, by means of biotechnological processes and the modeling of the phytotherapeutical principle's release mechanism Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0034 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO); UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/NEWBIOVECT/index.htm

Abstract:

The goal of the NEWBIOVECT consortium is to develop a new biomimetic biovectors – complex of the multi-membranes and active principles of a phytocomplex obtained from Symphytum officinale, Betonica officinalis, Salvia officinalis and Impatiens L. species concentrated extracts, such as polyphenols (can mimic the effects of cytokines, they have also been involved in the regulation of cell division and expansion), flavones, saponins (anti-inflammatory compounds that mimic the action of steroids), allantoin and polysaccharides (stimulate proliferation of keratinocytes and dermal fibroblasts). The project also aims to release in vitro and in vivo a therapeutic dosage of drug that heals wounds and reduces the inflammatory effects. The new biovectors will be will be kinetically characterized and will be establish of the mechanisms involved in the kinetic processes.

The development of new, advanced systems biovector phytotherapeutic compounds (active ingredients) aim to the skin wounds’ treatment improvement as well as shorter the hospital recovery time. This project focuses also on the superior valorizing of some well-known medicinal herbs (Symphytum officinale and Salvia officinalis), as well as the higher valorizing of Impatiens L. Species and Betonica officinalis which has not yet been introduced in Romania, for research and proceeding by now. Additionally, this project aims to transfer the new knowledge in the economic environment for a more efficient use of medicinal and aromatic plant species, and increase the quality and competitiveness of Romanian’s phyto-pharmaceutic products on domestic and foreign market.

The project results will get a technological impact considering the development of some new, nonconventional processes with high efficiency, in Romania, for obtaining and processing the herbs extracts.

The main objectives of the NEWBIOVECT project are: i) design and synthesis of novel polymeric and composite multi-membrane systems, macroporous and nanoporous membranes for active principles of a phytocomplex obtained from Symphytum officinale, Betonica officinalis, Salvia officinalis and Impatiens L. species concentrated extracts delivery; ii) kinetic studies concerning the active principles in vitro release from the obtained supports, and testing the obtained support for their biocompatibility; iii) accomplishment of the biovectors’ experimental lots for the phytopharmaceutical products with reproducible characteristics and evaluate in vivo therapeutic efficacy.

Flavone-Protein Systems Involved in Oxidative Stress Probed by Advanced Spectroscopic Methods Call name: Projects for Young Research Teams - TE-2012 call
PN-II-RU-TE-2012-3-0055 2013 - 2016

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation:

Project website: http://www.icf.ro/pr_2012/MVoicescu.pdf

Abstract:

The oxidative stress appeared as a necessity to express the bio-unbalance regarding the ratio between the antioxidant and oxidant chemical species, one of the major causes leading to organisms being taken ill. Based on previous experience and on the obtained results connected to the pro and anti oxidant activity of some molecules of biological interest, the main goal of this project is to develop quantitative methods to study biochemical aspects of some flavone-protein systems, in different media and partnership conditions (biommimetic and nanostructured systems), using Fluorescence, Raman, FTIR and EPR spectroscopies. The used systems are chosen in order to assure superior ways of organizing biological species. One follows/thinks of a detailed study regarding the spectrophotometric properties of flavonols and isoflavones in emulsion/micellar media and in lipidic bi-layers of lecithin on nanoparticles support. Monitoring and generating free radicals in the studied systems based on luminol-hydrogen peroxide are considered. The study is relevant for clearing up the antioxidant activity of different flavones classes and flavone-protein interactions in different media and partnerships conditions especially when associated with nanoparticles. These aspects lead to new insights on the oxidative stress process in the living organism, redox regulation and consequently, a priority in biochemical and biomedical domains.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects