BrainMap

Ana-Maria Prelipcean

Ph.D.

Researcher - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Researcher

Web of Science ResearcherID: not public

Curriculum Vitae (21/07/2021)

Expertise & keywords

Design of novel composite materials based on mesoporous matrices by exploring the nanoconfinement effect Call name: P 4 - Proiecte de cercetare exploratorie - PCE-2021
PN-III-P4-PCE-2021-1548 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO)

Affiliation:

Project website: https://comconf.chimie.upb.ro/

Abstract:

The project deals with antibiotic-free antibacterial strategies based on nanomaterials, a hot topic of research because mankind is facing with a growing resistance on bacteria and aims to develop novel composites containing polyphenols nanoconfined into mesoporous silica nanoparticles (MSN) chemical modified to enhance their stability and to improve health benefits due to synergistic effect of components for topic applications with antibacterial properties. The project will explore unconventional extraction techniques (pressurized liquid extraction or ultrasound-assisted extraction) and pre-treatments to obtain phenolic extracts with desired chemical profile, surface engineering for the design of modified MSN to develop novel formulations for extracts with health benefits, tailoring polyphenols - MSN interactions for enhanced phytocompounds stability when are encapsulated in MSN, as well as an appropriate release. Antimicrobial and effects at cellular levels of formulations containing polyphenols will be assessed. For extracts obtaining as vegetal material will be used wild berries from Romanian mountains. For envisaged application, mesoporous silica will be modified not only with organic groups, but also with inorganic nanoparticles (TiO2, ZnO, Ag, or Cu) to contribute to composites bactericidal activity. The polyphenols-silica composite with best features will be incorporated in a natural polymer for wound dressing applications.

INNOVATIVE NANOSTRUCTURED NUTRACEUTICALS WITH SYNERGISTIC BIOACTIVITIES FOR HEPATO-DIGESTIVE PROTECTION Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1788 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA OVIDIUS

Project partners: UNIVERSITATEA OVIDIUS (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO); STATIUNEA DE CERCETARE DEZVOLTARE PENTRU VITICULTURA SI VINIFICATIE MURFATLAR (RO)

Affiliation:

Project website: https://univovidius.wixsite.com/nutrasinpro

Abstract:

The project entitled “INNOVATIVE NANOSTRUCTURED NUTRACEUTICALS WITH SYNERGISTIC BIOACTIVITIES FOR HEPATO-DIGESTIVE PROTECTION (NUTRASINPRO)” falls in the priority research domain of the present competition call, Bioeconomy, Subdomain Biotechnology. The general objective is obtaining of controlled nanostructure delivery systems based on natural raw materials mixtures as fluid fruits extracts of bitter cherry (Prunus avium var. sylvestris L.) and blue honeysuckle (Lonicera caerulea L.), grape pomace (Vitis vinifera L.) as by-product of grape winemaking encapsulated into a hybrid silica–barley germs mass (Hordeum vulgare as prebiotics) nanomatrix enriched with Lactobacillus sp. strains as probiotic. The main objectives of the project are design of new nutraceuticals formula obtained from high functional food-grade bioactive agents (anthocyanins, carotenoids, polyphenols, flavonols, flavones, vitamins, lipids, oligominerals) present in vegetal extracts encapsulated within a hybrid silica matrix-barley germs biomass nanostructure in different ratio; obtaining an innovative series of nutraceuticals delivery nanosystems exhibiting synbiotic action of prebiotics–probiotics constituents with synergistic therapeutically action; controlled delivery systems by nanoscale targeted level, with synergistic bioactivities, antimicrobial, antioxidant, anti-inflammatory and hepato-digestive protection and development of new technologies to obtain nutraceuticals nano-formulations conditioned as orodispersible tablets, controlled release tablets and lyophilized powder for oral use, protected by property rights. The envisaged end products: 1. Patenting the optimal variant nanostructured nutraceutical formulas of the new nanostructured target delivery system and issued in improving oral bioavailability for all ages group; 2. Technological process development for widely implementation of nanostructured nutraceutical formulations, used without risk on human, animal or environment health.

3D laser printed absorbable scaffolds with a prolonged biomechanical stability in human body fluids. Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-0992 2021 - 2023

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation:

Project website: https://www.icf.ro/pr_2020/PCE-234-2021/index.html

Abstract:

Novel biomaterials for temporary orthopedic implants are one of the most challenging areas of exploratory research in advanced materials. Third generation biomaterials are designed to be both resorbable and bioactive, that is, the implant will be temporary, and once implanted, it will help the body heal itself. The aim of this project is to progress toward a novel absorbable scaffold biomaterial for temporary orthopedic implants, through hierarchically structured surfaces that protect the scaffold, effective to convey higher corrosion tolerance and increased scaffold strength retention for extended periods in body fluids while at the same time capable to stimulate human osteoblast cell proliferation behavior. Specific objectives are (i) the design and fabrication of 3D printed scaffold structures with biocompatible elements by rapid solidification from melt through laser additive manufacturing-3D printing; (ii) the development of original cost-effective surface modification procedures for surface protected scaffolds (SPS) with enhanced corrosion tolerance and bioactivity; (iii) the determination of bare and SPS corrosion rates and corrosion mechanisms in human physiological fluids of pH and chloride concentrations reproducing the most exigent conditions for implant use; and (iv) the assessment of the scaffold-cell constructs to initiate tissue repair processes and osteogenesis; contributing to Romanian research with: 1 patent, 4 scientific articles, 6 conference presentations

Technologies for preparation of some natural products with immunostimulatory properties Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-2118 2020 - 2022

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); HOFIGAL EXPORT IMPORT SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: https://unibuc.ro/cercetare/promovarea-rezultatelor-cercetarii/proiecte-de-cercetare/proiecte-cu-finantare-nationala/imunostim/ si https://unibuc.ro/cercetare/promovarea-rezultatelor-cercetarii/proiecte-de-cercetare/proiecte-cu-finantare-nationala/imunosti

Abstract:

The project scope proposal is the development of specific technologies for preparation of some vegetal extracts with immunostimulatory properties, which will be used in formulation of a food supplement for body invigoration. The novelties of this proposal are: a new own product, a combination of active principles with immunostimulatory properties; specific method of obtaining active principles with immunostimulatory properties; confirmation of non-aggressive effect of the nonconventional extraction techniques on the stability of extracted active principles.

The optimal plant extracts obtained by conventional and unconventional extraction methods will be selected. The optimal extracts contains the active principles from Hedera helix L. leaves and are obtained with the best possible extraction yield, without changing the structure of the extracted bioactive compounds. In all extraction stages, ecofriendly solvents (water, ethanol) will be used. Methods for analyzing and quantifying of selected bioactive compounds triterpene saponins, polyhydroxyalcohol-aldehyde (2-C-hydroxy-methyl-D-ribitol) , as well as corresponding standard compounds will be developed. Bioactive compounds of interest (from extracts and standard ones) will be analyzed qualitatively and quantitatively by spectroscopic methods ( 1H-NMR, 13C-NMR, IR, UV-Vis, HPLC / LC / MS / MS). The structure of the selected bioactive compounds will be highlighted by modeling methods and X-ray diffraction studies, to confirm their immunostimulatory properties. The bioactive compounds selected from the extracts and the standard ones will be tested by specific methods to highlight the immunostimulatory properties. The technology of obtaining the final product, dietary supplement, for the body's invigoration will be developed, with clinical impact.

Functional food with emergent properties to support hypocaloric diet Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3805 2020 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); SANTO RAPHAEL SRL (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/sinergem/

Abstract:

SINERGEM Project aims to develop a functional food as a protein bar used as adjuvant for hypocaloric diet, based on a combination with emergent properties of polyphenols and polysaccharides from forest fruits pomace (by-product resulting from obtaining the fruit juice at the economic agent partner) and chia seeds. The commercial opportunity is clearly established – the market for functional foods is increasing, driven by the requirement for healthier diets. The potential of forest fruits pomace as an affordable and sustainable source of polyphenol and polysaccharides is confirmed. Project objectives are (i) to select the synergistic composition of polyphenols and polysaccharides; (ii) to prepare a gastro-resistant nanoformulation of the synergic composition and (iii) to include the nanoformulated composition in a protein bar, verifying the preservation of emerging properties. The expected results of the project are: a mixture of polyphenols and polysaccharides (extracted from forest fruit pomace) and chia seeds, selected by a combination of high-throughput techniques and encapsulated into a gastro-resistant liposomal nanoformulation, which is included in a protein bar. Our proposed activities are intended to reach objectives related to: optimization of product composition (synergic composition); integration of product components into the demonstration model (nanoliposomes in a protein bar) and testing and validate its biological activity (as antioxidant, prebiotic and -amylase inhibitor) on laboratory level, on model systems. After the project implementation the economic agent partner will expand the range of functional foods that it can produce and sell.

Biotechnology for a new biomimetic composite hydrogel based on extracellular matrix components and Si-bioceramics enriched with small molecules (flavonoids) for osteochondral regeneration Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-1714 2020 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); CHEMI CERAMIC F SRL (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: https://www.incdsb.ro/p/biosicon/

Abstract:

Osteochondral defects are caused by severe trauma, accidental and sport-related injuries or diseases (osteoarthritis), which lead to pain and joint deformity. In 2012, it was estimated that 31 million people suffered from osteoarthritis in USA, among them 9.2% having osteochondral defects.

This project proposal aims the development of an innovative strategy for osteochondral regeneration by creating a novel biodegradable cross-linked composite hydrogel based on natural polypeptides (gelatin), natural polysaccharidic components (glycosaminoglycans) and silica-bioceramics (hydroxyapatite and tricalcium phosphate enriched with silica and akermanite) containing small molecules (flavonoids).

A key aspect is represented by Si-bioceramics use, as a better alternative to conventional bioceramics. The enrichment of the composite hydrogel with flavonoids (icariin and quercetin), as substitutes of growth factors will improve the healing of bone and cartilage. The physico-chemical and structural analysis of composite hydrogel will be performed by spectrometry, SEM-EDX, X-ray diffractometry, Raman spectroscopy, ion chromatography and mathematical modeling of the cristallization process. The validation of biomimetic system functionality and utility will be performed by analysis of genotoxicity, antimicrobial and antiinflamatory activity, the capacity of stem cells to proliferate and differentiate into osteoblasts and chondrocytes in the presence of composite hydrogel and angiogenesis in a co-culture of stem cells/HUVEC. In vitro biological activity will be demonstrated by experimental/demonstrative models in cell cultures using flow-cytometry, RT-PCR, ELISA, spectrometry and fluorescence microscopy. The original results regarding product and lab technology will be patented in view of transfer to the partner SME. The interdisciplinary public-private partnership will ease the development of new products that will bring benefits for people’s health and the access to European funds.

Novel biotehnologies of plant by-products complex valorisation for prevention and control of pathogens in agro-ecosystems Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3561 2020 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); HOFIGAL EXPORT IMPORT SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/hydropest/

Abstract:

Nowadays, one of the major challenges for the R&D sector is to develop an efficient conversion of agro-food waste or by-products into innovative products, within circular bioeconomy. In this context, our project proposes valorisation of aromatic plants by-products in the form of hydrosols through novel biotechnologies in order to develop active products against various pathogens found in agro-ecosystems. Within the project, the multidisciplinary R&D and SME partnership will develop a new formula of biopesticides with functional properties and it will establish treatment protocols in experimental cultures, validating in vitro and in vivo their efficiency and safety in the labs of both partners. The project will start at TRL2 formulating the technological concept of plant hydrosols as waste products and will advance at TRL3 obtaining experimental variants of hydrosols with pesticide potential and it will end with TRL4 achieving validated formula in seedlings and plant model systems, which will be patented. High-throughput techniques (HPLC, GC, flow cytometry, fluorescence microscopy, mathematic modelling, PCR, microbial and cell culture experimental models, etc) will be used for the chemical and biological screening of hydrosols, to select functional models of biopesticides. The exploitation of aromatic plant by-products as biopesticides in crop pest management could open new opportunities in ecological agriculture, promoting natural, safer and autochthonous products. Furthermore, the partnership between R&D and industry sector will be strengthen in order to apply to future European calls regarding plant waste recycling and food security.

Functionalized mesoporous bioglass based 3D scaffolds for hard tissue regeneration Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-0598 2020 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.icf.ro/pr_2019/BIOSCAFTIS/index.html

Abstract:

The project proposal “Functionalized mesoporous bioglass based 3D scaffolds for hard tissue regeneration“, aims to improve the well-being of people by treating them with new biomaterials. The objective of the project is to restore and improve the function of hard tissue by using functional bioactive scaffolds. These scaffolds will provide good mechanical properties in a suitable environment for tissue regeneration and repair. Sodium free mesoporous bioglasses (MBGs) doped with cerium will be used for scaffold manufacture using a combination of structure-directing agents and a polymer foam replication method. The BIOSCAFTIS project is based on our early results demonstrating that MBGs doped with cerium have good bioactivity and biocompatibility properties. In order to improve the growth and remodelling of bone tissue the surface of the scaffold will be functionalized with vitamin D3. The properties of the scaffolds e.g. bioactivity, mechanical strength, antimicrobial activity and drug delivery profile will be evaluated using adequate characterization techniques. The performance integration of 3D scaffolds to native tissues will be investigated using in vitro experimental models mimicking interaction with osteoblast cells. As a result of the research the project aims to disrupt the area of biomaterials by developing a new class of materials for medical applications.

Biorefining of the side streams resulted from cyprinids commercialization Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2019-0181 2020 - 2022

Role in this project: Key expert

Coordinating institution: MEDICA FARMIMPEX S.R.L.

Project partners: MEDICA FARMIMPEX S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://info.pro-natura.ro/colstim/

Abstract:

The aim of the project is to increase the competitivness of the coordinating company Medica Farmimpex and of the economic agents beneficiaries of the products obtained by the project, by assimilating some CDI results and by strengthening the partnership with research units in the fild of Bioeconomy-Biotechnology.

As result of this project it is expected to obtain high value-added products, trough an integrated extractive biotechnology, from the side streams of the commercialization of freshwater fish (cypridins).

Through the biotechnology that would be carried out at industrial level by the project coordinator, they will recover from the lateral flows of freshwater fish processing: collagen hydrolysate (nutraceuticals for human use) and gelatin like polypeptides (plant biostimulants). The remaining residue after the extraction of the peptides is processed into bone flour which is an essential nutritional supplement for feeding predatory fishes. Each of these products has a high use value associated with a significant market value.

The objectives of the project are: (i) to develope a pilot installation to obtain high valued products from the side streams of the fish commercialization; (ii) to validate the integrated technology in industrial environment; (iii) to demonstrate the functionality of the technology in the industrial environment by characterising and testing the obtained high added - value products.

The innovative character is given by the integrated concept of total capitalisation of the fish by-products. Another innovative aspect is the development of the quality assurance system, using NIR spectroscopic sensors coupled with a chemometric analysis.

The project parteners are INCDSB and INCD-ICHECHIM. INCDSB has the necessary expertise to transfer the technology for obtaining collagen hydrolysates. INCD-ICECHIM has the expertise to obtain and characterise the peptides as plants biostimulants.

COMPLEX VALORISATION OF BLACK SEA REGION BIORESOURCES BY DEVELOPING AND APPLYING INNOVATIVE AND EMERGING BIOTECHNOLOGIES Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0701 2018 - 2021

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA OVIDIUS

Project partners: UNIVERSITATEA OVIDIUS (RO); INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE MARINĂ "GRIGORE ANTIPA"-I.N.C.D.M. CONSTANŢA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); STATIUNEA DE CERCETARE DEZVOLTARE PENTRU VITICULTURA SI VINIFICATIE MURFATLAR (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: https://univovidius.wixsite.com/inobiomar

Abstract:

Natural products from marine species are increasingly studied as their functional properties are discovered. These properties have benefits for human health while depending on their geographical region of origin. As abundant marine resources with insufficiently exploited therapeutic potential exist, the present proposal aims to harness the Black Sea bioresources through developing innovative technologies for obtaining biorenewable pharmaceutics preparations. The membrane/bioadhesive disks preparations consist of bioactive compounds from marine extracts encapsulated into mesoporous functionalized silica matrices and have controlled release. The Black Sea bioresources valorization will be improved by using the residual biomass from technological flux as biofertilizer for vineyards. New technologies for efficient extraction and preservation of active ingredients, encapsulation in pharmaceutical and nanostructured silica matrices, obtaining modern, therapeutically/cosmetic efficient formulations tested in vitro, will be developed. The project will be completed by a multidisciplinary consortium composed of UOC, INCDM, UPB, INCDSB, having a new research center with personnel deficit (Romanian Academy-ICF) and a relaunching center- SCDVV Murtfatlar, which will develop and use the common infrastructure, existing and newly created human resources, both through the project implementation and future collaborations, while strengthening the partners’ institutional capacity through improving their services offers. The project will achieve TRL 5. The main goal of the complex project can be achieved through the complementarity of the 5 component projects, having 6 patent applications and developing new fabrication technologies for 3 pharmaceutical formulations with synergetic action as deliverables, which can be translated to economic beneficiaries.

Closing the bioeconomy value chains by manufacturing market demanded innovative bioproducts Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0569 2018 - 2021

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA "DUNAREA DE JOS" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); UNIVERSITATEA AUREL VLAICU ARAD (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=51&lang=ro

Abstract:

Agriculture and food industry in Romania generates large amounts of co/by-products, which are not used and turn into wastes, with negative impacts. The approach of the project PRO-SPER is to develop integrated processes, flexible and interconnected, to transform a number of agro-food by-products in bio-products, with market demand. This approach facilitates the achievement of project goals, complex-coordination and linking of the research organizations that are members of the Consortium, INCDCP-ICMPP, UDJ, ICECHIM, INCDSB and UAV, for improving their institutional performance in the field of nano-and bio-technologies of their application into bioeconomy.

The overall objective of the project PRO-SPER is to increase the impact of research and development activities and innovation of the RDI institutions, by developing and harnessing innovative technological solutions for bio-nano-processing of several by-products from the bioeconomy value chains, for recovering and/or formation of value-added components and their use in order to obtain products with high added value.

Expected results through the implementation of the project (21 new jobs, 23 national patent applications and international patent applications 6 EPO/WIPO; 10 technologies/new products resulting from the project, at a level of technological maturity to enable taking over by the operators, 5 services research and technological research services 10 cheques, 10 experiments cheques services

80 internship of young researchers from and within partner institutions, 50 visits for developing new techniques for working jointly in the Consortium, 30 training internships for new employees, 28scientific papers, 1 joint program CDI, in line with the development plan of institutional partners) have a significant impact on the capacity-building of the partners in the Consortium.

High performance technology for the development of novel 3D stem cells-matrix systems for guided tissue regeneration of complex oral tissues lesions Call name: P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0715 2017 - 2019

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://stematech-62-2017.unibuc.ro/

Abstract:

High number of scientific studies indicates the immediate need for new solutions in the treatment of damaged connective tissues from periodontium, since guided tissue regeneration market products showed variable efficacy, depending on the shape and size of the defect. A major issue in application of mesenchymal stem cells is their low rate of survival after implantation. In this context, STEMATECH project aims to develop a high performance technology for obtaining novel 3D cell culture systems based on spheroids from dental pulp stem cells (DPSC) cultivated in a biomimetic matrix engineered from extracellular matrix components, intended for regeneration of complex oral tissues lesions. The specific objectives target improvement of DPSC spheroids morphological and functional characteristics, investigation of complex interaction stem cells-matrix and 3D system functionality testing in several experimental models of inflammation, oxidative stress and tissue regeneration. The impact of this interdisciplinary project refers to added knowledge in regeneration mechanisms after data integration from complementary activities of preparation, characterization and testing. The elements of originality and innovation contain a thoroughly study of DPSC properties in correlation with patient age and cell cryopreservation. A comparative study of spheroids versus stem cell cultivation in a 3D biomimetic matrix will be performed for the first time, giving insights for novel tissue engineering strategies. An important outcome of this project will be results dissemination in journals with high visibility in the field and a patent demand. The project proposes optimization of a large variety of techniques, light and electron microscopy, immunocytochemistry, cell biology, biochemistry and molecular biology, in order to assess the efficiency of DPSC-matrix systems for treatment of complex oral tissues lesions.

Product for the maintenance and/or rebalacing of the vaginal microflora Call name: P 2 - SP 2.1 - Cecuri de inovare
PN-III-P2-2.1-CI-2017-0298 2017 - 2017

Role in this project: Key expert

Coordinating institution: LABORATOARELE MEDICA S.R.L.

Project partners: LABORATOARELE MEDICA S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/ReStart/ReStart.html

Abstract:

The project aims to develop an optimized composition for maintaining and/or re-balancing the vaginal microflora, product characterization, specification of technical conditions needed to scale-up of the manufacturing process and protection of intellectual property rights. The project is proposing a new composition that includes volatile oils, a new generation of polyphenolic prebiotics and postbiotic compounds, designed to protect and stimulate local populations of vaginal lactobacilli. It has been demonstrated that lactobacilli are protected against different types of stress by the new generation of prebiotics (e.g., polyphenols) and that their development is stimulated by post-biotic compounds resulted from prebiotics fibers fermentation. Such a composition has not been achieved until now. The innovative approach concerns the novelty of the composition and its conditioning form. The formulation is an adhesive gel, which responds to temperature variations (solid gel at room temperature and fluid gel at body temperature) and has the following advantages: reducing the loss of volatile oils during storage at room temperature, easiness of solid gel application, better mucoadhesive and viscosity characteristics after application. Research and innovation service to be provided includes the following activities: selecting the ingredients of a composition conditioned as a gel designed for the maintenance and/or re-balancing of the vaginal microflora; optimizing the composition by laboratory tests on lactobacilli strains and epithelial cell cultures; characterization of optimized composition included in a vaginal applicator; study for the manufacture of the product, support for intellectual property rights. The technological risk for obtaining this product and the commercial risk are reduced. The service provider (INCDSB) has appropriate and necessary expertise and infrastructure for product development.

Antimicrobial bionanocomposites for medical applications Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-0979 2012 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); I.C.P.E. BISTRITA S.A. (RO)

Affiliation:

Project website: http://www.icmpp.ro/intranet/grant_files/bionanomed/

Abstract:

BIONANOMED project aims both to obtain a new class of advanced materials, BIONANOCOMPOSITES based on mixtures of synthetic polymers with natural polymers, optimized with silver nanoparticles (antiallergenic effect), as well as the establishment of their processing technologies to obtain biocompatible, biodegradable, antimicrobial medical devices. In this context, our objectives are: bioactivation of biodegradable synthetic polymers (based on novel modified PLA, PVA, PU polymers synthetized during project development) with natural polymers (chitosan, starch, cellulose, elastin, chondroitin sulfate, hyaluronic acid) to increase their biocompatibility; obtaining silver nanoparticles with controlled sizes; optimization of bionanocomposites containing natural/synthetic polymers by imprinting antimicrobial properties; their physico-chemical and biological characterization to establish their domain of use; development of a technology for obtaining a biodegradable medical device with antimicrobial properties:"urinary drainage tube”-UDT. The selected natural polymers possess properties like biocompatibility, antimicrobial, hemostatic, fungistatic activity, have reactive hydroxyl groups available for further modification to impart required characteristics, are safe, non-toxic, exhibit regenerative effect on connective tissue, which are necessary to achieve the final purpose. New biological methods will be developed for in-depth characterization of new biomaterials which will assure their safe implementation in industrial and medical practice.

Based on optimized formulations and laboratory technology elaborated by research groups and also proved experience in obtaining traditional plastic medical devices, SME co-financing the project will realize the medical device – UDT which will be tested, packed and sterilized according to existing requirements for such products (Directive 93/42 CEE) and finally implemented in their production leading to diversify it, increased jobs and benefits

EEA/NO Mobility Grant - Ana-Maria STANCIUC Call name: NO - Proiecte de Mobilităţi - 2019
RO-NO-MG-2019-0256 2019 -

Role in this project: Project coordinator

Coordinating institution: National Institute of Research & Development for Biological Sciences

Project partners: National Institute of Research & Development for Biological Sciences (RO); University of Bergen (NO)

Affiliation: National Institute of Research & Development for Biological Sciences (RO)

Project website:

Abstract:

EEA Mobility Grant - Ana-Maria STANCIUC Call name: EEA - Proiecte de Mobilităţi
EEA-MG-RO-NO-2018-0126 2018 -

Role in this project: Project coordinator

Coordinating institution: National Institute of Research and Development for Biological Sciences Bucharest

Project partners: National Institute of Research and Development for Biological Sciences Bucharest (RO); School of Science and Engineering, Reykjavik University (IS)

Affiliation: National Institute of Research and Development for Biological Sciences Bucharest (RO)

Project website:

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects