BrainMap

Mr. Claudiu Filip

Dr

Scientific Director - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Curriculum Vitae (08/04/2016)

Expertise & keywords

Bio-inspired interfaces for the development of next generation degradable multi-phase materials Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-M-ERANET-3-InsBIOration 2022 - 2024

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); Leibniz Institut für Polymerforschung Dresden e.V. (DE); CNRS Institut Charles Sadron (FR); National Institute of Chemistry (SI); University of Turku (FI); Kunststofftechnik Bernt GmbH (DE)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/insbioration/

Abstract:

Societal needs demand substitution of processes with high energy consumption or using hazardous substances and reduction of waste by use of fully recyclable or biodegradable materials. The project addresses this by proposing a universal platform for bio-inspired surface and interface design basing on dopamine, a substructure of adhesive mussel proteins. A multidisciplinary consortium of researchers and industry aims at developing a portfolio of upscalable technologies for the “green” manufacturing of materials for selected applications (antipathogenic coatings, biodegradable energy sources and polymer-metal hybrids as examples for a broad application range) and their recycling or biodegradation and transferring them to mass production. The project outcome will enable European manufacturers to create sustainable production processes and a circular economy of the materials.

Unveiling the mystery behind the strong polydopamine adhesion: an original approach by introducing local isotopic markers Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1463 2021 - 2023

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/izopda/

Abstract:

Polydopamine (PDA) was discovered in 2007 as a biomimetic solution for the underwater strong adhesion of mussels. Since then, the interest in using PDA as an intermediate layer for developing functional surfaces has grown exponentially, due to many favorable properties: simple deposition process, strong adhesion to virtually any substrate, biocompatibility, and chemical reactivity. Despite the growing number of PDA applications, the exact mechanism by which it adheres so strongly to virtually any substrate is a fundamental challenge remained unsolved in the field. Conventional analytical techniques, including solid-state NMR applied on natural abundance samples, can give only global information, with no selectivity to the interactions between substrate and PDA molecular sites. In this context, the solution we propose here is to introduce local markers in PDA that can “report” about their interaction with the atoms at the substrate’s surface. The idea is implemented by 2H/13C/15N isotopic labeling of each distinct chemical site in dopamine monomer (selective labeling): the selectively labelled monomers will be used to synthesize multiple PDA@substrate samples, of which investigation by ss-NMR will give information with atomic resolution. The proposed scheme is original, representing the first proposed experimental approach that can address the problem of PDA adhesion at the atomic level in a realistic way, thus going well beyond the current state of the art in the field.

Rational design and generation of synthetic, short antimicrobial peptides. Linking structure to function Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0595 2012 - 2016

Role in this project:

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.science.research.uaic.ro/biopep/

Abstract:

Antimicrobial peptides (AMPs) are an integral part of the immune system and protect a host from invading pathogenic bacteria. To overcome the problem of antimicrobial resistance, AMPs are being considered as potential alternatives for antibiotics. Although over 1000 AMPs have been isolated and characterized from various hosts, only limited successes have so far been achieved in clinical trials. The major hurdles for converting them into drugs lie in the high cost of production, toxicity to host cells, and susceptibility to proteolytic degradation. Therefore, a better understanding of the structure–activity relationships of AMPs is required to facilitate the design of novel antimicrobial agents. Herein we plan to focus our effort on designing and optimizing novel short, cationic amphiphilic peptides. We will undertake rational design, synthesis, and extensive testing of a series of short cationic peptides, we envision proteolityc and salt resistant. They will be made of a limited set of L- and D-aminoacids based on an elementary amphipathic templates of up to to 11 aminoacids, searching for the minimum number of aminoacids and optimal architecture able to confer the peptide optimal lytic activity and specificity against various pathogens. In order to enhance antimicrobial activity with no additional hemolytic activity, peptide synthesis will be considered by using non-natural amino acid analogs that will substitute hydrophobic residues leucine, isoleucine and phenylalanine. This group of peptides will be designed and synthesized with shorter sequence and simpler molecular structure and could be easily modified upon a particular requirement. The structural simplicity also offer technological advantages for mass production and purification.

Open School for Academic Self-Improvement. Research, Academic Writing and Career Management Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0682 2012 - 2016

Role in this project:

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.econ.ubbcluj.ro/~rodica.lung/openres

Abstract:

Research management, research career development and academic writing have become in later days prerequisites for successful academic track records and/or research careers. Formal and informal support programs are already in place in many of the top universities worldwide. Nevertheless, in Romania, such an approach has not been yet prospected and tested. The project proposes to build and expand the research capacity at both undergraduate and graduate level, helping students and researchers not only to improve their research skills but also their capacity to manage and communicate research (through research management, career management and academic writing).An interdisciplinary group will be created at the end of the project implementation, which will have a comprehensive set of tested instruments, competencies and the necessary know-how for carrying out a Complex Research Competencies training program. Once developed and tested the open training program may become a cornerstone in the future academic and research career development of researchers, weather at the beginning of their career or more advanced ones. While keeping the open school concept, the project team will promote and propose that the program becomes a permanent offer for the academic community and to be included as a transversal skills development program for the various faculties within the Babes-Bolyai University. The partner in the project, INCDTIM Cluj, will continue to provide expertise in the hard sciences component of the program. If such decision is reached, the CRC training program will contribute to the creation, development and further advancement of the Romanian academic community, especially those at the beginning of their research career. This will create, on a long run, a pool of better prepared and trained candidates for research positions within the structures of the two partners.

Modern approaches for solid forms screening of active pharmaceutical ingredients and structural characterization on powders Call name: Postdoctoral Research Projects - PD-2011 call
PN-II-RU-PD-2011-3-0021 2011 - 2013

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare Dezvoltare pentru Tehnologii Izotopice si Moleculare Cluj-Napoca

Project partners: Institutul National de Cercetare Dezvoltare pentru Tehnologii Izotopice si Moleculare Cluj-Napoca (RO)

Affiliation: Institutul National de Cercetare Dezvoltare pentru Tehnologii Izotopice si Moleculare Cluj-Napoca (RO)

Project website: http://www.itim-cj.ro/PNCDI/ru53/

Abstract:

Through the present project we propose the obtaining by parallel crystallization methods of new solid forms (polymorphs, solvates/hydrates, salts) of Acyclovir, Ciprofloxacin, and Efavirenz pharmaceutical compounds, their identification and structural characterization by adequate combination of modern analytical techniques – i.e. powder X-ray diffraction, solid-state NMR and molecular modeling. The systematic study of the solid state is essential for pharmaceutical compounds since the understanding of their crystallization general behavior provides important contributions in defining the structure-biological activity relationships, and also, allows the selection of those new solid forms with improved therapeutic properties. The estimated results are also important from a theoretical point of view, because they lead to: (i) improvement of the general methodology of searching new solid forms, and (ii) characterization of the crystal packing modes and the responsible intra- and intermolecular interactions. The project novelty degree consists of: (i) implementation of parallel crystallization technology, which allows the parallel screening of hundreds crystallization conditions with the objective of rapid discovery of new solid forms, and (ii) development of alternative methods to identify the molecular and crystalline structure directly from powders by combining complementary techniques (X-ray powder diffraction, SS-NMR and molecular modelling).

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator	Download (199.37 kb) 08/09/2017
List of research grants as partner team leader	Download (199.37 kb) 22/08/2017
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects