BrainMap

Mr. COCOS RELU

PhD

Researcher - UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Web of Science ResearcherID: O-4134-2017

Expertise & keywords

Identification of novel genetic variants in patients with male infertility by NGS as an advanced molecular testing approach Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0527 2015 - 2017

Role in this project: Key expert

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Affiliation: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Project website: http://cercetare-umf.ro/proiecte_tinere_echipe_uefiscdi

Abstract:

Male infertility accounts for 40-50% of infertility and represents a complex reproductive health problem with a substantial genetic basis and various environmental risk factors. Our goal is to improve the knowledge on the molecular basis of male infertility by gaining insights into the interplay of causative disease-associated genes and genetic variants changes of the genome in male infertility. Given the recent evolution in the development of Next-Generation Sequencing (NGS) techniques and the growing number of candidate genes we propose to develop a targeted sequencing protocol for a 228-genes panel to further increase our knowledge on the molecular base of male infertility. A total of 220 affected patients and 130 healthy controls will be analysed. Targeted sequencing will be performed using Ion PGM 200 sequencing kit and Torrent Personal Genome Machine. Our approach will provide a robust and sensitive method to detect novel genetic variants and can represent a powerful method for investigating affected male in order to discover new key molecules that could represent in the future the target for personalized drug or gene therapy.

REVEALING BUCHAREST’S PAST: AN INTEGRATIVE STUDY OF ANCIENT DNA AND OSTEOARCHAEOLOGICAL DATA OF LATE MEDIEVAL POPULATIONS Call name: Complex Exploratory Research Projects - PCCE-2011 call
PN-II-ID-PCCE-2011-2-0013 2012 - 2016

Role in this project: Key expert

Coordinating institution: Francisc J. Rainer Institute of Anthropology–Romanian Academy

Project partners: Francisc J. Rainer Institute of Anthropology–Romanian Academy (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE CAROL DAVILA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE CAROL DAVILA (RO)

Project website: http://www.bioarchaeology.ro

Abstract:

This project will undertake an extensive comparative study of the history of Bucharest viewed from the perspective of cross-population changes in genetic structure, health, quality of life, adaptation to the external stress factors and lifestyle evolution based on the analysis of the skeletons discovered in the recently excavated Piata Universitatii archaeological site, one of the biggest medieval cemeteries from Romania. The project will integrate archaeological and historical data with the precise anthropological and genetic results that can bring more objectivity to historical anthropology in a promising way to investigate and validate over four centuries of local history. The field of ancient DNA experience a new era after new technologies and methodological approaches became available and large-scale population genetic studies are now possible. When population history reconstruction is based strictly on the analysis of contemporary human DNA material rather than ancient DNA samples, significant information regarding replacement, admixture and local minor migration events could be lost. Ancient population studies may yield interesting results in cases where are indications from archaeology and history that a population demographic modification like depopulation or replacement has taken place and shaped the gene pools of contemporary populations. The impact of lethal epidemics, wars, religious and cultural changes in historical periods would significantly reduce the genetic diversity via bottleneck effect and fundamentally affected the development of populations. Interpreting potential genetic signature and osteoarchaeological data left by the effects of such phenomena on population is important because may aid in the reconstruction of the real historical events which affected the Bucharest region during centuries.

Study on the molecular basis of male infertility Call name:
2003 - 2006

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Project website:

Abstract:

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