BrainMap

Mr. Adrian Albulescu

Scientific Researcher

Researcher - INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU"

Other affiliations

Researcher - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (Romania)

Researcher | PhD student

Web of Science ResearcherID: A-8619-2019

Curriculum Vitae (30/01/2024)

Expertise & keywords

Artificial Intelligence Algorithms in Male Infertility Diagnosis Based on New Molecular Approaches Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-4402 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU"

Project partners: INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO); INSTITUTUL NATIONAL DE ENDOCRINOLOGIE "C.I.PARHON" BUCURESTI (RO); NET - CONNECT BUSINESS SUPPORT SRL (RO)

Affiliation: INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO)

Project website: https://www.virology.ro/en/research/projects/male-infertility

Abstract:

Causes of male infertility were reported as mainly Y chromosome deletions. However only 10-15 % of infertile patients shows such anomalies. Studies regarding infertility expanded from the genetic level to epigenetic factors. The proposal aims to improve investigation protocols and diagnosis for male infertile patients. This scope will be achieved through developing a method for epigenetic profiler (panel) which will evaluate the level of methylation for selected genes involved in male infertility and to develop a decision support system (DSS) based on artificial intelligence (AI) that can predict the results a from a questionnaire, hormonal profile, infection status, methylation panel and semen analysis. The novelty of current proposal is to elaborate a new protocol and AI based algorithms to investigate infertile men, not only to diagnose, but to improve the selection for assisted reproduction techniques (ART). Such investigations, protocols are not introduced yet in the current practice worldwide, and are the subject of great interest for researchers and especially for clinicians who expect validating and transferring research results into the clinic as soon as possible. Despite the fact that the number of clinics performing assisted reproductive procedures is high, the success rate is low due to lack of opportunities for testing at the molecular level functionality sperm and oocytes.

Considering the team's experience in terms of experimental methods to be used in this project and the conceptual coherence supported by papers published in this field in recent years, along with the existent infrastructure, we believe that the project has a high feasibility to achieve the proposed goals in good conditions.

ND10 bodies dynamic switch in viral chromatin remodeling during early hrHPV infection. Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-1759 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU"

Project partners: INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO)

Affiliation: INSTITUTUL DE VIRUSOLOGIE "STEFAN S.NICOLAU" (RO)

Project website: http://www.virology.ro/en/research/projects/early-hrhpv-infection

Abstract:

Human papilloma viruses (HPVs) are non-enveloped double-stranded DNA genome viruses, divided according to oncogenic potential into low-risk (lrHPV) and high-risk (hrHPV) genotypes for which persistent infection is associated with cervical dysplasia and carcinogenesis. HPVs developed strategies to interfere with innate immune responses, to delay adaptive immune responses and thus to promote oncogenesis. Even if the HPV viral life cycle has been extensively studied, the regulatory proteins that influence viral chromatin and interactions of the viral DNA with complex nuclear structure in the infected cells are still under investigation. The proposal intends to unveil the mechanism of how hrHPV optimizes its own transcription in order to evade the intrinsic immune response being prone to use epigenetic mechanisms to regulate biological activities during virus life cycle.

In this context, we hypothesize an association between HPV genome and chromatin remodeling complexes interaction that influences the early viral gene transcription. In order to highlight this we propose the following specific objectives: identifying ND10 components involved in chromatin remodeling complexes and histone chaperones during early viral infection using as experimental models infected human cell lines with HPV16/18 pseudovirions; establishing if ND10 complex has a role in intrinsic immune response in hrHPV infection; discovering the role of histone H3.3 in viral chromatin status during first stages of infection (HPV and ND10 co-localization); understanding which viral factors may play a role in regulation of ND10 chromatin remodelers, which may help the virus escape from intrinsic immunity mechanism.

The obtained data will enrich the knowledge in the field of molecular biology and epigenetics of the HPV infection, which may represent a future challenge for developing new therapeutic targets and strategies in disease management. This may open new research direction for HPV–induced tumorigenes

PELL AMAR – A NAME IN SEARCH OF ITS LOST FAME Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1470 2014 - 2017

Role in this project: Key expert

Coordinating institution: PELL AMAR COSMETICS S.R.L.

Project partners: PELL AMAR COSMETICS S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO)

Project website: http://www.pellamar.com/dermatocosmetice/cercetare.php

Abstract:

PELL AMAR – A NAME IN SEARCH OF ITS LOST FAME

Finding that sapropelic mud has biotrophic, regenerating, sedative, analgesic, anti-inflammatory properties, Dr Ionescu Călineşti had two ideas that led to a Romanian brand of great success in 1970:

a) he inferred the synergistic effect of the combination of minerals, enzymes and organic substances, mainly its holistic healing action;

b) he obtained by atomization, a concentrate with enhanced curative effects.

The extract was called PELL AMAR and was used in over 40 products: pharmaceuticals (including injectables), cosmetics, food supplements. After some clinical trials (1980) PELL AMAR products were used for treating ailments such as rheumatoid polyarthritis, ankylosing spondylitis, cervical, dorsal, lumbar vertebro-peripheral osteoarthritis, gonarthrosis, coxarthrosis, scapulo-humeral periarthritis, tendonitis, synovitis, bursitis, sprains, bruises, dislocations, contusions, psoriasis and localized scleroderma, burns.

After 1990 the products disappeared from the market, at the same time with their production infrastructure, and with the legislative changes which cancelled the old authorizations. In 2010, the products reappeared with the establishment of SC PELL AMAR COSMETICS SRL, which in the last 3 years has demonstrated that the sapropelic mud extract can successfully cope with the technical and commercial demands of the cosmetics market.

This project aims to increase the quality and competitiveness of PELL AMAR - COSMETICS range, which are already produced and initiate a new category of PELL AMAR – PHARMA range, by significant changes in the technology, base product and derived products and also by upgrading the approach of production, verification and control process,.

The basic ideas are:

• Upgrading the technology by:

1) replacing the atomization concentration with the lyophilisation concentration;

2) introducing a new stage of irradiation treatment of the lyophilized extract;

• Upgrading and improving the base product - microbial sapropelic mud extract, because both elements of technology modernisation will have consequences in product upgrading.

• Introducing regulatory elements that improve the Quality Management System of SC PELL AMAR: standardizing the solid extract and establishing a set of physical, chemical, biological tests that unequivocally characterize the product, by following the model in the European Pharmacopoeia and thus facilitating the authorization of the products in the pharmaceutical range.

• Establishing and demonstrating the manufacturing technology on its range of derived products:

- Cosmetics (biotrophic effect, regenerating, sedative);

- Food supplements (boost immunity, relieve rheumatic pain)

• Demonstrating the therapeutic effect of a product with topical application (ointment in rheumatic diseases) and initiating the studies necessary to the documentation for changing its categorization from cosmetics to pharmaceuticals.

The dissemination of the project results will be one of the tasks of all members of the partnership. It will be focused on two target groups: a) persons and institutions having specialized technical & scientific knowledge - scientific articles, patents, national seminar, project’s site; here the focus will be on the technical & scientific results); b) the general public - articles, interviews in the media, brochures, newsletters, movies, showrooms; here the focus will be on improving the quality of life).

The consortium partners have been chosen according to three criteria: competence, complementarity and cohesion. Competence is proven by certification, accreditation, licensing.

Complementarity is needed for solving all the problems that the project will be facing, and cohesion is based on the previous relationships between the partners.

Project coordination is undertaken by the economic partner and the project director, an economist, is also the general manager of the economic partner.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects