BrainMap

Mrs. Flavia Adina Martin

PhD

Researcher - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Researcher

Web of Science ResearcherID: I-4925-2016

Curriculum Vitae (28/06/2024)

Expertise & keywords

Ketoconazole: from fundamentals to new antifungal formulations based on PAMAM dendrimers with improved biodisponibility Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0244 2022 - 2024

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/ket-in-pamam/

Abstract:

The goal of the proposed project is to create a young, multidisciplinary research team capable to promote new solid forms/formulations of active pharmaceutical ingredient (API) Ketoconazole with market potential. My research experience in APIs new solid forms development will be expanded with the knowledge about API-dendrimer encapsulation, antifungal activity and biocompatibility studies. The team consist of five young researcher (project leader - chemical engineer, 2 chemists, 1 biotehnologist, 1 dermatologist), one SR dermatologist and one postdoc.

Finding new solid forms/formulations of Ketoconazole with enhanced solubility and bioavailability can be the basis of a better product in order to maximize its therapeutic efficacy. For two new co-crystals, KTZ-Adipic Acid and KTZ-Sorbic Acid, with 100 and 40-fold increased solubility compared to commercial KTZ and for an KTZ-PAMAM complex, as APIs in optimized antifungal products with oral/topical administration, the research team will strengthen their market potential.

For the co-crystals we will complete the preliminary preformulation information with specific studies/assessment: compatibility with pharmaceutical excipients, in vitro and in vivo biocompatibility tests, a protocol for co-crystallization process at grams scale necessary in pharmaceutical industry for developing a successful industrial co-crystallization process.

Pathogenic microorganisms’ rapid detection and identification using high sensitive Raman spectroscopy Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0862 2015 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/ru381/

Abstract:

The bio-sensing for bacteria detection is currently explored by using various sensing materials and approaches but it is still a challenge to find an alternative to the conventional protocols, based on microorganisms’ cultivation. This project proposal provides an ultrasensitive and selective, but simple, rapid and inexpensive bacteria detection and identification method by using a receptor-free and innovative immobilization principle of the biomass. Raman spectroscopy, which combines the selectivity of the method with the sensitivity of the surface-enhanced Raman scattering effect (SERS), is used in correlation with Principle Component Analysis (PCA) in order to develop biosensors for pathogenic microorganisms. Most common pathogenic bacteria will be tested by applying an original immobilization protocol and the in situ synthesis method of the SERS-active nanostructures. The specific molecular information gathered from the spectroscopic data will be uploaded and analyzed by means of advanced statistical methods, with the final goal of creating an appropriate protocol which will be used on complex biological samples. The rapid pathogens identification and differentiation between multiple species, down to strain level will be carried out by means of SERS-PCA bio-sensing. Furthermore, the efficiency of multiple classes of antibiotics on bacteria viability will be investigated by SERS in order to obtain rapid and precise diagnostic and targeted treatment.

The improvement of the manufacturing technology of lead-acid batteries to be used for start-and-stop automobiles Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1226 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BABES BOLYAI (RO); ROMBAT S.A. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/rombss/

Abstract:

We propose a methodology for the improvement of fabrication technology for the positive electrodes used as components in the lead-acid batteries produced at sc rombat sa . The final goal of our consortium is to improve the current technology used by industrial partner for fabrication of the batteries to be used for start-and-stop automobiles (i.e . To satisfy the j240 – sae and en 50342-6 quality tests) . The proposed approach is designed for the optimization of the scientific and technological steps involved in the fabrication of positive electrodes . It integrates the fundamental knowledge obtained from ab initio calculations, synthesis of new chemical compounds, fabrication of new alloys and structural characterization of the materials used to fabricate the electrode, at both nanoscopic and mesoscopic scale . The key element for the integration of all these activities is the fabrication and characterization of functional prototypes by the industrial partner.

The main problem to be solved is to control the corrosion of the positive electrode during the charge-discharge cycles, imposed by the requests of the start-and-stop technology . The solutions proposed by our consortium are: (i) fabrication of new alloys to be used for the production of the metallic grid that support for the active mass of the electrode (ii) improving the fabrication technology of the metallic grid (iii) improving the electrochemical properties of the active mass by new fabrication technology and by the use of new additives to the active mass. We note here that for the negative electrode as well as for the electrolyte the standard products fabricated by sc rombat sa will be used . The project’s goal will be achieved by using a feed-back loop: the design of materials and the fabrication steps involved by each prototype will be refined by successive fabrication of the prototypes that will gradually incorporate the information produced by each partner . At each step of our methodology the full characterization of the electrochemical and structural properties of the materials and prototypes already fabricated will be used as starting point for further refinement of the fabrication technology . A continuous exchange of data between the research Institutes and the industrial partner is foreseen for the whole duration of the project . This will allow us to tune the results obtained in the laboratory with those produced in industrial conditions . At project’s term we will discuss the technological steps needed for the implementation of the results by using the infrastructure available at sc rombat sa.

ITERATIVE SYNTHESIS. NOVEL DENDRITIC MELAMINES INCORPORATING SERINOLIC UNITS. DESIGN, PREPARATION, STRUCTURAL ANALYSIS AND POTENTIAL APPLICATIONS. Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0128 2011 - 2016

Role in this project: Key expert

Coordinating institution: Universitatea BABES-BOLYAI Cluj-Napoca

Project partners: Universitatea BABES-BOLYAI Cluj-Napoca (RO)

Affiliation: Universitatea BABES-BOLYAI Cluj-Napoca (RO)

Project website: http://chem.ubbcluj.ro/~darab/projects.html

Abstract:

The Project deals with design, iterative synthesis, structural characterization and applications of new melamine of type G-2-D Dendrimers and dimeric G-2-Dendrons (G-2-D)2, having the general formulae CR{LT[LT(PG1,PG2)]2}2 and CL{T{LT[LT(PG1,PG2)]2}2}2 respectively [CR: CoRe; CL: Central Linker; L: Linker; T: 1,3,5-triazin-2,4,6-triyl unit (Branch Cell)]. PG1 and PG2 stand for two types of Peripheral Groups : C-2-(Me, Et, CH2OH)-substituted-2-aminopropane-1,3-diols (“Serinols”) as “Open Chain Units”, PG1) in tandem with “Closed Chain Units” (PG2): (O-masked)-4-piperidone derivatives or enantiopure cyclic acetals (4S,5S)-5-amino-4-aryl-1,3-dioxanes based on C-1-(p-nitrophenyl, optionally phenyl)-substituted-2-aminopropane-1,3-diols “Phenylserinols”). Contributions to iterative synthesis of highly elaborated melamines by repetitive amination of cyanuric chloride with different as versatile amino-nucleophiles are envisaged. Contributions to the use of rotational restricted interactions about Csp2(s-triazine)-N(exocyclic) partial double bonds in dendritic melamines, directed to their Host-Guest aptitude as supramolecular status, are targeted in solution and in solid state. Potential applications in medicinal chemistry (new delivery drug systems) and organic nanomaterials are under consideration. First use of C-2-substituted-2-amino-3-mercaptopropanols (“cysteinols”, available via our improved “serinolic” synthetic approach) in the above chemistry is also explored.

Ion sensing and separation through modified cyclic peptides, cyclodextrins and protein pores Call name: Complex Exploratory Research Projects - PCCE-2011 call
PN-II-ID-PCCE-2011-2-0027 2012 - 2016

Role in this project: Key expert

Coordinating institution: “Alexandru Ioan Cuza” University

Project partners: “Alexandru Ioan Cuza” University (RO); National Research and Development Institute of Isotopic and Molecular Technologies (RO); “Babes-Bolyai” University (RO); “Horia Hulubei” National Institute for Physics and Nuclear Engineering (RO); “Carol Davila” University of Medicine and Pharmacy (RO)

Affiliation: National Research and Development Institute of Isotopic and Molecular Technologies (RO)

Project website: http://science.research.uaic.ro/biosens/

Abstract:

Development of nanostructures capable of detecting and separating individual molecules and ions has become an important field of research. Particularly, protein-based nanostructures are attractive due to their ability for tunable molecular recognition and ease of chemical modification, which are extremely important factors on various applications. In this project, self-assembly functionalization will be approached, aimed at providing an efficient design for molecular recognition, ion sensing and separation, through new host-guest chemical methodologies, bio-nanofabrication and physicochemical manipulations methods. New crown ether type macrocycles, functionalized cyclodextrins and cyclic peptides will be engineered to work as specific molecular adaptors for the -hemolysin protein, giving rise to hybrid molecular superstructures possessing ion sensing and selectivity properties. The size and functionality of the macrocycles are targeted to ensure the anchorage in the pores and the selectivity of specific host-guest complexation processes. A surface detector array device suitable for use with a biosensor is envisioned, through ink printing nanotechnologies. The device architecture will be formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. Custom designed nanoscale bilayers containing selected receptors through cyclodextrins derivatives and macrocyclic peptides, self-assembled on different micro-nano arrays surfaces (polymers, Au or Si) will be fabricated. Further engineering of such functionalized nanomaterials based on molecular recognition and host-guest methodologies, in conjunction with flexible and mechanically robust enough substrate platforms, have the great potential for applications such as separation of nanoparticles, sensors, drug delivery, removal of heavy metals from aqueous solutions and chiral separation.

Modern high-troughput methodologies for obtaining and characterizing new solid forms of pharmaceutical compounds Call name:
POSCCE ID 536 2010 - 2014

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/pos/htpharma/

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects