BrainMap

Elena-Luiza Epure

Lecturer

Lecturer - UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Researcher | Teaching staff | Scientific reviewer

Web of Science ResearcherID: 57217869363

Expertise & keywords

Dynamic platforms based on oligo/polysaccharides networks obtained through thiol-ene coupling for biomedical applications Call name: P 4 - Proiecte de cercetare exploratorie - PCE-2021
PN-III-P4-PCE-2021-1365 2022 - 2024

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Project partners: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO)

Affiliation: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO)

Project website: https://icpm.tuiasi.ro/cercetare/proiecte-de-cercetare/

Abstract:

Current project proposal is focused on the development of chitosan based materials for preparation of hydrogels and submicronic particles (micro- and/or nano-gels) for medical applications. The proposal has an interdisciplinary character which can be resumed by the following key words: thiol-ene, chitosan, cyclodextrins, hydrogels, micro/nanoparticles and drug delivery. The general objective is to prepare innovative biomaterials based chitosan and cyclodextrin through radical addition thiol-ene covalent crosslinking reaction. The experimental objectives envisaged are: finding the optimal conditions for synthesis of chemically modified chitosan and cyclodextrin with double bonds and thiol groups; preparation and characterization of novel hydrogels and micro/nanoparticles and testing the applicative potential of the new developed biomaterials. The most important elements of originality are the following: synthesis of chitosan/cyclodextrin materials with improved drug absorption/delivery kinetics; the thiol-ene coupling between chitosan and cyclodextrin derivatives with a controlled amount of functionalities available for thiol-ene reaction will be used for the first time. In addition, a systematic study of the structural factors which are influencing the covalent crosslinking will be performed.

Using the combined computational techniques in predicting the transition temperatures of polymers Call name:
GnaC2018_91/2019 2019 - 2020

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Project partners: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI ()

Affiliation: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI ()

Project website: http://www.cercetare.icpm.tuiasi.ro/proiecte/tranzcomb/

Abstract:

Interesul industriei de prelucrare a polimerilor pentru tranzițiile termice crește în perspectiva corelării temperaturilor de tranziție cu structura polimerică. Design-ul rațional al polimerilor cu bune proprietăți termice se poate realiza cu ajutorul rețelelor neuronale. Modelarea moleculară fenomenologică, care aduce informații importante despre rolul interacțiunilor intra- și intercatenare asupra dinamicii structurale a polimerilor, ajută la dezvoltarea descriptorilor rețelelor neuronale.

Nanostructured azo-polymer films used as supports for cell cultures Call name: P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0508 2017 - 2019

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Project partners: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO)

Affiliation: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO)

Project website: http://www.cercetare.icpm.tuiasi.ro/proiecte/azonanosurf/

Abstract:

The subject of the present proposal has a strong interdisciplinary character, being situated at the interface between chemistry, physics and biology. The main research direction will be focused on the interactions between the surface relief profile of the cells substrate and the cells response (cell fate) to the mechanical signals induced by the substrate. In the last period more and more biological studies were dedicated to this problem, especially in the case of stem cells, taking into consideration the possibility of cells differentiation using only mechanical signals. In the tissue engineering this type of interactions between the substrate and the cells will be decisive for the fabrication of smart biomaterials. Ideal candidates for new types of cells’ supports are the azo-polymers, because in their case one can change the film surface configuration, elasticity, or other mechanical parameters using only the light as external stimulus. All the other external stimuli usually used for the modification of the mechanical properties of a material (pH, temperature, salts concentration etc.) will affect the cell function making difficult to understand the cells’ response. In the case of azo-polymers, using a polarized laser source one can generate surface relief gratings on the film surface. The geometrical parameters of the gratings (amplitude and periodicity) can be very well controlled through laser operational conditions. Different chemical structure of the azo-groups will be synthesized in order to evaluate the cells adhesion capacity and the cells fate, as a function of the relief characteristics. More of than the surface relief type (grating or islands) can be changed in contact with water, creating so-called dynamic surfaces.

Analytical methods for characterization of oligo/polypeptides and polysccharides applied in cosmetics and foods: proposal, development and validation Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0175 2016 - 2018

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Project partners: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Affiliation: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO)

Project website: http://www.ch.tuiasi.ro/cercetare/proiecte/AnaMet/default.html

Abstract:

This project aims to contribute to knowledge development in the area of physicochemical characterization methods applied to oligo/peptide and/or polysaccharide systems using the modern equipment recently acquired by SANIMED International Impex SRL company and the extensive expertise of two research teams: one from the Faculty of Chemical Engineering and Environmental Protection, „Gheorghe Asachi” Technical University of Iasi and the second one from the „Petru Poni” Institute of Macromolecular Chemistry from Iasi. Highly skilled professors, researchers and specialists from both institutions will be actively involved in designing experiments, analyzing, testing and validation of SANIMED equipment and technology in order to help them adapt to the new trends by developing innovative products and processes. Special emphasis will be placed on establishing structure - properties correlations. Knowledge transfer will create premises for the development and optimization of technologies involved in the industry of cosmetics and nutritional products.

The main directions of interest are: (i) Transfer of knowledge regarding the properties of oligo / polypeptides, and polysaccharides; (ii) Studies regarding the correlation between structure of raw materials and the properties of the final products using modern analysis methods (chromatography, spectroscopy, microscopy, rheology) and SANIMED equipment; (iii) Studies on the physicochemical properties of the considered materials, using high performance equipment, present at the research units, to identify the needs of the economic agent; (iv) Studies to assess the influence of the nature of the analyzed compounds on the texture and sensory properties of the final products; (v) The use of modern methods of study in the morphological analysis of formulated products; (vi) Optimization of the formulation step and application of design of experiments; (vii) Interconnection of information in terms of chemistry, physics and informatics.

Researcher Mobility Projects Call name:
PN-III-P1-1.1-MC-2017-2592 2017 - 2017

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Project partners: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (); Stockholm University ()

Affiliation: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI ()

Project website: https://uefiscdi.gov.ro/resource-87557?&wtok=4223018045cf45ba3705f29c2e8dd2771f730b40&wtkps=XY9bDoIwEEX3Mt+KndbaOuzBmLgCQosO8pLy+DDuXUASo383N+fcySRk6BlIE4zdvQgQM6EUR4FWxIEUQWAHczoQDFmuD5pzj6o5mgfaBqtmW+el5XyLqVC31swsEjB8bKX3a0rdOo4zYQica6rzZaeMkFZaoe0Mysn9

Abstract:

Instruction in the molecular modeling field

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader	Download (38.26 kb) 23/02/2024
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects