BrainMap

Bogdan Feier

- UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Researcher | Teaching staff

Web of Science ResearcherID: not public

Expertise & keywords

European integration of new technologies and social-economic solutions for increasing consumer trust and engagement in seafood products Call name: EC - Horizon Europe
Horizon-241861-101060712 2022 - 2026

Role in this project: Key expert

Coordinating institution: Institution

Project partners: WRG EUROPE LTD (GB); EUROPEAN AQUACULTURE SOCIETY (BE); INSTITUT JOZEF STEFAN (SI); DE LA CUEVA GONZALEZ COTERA JAVIER (ES); INSTITUTO PORTUGUES DO MAR E DA ATMOSFERA IP (PT); UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA (RO); UNIVERSITA DEGLI STUDI DI FIRENZE (IT); UNIVERSITA DEGLI STUDI DI PADOVA (IT); MICRUX FLUIDIC SL (ES); CLUSTER DE LA ACUICULTURA DE GALICIA ASOCIACION (ES); EUROPEAN FOOD INFORMATION RESSOURCE AISBL (BE); REDINN - SRL (IT); AQUABIOTECH LIMITED (MT); BUGENVILA INVESTICIJE DOO (HR); DANMARKS TEKNISKE UNIVERSITET (DK); ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA (IT); PREDUZECE ZA INFORMACIONE TEHNOLOGIJE I ELEKTRONSKO TRGOVANJE BELIT DOO (RS); OXYGUARD INTERNATIONAL AS (DK); BRANDENBURGISCHE TECHNISCHE UNIVERSITAT COTTBUS-SENFTENBERG (DE); DRUSTVO SA OGRANICENOM ODGOVORNOSCU DIGITALSMART DOO PODGORICA (ME); NORCE NORWEGIAN RESEARCH CENTRE AS (NO); INTERNATIONAL ORGANISATION FOR THE DEVELOPMENT OF FISHERIES AND AQUACULTURE IN EUROPE (DK)

Affiliation: DE LA CUEVA GONZALEZ COTERA JAVIER (ES)

Project website:

Abstract:

Nanoplatforms for the rapid electrochemical detection of Staphylococcus aureus by specific markers Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0846 2023 - 2024

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Project website: https://sites.google.com/view/starsens/home

Abstract:

Staphylococcus aureus (S. aureus) is a dangerous pathogenic agent responsible of many diseases, from mild to life-threatening ones, frequently causing healthcare-associated infections. Knowing the high risks that pathogens pose and their resistance to antibiotics, it is crucial to develop new methods for their early real-time detection to be able to initiate therapy and prevent severe complications. Electrochemical sensors emerged as alternatives to conventional methods (microbiological culture, ELISA, PCR) due to their advantages: high sensitivity and selectivity simplicity, low cost, short analysis time, robustness, possibility for portability (suitable for point-of-use/care devices). The purpose of StarSens is represented by the development of new strategies for rapid diagnosis of S. aureus infection through the electrochemical detection of Staphyloferrin A and Protein A, as specific markers. The project has several goals: (1) Development of nanostructured surfaces for the direct electrochemical detection of Staphyloferrin A, siderophore of S. aureus; (2) Development of an aptasensor for Protein A; (3) Evaluation of the (apta)sensors in real samples (human serum, real samples from volunteers, and culture plates). The foreseen results will contribute to advancing the know-how in the biomedical and analytical chemistry fields offering new perspectives for the development of novel (bio)sensors and methods applicable for microbiology diagnosis and therapeutic monitoring.

Wearable electrochemical sensors for the non-invasive detection of inflammatory mediators expressed in post-COVID-19 condition Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-1543 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation:

Project website: https://wear-4-postcovaid.wixsite.com/wearable

Abstract:

Post-COVID-19 condition is characterized by a wide range of symptoms that may last more than 24 weeks after the onset of the infection, with high socio-economic impact. According to WHO, research on predictors for post-COVID-19 condition is of paramount importance to provide new strategies for minimizing SARS-CoV-2 post-infection consequences. The theme of WEAR-4-postCOVaID is very important, aiming for the validation of a panel of different types of biomarkers: interleukin 6, tumour necrosis factor-α, cortisol and kynurenic acid that can be used to early predict medical complications and to monitor patients’ rehabilitation after SARS-CoV-2 infection. The purpose of WEAR-4-postCOVaID is to develop a device for the rapid detection of biomarkers expressed in post-COVID-19 syndrome as a tool for medical staff for easier diagnosis and monitoring of patients. Deepening the knowledge about post-COVID-19 condition (1) and finding the interconnection between biomarkers levels in different body fluids and the main symptoms of this medical condition (2) are the goals of the project with specific and interconnected objectives. The originality of the project consists in the elaboration of innovative electrochemical sensors for the salivary detection of the four biomarkers, the correlation between the levels of the biomarkers (IL-6 and cortisol) in saliva and sweat, and the development of a dual wearable sensor for monitoring their levels in sweat with biomedical applications.

Border detection of illicit drugs and precursors by highly accurate electrosensors Call name:
833787 2019 - 2023

Role in this project: Key expert

Coordinating institution: University of Antwerp

Project partners: University of Antwerp (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: University of Antwerp (RO)

Project website: http://www.bordersens.eu

Abstract:

Combining robust sensor technologies with the inherent advantages of electrochemical strategies, nano-molecularly imprinted polymers, and multivariate and pattern data analysis, BorderSens will enable highly accurate selective detection of trace levels of illicit drugs and precursors. With borders being important gateways for the entrance of illicit drugs and their precursors, custom and border control authorities are facing pertaining challenges to detect such dangerous substances and safeguard the public. The main challenges posed by currently used on-site methods to detect illicit drugs and precursors are low accuracy, in the case of colour tests, and high cost and low portability, in the case of spectroscopic tests. In the light of a pressing need for better drug test systems at EU borders, the ultimate research aim of the BorderSens is to develop a portable, wireless single prototype device with the capability to quickly test for different types of drugs, precursors and adulterants/cutting agents, with outstanding accuracy and reduced false positives and false negatives. BorderSens will demonstrate the innovative technological solutions at seven demonstrations sites at EU borders with end-users and ensure exploitation plans guaranteeing strong impact. BorderSens brings together universities, a big manufacturer of electrochemical sensors, a specialised SME, ten end-users i.e. forensic institutes, police forces and border authorities, and a high quality external advisory board, to provide an excellent scientific-technical perspective and a straightforward exploitation route, with great impact on the safety of EU citizens.

Pathogen Contamination Emergency Response Technologies Call name: EC - H2020
H2020-229396-883484 2020 - 2023

Role in this project: Key expert

Coordinating institution: UNIVERSITY OF CYPRUS

Project partners: UNIVERSITY OF CYPRUS (CY); ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS (EL); WATER EUROPE (BE); COMMUNICATION AND INFORMATION SYSTEMS DIRECTORATE (BG); AQUA-Q AB (SE); KWR WATER B.V. (NL); ETAIRIA HYDREFSIS KAI APOCHETEFSIS THESSALONIKIS AE (EL); SUNDOSOFT LTD (KR); UNIVERSITATEA DE MEDICINA SI FARMACIE IULIU HATIEGANU CLUJ-NAPOCA (RO); MINISTRY OF INTERIOR (CY); Korea Institute of Science and Technology (KR); ELLINIKI OMADA DIASOSIS SOMATEIO (EL); NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA (EL); MicroLAN (NL); CETAQUA, CENTRO TECNOLOGICO DEL AGUA, FUNDACION PRIVADA (ES); AYUNTAMIENTO DE GRANADA (ES); FUNDACIO EURECAT (ES); SATWAYS - PROIONTA KAI YPIRESIES TILEMATIKIS DIKTYAKON KAI TILEPIKINONIAKON EFARMOGON ETAIRIA PERIORISMENIS EFTHINIS EPE (EL); COLLABORATING CENTRE ON SUSTAINABLE CONSUMPTION AND PRODUCTION GGMBH (DE); STICHTING WATERNET (NL); FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE); PHOEBE RESEARCH AND INNOVATION LTD (CY); ENGINEERING - INGEGNERIA INFORMATICA SPA (IT); FUNDACION CENTRO ANDALUZ DE INVESTIGACIONES DEL AGUA (ES); EMPRESA MUNICIPAL DE ABASTECIMIENTO Y SANEAMIENTO DE GRANADA SA (ES); UNIVERSITY OF STUTTGART (DE); LABAQUA SA (ES)

Affiliation: ETHNIKO KENTRO EREVNAS KAI TECHNOLOGIKIS ANAPTYXIS (EL)

Project website:

Abstract:

Border detection of illicit drugs and precursors by highly accurate electrosensors Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2020-0095 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation:

Project website: https://bordersens.eu/

Abstract:

Combining robust sensor technologies with the inherent advantages of electrochemical strategies, nano-molecularly imprinted polymers, and multivariate and pattern data analysis, BorderSens will enable highly accurate selective detection of trace levels of illicit drugs and precursors. With borders being important gateways for the entrance of illicit drugs and their precursors, custom and border control authorities are facing pertaining challenges to detect such dangerous substances and safeguard the public. The main challenges posed by currently used on-site methods to detect illicit drugs and precursors are low accuracy, in the case of colour tests, and high cost and low portability, in the case of spectroscopic tests. In the light of a

pressing need for better drug test systems at EU borders, the ultimate research aim of the BorderSens is to develop a portable, wireless single prototype device with the capability to quickly test for different types of drugs, precursors and adulterants/cutting agents, with outstanding accuracy and reduced false positives and false negatives. BorderSens will demonstrate the innovative technological solutions at seven demonstrations sites at EU borders with end-users and ensure exploitation plans guaranteeing strong impact. BorderSens brings together universities, a big manufacturer of electrochemical sensors, a specialised SME, ten end-users i.e. forensic institutes, police forces and border authorities, and a high quality external advisory board, to provide an excellent scientific-technical perspective and a straightforward exploitation route, with great impact on the safety of EU citizens.

Electrochemical detection of bacterial quorum sensing molecules and biofilm formation Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-1360 2020 - 2022

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Project website: https://sites.google.com/view/quorel-sens/home

Abstract:

Quorum sensing (QS) plays an important role in the pathogenesis of certain bacteria due to its involvement in virulence factors synthesis and formation of the biofilm, which is resistant to the immune system and to antibiotics. QS is a form of cell to cell communication between bacteria using substances called autoinducers, such as N-acyl derivatives of homoserine lactone (HSLs) or cyclic dimeric guanosine monophosphate (c-di-GMP), the latter being involved in biofilm formation.

The main purpose of this project consists in facilitating the fast identification of nosocomial infections and their proper antibiotic treatment, by electrochemical detection of molecules involved in QS and biofilm formation from microbiological cultures and different biological samples.

The QUOREL-SENS project includes several goals: development of a global strategy for obtaining electrochemical biomimetic sensors capable of (1) selective and sensitive detection of QS in P. aeruginosa, (2) of the biofilm formed by P. aeruginosa, and of (3) simultaneous electrochemical evaluation of the concentration of QS molecules or biofilm formation and the concentration of different antibiotics.

The envisioned goals will be achieved by two different, interconnected strategies, with specific objectives: (1) modification of the electrodes with molecularly imprinted polymers (improving the selectivity) and with nanomaterials (improving the electrochemical properties and the sensitivity) for the detection of HSLs and of c-di-GMP produced by P. aeruginosa; (2) development of electrochemical aptasensors for the detection of HSLs and of c-di-GMP; (3) evaluation of the concentration of molecules involved in QS or biofilm formation in the presence of different antibiotics, their concentration being detected electrochemically before and after exposure to antibiotics; (4) complete characterization of the developed electrochemical sensors and their adaptation for real samples analysis.

Synergy of plasmonic structures, affinity elements and photosensitizers for electrosensing of pharmaceuticals Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERANET- RUS-PLUS-PLASMON-ELECTROLIGHT 2018 - 2021

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO); University of Antewerpen, Antwerp, Belgium (BE); Federal State University M.V. Lomonosov, Moscow, Russia (RU)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Project website: https://eranetrusplus.wixsite.com/plasmonelectrolight

Abstract:

The main objective of the PLASMON-ELECTROLIGHT project is to elaborate an efficient sensor strategy to measure pharmaceuticals in surface water near big cities, farms, pharmaceutical industry, etc. The detection

technique will be developed from an original photoelectrochemical detection strategy that is boosted by advanced photosensitizers, plasmonic enhancement, and affinity recognition.

Recently, we have developed an original electrochemical detection principle based on photocatalytic

oxidation mediated by singlet oxygen (Trashin et al., Nature Communications, 2017). We applied this

strategy for the detection of the antibiotic amoxicillin at the concentration level of 20 nM. Within this new

project we will now explore and advance the detection strategy, by preparing more efficient photoactive

materials (gaining sensitivity) and by introducing affinity elements (gaining selectivity).

The photoactive hybrid materials must be designed carefully through rational choice of photosensitizers and metallic nanostructures, theoretical modeling, and experimental correlations. Next, the materials will be combined with biorecognition using aptamers and employed for preparation of a photoelectrochemical

sensor. One of the important features of the photoelectrochemical detection strategy is that the signal and background can be simultaneously measured in the presence of an analyte by simply switching light on and off. This makes the measurement more robust in changeable medium even without or minimal sample preparation.

Beside elaboration the superior sensing strategy for environmental monitoring, our objectives include a better understanding of the mechanism for plasmonic enhancement of photosensitizers’ activity, developing new photoreactive materials and better methods to tests them. This will contribute to different field of chemical

sensing, material science, and energy conversion.

High accuracy innovative approach for the robotic assisted intraoperatory treatment of hepatic tumors based on imagistic-molecular diagnosis Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0221 2018 - 2021

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA TEHNICA DIN CLUJ - NAPOCA

Project partners: UNIVERSITATEA TEHNICA DIN CLUJ - NAPOCA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO); INSTITUTUL DE MECANICA SOLIDELOR (RO); INSTITUTUL REGIONAL DE GASTROENTEROLOGIE - HEPATOLOGIE PROF. DR. OCTAVIAN FODOR CLUJ-NAPOCA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Project website: https://cester.utcluj.ro/improve/home

Abstract:

The IMPROVE project will be developed by a transdisciplinary group, which integrates the knowledge of multiple specialists from the technical field (such as mechanical engineers, computer science engineers and material sciences engineers), a team of medical doctors (surgeons, gastroenterologists, oncologists, and radiologists), and a team of chemical scientists. The IMPROVE group will develop an innovative solution for the treatment of the patients diagnosed with non resectable hepatic tumors, based on a novel robotic system, and an novel medical imaging diagnostic tool. The majority of the hepatic tumors are not resectable due to a variety of factors such as tumor placement, size, and the patient general condition. In order to deliver a better palliative care towards the patient, and a better quality of life, the IMPROVE project proposes an integrated system to deliver treatment in the form of brachytherapy or chemotherapy. The treatment will be delivered in a minimally invasive manner, guided by a robot (which delivers the treatment agent through needles), based with a non-invasive diagnostic method. The diagnosis stage consists of the development of “smart” image analysis algorithms which can detect and define some hepatic diseases such as cancers. The preplanning stage will define the treatment method as well as the needle trajectories. For the treatment delivery a robotic structure will be developed to help the clinicians in the minimally invasive (laparoscopic) in situ procedure. The treatment agent (brachytherapy of chemotherapy) will be precisely delivered within the tumor using specialized instruments (for needle insertion and delivery) guided by the robotic system. The IMPROVE team is composed out of experienced researchers whit excellent results in the medical field, and well based former collaborations. The group synergy represents a key factor in obtaining positive results in the survival outcome of the hepatic cancer patients.

Development of electrochemical sensors for monitoring the vancomycin and gentamicin treatments Call name: P 1 - SP 1.1 - Proiecte de cercetare Postdoctorală
PN-III-P1-1.1-PD-2016-1132 2018 - 2020

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Project website: https://sites.google.com/view/vangeldet

Abstract:

Vancomycin and gentamicin are antibiotics widely used for the prophylaxis and treatment of severe infections with Gram-positive and negative bacteria, respectively, but their use can lead to ototoxicity, nephrotoxicity and bacterial resistance to antibiotics, needing a therapeutic drug monitoring of these antibiotics that maximizes efficacy, reduces toxicity and avoids the under-dosing, reducing the antibiotic resistance.

The main purpose of the project consists in facilitating the monitoring of vancomycin and gentamicin treatments, by their electrochemical detection from biological samples (serum, urine), in order to help the proper use of these antibiotics, diminishing their toxicitiy and impairing the development of antibiotics resistance.

The project objectives are to develop a global strategy for obtaining portable, inexpensive, non-toxic, electrochemical (bio)sensors, able to selectively detect low concentrations of vancomycin and gentamicin (ng/L), to adapt these (bio)sensors for simultaneous detection of the two antibiotics and for the routinely monitoring of vancomycin and gentamicin treatments, replacing the chromatographic, spectrophotometric and immunochemical methods, that are expensive, time-consuming and inadaptable for bedside testing.

The objectives will be achieved by three interconnected strategies: the direct electrochemical detection of vancomycin and gentamicin, taking into account that both of them present electroactive functional groups, the modification of the electrodes with nanomaterials and polymeric films, leading to better electrochemical properties, with an increase of the sensitivity of the analysis and the development of selective biosensors using as biorecognition elements antibodies or peptides, capable to interact specifically with the target molecules. Different electrode modification strategies will be tested, increasing the chances of successful development of highly selective and sensitive electrochemical (bio)sensor.

Nano-Enabled Optical Fiber Biosensor Device with Smartphone Interface for Fast and Selective Detection of Antibiotics in Water Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0172 2017 - 2018

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA TEHNICA DIN CLUJ - NAPOCA

Project partners: UNIVERSITATEA TEHNICA DIN CLUJ - NAPOCA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Project website: http://bel.utcluj.ro/~galatusr/PED67UEFISCDI.html

Abstract:

The water quality of the water subsystem network is important to be monitored in order to protect the public health and the local ecosystems from the harmful effects of the substances with risks to human and wildlife organisms. The European Union follows the strategic plan implementation of the Water Framework Directive 2000/60/EC. Current EU guidance on the implementation of the Water Supply Regulations for water quality monitoring includes the option for using online instrumentation to gather compliance data, rather than using sampling and laboratory analysis. Efficient tools for rapid detection of antibiotics in water are urgently needed and represents the core of the proposal. In the US alone, every year 3400 tons of antibiotics are used on patients, while 8900 tons are used on animals-2015. Up to 85% unmetabolized antibiotic is excreted in urine/feces by the human body On livestock animals are consumed more than twice the amount of antibiotics than on humans. Evidence of antibiotic resistant microorganisms has been found in surface wastewater, groundwater and drinking water. Based on a 2013 report regarding the sales in the community pharmacies of the systemic antibiotics from J01 class, Romania is the third biggest consumer of antibiotics in the EU. The present proposal aims to develop a water quality sensor system (WQSS) by integrating the facilities of the optical fibers technology and smartphone. The system is based on low-cost fiber optic sensors (FOS), with nanostructured plasmonic area, SPR(gold, Molecularly Imprinted Polymer and graphene). FOS, being intrinsically robust, reliable and immune to electromagnetic interference, are especially suitable for in situ real-time detection, being fully compatible with out-of-lab continuous monitoring. FOS offer strong arguments over traditional methods of sensing. Based on the expertise of two partners, the project will start at TRL2 and will end at TRL4 with SPR sensor integration remote monitoring station(WOSS).

Design sensing platforms for detection and quantification of biomarkers involved in neurological disorders Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0460 2015 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO)

Project website: http://www.granturi.umfcluj.ro/BIO-NEURO-SENS

Abstract:

Neurological disorders are numerous, diverse, frequently severe, affecting a large portion of the world’s population, with challenges in their diagnosis and treatment. The current project proposes the development of a global strategy for designing (bio)sensors, involving an ultrasensitive electrochemical setup based on a specific and selective nanoplatform capable of simultaneous detection of some biomarkers involved in neurological disorders. The originality of the proposed project resides from the use of electroanalytical methods involving electrodes modified in a controlled and optimized way with a novel association of nanomaterials with bioelements. Various strategies are envisaged for the functionalization of different types of electrodes and the use of various nanomaterials, design of new and innovative way that will allow their immobilization. The obtainment of the completely functional nanoplatforms will be followed by the optimum immobilization of the bioelements (enzyme, antibody, aptamer) will be determined, assuring highly specific detection. After the complete characterization of the elaborated sensors in terms of properties and performances, their application for real samples analyses will be tested, as a first step in development of point-of-care devices.

The success of the project could assure an early diagnosis of neurological disorders with improvement in the health of the population.

Innovative electrochemical sensors for sensitive and selective detection of some biogenic amines Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-Franța (bilaterale)
PN-III-P3-3.1-PM-RO-FR-2016-0003 2016 -

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); Université Rennes 1, Campus de Beaulieu, nstitut des Sciences Chimiques de Rennes (ISCR), UMR CNRS 6226, "Matière Condensée et Systèmes Electroactifs" (MaCSE) (FR)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO)

Project website:

Abstract:

Aminele biogene (dopamina, serotonina) prezintă un rol important în controlul și reglarea principalelor funcții neuronale, fiind incriminate de apariţia unor patologii psihologice și neurologice. Acești compuși pot fi consideraţi atât biomarkeri în apariția și monitorizarea evoluţiei unor boli neurodegenerative cât și ținte pentru noi metode terapeutice. În vederea diagnosticării și monitorizării eficacității terapiei propuse, se impune dezvoltarea unor metode de detecție și cuantificare rapide ale acestor amine. Proiectul propus urmărește obținerea unor platforme selective pentru detecția specifică a aminelor biogene cum sunt dopamina sau serotonina. Astfel, posibilitatea implementării unor metode și dispozitive care să permită identificarea și cuantificarea acestor compuși rapid, cu costuri scăzute și fără a necesita separarea în cazul determinărilor efectuate pe matrici complexe, este de mare interes pentru lumea medicală. Originalitatea acestui studiu constă în implementarea unor platforme pe bază de nanoparticule de aur si polipirol care să permită analiza calitativă și cantitativă a unor amine biogene prin intermediul tehnicilor electrochimice precum si a unor catalizatori biomimetici pe baza de cupru. Tehnicile abordate permit sintetizarea unor nanostucturi care prezintă densitate crescuta de centrii activi disponibili pentru legarea analitului de interes pe o suprafaţă geometrică relativ redusă și posibilităţi de miniaturizare cu creşterea spectrului de aplicaţii.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects