BrainMap

Diana-Speranța Bogdan

Dr.

Scientific Researcher II - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Researcher

Web of Science ResearcherID: C-1264-2011

Curriculum Vitae (23/06/2024)

Expertise & keywords

Bio-inspired interfaces for the development of next generation degradable multi-phase materials Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-M-ERANET-3-InsBIOration 2022 - 2024

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); Leibniz Institut für Polymerforschung Dresden e.V. (DE); CNRS Institut Charles Sadron (FR); National Institute of Chemistry (SI); University of Turku (FI); Kunststofftechnik Bernt GmbH (DE)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/insbioration/

Abstract:

Societal needs demand substitution of processes with high energy consumption or using hazardous substances and reduction of waste by use of fully recyclable or biodegradable materials. The project addresses this by proposing a universal platform for bio-inspired surface and interface design basing on dopamine, a substructure of adhesive mussel proteins. A multidisciplinary consortium of researchers and industry aims at developing a portfolio of upscalable technologies for the “green” manufacturing of materials for selected applications (antipathogenic coatings, biodegradable energy sources and polymer-metal hybrids as examples for a broad application range) and their recycling or biodegradation and transferring them to mass production. The project outcome will enable European manufacturers to create sustainable production processes and a circular economy of the materials.

Unveiling the mystery behind the strong polydopamine adhesion: an original approach by introducing local isotopic markers Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1463 2021 - 2023

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/izopda/

Abstract:

Polydopamine (PDA) was discovered in 2007 as a biomimetic solution for the underwater strong adhesion of mussels. Since then, the interest in using PDA as an intermediate layer for developing functional surfaces has grown exponentially, due to many favorable properties: simple deposition process, strong adhesion to virtually any substrate, biocompatibility, and chemical reactivity. Despite the growing number of PDA applications, the exact mechanism by which it adheres so strongly to virtually any substrate is a fundamental challenge remained unsolved in the field. Conventional analytical techniques, including solid-state NMR applied on natural abundance samples, can give only global information, with no selectivity to the interactions between substrate and PDA molecular sites. In this context, the solution we propose here is to introduce local markers in PDA that can “report” about their interaction with the atoms at the substrate’s surface. The idea is implemented by 2H/13C/15N isotopic labeling of each distinct chemical site in dopamine monomer (selective labeling): the selectively labelled monomers will be used to synthesize multiple PDA@substrate samples, of which investigation by ss-NMR will give information with atomic resolution. The proposed scheme is original, representing the first proposed experimental approach that can address the problem of PDA adhesion at the atomic level in a realistic way, thus going well beyond the current state of the art in the field.

Emerging technologies for the industrial capitalization of 2D structures (graphene and nongraphenic) Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0387 2018 - 2021

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA DIN CRAIOVA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=49

Abstract:

EMERG2Ind is a complex solution that responds to the needs of Romanian research on one side through a institutional management and development mechanism, but at the same time it is a complex interface tool for the Romanian automotive industry as a development engine and integrator for the horizontal and vertical integration of the Romanian economic resources. International expertise is available in an attempt to develop concrete solutions in the country. Emerging technologies are being developed up to TRL4 and TRL5, through complementary harmonization of three strategic subprojects. The complex project approach is regional and institutional with cumulative indicators that fully meet the requirements and seeks to maximize the use of the funding instrument.

Emerging molecular technologies based on micro and nano-structured systems with biomedical applications Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0010 2018 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO); UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/tehnobiomed/

Abstract:

The TehnoBioMed project aims to increase the institutional performance of 6 partners with a rich tradition in research, development and innovation (RDI) joined in a consortium with a strong interdisciplinary character designed to develop emerging molecular technologies based on micro- and nanostructured systems and dedicated to biomedical applications.

The project consortium consists of 6 partners distributed in 3 university centers with a tradition in the RDI activity: Cluj-Napoca, Bucharest, Iasi, and consists of 3 national institutes and 3 prestigious universities. The consortium partners are distributed in three different development regions of Romania.

The specific objectives of the project can be synthesized by: i) Manufacturing and testing of surfaces with antimicrobial properties obtained by micro- and nano-fabrication techniques and functionalized with antimicrobial peptides; ii) Development of molecular targeting drug systems by encapsulation in supramolecular structures of the dendrimeric type; iii) Carrying out, calibrating and testing a complex diagnostic equipment based on the principles of coherent optics and dedicated to obtaining high-resolution images in medicine and material science; iv) Development of new technologies for the detection and analysis of molecular biomarkers; v) Development of the technological potential of phycobiliproteins for the production of photosensitive materials with applications in new solar cells and new immunological sensors.

The project aims to develop new or significantly improved products / technologies / services of which we mention the following: Developing a high-resolution OCT imaging equipment with applications in biomedicine and material science; Designing, manufacturing and testing of a nano-ELISA technology; Making new systems with improved antimicrobial activity and increased efficiency against bacterial biofilm formation; Obtaining compounds/materials with impact in the prevention and control of infections.

Optical Nanofabrication in the domain 5 nm - 50 nm Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1374 2014 - 2017

Role in this project: Key expert

Coordinating institution: STOREX TECHNOLOGIES SRL

Project partners: STOREX TECHNOLOGIES SRL (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); TEHNO ELECTRO MEDICAL COMPANY SRL (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU INGINERIE ELECTRICA ICPE - CA BUCURESTI (RO); REGIA AUTONOMĂ TEHNOLOGII PENTRU ENERGIA NUCLEARĂ - RATEN PITEŞTI SUCURSALA CENTRUL DE INGINERIE TEHNOLOGICĂ OBIECTIVE NUCLEARE BUCUREŞTI MĂGURELE CITON (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://storextech.github.io/nanofab/

Abstract:

The main objective of the Project “Optical Nanofabrication in the domain 50 nm – 5 nm” is to valorize the last results of Quantum Optical Lithography with resolution of 2 nm [1] to 3D optical nanofabrication.

Secondary objectives of NANOFAB Project are the following: i) development of metamaterials (3D photonic crystals) able to improve telecommunications ii) realization of nanochannels and nanoarrays for DNA studies and iii) production of metallic components such as gear for the prototype nanorobots.

Initially, complex 3D structures were produced by stacking multiple 2D layers. The patterns were realized by lithography (optical lithography and Electron Beam Lithography). A new opportunity in 3D fabrication has been started by the development of femtosecond lasers. Materials processing technology by using femtosecond laser irradiation has attracted tremendous interest from the scientific and technological communities. Studies have indicated that diffraction limit creates a major difficulty to obtain 3D structures with dimension smaller than 100 nm. Quantum Optical Lithography broke the diffraction barrier by using new approaches and materials (fluorescent photosensitive glass-ceramics, resist). Fluorescent photosensitive glass-ceramics were successfully tested to produce 3D nanostructures at 2 nm resolution.

The expected results are interesting and the exploitation of this new technique could be economically attractive. A group of novel technologies relating to laser nanomachining using Quantum Optical Lithography will be developed. This advanced materials processing technique opens the door to a new generation of optical devices for telecommunications, nanofluidics and biological sensing.

In present days, optical fiber telecommunications are carried out by infrared lasers. Optical Nanofabrication based on Quantum Optical Lithography with 2 nm resolution is the only technology able to realize at low price and high quality optical components dedicated for optical fiber telecommunications with visible light. This shift of wavelength from infrared to visible light will improve in a major way the performances of telecommunication systems.

US government agencies granted funds to universities and research institutes exceeding billion towards research developing nanodevices for medicine.

Large corporations like Alcatel-Lucent, NEC, Corning, Nippon Telegraph and Telephone invest in optical fiber telecommunications R&D and General Electric, Hewlett-Packard, Northrop Grumman work in the development of medical nanorobots. All these companies could be interested in the application of Optical Nanofabrication in production.

The 1961 classic science-fiction movie Fantastic Voyage movie was about a team of scientists who are shrunk down and sent in a miniature submarine inside the body to repair a blood clot in an ailing colleague’s brain.

The Project NANOFAB will start to convert this dream into reality by producing first metallic components needed for a prototype medical nanorobot.

[1] Pavel E, Jinga S, Andronescu E, Vasile B S, Kada G,

Sasahara A, Tosa N, Matei A,Dinescu M, Dinescu A and

Vasile O R 2013 2nm Quantum Optical Lithography ,

Optics Communications 291 259–263

Novel advanced smart biomaterials of giomer type with applications in dentistry Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1419 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); REMED PRODIMPEX SRL (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://granturi.ubbcluj.ro/giodent

Abstract:

The present research project proposed the elaboration, achievement and experimentation of novel, advanced, smart biomaterial formulations belonging to the giomers class with low polymerization shrinkage, continuous release of fluoride in time, improved adhesion to tooth tissues, high mechanical properties and good biocompatibility to be used in different applications in dentistry.

Given the ample and varied activities to be undertaken, the project requires a consortium to be constituted from five partners, two Universities, one National Research Institute, one Institute of the Romanian Academy and one commercial entity, forming an interdisciplinary team of specialists with experience in chemistry, engineering, physics, materials science, biology and medicine .

The planed results of the research activities are the following: 3 products of giomer type for the restoration of the anterior and posterior teeth, for the prophylaxis of caries with children and as liner/base material; 1 dentin adhesive with improved adhesion to tooth structure, 4 laboratory technologies, 3 Feasibility studies, 3 marketing studies, 4 technical specifications, 6 ISI articles and 2 registered patents.

By achieving the proposed project, contribution is brought to the sustaining of the national policy in the field, by creating the transfer and capitalization opportunities which will lead to the development of a Romanian industry of performing dental products, at

European standards level, having in view the specialized human potential with experience in the field.

Homogenous immunoassay technique based on functionalized nanoparticles. Application to detection of pesticide contaminant 2,4-dichlorophenoxyacetic acid from alimentary and environmental samples Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0402 2012 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://proiecte.nipne.ro/pn2/138-proiecte.html

Abstract:

Immunological methods such as enzyme linked immunosorbent assay (ELISA) are increasingly becoming important for pesticides residual analysis due to the high specificity of detecting molecules like antibodies. These immunoassay methods are highly specific, sensitive (nanogram or picogram) and accuracy for the detection of low molecular weight contaminants presents in our environment. ELISA is a technique based on the ability of non-labeled antigen (e.g. pesticide) in a specific volume of standard solution or in an unknown sample to compete with a fixed of amount of enzymatic labeled antigen for a limited number of binding sites of a specific binding antibody protein. The objective of the project is to develop a new and innovative immunochemical technique based on functionalized nanoparticles, homogenous enzyme linked immunosorbent assay (HnELISA) technique for detection of pesticide contaminant 2,4-dichlorophenoxyacetic acid (2,4D) from alimentary and environmental samples. 2,4D is one of the most used herbicide in agriculture to control and destroy of the weeds that can affect agricultural crops. The remanence of this organochlorurate compound in alimentary products, transfer and contamination of ground water in the areas where this pesticide is used require the analysis of this chemical in order to establish the contamination level of the alimentary products and the environmental factors (water, soil).

The objective of the project is to develop an immunoassay technique with improved qualities in comparison with traditionally ELISA technique existed on the market for detection of pesticide contaminants from alimentary and environmental factors. Qualitative characteristics as sensitivity, accuracy, stability of the nanoimmunosorbent and low cost per assay are finally taken in account. Development of HnELISA technique would have practical application in monitoring of the pesticide contaminant 2,4D from alimentary and environmental samples.

Open School for Academic Self-Improvement. Research, Academic Writing and Career Management Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0682 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.econ.ubbcluj.ro/~rodica.lung/openres

Abstract:

Research management, research career development and academic writing have become in later days prerequisites for successful academic track records and/or research careers. Formal and informal support programs are already in place in many of the top universities worldwide. Nevertheless, in Romania, such an approach has not been yet prospected and tested. The project proposes to build and expand the research capacity at both undergraduate and graduate level, helping students and researchers not only to improve their research skills but also their capacity to manage and communicate research (through research management, career management and academic writing).An interdisciplinary group will be created at the end of the project implementation, which will have a comprehensive set of tested instruments, competencies and the necessary know-how for carrying out a Complex Research Competencies training program. Once developed and tested the open training program may become a cornerstone in the future academic and research career development of researchers, weather at the beginning of their career or more advanced ones. While keeping the open school concept, the project team will promote and propose that the program becomes a permanent offer for the academic community and to be included as a transversal skills development program for the various faculties within the Babes-Bolyai University. The partner in the project, INCDTIM Cluj, will continue to provide expertise in the hard sciences component of the program. If such decision is reached, the CRC training program will contribute to the creation, development and further advancement of the Romanian academic community, especially those at the beginning of their research career. This will create, on a long run, a pool of better prepared and trained candidates for research positions within the structures of the two partners.

Petabyte Optical Disc Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-0210 2012 - 2016

Role in this project: Key expert

Coordinating institution: STOREX TECHNOLOGIES SRL

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://storextech.github.io/petopt/

Abstract:

The research activities regarding memory cells with storage densities over 5 Tbits/sq.in are challenging tasks for scientific community.

2D data storage systems need structures able to store 1 bit on a surface smaller than 129 sq.nm,only realizable by extreme lithographic techniques with resolution below 5nm. A way to further boost the effective data density is volumetric storage. A 3D solution, such as a compact disc, should have a capacity of 10 TB.

Fluorescent photosensitive glass-ceramics have been studied for the recording data over a number of years. In 2010, Petabyte Optical Disc [1], realized by a fluorescent glass-ceramics disc with 40 nm marks organized in virtual multilayers, was announced at Optical Data Storage Conference. This makes fluorescent photosensitive glass-ceramics very suitable for industrial applications.

The project named “Petabyte Optical Disc” will focus on the development of dedicated media disc and specific optical, optoelectronic and electronics components. Proposed research will cover the physical basis of the volume recording, as well as physicochemical mechanisms occurring in these materials.

Recent developments in writing procedures and materials [2] could increase the recording capacity of the optical disc up to 1 Exabyte

(1 billion GB).

Objectives:

•To develop fluorescent photosensitive glass-ceramics

•To analyze the mechanisms of recording and readout in optical storage

media, and to develop theoretical models for these mechanisms

•To characterize the storage media in terms of importance in optical

data storage

•To realize a Reader Drive demonstrator for Petabyte Optical Disc

References:

[1] E. Pavel, Optical Data Storage 2010, 23-26 May 2010, Boulder,

Colorado, USA, “Petabyte Optical Disc”

[2] E. Pavel, S. Jinga, E. Andronescu , B. S. Vasile, E. Rotiu ,

L. Ionescu and C. Mazilu,2011 Nanotechnology, 22, 025301, “5 nm

structures produced by direct laser writing”

Ion sensing and separation through modified cyclic peptides, cyclodextrins and protein pores Call name: Complex Exploratory Research Projects - PCCE-2011 call
PN-II-ID-PCCE-2011-2-0027 2012 - 2016

Role in this project: Key expert

Coordinating institution: “Alexandru Ioan Cuza” University

Project partners: “Alexandru Ioan Cuza” University (RO); National Research and Development Institute of Isotopic and Molecular Technologies (RO); “Babes-Bolyai” University (RO); “Horia Hulubei” National Institute for Physics and Nuclear Engineering (RO); “Carol Davila” University of Medicine and Pharmacy (RO)

Affiliation: National Research and Development Institute of Isotopic and Molecular Technologies (RO)

Project website: http://science.research.uaic.ro/biosens/

Abstract:

Development of nanostructures capable of detecting and separating individual molecules and ions has become an important field of research. Particularly, protein-based nanostructures are attractive due to their ability for tunable molecular recognition and ease of chemical modification, which are extremely important factors on various applications. In this project, self-assembly functionalization will be approached, aimed at providing an efficient design for molecular recognition, ion sensing and separation, through new host-guest chemical methodologies, bio-nanofabrication and physicochemical manipulations methods. New crown ether type macrocycles, functionalized cyclodextrins and cyclic peptides will be engineered to work as specific molecular adaptors for the -hemolysin protein, giving rise to hybrid molecular superstructures possessing ion sensing and selectivity properties. The size and functionality of the macrocycles are targeted to ensure the anchorage in the pores and the selectivity of specific host-guest complexation processes. A surface detector array device suitable for use with a biosensor is envisioned, through ink printing nanotechnologies. The device architecture will be formed of a substrate having a surface defining a plurality of distinct bilayer-compatible surface regions separated by one or more bilayer barrier regions. Custom designed nanoscale bilayers containing selected receptors through cyclodextrins derivatives and macrocyclic peptides, self-assembled on different micro-nano arrays surfaces (polymers, Au or Si) will be fabricated. Further engineering of such functionalized nanomaterials based on molecular recognition and host-guest methodologies, in conjunction with flexible and mechanically robust enough substrate platforms, have the great potential for applications such as separation of nanoparticles, sensors, drug delivery, removal of heavy metals from aqueous solutions and chiral separation.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects