BrainMap

Anca-Roxana Petrovici

- INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Researcher | Scientific reviewer

Web of Science ResearcherID: K-2056-2016

Expertise & keywords

Innovative multifunctional, bioactive topical formulation for the management of malignant wounds Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2193 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://bios.unibuc.ro/Proiecte/proiect-pn-iii-p2-2-1-ped-2021-2193.html

Abstract:

Malignant fungating wounds (MFW) are incurable, severe, and debilitating conditions normally occurring in the last (six) months of oncologic patient’ life, affecting the overall quality of life and requiring appropriate palliative care to alleviate pain and suffering. MFW’s microbiome may influence the development and severity of wound symptoms, causing foul odors, peri-wound skin damage, inflammation, and ultimately, delays in the healing proliferative phase. ARGOS project is implemented by a consortium of two research institutions and one company with previous experience in developing collagen-based pharmaco-cosmeceutic products and is aiming to develop an innovative multi-purpose, bioactive topical formulation to assist the physical management of malignant fungating wounds, by addressing the microbiome-related symptoms such as pain, odor, and exudate. The proposed solution is based on collagen and inorganic - gold, silver and magnetic – nanoparticles functionalized with plant-derived bioactive compounds (such as polyphenols contained in Chelidonium majus L. and Tamarix gallica extracts, with previously demonstrated antioxidant, antimicrobial, antiproliferative, antiviral and immunomodulatory activity). Therefore, the main novelty of the proposed solution is that it provides not only a wide antimicrobial effect, but also anti-cancer activity and pro-healing properties on the site of malignant wounds. The physico-chemical, mechanical and biological properties of the collagen-based optimized product will be validated by standard protocols and the technological scaling documentation and argumentation of the investments required for in vivo tests will be elaborated (TRL4).

Versatile molecular vectors with tailored carrying and actuating abilities, dedicated to gene and drug delivery in fight against cancer Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1523 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://www.intelcentru.ro/tm-vector/index.php

Abstract:

Gene therapy represents nowadays one of the most challenging promises for the cure of cancer, rare, and severe diseases. The speed of the steps toward it strongly depends on the efficacy and reliability of the molecular tools involved in the manipulation (isolation, reconfiguration, multiplication) and vehiculation (native state preservation, dense packaging, targeted and “stealth” delivery, local protection) of the nucleic acids.

The main objective of TM-Vector project is to develop a highly reproducible macromolecular edifice capable to function as a cooperative carrier for nucleic acids, characterized by the ability to be post-decorated with biochemical and / or pharmacologic active molecules, by virtue of dynamic processes of selective affinity of host-guest type. The particular architecture of the carrying vector will offer three unique functional properties, representing our original contribution to the practice of nucleic acid vectorization: (i) the ability to target various cell receptors; (ii) the possibility to concomitantly vectorize several types of active molecules (e.g. nucleic acid molecules and pro-drug molecules); (iii) the capacity to selectively attach molecules having neat different volumes and conformations.

TM-Vector project could have societal impact, contributing to the improvement of the quality of life of sufferers. The applied research directions could also contribute to the technology of gene and drugs carriers produced at biopharmaceutical scale.

Intelligent therapies for non-communicable diseases based on controlled release of pharmacological compounds from encapsulated engineered cells and targeted bionanoparticles Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0697 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU''

Project partners: INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/intera.html

Abstract:

Non-communicable diseases (atherosclerosis, diabetes, obesity), a major cause of mortality, are characterized by associated inflammatory processes. The complex project INTERA aims to develop innovative therapeutic methods to ameliorate the pathological progression by reducing the inflammatory process. The multidisciplinary studies proposed by INTERA can create and define new nano- or micro-medical devices usable for smart and innovative anti-inflammatory therapies. INTERA includes 4 projects: (1) Encapsulation of genetically manipulated eukaryotic cells for controlled release of pharmacologically active products; (2) Development of a 3D platform designed for pre-clinical drug testing composed of cells incorporated into three-dimensional bio-matrices; (3) Intelligent nanobioparticles designed for bioactive compounds vectoring to pathological sites for vascular inflammation targeting. (4) Polymeric conjugates for efficiently inducing the expression of genes of interest with applicability in cellular therapy. The consortium consists of 4 partner research units - two institutes of the Romanian Academy (IBPCNS, ICMP), a university (UPB) and a national CD Institute (INCDFM) with good territorial coverage (Bucharest-Ilfov-Iasi). Predicted Indicators: 10 new R & D jobs, 8 ISI articles, 4 patent applications, 8 new technologies, 7 new service offers posted on the ERRIS platform. Institutional development: the new competences and the improvement of existing ones in partner units will attract the attention of the economic environment towards a better correlation of scientific and economic interests and better valorization in the field of drug science. From a social point of view, institutional development will lead to lowering the cost of these pathologies through new therapeutic approaches, more accessible to the population and hence, improving the quality of life.

SupraChem Lab - Laboratory of Supramolecular Chemistry for Adaptive Delivery Systems - ERA Chair initiative Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2016-0011 2016 - 2020

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.intelcentru.ro/suprachem_lab/PNIII/

Abstract:

The SupraChem Lab - Support Project aaims to complements the European funding for the WIDESPREAD 2-2014 project: ERA CHAIR, no. 667387: SupraChem Lab - Laboratory of Supramolecular Chemistry for Adaptive Delivery Systems ERA Chair initiative Project.

The Orizont 2020 project started in July 2015 and aims to create a team to conduct advanced research on supramolecular chemistry. The SupraChem Lab project benefits from the scientific support of several high-level chemists, including Nobel Prize-winning Professor Jean-Marie Lehn in 1987 and is considered the founder of the global supramolecular chemistry school.

Analytical methods for characterization of oligo/polypeptides and polysccharides applied in cosmetics and foods: proposal, development and validation Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0175 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Project partners: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.ch.tuiasi.ro/cercetare/proiecte/AnaMet/default.html

Abstract:

This project aims to contribute to knowledge development in the area of physicochemical characterization methods applied to oligo/peptide and/or polysaccharide systems using the modern equipment recently acquired by SANIMED International Impex SRL company and the extensive expertise of two research teams: one from the Faculty of Chemical Engineering and Environmental Protection, „Gheorghe Asachi” Technical University of Iasi and the second one from the „Petru Poni” Institute of Macromolecular Chemistry from Iasi. Highly skilled professors, researchers and specialists from both institutions will be actively involved in designing experiments, analyzing, testing and validation of SANIMED equipment and technology in order to help them adapt to the new trends by developing innovative products and processes. Special emphasis will be placed on establishing structure - properties correlations. Knowledge transfer will create premises for the development and optimization of technologies involved in the industry of cosmetics and nutritional products.

The main directions of interest are: (i) Transfer of knowledge regarding the properties of oligo / polypeptides, and polysaccharides; (ii) Studies regarding the correlation between structure of raw materials and the properties of the final products using modern analysis methods (chromatography, spectroscopy, microscopy, rheology) and SANIMED equipment; (iii) Studies on the physicochemical properties of the considered materials, using high performance equipment, present at the research units, to identify the needs of the economic agent; (iv) Studies to assess the influence of the nature of the analyzed compounds on the texture and sensory properties of the final products; (v) The use of modern methods of study in the morphological analysis of formulated products; (vi) Optimization of the formulation step and application of design of experiments; (vii) Interconnection of information in terms of chemistry, physics and informatics.

INNOVATIVE BIOPOLYMER-BASED HYDROPHILIC MATRICES WITH TAILORED PROPERTIES FOR MEDICAL APPLICATION Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0558 2015 - 2017

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://dciolacu02.wix.com/start-from-scratch-n

Abstract:

This project aims to develop innovative hydrogels based on biopolymers with properties designed for high-values medical applications. The extraordinary versatility of these materials has its origins in the diversity of the constituent biopolymers, ranging from vegetable polysaccharides (cellulose and its various allomorphic forms) to the bacterial polysaccharides (alginate, xanthan, etc.), coupled with the presence of materials reinforcement of high-tech, such as cellulose nanoparticles (CNs). The purpose is not only the assembly of biopolymers in hydrophilic matrices by chemical cross-linking, but also the biosynthesis of new exopolysaccharides (EPS) with well-defined chemical and structural characteristics. The new series of EPS will be biosynthesized by lactic acid bacteria (Lactobacillus spp., Weisella sp., Pediococcus sp.) in order to provide a controlled compositions, degrees of branching and molecular weights. Moreover, the isolation of CNs by novel methods for a low environmental impact (enzymatic hydrolysis with specific cellulases together with molecular fragmentation at low temperatures or chemical modifications) emphasizes the complexity of the project. Its originality is given also by the isolation of cellulose CNs from the corresponding allomorphic forms. Finally, the biocompatibility of new hydrogels in order to determine their uses, either as systems for controlled release of active principals or as scaffolds in tissue engineering, will be tested.

Innovative system for products and technologies to stimulate the eco-efficiency of the leather industry Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0436 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I.

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); PIELOREX S.A. (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://icpi.ro/icpi/?param=1

Abstract:

The specific topic of this complex project is of great interest and the conclusive evidence is the great number of international research works on increasing eco-efficiency of the leather processing industry, which is currently classified as an industry with controlled environmental aggression tending to become an industry with limited aggression.

The objectives proposed for this project are consistent with the purpose and overall goal of the PN II_PT_PCCA program to increase competitiveness of research and development by developing solutions to problems of socio-economic interest, resulting in innovative products and technologies, developed in partnership between research organizations. The problems addressed by the proposed project place it into Research area 7 - Materials, processes and products, Research direction 7.1. Advanced Materials, Research theme 7.1.3. Environmentally friendly materials in processes related to their production and use.

The main goal of this project is to promote best practices specific to ecological leather processing industry (at least in terms of eco-tolerability) by developing and implementing new materials and innovative technological principles that lead to the harmonization of economic performance criteria with environmental protection and human security.

The originality of this project lies in the idea of transforming difficult to manage waste into an eco-efficiency growth factor for the industry generating it, namely recovery of solid waste with protein content (leather, wool, hair) resulting from leather processing (as well as from other industries) to obtain added-value products (biopolymers).

These innovative products are used in biomimetic hybrid tanning systems and as vehicle agents for a new leather dyeing system with non-specific materials, namely organic pigments formulated/functionalized in water-soluble liposomal micro/nanocapsules.

Developing these relatively low-cost materials will be possible through simple processes and their application will not essentially change existing industrial technologies, but will induce multiple economic effects (by reducing production and pollution treatment costs), environmental effects (through recovery and use of difficult to manage waste, removing substances with high toxic potential, such as chromium salts used in tanning and carcinogenic amines used in dyeing, from leathers and effluents), and, last but not least, social effects (by protecting the individual, from workers in tanneries to users of objects made of leather, creating new jobs as a result of lower production costs and re/opening waste processing units).

Biologically inspired systems for engineered structural and functional entities Call name: Complex Exploratory Research Projects - PCCE-2011 call
PN-II-ID-PCCE-2011-2-0028 2012 - 2016

Role in this project:

Coordinating institution: "Petru Poni" Institute of Macromolecular Chemistry

Project partners: "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "N. Simionescu" Institute of Cellular Biology and Pathology (RO); " Gheorghe Asachi" Technical University of Iasi (RO); " Costin D. Nenitescu" Institute of Organic Chemistry (RO)

Affiliation: "Petru Poni" Institute of Macromolecular Chemistry (RO)

Project website: http://www.intelcentru.ro/Biomimetics_PCCE

Abstract:

The project aims to study, to develop and to preliminary test biomimetic structural and functional entities, able to act as gene transfection vehicles of non-viral type, and having a DNA packaging capacity of about 2  5 kilobases. The main features of these entities are: (i) the general structure of a polyplex, (ii) the functionality of a cargo-complex that chemomimic the histones, morphomimic the nucleosome and biomimic a virus like gene vector, (iii) the ability to include or to reversibly bind and transport (bio)chemical species necessary to assist the DNA vehiculation and trafficking, (iv) are based on fullerene-rich polymers and / or dendrimers, (v) the capacity to associate to artificial extracellular matrices, in order to generate gene delivery systems with transfection ability, for ex vivo applications. The developed entities will represent effective tools in genetic and tissue engineering, useful in health restoration, life quality enhancement, and to cure tissue and human organism deficiencies. The envisioned engineering strategy to build biomimetic entities may sustain a spin-off type transfer of knowledge towards hi-tech application areas, with a clear echo in clinics and, finally, in human health. The project involves seven complementary teams hosted by four research and academic institutions. In equilibrated ratios, senior, young and junior researchers will collaborate inside the project frame.

Synthesis and in vitro/in vivo assessmnet of new conjugates with antimicrobial activity Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-Moldova (bilaterale)
PN-III-P3-3.1-PM-RO-MD-2016-0110 2016 -

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); Institutul de Chimie al Academiei de Științe a Moldovei (MD)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website:

Abstract:

Propunerea de proiect se axeaza pe o cercetare interdisciplinara prioritara a nanomedicinei: nanosisteme de transport cu eliberare controlata de medicamente, incadrandu-se in prioritatile tematice ale programelor PN III si Orizont 2020. Obiectivul strategic al acestui proiect este de a dezvolta o colaborare stiintifica intre parteneri din diferite tari cu competente complementare, care sa creeze premisele recunoasterii si integrarii colectivelor in proiecte internationale. Proiectul isi propune instruirea si perfectionarea tinerilor cercetatori, eficientizarea schimbului de experienta intre parteneri, cresterea transparentei si credibilitatii in fata partenerilor internationali prin implicare in propunerile de proiecte europene. Prezentul proiect are trei obiective stiintifice majore: (i) sinteza, caracterizarea fizico-chimica si testarea in vitro si in vivo de noi compusi mic moleculari cu activitate antimicrobiana (derivaţi ai oxindolului, oxadiazolului, triazolului, tiazolidinelor); (ii) sinteza, caracterizarea fizico-chimica si testarea in vitro si in vivo a complecsilor de incluziune pe baza de ciclodextrine adecvat functionalizate si compusi mic moleculari sinteti in cadrul obiectivului (i), pentru a obtine sisteme de transport si eliberare controlata de medicamente; (iii) valorificarea rezultatelor prin prezentarea la manifestari stiintifice,vpublicarea in reviste cotate ISI si pregatirea de proiecte stiintifice pentru competitii lansate in Programul Orizont 2020.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects