BrainMap

Mrs. Ana-Mihaela GAVRILA (FLOREA)

Dr. eng.

Scientific Researcher 1st degree - Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Researcher | Scientific reviewer

Dr. Eng. Scientific Researcher, aiming to develop ambitious research ideas via RTD projects addressing advanced and smart polymeric materials. Track record: 50 Published Papers sumarizing over 300 total citations according to Web of Science&Scopus (44 ISI Q1/Q2 category, from which 20 ISI as main author), 27 National Patents (17 patent applications and 10 granted, from which 2 as main author), 35 Honor Awards (10 Gold Medals, 7 Silver Medals and 1 Bronze Medal, particularly 2 Medals at International Exhibition of Inventions Geneva, Switzerland), Project Coordinator/Responsible of 6 National Projects, post-doc position on 6 projects and Key person/Member in 16 National and 8 International Projects, 1 book chapter, more than 150 communications at national and international conferences, from which 2 invited.

Web of Science ResearcherID: https://publons.com/researcher/4550577/ana-mihaela-gavrila/

Curriculum Vitae (21/07/2023)

Expertise & keywords

New technology for pH sensitive hybrid materials based on halloysite and cyclodextrin for Inflammatory Bowel Diseases treatment Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2488 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Affiliation:

Project website: https://ghebauradi.wixsite.com/medexibd

Abstract:

The current project aims to contribute to biomedical scientific knowledge meeting also the environment requirements by proposing a new strategy to achieve new pH-sensitive drug delivery with high therapeutic effect for Inflammatory Bowel Diseases (IBD) through the usage of renewable resources as starting materials.

In this context we intend to synthesis several new drug delivery systems for targeted mesalazine release (with therapeutic effect on IBD) based on chemically modified halloysite and cyclodextrin. MEDEXIBD aims to rationally functionalize the structure of the natural clay nanotube and also cyclic polysaccharide in order to obtain methacrylated compounds with increased reactivity who also favors a targeted release of the drug from the final forms into the colon. To accomplish these statements the two types of modified natural compounds will be subsequently reacted together, into a binary system (clay-polysaccharide) using an environmentally friendly photo-chemical polymerization technique using visible radiation obtaining halloysite tubes coated to supramolecular structures of β-cyclodextrin which grace to the vinyl radicals configures a pH sensitive system. Mesalazine active substance will be charged both into the tube and cyclic compounds and the release profile into a colon pH value will be established by well defined tehniques. With two different hosts for the specific drug, the final systems have the ability to inhibit the release of the active substance when they encounter different media with acid or neutral pH and also have a great capacity to exert an immediate therapeutic effect in the affected area. All the promising synthesized drug release systems (after a rigorous selection based on preliminary laboratory evaluation) will be tested in vitro in terms of toxicology, pharmacology, biochemistry and anatomopathology establishing a thorough pharmacotoxicological profile of mesalazine from the pharmaceutical forms formulated and defined by MEDEXIBD.

Environmental responsible composite propellant for unguided propulsive systems Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2021-0211 2022 - 2024

Role in this project:

Coordinating institution: COMPANIA NATIONALA ROMARM S.A.

Project partners: COMPANIA NATIONALA ROMARM S.A. (RO); Academia Tehnică Militară „FERDINAND I” (RO); Ministerul Apărării Naționale prin Centrul de Cercetare și Inovare pentru Apărare CBRN și Ecologie (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation:

Project website: https://romarm.ro/proiecte-cercetare/

Abstract:

Common unguided propulsion systems of great importance for any army include portable grenade/ missile launchers, rocket launchers placed on vehicles, aircrafts and boats. The main goal of this project is to recreate a vital capability of the national defense industry, by transferring from academia and research to the industrial partner C.N. ROMARM S.A. an innovative technology for the manufacture of a composite fuel for rocket engines, by development at industrial prototype level. The manufacture of the rocket fuels involve the use of an affordable oxidizer, with low sensitivity and minimal impact on the environment, and energy binder systems that can also include materials obtained by recycling PET. These new propellants have performances at least similar to those of double-based propellants (based on cellulose nitrates and glycerin trinitrate), while having a low sensitivity and a low impact on the environment. The solid composite fuel will have a dual use at national level in defense and civil propulsion applications, among which we mention the national system of interventions in the atmosphere with anti-hail missiles (also made by ROMARM SA), which currently uses obsolete and toxic fuels from import.

The consortium from the academic and research environment that developed and validated the experimental model and that will assist ROMARM SA in the development of this new technology encompasses prestigious institutions with long experience in research and development of military equipment and advanced materials: Military Technical Academy-Ferdinand I, Research-Innovation Center for CBRN Defense and Ecology and the National Research and Development Institute for Chemistry and Petrochemistry.

Ecotechnology for obtaining phytoingredients encapsulated in hydrogel based on bioactive complexes immobilized in a layer double hydroxide matrix Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1870 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO)

Affiliation:

Project website: https://www.chimie.unibuc.ro/cercetare/cataliza/PN-III-P2-2_1-PED-2021-1870/DUACTIVMER.pdf

Abstract:

The project aims the development of integrated validated eco-technologies (TRL4) with double action: 1) obtaining hydrogel encapsulated bioactive ingredients based on phytocomplexes from 2 medicinal plants (e.g. Rhamnus frangula L (RfL) and Helianthus tuberosus L (HtL)) with increased biocompatibility and protected from degradation by immobilization in a layer double hydroxide (LDH) matrix, and 2) valorization of spent vegetal after extraction as cheap adsorbent of pollutants from wastewaters. The basic concept of the technology (TRL2) lays on preliminary results obtained by consortium partners in: i) extraction of RfL and HtL phytocomplexes; ii) immobilization of different organic anions in Mg/Al-LDH and Zn/Al-LDH matrices, iii) obtaining of hybrid hydrogels containing bioactive phytoextracts from Rosa Canina and Hypericum Perforatum L immobilized in natural zeolite and iv) treatment of wastewaters polluted with heavy metals and organic pollutants. This project extends the application of double-protected bioactive phytoextracts to new systems based on RfL and HtL phytoextracts incorporated in Mg,Ca/Al,Fe-LDH matrices and further encapsulated into hydrogels. The integrated technology ensuring minimum waste production, will allow the further utilization of obtained active ingrediends in food supplements with benefic effects for improving a lazy intestinal transit due to a constant low apport of glucofrangulins brought by RfL along with electrolytes such as Mg/Ca and Fe, while acting also as prebiotic and promoter of mineral absorption and cholesterol-lowering due to HtL. A benefit for wastewater treatment would also be brought. The use of the obtained products in food supplements could be benefic to people well-being, by reducing the negative effects of their chaotic lifestyle, with too many working hours, continuous stress and most important, poor dietary decisions, all leading to tremendous repercussions on the health of the digestive system.

Synthetic nanogel antibodies molecularly imprinted with the Spike S1 protein Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-1239 2022 - 2024

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation:

Project website: https://icechim.ro/project/antispike-ro

Abstract:

SARS-CoV-2 is a new coronavirus type and it is responsible for causing COVID 2019 in humans, with very high contagion rate all over the world. The viral entry of SARS-CoV-2 is conferred by the presence of Spike S1 protein on the surface that can direct attachment and enter the plasma membrane of the human cell. The Spike protein through its location is a significant therapeutic target, and targetable using antibodies. Despite recent technological developments, effective and safe therapies are currently not available for treating the infected victims. Thereby, the general objective of the project targets the synthesis of synthetic nanogel antibodies molecularly imprinted with Spike S1 (MIP-SNAs) for recognizing and retaining coronavirus-originated Spike S1 proteins. In this respect, the MIP-SNAs are able to recognize and bond to the Spike S1 proteins, acting as nanogel caps, and thus inhibiting the activity of SARS-CoV-2 antigen to penetrate the human cells. Hence, ANTISPIKE holds significant influence upon the scientific community by new concepts and methodologies for ligand-free delivery systems as MIP-SNAs (short-term impact: scientific ISI papers and communications, and national patent claim) and by opening new research directions associated with the side-benefits of the research (like new immuno-therapies) as long term impact. Implementation of this project will also bring specific scientific, economic and social benefits at the national and international level.

Rational design of composite membranes for advanced heavy metal removal in wastewaters Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0915 2022 - 2024

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation:

Project website: https://icechim.ro/project/ionmem-en/

Abstract:

Water pollution by heavy metal ions is becoming a major environmental problem because of the high toxicity of some of these elements and their tendency to accumulate through the food chain, affecting all living organisms in a given ecological system. The present project proposes a new concept for the water treatment membranes with improved features in terms of hydrophilicity, porosity and specific surface area and higher retention capacity at low concentration of heavy metal ions in effluent. In this respect, I-ON-MEM proposal describes a feasible and original method for preparing performant and low-cost composite membranes, based on functionalised MWCNTs and terpolymer formulations for advanced wastewater treatments. An original part of the project refers to selecting terpolymer formulations for preparing either 100% synthesic or biofriendly matrix. Another original aspect will be represented by addressing the possible effects of various functionalization agents and methods upon the WMCNT-copolymer compatibility pore size of membranes and retention efficiency of different heavy metals. Non-covalent functionalization of MWCNTs by surfactants and by silylation with various organosilica agents will be performed. The results will be disseminated as follows: at least 3 scientific publications in ISI journals; at least 3 scientific communications, and patenting of any original aspect.

RECYCLING CRUSTACEANS SHELL WASTES FOR DEVELOPING BIODEGRADABLE WASTEWATER CLEANING COMPOSITES Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-BLUEBIO-BIOSHELL 2020 - 2023

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); EDAS-EXIM SRL (RO); Norwegian Institute of Bioeconomy Research (NO); University of Coimbra (PT); Brinova Bioquimica Lda. ID&T (PT)

Affiliation:

Project website: https://icechim.ro/project/bioshell-ro/

Abstract:

Wastes from agriculture and fishery cause harmful effects on the environment and implicitly on humans. But, many of these wastes can be recycled. One of the current global issues refers to minimizing waste production, effective wastewater treatment, biosafe food production, and reducing hazards from the exposure to pathogens. Most of the threatening microorganisms especially emerging pathogens (EPs) derive from wastewater. Moreover, antibiotics residues present in wastewater lead bacterial pathogens to develop antibiotic resistance genes (ARGs). In addition, heavy metals are among the most harmful non-microbial pollutants due to their toxicity to humans. BIOSHELL aims at synergistically solving economic, environmental and health problems. The project focuses on utilizing the wastes from sea food preparation such as crustacean carcasses in the development of innovative and efficient inorganic-organic functionalized hydrogel nanocomposites, suitable to facilitate the sustainable wastewater purification technologies about heavy metals retention, antibiotics elimination, EPs and ARGs removal.

Advanced polymeric materials for innovative applications Call name:
PN. 19.23.02.01/2019 2019 - 2022

Role in this project: Project coordinator

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website:

Abstract:

Strippable coatings for heavy metals and radionuclids decontamination Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2019-0400 2020 - 2022

Role in this project:

Coordinating institution: STIMPEX S.A.

Project partners: STIMPEX S.A. (RO); Academia Tehnică Militară „FERDINAND I” (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); Ministerul Apărării Naționale prin Centrul de Cercetare și Inovare pentru Apărare CBRN și Ecologie (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://www.stimpex.ro/single-post/pelicule-detasabile-pentru-decontaminarea-metalelor-grele-si-radionuclizilor

Abstract:

The main objective of this project is represented by the transfer of an innovative decontamination technology that involves the utilisation of some strippable polymeric coatings for the decontamination of radioactive or heavy metals, from the academic research towards the industrial partner STIMPEX SA. This project idea appeared due to the extremely important problems related with environment protection, because every year increasing quantities of hazardous waste like radioactive or heavy metals are identified as result of the use of these contaminants in defense and security industry (primers, detonators), nuclear power industry, medicine, which lead to negative consequences. In order to reduce the harmful effects caused by these contaminants, this consortium aims to develop an innovative decontamination method for the surfaces. The polymeric films will be obtained on an industrial prototype scale, using a green synthesis method based on ecofriendly, biodegradable, nontoxic and low-cost raw materials. The synthesized decontamination solutions will be applied by spraying them over contaminated surface or they can be stretched with a roller or a brush and after drying, the resulting films can be removed by their simple exfoliation, thus removing also the contaminating agent embedded in their polymeric matrix.

Environment friendly technology for obtaining polyester polyols for polyurethane spray foams from PET wastes and renewable raw materials Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2019-0355 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CERCETARI PRODUSE AUXILIARE ORGANICE S.A.

Project partners: INSTITUTUL DE CERCETARI PRODUSE AUXILIARE ORGANICE S.A. (RO); INSTITUTUL DE CHIMIE ORGANICĂ ŞI SUPRAMOLECULARĂ "COSTIN D.NENIŢESCU" (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://icpaomedias.ro/index.php/proiecte-in-derulare/ecorepol

Abstract:

The present project proposal refers to developing on industrial pilot scale of an ecological technology for the synthesis of oligoester-polyols with tailored chemical structure and designed properties, so that they are suitable for use as intermediates in rigid polyurethane foams (PURs) formation, by chemically recycling. polyethylene terephthalate (PET) wastes, using as cleavage and / or chemical modification agents renewable co-monomers, or which can be obtained from renewable materials by biochemical and / or chemical processes, in the presence of organic catalysts, in order to increase the process performance and energy efficiency, and to avoid contamination of products with heavy metals.

The laboratory technology for the synthesis of polyester-polyols from PET waste and renewable materials, in the presence of organic catalysts, was developed by the Center for Organic Chemistry CD Neniţescu of the Romanian Academy (CCO) and the National Institute for Research and Development for Chemistry and Petrochemistry (ICECHIM), in collaboration, within a PN-II project and, based on it, a patent application has been submitted to OSIM.

The project aims to improve the technology, in the sense of maximizing the PET waste and renewable monomers content of the chemical composition of polyester-polyols and optimizing the reaction parameters for maximum economic and energy efficiency of the process, as well as the development and validation of the technology at industrial pilot level to the economic agent partner, the Research Institute for organic auxiliary products (ICPAO) Medias, by demonstrating the functionality in real operating conditions, testing the product in polyurethane spray foams formation under real working conditions (performed by a polyurethane spray foams producer as service employed with third parties), and validating the classification of their characteristics into those of standard PUR spray foams.

Screen-Printed Hybrid Electrodes for Detecting and Monitoring Lipopolysaccharides Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-2443 2020 - 2022

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); EPI-SISTEM S.R.L. (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://icechim.ro/project/toxisens-en/

Abstract:

The project TOXINSENS refers to designing innovative, versatile and re-usable biosensors for the fast, qualitative and quantitative detection and monitoring of lipopolysaccharides (LPS- endotoxin derived from Gram-negative bacteria, GNB) in various biological, food or water samples. For this matter, a medium consortium was created taking into account the project interdisciplinary and complexity, which includes the Project Coordinator ICECHIM that owns the background of the Concept approached in this project proposal, a Partner with state-of-the art facilities for characterisation i.e. UPB and a SME Partner-EPI SISTEM SRL capable of testing the project prototypes, adsorbing the know-how of manufacturing and commercialise the resulted LPS-biosensors. The project on-set refers to the following bioinspired concept: Methodology for the preparation of LPS-sensitive films-TRL 2. The concept was originally proposed by the Project Leader and developed within the Advanced Polymer Materials & Polymer Recycling Group from ICECHIM on project TE123/2018 BACTERIOSENS. Starting from this point, TOXINSENS targets first the upgrade of this former concept by addition of electro-active nanoparticles to the precursor films solution. In this way, an electro-active hybrid paste will be generated and used to print LPS-hybrid films directly on blank ceramic electrodes (TRL 3). The prepared LPS-Screen-printed hybrid electrodes will be further tested in laboratory-relevant environments and the innovative technologies will be thus validated (TRL 4). The specific output of the project will lead to several outcomes during project implementation (short-term scenario: at least 3 publications, 3 communications at prestigious Symposia or Congresses and 1 patent claim), and also after project end (long-term scenario: research and development roadmaps, performance data, transferable knowledge).

Contingency of CBRN hazards and improvement of national security resources Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0395 2018 - 2021

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie (RO); Academia Tehnica Militara (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); Centrul de Cercetare Stiintifica pentru Fortele Navale Constanta (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=40&lang=ro si http://icechim-rezultate.ro/proiect.php?id=33&lang=en

Abstract:

SECURE-NET is a Complex Project designed to improve the institutional performance of the Consortium Research Partners (Institutions with Re-launch Capabilities in the Field of National Security). In this respect, the Complex Project proposes five research themes corresponding to the five Component Projects, which aim at: (i) contingency of chemical, biochemical, radiological and nuclear (CBRN) hazards by developing new decontamination products and by developing specific sensors for detecting chemical agents of combat, and (ii) improving national security by developing shock-absorbing composites, solid rocket fuel and multispectral camouflages. This Complex Project brings together institutions with tradition, having either similar specialisation or complementary specialisation, to strengthen scientific and technical competences in the field of National Security and Advanced Materials for military applications. The Project Consortium has a gender-balanced staff and promotes the involvement of a large number of teachers, researchers, doctoral students and post-doctoral students in all activities proposed by the Common Agenda. In addition, the project facilitates the transfer of scientific knowledge between participating institutions as well as the recruitment and training of new staff. The multitude of results generated by the implementation of SECURE-NET express the potential for significant influence upon (i) the scientific community through communication and dissemination of results (as a short- and medium-term impact), and (ii) the public and private environment by promoting new research services and new transferable products / technologies to the external environment of the Consortium, particularly to the national defence industry (as a long-term impact).

Smart materials for medical applications Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0407 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://intelmatupb.wixsite.com/intelmat

Abstract:

INTELMAT project represents advanced research in the field of synthesis and application of smart materials for medical engineering in order to solve essential features of some acute/chronic diseases of large occurrence. 5 thematic directions are taking into consideration: 1. Developing of a controlled-release system of complex micro-colloidal architectures based on bacterial cellulose and hydrogels used for management of chronically wounds which aims to overcome the limitations of classical treatments; 2. Developing of new biomaterials specially designed with targeted action for treatment of inflammatory diseases of gastrointestinal segment; 3. Synthesis of new generation of composite membrane materials for artificial kidneys based on biocompatible polymers and derivative graphene; 4. Developing of some auto-assembly 3D platforms with controlled-released drugs based on polymeric nanoparticles and composite nanogels for the therapy of colon-rectal cancer; 5. Developing of innovative technologies for the synthesis of some 1D nano-architectures (nanowires) with controlled morphology, with applications in producing of non-enzimatic electrochemical biosensors.

Innovative technologies based on polymers for the obtaining of new advanced materials Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0428 2018 - 2021

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=41&lang=ro

Abstract:

The project is aimed at using the expertise that involved in consortium entities acquired in materials science. The consortium consists of three representative national institutes: INCD for Chemistry and Petrochemistry – ICECHIM Bucharest, INCD for Electrochemistry and Condensed Matter - INCEMC Timisoara and INCD of Chemical Pharmaceutical - ICCF Bucharest, and of two prestigious universities: University POLITEHNICA of Bucharest and the University of Bucharest and a remarkable institute of Romanian Academy: Institute of Macromolecular Chemistry – Petru Poni Iasi. Although having great tradition and noteworthy results, the first five institutions face a series of problems, from the lack of financial funds, equipment and the aging employees for ICCF and partly for INCEMC and ICECHIM, to the lack of highly qualified staff required for recent investments in equipment for all 5 institutions. In this respect, the project attempts relaunching the activity in the first 5 institutions of the consortium, by putting together the existing competencies, so as to develop new technologies in order to obtain new materials with high performance properties. Given that, 3 of the research teams are specialized in polymers (ICECHIM, Petru Poni and UPB) the developed technologies will use the polymers as intermediates or as a component in the finished product. To this end it is envisaged getting the titanium nitride for prosthetic coatings via inorganic-organic polymer nanocomposites, obtaining photocatalytic materials and antibacterial coatings by sol- gel reactions, obtaining of short-life or one-time use biomaterials from aliphatic polyesters and micro or nanocellulose and the development of new polyphase materials with medium or long life, based on biopolymers, through 3D printing. The project intends the full use of A1, A2, B and C checks in order to increase the institutional performance of partners.

HOW TO PROTECT WATER, SOIL AND PLANTS PRODUCTION ALL TOGETHER Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-WATER WORKS ERANET 2015-ProWsper 2017 - 2020

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU PEDOLOGIE, AGROCHIMIE SI PROTECTIA MEDIULUI - ICPA BUCURESTI (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=23&lang=en

Abstract:

The need for innovative strategies for water and soil protection that substitute the time-, energy- and resource-consuming remediation processes with other more efficient and environmentally-friendly is becoming urgent. In this respect, the interest of this project is to promote such solutions for public and private practitioners and to up-rise industrial competitiveness through economically sustainable technologies/products, in the Agriculture Field and indirectly in the Water Management aria. Therefore, this project practically develops protective composite layers (as end-products) with high efficiency towards pollution of underground water and soil, but without affecting the plants growth. ProWsper is an experimental and demonstrative research project conducted in partnership with four prestigious Institutions, from three European countries (Romania, France and Portugal) that face these common problems. In order to succeed, the implementation gap from Prototyping to Marketing and thereafter to practitioners will be narrowed by social/industrial awareness campaigns using various channels.

Ligand-free targeted delivery nanogels for phospholipase A2 retention Call name:
PN-III-P1-1.1- TE-2016-1876, no. 91/02.05.2018 2018 - 2020

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website:

Abstract:

Innovative technologies based on polymers for the obtaining of new advanced materials Call name:
PN-III-P1-1.2-PCCDI-2017-0428 2018 - 2020

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=41

Abstract:

Detection of persistent warfare chemical agents with specific screen-printed sensors Call name:
PN-III-P1-1.2-PCCDI-2017-0395 P3 2018 - 2020

Role in this project: Project coordinator

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); Academia Tehnica Militara (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie (RO); Centrul de Cercetare Stiintifica pentru Fortele Navale Constanta (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=33&lang=en

Abstract:

Chemical weapons are a means of mass destruction of personnel, the destruction of crops, or the deterioration of some military equipment, and the debilitation of combat troops by the contamination of air, land, fighting techniques, and various materials with warfare chemical agents (ACLs). Given that ACLs are very toxic (producing irritations, temporary physiological effects, serious illness or even death when used in combat concentrations) it is relevant to emphasize the development of small portable devices that can quickly and efficiently detect ACL traces. Although conventional analytical techniques for detecting ACLs (HPLC, LC, GC) are sensitive and specific, some drawbacks can be identified, namely extensive preparation and extraction steps, high organic solvent consumption, and expensive equipment. Therefore, literature provides important information on a simple and inexpensive method which can be applied for detecting ACLs in the atmosphere. This particular technique is based on the use of molecular imprinted polymers (MIPs) for sensors development. MIPs are synthetic materials that have specific complementary cavities of same shape, size and electronic entourage with a target molecule called template. Sensors with MIP recognition elements can identify and quantify the target molecules by transforming the MIP-analyte re-binding event into information, and thereafter, into a measurable physical signal. Thus, the overall objective of the project is to develop a new electrochemical sensor based on MIPs and sol-gel technologies to develop a simple, fast and efficient detection method for persistent ACLs.

Smart materials for medical applications Call name:
PN-III-P1-1.2-PCCDI-2017-0407 2018 - 2020

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GR. TH. POPA" (RO); INSTITUTUL DE STIINTE SPATIALE-FILIALA INFLPR (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website:

Abstract:

Advanced hybrid surfaces for biosensing Bacteria Endotoxins Call name:
PN-III-P1-1.1-TE-2016-1006, no. TE 123 ⁄ 2018 2018 - 2020

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website:

Abstract:

Advanced hybrid surfaces for biosensing Bacteria Endotoxins Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2016-1006 2018 - 2020

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=34&lang=en

Abstract:

One of the current global issues refers to drinking water or food quality and medical hazards from the exposure to pathogenic bacteria. Despite the gross investment on research to reduce the incidence of infections in humans, the simplest and most successful strategies in preventing bacteria spreading have proven to be the best hygiene practices. Hence, bacterial contamination can be prevented if properly detected. In this respect, biosensors can be applied to a large variety of samples including body fluids, food samples, cell cultures to analyze environmental samples. As a result, the project BACTERIOSENS proposes the preparation of advanced hybrid surfaces (namely molecularly imprinted polymer nanofilms, MIP NFs) able to sense lipopolysaccharides (LPS)-the endotoxin membrane of Gram negative bacteria (GNB). This is a multidisciplinary project resulting in innovative synthesis technologies for LPS-MIP NF and LPS biosensors. The specific output of the project will lead to various outcomes during project implementation (mid-term scenario: at least 3 ISI publications and 3 communications, 1 national patent claim and website of project) and also after project end (long-term scenario: new research themes, research and development roadmaps, performance data, transferable knowledge to lead-users). The scientific outcomes are expected to have several impacts with potential benefits within scientific, economic and social areas at the national level (during project implementation) and at the international level (when the innovative technologies for the preparation of LPS biosensors are transferred to potential beneficiaries). The work plan and methodologies are straightforward and the resources (meaning the infrastructure: laboratories and instruments; and the highly qualified Project leader and the young team members: 3 Postdocs, 2 PhD fellows, and other 5 young specialists) are well-balanced according to the activities employed for the project successful implementation.

Bactericidal hybrid surfaces against Gram-negative and Gram-positive pathogenic bacteria: Smart Tools for Wastewater Purification Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-M-ERA.NET II-TANDEM 2017 - 2020

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); EDAS-EXIM SRL (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=25&lang=en

Abstract:

After major efforts for hygienize the wastewaters, the presence of pathogenic bacteria is still detected in the water, soils and even crops, causing public and environmental hazards. This issue is of high concern as most pathogens responsible for waterborne diseases originate from faecal or food waste contamination caused by insufficient- or not treated wastewater. As a result, TANDEM project focuses on developing innovative and efficient bactericidal hybrid surfaces for Gram-negative and Gram-positive bacteria that can be transposed into special building blocks (i.e. smart tools) for creating more efficient bio-tanks and sustainable wastewater purification technologies with regard to pathogenic bacteria removal. The project consortium is well-balanced having aside two renowned RT&D entities from Romania and Norway that will guaranty the successful implementation of the project. In addition, one medium enterprise from Romania is entrusted with prototyping/testing the tandem bio-tank.

Ligand-free targeted delivery nanogels for phospholipase A2 retention Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2016-1876 2018 - 2020

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: https://icechim-rezultate.ro/proiect.php?id=32&lang=en

Abstract:

It is well known that the venom from the Hymenoptera insect class (bees, wasps, ants) are potent neurotoxic due to secreted phospholipase A2 enzyme (PLA2). For instance, bee venom PLA2 enzyme acts synergistically with the polyvalent cations (toxins) in the venom creating an increased haemolytic effect and a quick access of toxins into the blood flow, targeting important organs like the brain, kidney and liver. In spite of recent technological developments, effective and safe therapies are currently not available for treating the victims of mass insect attacks. Yet, thanks to advances in the fields of Nanotechnology, removing of PLA2 enzyme from sting zone, can be accomplished by targeted delivery systems called ligand-free nanogels. The proposed concept for preparing ligand-free nanogels is original and uses bifunctional macromonomers, small molecule cross-linkers and PLA2 template molecules to create antibody-like recognition sites for PLA2 subsequent retention. Hence, PLANano holds significant influence upon the scientific community by new concepts and methodologies for free-ligand nanogel targeted delivery systems (short-term impact: 3 ISI papers, minimum 3 communications, 1 national patent claim, web site of project) and by opening new research directions associated with the side-impacts of the research (like new imuno-therapies) as long term impact. Implementation of this project will also bring specific scientific, economic and social benefits at the national level and at the international level. The greatest impact is given by the health value, if taken in consideration the advantages of the innovative ligan-free nanogels over conventional antivenom production. Plus, the existing infrastructure of the Host Institution is appropriate to sustain the proposed tasks for PLANano successful implementation. But most importantly, the young research team composed of young specialist, post-docs and PhD fellows is highly qualified in this direction.

Molecularly imprinted polymers for electrochemical sensors for the detection of aromatic compounds in water Call name:
PN 16.31.02.02 2016 - 2018

Role in this project: Project coordinator

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/uploads/fisiere/raport-final-activitate.pdf

Abstract:

Surface plasmon resonance multi-sensor for real time illicit drugs detection Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
ERA.NET.RUS PLUS-SNIFF - ICECHIM 2016 - 2018

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=20&lang=en

Abstract:

All over the world, billions of dollars are spent annually on chemical/biological detection related to medical diagnosis, environmental monitoring, public security and food safety because laboratory analysis using expensive equipment is usually cumbersome and time-consuming. During the last 20 years, global research and development on the field of sensors has expanded exponentially in terms of financial investment, the published literature, and the number of active researchers. Bio mimetic sensors will be used as “on-site” method by the authorities to provide enough information for routine testing and screening of transportation. The main advantages of using versatile sensors for fast drug tracing refer to cost-efficiency and “on-site” legal measures to prevent drug traffic and consumption. The general objective of “SNIFF” proposal is to develop efficient optical micro sensor arrays (optical multisensor) using surface plasmon resonance (SPR) for detecting various drug compounds i.e. LDS, cocaine, heroin or methamphetamine to prevent illegal transit and consumption of drugs. Furthermore, the sensitive membrane of the optical sensor will be tailored, using a molecularly imprinting technique (MI), to “sniff” (sense and detect) only the targeted drugs. The most obvious advantage of SPR sensors using MIPs as selective films is having a wide range of low cost functional monomers as well as cross-linking agents available which may be selected by various experiments to match the functional groups of the template molecule. MIP are to be synthesized directly on the thin golden layer of SPR sensor using two procedures: deposition of the compatible synthetic MI layer directly on the golden concave surface and grafting the MIM onto the Au functionalized surface. Apart the low cost, the new sensor will have a very good resistance in time, due to the synthetic polymer, the possibility of continuous monitoring and of the recovery and reuse.

“New drug delivery systems based on micro/nanogel composites containing natural bioactive substances” Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0953 2015 - 2017

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation:

Project website: http://www.icechim-rezultate.ro/proiect.php?id=22

Abstract:

The overall objective of the project consists of obtaining micro/nanoparticles of covalently crosslinked hydrogels based on polyethylene glycol and aliphatic polyamines (injectable micro/nanogels) having embedded both natural nanozeolites but also of natural bioactive substances in their polymer structure, with potential pharmaceutical applications. These new micro/nanogel composite structures are of great interest as they are aimed at being used as devices for subcutaneous or intravenous injection, ensuring the release of bioactive substances in hard-to-reach areas (by macroscopic hydrogels). The role of natural nanozeolites incorporation is to allow for a much slower and controlled release of the embedded active substances and to improve the viscoelastic features of hydrogels. Nowadays bioactive substances play an important role in the development of controlled release systems in medicinal chemistry for the production of new drugs with fewer side effects. The use of phytoextracts as bioactive substances is a big challenge of the project proposal. These new micro/nanodevices with controlled release will have significant influence, both nationally and internationally on the scientific, social and economic field. The results will be disseminated as follows: three articles published in ISI journals; three scientific communications at international conferences, and patenting of any original aspect.

DEVELOPMENT OF MULTIPLE AND SELECTIVE SENSOR FOR DETECTION OF REPRESENTATIVES EXPLOSIVES Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0474 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA (RO); Academia Tehnica Militara (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); MIRA TELECOM S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation:

Project website: http://sensorex.incemc.ro/

Abstract:

Globalization of terrorism became a reality that can not be disputed, a threat to national and international security and, thus, a phenomenon under the responsibility of the entire international community. Terrorist threat, theatres of operations with explosive traps everywhere, with the possibility of using biological weapons of various viruses, drugs, etc are a constant threat to the civilian population, unwittingly victim of varied interests. It is an ongoing concern of many laboratories in the world to detect traces of explosives in the atmosphere, in order to minimize the risks arising from them. To avoid or prevent serious incidents that could endanger people's lives, EU adopted new security rules. These rules apply to security checkpoints at airports, the senior public institutions, in the cultural and artistic events with massive participation, etc. However, there are situations in which all efforts to prevent terrorist acts are not sufficiently effective, creating holes that are exploited by potential attackers. Therefore, rapid detection of explosive compounds is of great interest given the need to prevent any human casualties and material damages caused by their use in different ways and for destructive purposes. The principle SENSOREX will bring an additional performance in the field of detection devices for dangerous substances with the low response time, high specificity, greater functionality and last but not least a low production price. Practical relevance of the project subject is to develop innovative products and manufacturing processes that underlie the development of sensitive, selective, reliable and low cost sensors detection of explosives. Appearance is very important from the perspective of efficient procedures for prevention of terrorism threats by using them in areas where existing equipment besides being very expensive, are almost impossible to use due to ergonomic aspects, reducing processing time suspicious persons and packages various strategic points and last but not least reduce additional costs. The main objective of SENSOREX project is to develop through this national partnership, a sensor with high sensitivity detection of explosives traces . Implementation status of this sensitive platform will be a sensor – demonstrator model tested and calibrated with low response time, high sensitivity and specificity, easy to use and interpreted by a non-specialist user and not least a low cost. Progresses that SENSOREX project brings through its results are: innovative methodologies for obtaining titanium dioxide films and molecularly imprinted polymers; creating scientific premises for serial production of a device with high sensitivity to reduce the most important barriers to personal and group security; final product of the project, sensor – demonstrator model, by its future implementation in production strategy of the private company, partner in this project, it will cover a hole on external and internal market of the profile products.

Wastewaters treatment through flocculation- oxidation processes mediated by red mud derived flocculants and catalysts Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0177 2014 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU METALE NEFEROASE SI RARE - IMNR (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); EDAS-EXIM SRL (RO)

Affiliation:

Project website: http://www.unibuc.ro/depts/chimie/chimie_organica_biochimie_si_cataliza/PROIECTE-DE-CERCETARE/pn-ii-pt-pccaPN-II-PT-PCCA-2013-4-0177-2013-4-01770/

Abstract:

The project aims the development of an innovative technology for the treatment of wastewaters with high organic loading which may occur from different sources such as: food processing, stock farming, tanneries, oil pumping stations, engine cleaning stations.

The ground principle for the new technology is fighting pollution by valorizing the useful components from pollutants, or briefly ”Pollutants fighting pollution”. In this way the benefic impact on the environment is practically doubled. On one hand the volume of industrial wastes polluting the soil and waters is diminished, and on the other hand after the treatment clean water is obtained while decreasing the consumption of chemical grade reagents utilized in water treatment, as well as the costs related to the consumption of energy, raw and auxiliary materials needed for their manufacture avoiding also the emissions of other pollutants.

The industrial waste which is going to be valorized for this purpose is the red mud which is yielded in huge quantities from alumina manufacturing by Bayer process. Red mud is a highly alkaline residue (pH >11,5) with high concentration of iron oxides (40-50%) along with other oxides such as Al2O3, SiO2, TiO2, Na2O, CaO. It has elevated sodium concentration (>30 g/kg), and soluble alkalinity (≈30 g/kg as equivalent CaCO3). Due to its alkalinity and high content of fine-grained particles (>90% have sizes
Taking into account the high concentration of iron oxides in red mud waste, this project aims the utilization of red mud as iron source in order to replace partially the chemical reagents (generally synthesis grade Fe(III) salts) used in the obtaining of coagulation-flocculation-oxidation agents and advanced oxidation catalysts used in wastewaters treatment, laying the grounds for a sustainable green technology for the treatment of high organic loaded wastewaters.

The following original aspects that were not investigated up to now will be addressed:

a) the utilization of red mud suspensions for the generation of ferrate anions (FeO42-) which are the most powerful oxidation agents that may be used in water treatment (as it may be seen from the variation of the redox potentials: FeO42- (2,2eV) > O3 (2,03 eV) >H2O2 (1,78 eV) > MnO42- (1,68 eV) > Cl2 (1,36 eV) > O2 (solved) (1,23 eV) > ClO2 (0,95 eV)). The ferrate anions are considered to be a „green oxidant” since after the ferrate (VI) treatment there are no toxic by-products and following the redox cycle Fe(VI) is reduced to Fe(III) which is a very good coagulant/flocculant. Subsequently, in the stage following the oxidation it may serve as coagulant/flocculant able to remove the non-degradable impurities.

b) the obtaining of red-mud derived ceramic foams by gel-casting method - water treatment advanced oxidation catalysts

c) the obtaining of nanostructured amphiphilic magnetic materials - carbon nanofibers/red mud ceramic foams by chemical vapor deposition (CVD) method – efficient adsorbents of hazardous organic contaminants in wastewaters.

d) integration of the above mentioned obtained materials in the technology for the treatment of wastewaters with high organic loading.

The project enables the partnership between public and private areas in the priority domain 3- Environment. The partnership includes 5 participants: an university, 3 national research-development institutes, a private company EDAX EXIM SRL provider of equipments and specific tasks in the domain of wastewaters and water treatments which co-finances the project. The participation of the co-financer has the role to create the mechanisms for implementing the technologies developed by this project.

Cellular materials with thermal insulation and fire resistance properties, via energetic efficient recycling process of PET wastes, for minimizing heat loss in civil and industrial buildings Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1388 2014 - 2017

Role in this project:

Coordinating institution: CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU"

Project partners: CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); EUROPLASTIC S.R.L. (RO)

Affiliation:

Project website: http://ccocdn.ro/index.php?id=21

Abstract:

The present project proposal refers to a sustainable process of obtaining rigid polyurethane (PUR) foams, cellular materials with excellent thermal insulating and fire resistance properties. The process consists in chemically recycling poly(ethylene terephthalate) (PET) wastes, using as depolymerization and/or modification agents renewable materials, mainly carbohydrates and natural oils derivatives. Novel modified organocatalytic systems, different from conventional metallic compounds, will be developed and optimised in order to increase process performance, maximize energy efficiency and eliminate the need for solvents

The scientific challenge of the project consists in tailoring the novel catalytic systems, in order to drastically reduce energy consumption associated to the depolymerization reactions of PET wastes (in particular in the presence of some renewable materials), and enhance catalytic activity for these specific reactants, by using theoretical modelling, as well as experimental studies. In this respect, researh will be conducted in two main directions: i) modifying existing organocatalysts, in order to improve their performance or their stability; ii) proposing new organocatalyst that have not been used yet in catalyzed PET solvolysis. A library of new modified organocatalysts and/or combinations thereof, with synergistic effect, suitable for selective solvolytic attack of PET by various cleavage agents, will be, finally, provided. Optimal versions will be selected, in order to be used to further develop the technology for rigid PUR foams preparation, from PET wastes and renewable resources.

Lab-scale technologies for synthesis of selected catalysts will furnish information, useful for modifying commercial organocatalysts into new structures, or use new organocatalysts for PET chemical recycling, in order to apply such energy efficient technologies, on industrial scale.

The main objective of the project consists in developing a series of oligoester-poliols with tuned chemical structure (i.e. rigid and/or flexible moieties content) and properties (adequate for specific applications), starting from PET wastes and renewable materials, by using the correlations between reaction parameters (including organocatalysts), the products’ chemical structure and target properties. Using these oligoesters and designing the foams formulations, polyurethane and polyisocyanurate thermo-insulating rigid foams with tailored chemical structure will be obtained, adapted for various applications and showing (in some imbodiments) improved physico-mechanical and fire resistance properties The innovative and flexible pilot-scale technology for oligoester-polyols synthesis, using organocatalysts, as well as PET wastes and renewable resources as raw materials, would represent an exemplary case of meeting “green chemistry” standards by drastically reducing experimental conditions, eradicating the need for organic solvents, recycling a plastic waste which is accumulating in landfields and is not biodegradable, and providing, instead, innovative eco-friendly products, for long term applications. A innovative and flexible pilot-scale technology for PUR thermo-insulating rigid foams preparation using the respective oligoester-polyols will be developed, as well.

As a total result, a sustainable technology, with low energy consumption, significantly reducing the price of rigid polyurethane foams, would provide an exceptional solution to replace materials commonly used for insulation in buildings with new materials exhibiting outstanding properties and available for various applications, from building envelope to insulations for utility routes.

DRUG DELIVERY HYBRIDS BASED ON POLYMERS AND POROUS CLAY HETEROSTRUCTURES Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1432 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO); METAV - CERCETARE DEZVOLTARE S.R.L. (RO)

Affiliation:

Project website: http://www.tsocm.pub.ro/cercetare/DELPOCLAY

Abstract:

The research project is focused on the synthesis of new hybrid materials based on polymers and various organophylized porous clay heterostructures designed for controlled delivery of drugs which exhibit a low water solubility and high toxicity.

SUPERABSORBENTS BIOPOLYMER MATERIALS FOR AGRICULTURE USES Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-0115 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Affiliation:

Project website: http://www.sabiom.ro

Abstract:

The aim of the SABIOM project is to obtain new superabsorbent materials which could be used in agriculture for water reserving and soil conditioning, starting from biopolymers and using especially green chemistry methods.The superabsorbent materials which will be prepared will also have the capacity of active agrochemicals delivery to the plants in order to protect them against different diseases or to enhance their growth. The novelty of this project is to use bacterial cellulose and other biopolymers in order to obtain superabsorbent hydrogels. This choice was determined by the fact that the majority of the superabsorbent polymers used as commercial products are synthetic polymers as crosslinked polyacrylates or polyacrylamide, and hydrolized cellulose polyacrylonitrile (PAN) or starch-PAN graft copolymers. This project is enrolled in the research efforts which are devoted to develop natural-based superabsorbent polymers starting from polysaccharides and polypeptides (proteins).

EXPLOITATION OF SPONTANEOUS FLORA RESOURCES BY NANOTECHNOLOGY FOR THE OBTAINING OF HIGH BIOACTIVE HYPERICIN CONCENTRATES Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-0548 2012 - 2016

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO)

Affiliation:

Project website: http://www.icechim-pd.ro/en/pol_hitech/polimeri_hitech_spoflorahyp_en.html

Abstract:

The naphthodianthrones hypericin and pseudohypericin occur in the flowers and leaves of SJW. Hypericin act as an antibiotic and non-specific kinase inhibitor. Hypericin, is being clinically evaluated as an antiviral agent in the treatment of human immunodeficiency virus (HIV) infection. Hypericin was proven to be anti cholesterol and useful for blood circulation. In addition, hypericin is under research as an agent in photodynamic diagnosis (PDD) and therapy (PDT), of cancer.

The project target is to elaborate the production technologies for molecular imprinting of polymers with hypericin 1 enantiomer and for using these new materials in selective separations (MISPE), in order to obtain high bioactive concentrates of hypericin. This will allow the better exploitation of the resources of spontaneous flora and hereby to obtain by the “green chemistry” approaches dietary supplements able to prevent or to cure some diseases of the population. The main novelty of the project proposal is that it is intended to obtain molecularly imprinted polymer materials using as template the enantiomer 1 of hypericin, the materials being appropriate for preparative extraction of this enantiomer from primary SJW extracts. The second novelty of the project is the identification of technological parameters for MISPE separation of hypericin on the new materials. The third novelty of the project is the obtaining of high bioactive dietary supplements (concentrates) of hypericin. The many original idea involved in the project realization insures the deposition of at least 2 patent askings.

The hypericin concentrates that we intend to produce from St. John’s Wort are a world novelty. Such products are not yielded in Romania or abroad. Their enhanced bioactivity in preventing or curing some very dangerous diseases such as cancer, HIV, blood circulation disorders and depressions, will enable them to penetrate quickly on national and European markets.

New approaches for SiC and Si3N4 obtaining via polymer nanocomposites and their use for structural ceramics Call name:
MANUNET ERA-NET 7-074 2013 - 2015

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); CALORIS GROUP SA (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU METALE NEFEROASE SI RARE - IMNR (RO); MDA Ileri Teknoloji Seramikleri Ltd. Sti. (RO); Istanbul Technical University (ITU) (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.icechim-pd.ro/en/pol_hitech/polimeri_hitech_nasiponac_en.html

Abstract:

The project: "New approaches for SiC and Si3N4 obtaining via polymer nanocomposites and their use for structural ceramics" aims to obtain products with high performance and quality parameters, according to market current requirements, through new, simplified methods. The procedures will use integrated technologies for industrial applications intending integration of knowledge about nanotechnologies and nanomaterials in production of materials for various applications. The project provides the obtaining of two advanced ceramics powders: silicon carbide and silicon nitride, by the valorization of insufficiently used mineral resources, such as serpentinite reserves. Also, the project aims the processing of new powders in high performance ceramic articles as engines parts and body and military vehicles armors.

Innovative materials for waste water purification systems to be installed in tourist and other small polluting objectives on the Black Sea Coast Call name:
BS ERA NET 7-045/2011 2011 - 2014

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); Institute of Organic Chemistry - Bulgarian Academy of Sciences, Chemistry of Solid Fuels Laboratory (RO); Space and Solar-Terrestrial Research Institute - Bulgarian Academy of Sciences (RO); Istanbul Technical University (ITU), Department of Chemical Engineering (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.icechim-pd.ro/en/pol_hitech/polimeri_hitech_imawatco_prezentare_en.html

Abstract:

The overall goal is to contribute to the implementation of environmental-friendly technologies in the BSEC countries with particular attention paid to the promotion of innovative, cost-effectively and resource saving technologies.

Taking into consideration the BSEC Action Plan for Cooperation in the Field of Environmental Protection this project is a practical instrument to address the environmental challenges arising in the Black Sea coast.

The main goal of IMAWATCO project is to develop and improve the purification process of the waste waters exhausted into the Black sea mainly from polluting sources as industry and tourism, agriculture and different social objects.

An effective and cost-saving model solving the small industry and tourism pollution will be developed based on the integration of innovative filtration systems within local installations for purification, attached to the objects which are sources of pollution.

The proposed filtering-treatment unit for water purification has an integrated conception: natural zeolites as the filtrating and primary purifying layer, polymer membranes as second ultra filtration layer and selective adsorption layer and an adsorbent for complete purification of exhaust water

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects