BrainMap

Mrs. Codruta Marinela Soica

PhD

Professor - UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Researcher | Teaching staff | Scientific reviewer | Manager | Consultant

Web of Science ResearcherID: C-2585-2011

Curriculum Vitae (17/05/2024)

Expertise & keywords

Synthesis and assessment of novel triazole-triterpene-gold nanoparticle bioconjugates, used as active agents in malignant melanoma Call name: P 1 - SP 1.1 - Proiecte de cercetare Postdoctorală
PN-III-P1-1.1-PD-2019-1078 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Project website: http://old.umft.ro/heterotera_931

Abstract:

Cancer is an intensively studied pathology, representing the second leading cause of death worldwide. Plant natural occurring compounds are an important source for the development of drugs with anticancer effect, with a more targeted mechanism and reduced adverse effects. One of the most studied such classes for their anticancer activity, is represented by pentacyclic triterpenes. The main drawback of using such compounds as an efficient anticancer treatment is represented by the increased hydrophobicity of these molecules, which correlates with a low bio-availability. On this note, a large plethora of synthesized triterpene derivatives were reported in the literature, multiple such compounds showing superior anticancer activities. Recently the use of gold nanoparticles as carriers for compounds with anticancer activity is extensively investigated. Gold nanoparticles provide excellent means for controlled synthesis (shape and size), easy functionalization, and the ability to transport and protect large amounts of loaded drugs. The current proposal aims to obtain triazole-triterpene derivatives and their subsequent formulation as gold nanoparticles bioconjugates, with potential activity in malignant melanoma. Triterpenes selected for derivatization, ursolic, oleanolic and betulinic acid, are substances with already reported antiproliferative effect in melanoma, which will be functionalized at the COOH group through a condensation reaction with a primary amino group present in the structure of several 3-R-4-amino-5-mercapto-1,2,4-triazole derivatives. The selection of triazole structures to be synthesized and used to functionalize triterpenes will be performed using docking based virtual screening methods, by targeting key enzymes overexpressed in malignant melanoma. The synthesized novel triterpene derivatives and their gold nanoparticles formulations will be biologically assessed for their antiproliferative activity in malignant melanoma.

Innovative nanobiostructures based on ferrimagnetic nanoparticles bioconjugated with cyclodextrins for increasing efficacy and reducing toxicity in therapy of cancer by superparamagnetic hyperthermia Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3067 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA DE VEST TIMISOARA

Project partners: UNIVERSITATEA DE VEST TIMISOARA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Project website: https://ped263.projects.uvt.ro/

Abstract:

In this project we propose to obtain and experimentally test an innovative magnetic nanobiomaterial, made of ferrimagnetic nanoparticles bioconjugated with gamma-cyclodextrins, forming a hybrid biostructure "core-shell" (core: ferrimagnetic nanoparticle, shell: cyclodextrins), in order to be used with high efficiency and reduced toxicity in the alternative therapy of cancer by superparamagnetic hyperthermia. The obtained nanobiomaterial will be tested in vitro and in vivo for the therapy of breast and skin cancer, cancers with high incidence in the population.

Professional development center in the field of dermato-cosmetic products based on medicinal plants Call name:
CNFIS-FDI-2019-0393 2019 - 2019

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Project website:

Abstract:

Practical skills development center in the field of medicinal plants Call name:
CNFIS-FDI-2018-0159 2018 - 2018

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Project website:

Abstract:

Nanoencapsulated eugenol advanced compounds with addressability in dental medicine Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0455 2016 - 2018

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); TITUS & SONS SRL (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Project website: http://www.umft.ro/pniiip221bg20160455_519

Abstract:

The aim of the present project proposal is to increase the performance and competitivity of S.C TITUS&SONS S.R.L using the expertise and technology existent in the University of Medicine and Pharmacy Victor Babes Timisoara and Politehnica University of Bucharest. The success of the present project proposal is guaranteed by the team who is comprised by members with national and international research expertise. They will be involved in the research activities, as well in the data analysis, validation, and improvement of the S.C TITUS&SONS S.R.L products, the final endpoint being the increase of their competitivity and quality. The specific objectives of the project are: 1. The manufacture of new compounds starting from the original formula of the company product with the addition of nanoencapsulated eugenol. 2. Evaluation of the in vitro effects of these novel compounds on primary normal human oral keratinocytes - NHOK and tumor line cells of oral squamous cancer - SCC-4. 3. Evaluation of bioenergetic profile of normal and tumor cells treated with these compounds. 4. Evaluation of the in vivo effects on SKH-1 animal models of these novel compounds with histopathologic analysis. 5. The assessment of physical-chemical parameters. 6. Interconnection of informations from chemical, biological, physical, and informatics point of view

Betulin and gold nanoparticles - based formulations in preventing skin aging Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0354 2016 - 2018

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO); FAVISAN SRL (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Project website: http://www.umft.ro/betgoskin_518

Abstract:

The aging phenomenon and the aging itself are considered major challenges in cosmetology and dermatology research and the use of vegetable principles in combination with nanotechnology represents a current topic in the formulation of therapeutic and prophylactic products.

The current proposal focuses on the synthesis and testing of a dermatocosmetic formulation based on gold nanoparticles and betulin, with anti-aging valences due to gold, considered as both therapeutic agent and delivery vehicle, as well as betulin, active agent that requires suitable delivery at skin level. The main objective, consisting in the preparation of semisolid modern formulations with gold nanoparticles and betulin, can be accomplished through the implementation of appropriate standard technologies (ISO), in addition to the practical training. The project proposes the analysis of a dermato-cosmetic product starting from the preparation and characterization up to the industrial scale production, involving the quality control of the final product.

Due to the beneficial effects at skin level of both compounds, the project proposes a thereof association in order to achieve an optimal semisolid pharmaceutical formulation in preventing and treating skin aging. The related activities are focused on: the preparation and analysis of betulin-gold nanoparticles formulations, the in vitro assessment of their toxicity and effectiveness, according to ISO 10993 and other current standards, the antimicrobial testing and testing on healthy volunteers through: consumer test, sensory evaluation, non-invasive tests.

The final goal of the proposal is the transfer of academic scientific research results towards the economic agent in order to implement a continuous flow of production and testing for modern cutaneous cosmetic formulations.

In vitro and in vivo evaluation of cell death mechanisms induced by magnetic nanoparticles in interaction with tumor cells Call name:
P III-C4-PCFI-2016/2017-03 2016 - 2017

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Project website:

Abstract:

Advanced recovery of useful materials from used catalyst wastes Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0612 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE

Project partners: INSTITUTUL DE CHIMIE (RO); PRO AIR CLEAN ECOLOGIC S.A. (RO); INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Project website: http://acad-icht.tm.edu.ro/granturi/REMACAT.html

Abstract:

Responsible management of wastes coming from technological processes is a great priority highlighted by the internal and European legislation. According to the European legislation this means responsible management of chemical wastes by each member state, and also, of all the factors implied the life cycle of all products, and an important economical opportunity as well.

This project has, as main goal, the environment protection by recycling used complex catalysts having as support and flowing agent organic solvents in the purpose of reducing the emissions of heavy metals in environment and reducing pollution with aromatic organic materials. The second major objective, the economical one, deals with the valorisation of metallic compounds as advanced materials for the use in water cleaning systems and the advanced recycling of used solvents and water by means of green chemistry principles. The object of the project refers to the used complex catalyst CuAlCl4*toluene resulted from the COSORB processes, according to the following: separation and purification of toluene, recovery of copper as metallic powder, valorisation of aluminum(III) as flocculation agent in the cleaning water systems. The last objective also means the valorisation of the existent iron wastes at industrial partner, in order to obtain a complex flocculation agent Al(III)-Fe(III).

The objective of the project is placed in the research frame 3. Environment – 3.2.5. Theme Technologies for treating hazardous wastes. According to this theme, we accomplish:

- Chemical evaluation of the used complex catalyst – as waste;

- Establishing a unitary technology starting from the used complex catalyst and iron waste and providing reusable materials as an outcome.

The following steps are involved:

- setting up the separation and purification technology for the organic and inorganic components;

- elaborating the technology of metallic components valorisation as advanced materials;

- elaborating the technology of inorganic components valorisation as flocculation agents for water treatment;

- the design and making of the industrial plant;

- technological processes implementation;

- toxicological control and pollution impact on each step and products.

The novelty of the proposed solution refer to: (i) setting up a unitary technological flow; (ii) selection of the most adequate chemical methods for elaboration of economical and efficient technologies following the principles of green chemistry; (iii) obtaining high purity materials (toluene, copper, flocculation agents); (iv) obtaining a composite flocculation agent (also the technology) Al(III)-Fe(III) within the desired proportions and synergic effect;(v) the toxicological and pollution control of each technological step in order to control the ecological risk.

Participative management will be implemented in the partners’ relationship, the coordination of the activities and the relation with the Contractual Authority. Structured into 5 chapters, corresponding also to the 5 working packages, this proposal is the outcome of the project management activities to which all partner entities have contributed.

The impact of the project, generated by its results, is found in the environment protection (reducing the metal and hydrocarbon pollution risk), technical/scientific (elaboration of technologies and toxicological and chemical analysis systems), economical (efficiency/costs ratio) and social (eliminating the risk regarding people’s health and creating new work places) aspects.

Solving this multi-, inter- and transdisciplinary project implies activities specific to industrial research supported on fundamental knowledge and activities. The results obtained in the frame of this project is a unitary technological process and corresponding industrial plant implemented at the industrial partner and will be disseminated by two patents, communications, publications both on national and international levels and by organizing one workshop.

Evaluation of the impact of UV radiation and antitumor therapy for dermal fibroblasts and cutaneous experimental cancer Call name:
2013 - 2015

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA (RO)

Project website:

Abstract:

Synthesis of potential antitumor compounds by derivatisations and their characterization by hyphenated techniques. Evaluation of the antiangiogenic, antitumor and antiinflammatory activity Call name:
PIII-C1-PCFI-2014/2015 2014 - 2015

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Project website:

Abstract:

Strategic partnership to improve the quality of scientific research in medical universities through doctoral and postdoctoral scholarships Call name:
POSDRU/159/1.5/S/136893 2014 - 2015

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (); UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Project website:

Abstract:

Evaluation of some modern pharmaceutical formulations prepared by pentacyclic triterpenes complexation with functionalised polysaccharidic derivatives Call name:
2013 - 2014

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA (RO); University of Szeged (RO); University of Szeged (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA (RO)

Project website:

Abstract:

Triterpenele pentaciclice, implicit şi acizii oleanolic şi ursolic, suscită un real interes în cadrul cercetărilor privind compuşii naturali antitumorali şi antiinflamatori. Dezavantajul major prezentat de triterpene este solubilitatea lor extrem de scăzută în apă, care poate determina o biodisponibilitate redusă. Proiectul îşi propune optimizarea solubilităţii în apă a unor triterpene pentaciclice, ce se poate realiza prin complexarea cu ciclodextrine hidrofile. Complecşii ciclodextrinici se obţin prin diverse metode şi se pot analiza fizico-chimic prin metode consacrate (dizolvare in vitro, analiza termică, difracţie de raze X, difuziune in vitro, etc.). Obţinerea nanostructurilor cu ciclodextrine amfifile şi triterpene se poate realiza spontan, în anumite condiţii, şi duce la posibilitatea terapiei la ţintă cu o cantitate mai mare de substanţă activă. Complecşii obţinuţi sunt supuşi analizei in vitro, prin testul MTT pe linii celulare tumorale, linii celulare care se vor utiliza pentru producerea modelelor animale prin inocularea la şoarecii C57BL/6J şi la şoarecii atimici BALB/c. Testele in vivo constau în testul CAM, pe ouă embrionate, pentru relevarea capacităţii antiangiogenice ale substanţelor active, precum şi în teste pe modelele animale obţinute anterior. Ultima etapă este reprezentată de evaluarea histologică şi imunohistochimică. Formulările cele mai performante vor fi brevetate şi publicate.

Quality standards and specific performance indicators for high education in health Call name:
POSDRU/1.8/1.2/G/40067 2012 - 2013

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (); UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Project website:

Abstract:

Antioxidant activity of chinese materia medica and its chemical composition Call name:
PN II 39-4/ANCS 198/2009 2009 - 2011

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Project website:

Abstract:

Development of phytopharmaceutical product destined to adjuvant and preventive therapy of mammary neoplasia Call name:
PN-II--69/207 2007 - 2010

Role in this project: Key expert

Coordinating institution: BIOTEHNOS SA

Project partners: BIOTEHNOS SA (RO)

Affiliation: BIOTEHNOS SA (RO)

Project website:

Abstract:

Study of some triterpenic antitumoral vegetal bioproducts implementation through their nanostructure inclusion, in cutaneous terapies by eficacy/toxicity analysis Call name:
PNCD II IDEAS 1257/2007 2007 - 2010

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA (RO)

Project website:

Abstract:

Biotechnology for obtaining bio–products resulting from Plant indicators of recovery metals in soil Call name:
CEEX–ET. Contract: 5899/18.09.2006 -

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA A BANATULUI "REGELE MIHAI I AL ROMANIEI" DIN TIMISOARA

Project partners:

Affiliation:

Project website: http://www.cnmp.ro/ceex/comp2_2006/oferta.php?id=17

Abstract:

Studiul propus intentioneaza sa furnizeze date noi privind valorificarea indicatorilor vegetali ai metalelor din sol. Se vor corela datele despre calitatea solului cu cele privind compozitia chimica a acestor plante. Proiectul urmareste stabilirea unei interfete intre studiul esentialmente chimic (det erminarea cantitatii de metal) si studiul anatomo-morfologic al plantelor, evidentiind modificarile structurale si functionale pe care metalul le poate induce plantelor, la nivel macroscopic si microscopic. Se va porni de la premisa necesitatii protejarii atat a mediului natural (solul, subsolul, apa, aerul, flora si fauna), cat si a mediului antropizat, cu toate elementele artificiale introduse de om. Studiul va oferi un instrument rapid de evaluare a calitatii solului, prin detectarea din timp a unor eventuale modificari functionale si structurale a sistemelor biologice. Va fi studiata si reactia biosistemelor la modificarile survenite in mediu. O componenta importanta a proiectului este valorificarea plantelor analizate, prin obtinerea de extracte vegetale bogate in metale. Ca lucrarea de cercetare, studiul va largi baza de cunostinte privind influenta metalelor grele asupra cresterii si dezvoltarii unor specii de plante. In vederea cresterii capacitatii productive a plantelor, precum si obtinerii de produse noi, cu impact pozitiv asupra sanatatii oamenilor, finalitatea acestui proiect va consta in cercetari privind elaborarea de biotehnologii prin care sa se obtina produse noi, naturale, utilizabile in scopuri terapeutice.

Elaboration of bioproducts with triterpenic compounds and cyclodextrins and their efficacy/toxicity analysis in skin pathologies Call name:
AT 173/2007 2007 - 2008

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABES " TIMISOARA ()

Project website:

Abstract:

DEZVOLTAREA CONTINUĂ A ACȚIUNILOR ANTREPERNORIALE STUDENȚEȘTI PRIN ȘI PENTRU STUDENȚI ȘI ABSOLVENȚI ÎN CADRUL UMFVBT Call name: Fondul de Dezvoltare Instituţională - FDI - Competiţia 2023
CNFIS-FDI-2023-F-0450 2023 -

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Affiliation:

Project website:

Abstract:

Proiectul de față are trei obiective specifice stabilite în concordanță cu atingerea scopului principal.

Ob. I. Dezvoltarea de competențe și abilități antreprenoriale pentru studenți, doctoranzi și absolvenți în primii trei ani de la finalizarea studiilor (lunile 2-9)

În cadrul acestui obiectiv au loc mai multe activități menite să: (i) dezvolte grupul SAStart Health în vederea continuării promovării acțiunilor antreprenoriale studențești, (ii) îmbogățească volumul de cunoștințe antreprenoriale în rândul studenților, (iii) faciliteze colaborarea mentor-student. Concomitent au loc manifestări interdisciplinare de conectare antreprenorială a domeniilor sănătate, economic cultural (ex. „Săptămâna antreprenoriatului în UMFVBT” ediția a II-a) și desfășurarea programului „Antreprenoriatul între vis și realitate” (a doua ediție) cu scopul realizării de training-uri și ateliere de lucru la sediul unor firme/organizații recunoscute în prezența unor antreprenori de succes. Se pregătesc materiale destinate informării și orientării studenților împreună cu alte structuri interconectate (organizaţiile studenţeşti legal constituite în instituţie, structurile de alumni, centrele de consiliere şi orientare în carieră).

Ob. II. Sprijinirea inițiativelor de afaceri ale studenților, doctoranzilor și absolvenților din primii trei ani de la finalizarea studiilor (lunile 3-9)

Se desfășoară sesiuni speciale de expunere, selecție/planificare finanțare a planurilor de idei și afaceri inovative (concept Health-Art-Community) cu implicarea studenților voluntari, realizarea de materiale de promovare, stabilirea de comisii de analiză și facilitarea contactului cu posibili investitori.

Ob. III. Managementul proiectului (lunile 1-9)

Este asigurat pe toată perioada proiectului și presupune supravegherea si coordonarea activităților propuse în proiect. Se realizează totodată toată partea birocratică (acte ale mebrilor echipei, proceduri de achiziții, rapoarte etc.)

Consolidarea și dezvoltarea activităților antrepernoriale studențești prin și pentru studenți și doctoranzi în cadrul UMFVBT Call name: Fondul de Dezvoltare Instituţională - FDI - Competiţia 2022
CNFIS-FDI-2022-0474 2022 -

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Affiliation:

Project website:

Abstract:

Pentru atingerea scopului principal proiectul are stabilite trei obiective specifice.

OB1. MANAGEMENTUL PROIECTULUI (lunile 1-9)

OB2. CONSTITUIREA ȘI DEZVOLTAREA UNUI GRUP DE STUDENȚI/ABSOLVENȚI CU ABILITĂȚI ANTREPRENORIALE PROMOTOR AL ANTREPRENORIATULUI ÎN CADRUL UMFVBT ȘI LIANT ÎNTRE MEDIUL UNIVERSITAR ȘI MEDIUL DE AFACERI.(lunile 2-8)

Se are în vedere constituirea grupului SAStart Health compus din studenți/absolvenți, doctoranzi și tineri cercetători cu aptitudini antreprenoriale, șase mentori principali și o serie de formatori care să fie promotori ai implementării antrreprenoriatului în rândul organizațiilor studențești din domeniul sănătate. Totodată au loc manifestări specifice (ex. „Săptămâna antreprenoriatului în UMFVBT”, implementarea programului „Antreprenorialul între vis și realitate”), sistematizarea activităților de mentorat și formarea tinerilor antreprenori.

OB3. SUSȚINEREA IDEILOR INOVATOARE DE AFACERI ALE STUDENȚILOR/ABSOLVENȚILOR UMFVBT. CREAREA UNUI PROGRAM DE TIP START-UP. Sunt prevăzute sesiuni de participare a studenților/absolvenților cu proiecte personale sau proiecte de echipă (idei teme interdisciplinare) în prezența unor comisii alcătuite din mentori și antreprenori de succes în domeniu, concursuri pentru selectarea proiectelor cu idei inovatoare, manifestări de expuneri a planurilor de afaceri și constituirea punctului central de lucru și al platformei on-line SAStart Health.(lunile 2-9)

Nanostructures with aurones, chalcones and standardized plant extracts: development of a new prototype of chemopreventive and anti-inflammatory agent Call name: Programul de actiuni Integrate Romania-Franta (bilaterale)
PN-II-CT-RO-FR-2014-2-0053 2014 -

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO); Aix Marseille Université, Faculte de Pharmacie (FR)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Project website:

Abstract:

Flavonoids are a class of natural molecules with multipotent biologic properties arousing a true interest in therapeutics and micronutrition for their capacity to reduce the incidence of various cancer types. Among them, aurones and chalcones are less studied subclasses, with emerging biological potential. A major drawback on the therapeutic use of flavonoids is their reduced solubility in water. The project aims at preparing nanostructures with maximal bioavailability employing a standardized plant extract and chemopreventive flavonoids. The objectives of the project are : 1) to obtain an extract enriched in aurone and chalcone type flavonoids using as prime matter the wood of Cotinus coggygria; 2) the inclusion of the extract and some active principles (sulfuretin, butein) in cyclodextrins in order to enhance their hydrosolubility; 3) to obtain bioconjugates with rapid metabolization by derivatizing active flavonoids (sulfuretin, butein) followed by their complexation with cyclodextrins; 4) physic-chemical characterization of the obtained products; 5) in vitro evaluation of the soluble complexes on normal cells and five cancer cell lines (A375, A431, MDA-MB-231, HepG2, HT29) as well as the evaluation of anti-inflammatory activity on murine macrophages RAW264.7; 6) in vivo tests on embryonated eggs (CAM test for the evaluation of anti-angiogenic capacity) and on athymic Balb/c mice inoculated with cancer cells. The most efficient formulations will be subjects for patents.

Obtaining pentacyclic triterpene micro - crystals and pharmaceutical toxicology study of their changes in experimental models Call name: Programul de actiuni Integrate Romania-Franta (bilaterale)
PN-II-CT-RO-FR-2014-2-0060 2014 -

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO); CRM2 Université de Lorraine Faculté des Sciences et Technologies Laboratoire Cristallographie Résonance Magnétique et Modélisations BP 70239 54506 Vandoeuvre-les-Nancy Cedex (FR)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO)

Project website:

Abstract:

Pentacyclic Triterpene is interesting in research of antitumor and anti-inflammatory natural compounds. Preparation of amphiphilic cyclodextrins and triterpene nanostructures can lead to therapy target with a greater amount of the active ingredient. The project aims to achieve and analyse pentacyclic triterpenes in microcrystalline form .

In the first stage, the packing interactions within existing pentacyclic triterpenes crystals will be studied in terms of electrostatic complementarity. A series of non-toxic molecules, which are likely to form interaction synthons in periodic arrangement will be proposed to be co-crystallized with the medicinal compounds.

In the second stage, we try to obtain these co-crystals in the French laboratory and determine they X-ray structure.

In stage three, the complexes obtained as microcrystals will be analyzed as pharmacological products to see whether or not the new microcrystals obtained lead to the modulation of pharmacokinetic respective pharmacological properties. Analyses of these inclusion complexes can be made in vitro on human tumour cell lines, animal models in mice by inoculation. Analyses of these complexes in vivo can reveal the capacity of anti-angiogenic activity in animal models previously obtained. Most advanced formulations will be patented and published.

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